Search Results - Ophthalmology Glaucoma ( 2024-10)

Ophthalmology Glaucoma, Elsevier BV, ( 2024-10)

Online Resource

2589-4196

English

Elsevier BV

2024

2945344-6

JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga, Universitas Airlangga, Vol. 15, No. 1 ( 2024-01-10), p. 41-43

Highlights: POAG is a common type of glaucoma. POAG patients were predominantly 〉 60 years old, with males being more dominant than females.   Abstract Introduction: Primary open-angle glaucoma (POAG) is a progressive, chronic optic neuropathy characterized by distinct optic nerve atrophy and impairment of the visual field. The purpose of this study was to describe the characteristics of primary open-angle glaucoma patients in the ophthalmology outpatient clinic of Dr. Soetomo General Academic Hospital, Surabaya, in 2013–2015.  Methods: This was a descriptive-retrospective study. Samples were patients with a primary open-angle glaucoma (POAG) diagnosis in the ophthalmology outpatient clinic at Dr. Soetomo General Academic Hospital, Surabaya, in 2013–2015. Results: There were 88 samples of POAG patients in the ophthalmology outpatient clinic at Dr. Soetomo General Academic Hospital, Surabaya, in 2013–2015. POAG was dominated in the age group 60–69 years old, with a percentage of 37.50%. Males were more dominant than females, with a percentage of 55.70%. Many POAG patients were unemployed, with a percentage of 56.82%. Most patients with POAG did not have a history of hypertension or diabetes mellitus, with a percentage of 73.86%. Patients who had a history of hypertension were 11.36%, those with diabetes mellitus were 9.09%, and those who had a history of both hypertension and diabetes mellitus were 5.68%. Conclusion: POAG was a higher risk in older adults, with males being more dominant than females. Most patients did not have a history of either hypertension or diabetes mellitus.

Online Resource

2684-9453, 1907-3623

Undetermined

Universitas Airlangga

2024

3138418-3

Delta Journal of Ophthalmology, Medknow, Vol. 25, No. 4 ( 2024-10), p. 210-218

There has been increasing interest in investigating the role of the choroid in the pathogenesis of glaucomatous optic neuropathy. While measurement of the choroidal thickness (CT) by spectral domain optical coherence tomography (SD-OCT) would be an attractive add in the diagnosis and monitoring tools in glaucoma, the potential role of CT as a risk factor requires further investigation. Objective The aim of this study was to correlate between the subfoveal choroidal thickness (SFCT) and optic nerve head changes using SD-OCT in cases of primary open-angle glaucoma (POAG). Patients and methods This is a cross-sectional observational case–control study. It included 82 eyes: 42 eyes of 23 POAG patients and 40 eyes of 20 normal controls. Measurement of the SFCT, retinal nerve fiber layer (RNFL), and ganglion cell complex (GCC) thickness was done using SD-OCT at the Investigative and Laser Unit of the Ophthalmology Department of Fayoum University Hospital and Giza Memorial Institute of Ophthalmic Research from September 2019 to February 2022. Results The SFCT was statistically significantly less the POAG patients than in normal eyes ( P 〈 0.0001), with a cut-off value of SFCT less than or equal to 316 μm (sensitivity=95% and specificity=83%). There was a statistically insignificant difference between CT and average RNFL thickness ( r =0.040, P =0.802) and insignificant weak negative correlation between the SFCT and average GCC thickness ( r =−0.027, P =0.863). Conclusion The SFCT was significantly less in the POAG eyes than in normal eyes, with a cut-off value of SFCT less than or equal to 316 μm, with an insignificant difference between CT and average RNFL thickness and average GCC thickness in the glaucoma group indicating a negative correlation between CT and glaucoma severity.

Online Resource

1110-9173

English

Medknow

2024

2987748-9

The Open Ophthalmology Journal, Bentham Science Publishers Ltd., Vol. 18, No. 1 ( 2024-10-01)

Cyclodestructive laser technology has been developed with the aim of achieving a greater reduction in Intraocular Pressure (IOP) with minimal complication. Micropulse transscleral cyclophotocoagulation (MP-TSCPC) and slow-coagulation continuous-wave transscleral cyclophotocoagulation (SC-TSCPC) are considered to have less complications than conventional techniques using continuous-wave transscleral cyclophotocoagulation. Purpose To compare IOP reduction and complications in refractory glaucoma after SC-TSCPC and MP-TSCPC procedures. Methods This study is a prospective interventional study in refractory glaucoma patients. Measurement of IOP using Goldmann applanation tonometry was performed preoperatively, and all patients were monitored at days 1, 7, and 30 in the postoperative period. Success was defined as postoperative IOP reduction of 〉 20% from baseline with or without glaucoma medication. Complications were identified by evaluating subjective complaints and slit lamp examination. Results The study included a total of 66 eyes, with 33 eyes in each group. Baseline IOP was 50.58 ± 9.937 mmHg and 48.45 ± 12.792 mmHg in SC-TSCPC and MP-TSCPC group, respectively. The mean IOP reduction was 27.44 ± 19.96% vs 14.39 ± 23.52% (p=0.018) in day 1, 46.19 ± 27, 7 3% vs 45.83 ± 24,80% (p=0,956) in day 7 and 46.49 ± 24.63% vs 27.09 ± 23.86% in day 30 (p=0.002), in SC-TSCPC and MP-TSCPC group respectively. Complications between groups were not significantly different. However, hypotonia (IOP 〈 6 mmHg) was found in the SC-TSCPC group. Conclusion SC-TSCPC showed greater IOP reduction than MP-TSCPC, with no significant differences in complications between the two groups.

Online Resource

1874-3641

English

Bentham Science Publishers Ltd.

2024

2395991-5

Biomedicines, MDPI AG, Vol. 12, No. 10 ( 2024-09-27), p. 2212-

Background/Objectives: Recent prospective studies have shown that selective laser tra-beculoplasty (SLT) is a safe and cost-effective alternative to pressure-reducing eye drop therapy as a first-line treatment for ocular hypertension or open-angle glaucoma. In addition to its comparable efficacy to eye drop therapy, SLT has been particularly effective in delaying the time until a surgical intervention is needed. The aim of our evaluation is to analyze patients who have received SLT following a pressure-reducing procedure. The primary endpoint is the duration until a subsequent interventional or surgical procedure is required. Methods: A retrospective analysis of 98 patients who underwent selective laser trabeculoplasty following a previous pressure-reducing procedure between 2017 and 2023. The statistical analyses included Cox regression and Kaplan–Meier survival estimations. Results: In total, 122 eyes of 98 patients received selective laser trabeculoplasty following a previous pressure-reducing procedure at the Department of Ophthalmology in Freiburg. The median follow-up period was 381.5 days (range 43.25–862.75 days). Approximately 68% of the eyes did not require another pressure-reducing procedure 365 days after the intervention, while about 58% of the eyes remained without another procedure after 730 days, according to Kaplan–Meier analysis. No significant difference was found between the different types of glaucoma regarding the duration until a subsequent pressure-reducing procedure was needed. The study indicated a tendency for patients with pseudoexfoliation glaucoma to undergo a secondary intervention earlier compared to those with primary open-angle glaucoma (p = 0.16). The intraocular pressure before SLT had a significant impact on the duration until the subsequent operation (p = 0.005). Conclusions: SLT is an effective method even after a previous pressure-reducing procedure for patients in whom further pressure-reducing interventions need to be delayed.

Online Resource

2227-9059

English

MDPI AG

2024

2720867-9

Pakistan Journal of Ophthalmology, Ophthalmological Society of Pakistan, Vol. 40, No. 4 ( 2024-10-01)

The prevalence of glaucoma in Pakistan, as in many developing countries, poses a significant challenge to the healthcare system. Globally, glaucoma is the second leading cause of blindness, affecting millions, often progressing

Online Resource

2789-4347, 0886-3067

Undetermined

Ophthalmological Society of Pakistan

2024

2568101-1

Turkish Journal of Ophthalmology, Galenos Yayinevi, Vol. 54, No. 5 ( 2024-10-25), p. 257-262

Online Resource

1300-0659, 2147-2661

Undetermined

Galenos Yayinevi

2024

2586160-8

Clinical Ophthalmology, Informa UK Limited, Vol. Volume 18 ( 2024-10), p. 3009-3015

Online Resource

1177-5483

English

Informa UK Limited

2024

2415713-2

Graefe's Archive for Clinical and Experimental Ophthalmology, Springer Science and Business Media LLC

To investigate the risk factors for intraocular pressure (IOP) elevation in eyes with intraocular lens (IOL) subluxation or dislocation. Methods We retrospectively examined the eyes with IOL displacement (either IOL subluxation or IOL dislocation) who underwent IOL refixation combined with vitrectomy between September 1, 2012, and May 31, 2024, at Fukui University Hospital. Patients were divided into two groups: those with IOL subluxation and those with IOL dislocation. Additionally, subgroups were created for eyes without glaucoma and those without both glaucoma and exfoliation syndrome. IOL subluxation was defined as the movement of the IOL–capsular bag complex in the posterior chamber, while IOL dislocation was defined as a fall of the IOL–capsular bag complex into the vitreous space. Risk factors for preoperative IOP elevation in eyes with IOL displacement were identified using multivariate analysis with a multiple linear regression model. Results This study included 155 eyes with IOL displacement (IOL subluxation; 73 eyes and IOL dislocation; 82 eyes). Multivariate analyses revealed that IOL subluxation and the number of glaucoma medications were significantly associated with a higher preoperative IOP ( P 〈 0.01). The preoperative IOP and the number of glaucoma medications were significantly higher in the IOL subluxation group than in the IOL dislocation group (22.7 ± 9.0 vs. 15.5 ± 3.9 mmHg, P 〈 0.01, and 1.2 ± 1.7 vs. 0.2 ± 0.8, P 〈 0.01, respectively). The number of patients with exfoliation syndrome and glaucoma was significantly higher in the IOL subluxation group than in the IOL dislocation group (49% vs. 10%, P 〈 0.01, and 25% vs. 7%, P 〈 0.01, respectively). In the subgroup analysis in eyes without glaucoma (131 eyes), IOL subluxation and the number of glaucoma medications were significantly associated with a higher preoperative IOP ( P 〈 0.01). In this subgroup, the preoperative IOP and the number of glaucoma medications were significantly higher in the IOL subluxation group than in the IOL dislocation group (20.6 ± 8.5 vs. 15.5 ± 3.9 mmHg, P 〈 0.01, and 0.4 ± 1.0 vs. 0.04 ± 0.3, P 〈 0.01, respectively), and the incidence of exfoliation syndrome was significantly higher in the IOL subluxation group than in the IOL dislocation group (40% vs. 8%, P 〈 0.01). In another subgroup analysis in eyes without glaucoma and exfoliation syndrome (103 eyes), IOL subluxation and the number of glaucoma medications were significantly associated with a higher preoperative IOP ( P 〈 0.01). In this subgroup, the preoperative IOP and the number of glaucoma medications were significantly higher in the IOL subluxation group than in the IOL dislocation group (19.3 ± 7.3 vs. 15.7 ± 4.0 mmHg, P = 0.049, and 0.3 ± 0.9 vs. 0.0 ± 0.0, P 〈 0.01, respectively). Conclusions IOL subluxation, but not dislocation, is a risk factor for elevated IOP in eyes with IOL displacement.

Online Resource

0721-832X, 1435-702X

English

Springer Science and Business Media LLC

2025

1459159-5

Korean Journal of Ophthalmology, Korean Ophthalmological Society, Vol. 38, No. 5 ( 2024-10-05), p. 342-353

Purpose: To compare changes in the swept-source (SS) anterior-segment optical coherence tomography (AS-OCT) parameters and intraocular pressure (IOP) control after lens extraction in various spectra of primary angle-closure disease (PACD).Methods: A total 92 eyes from 92 patients with PACD who underwent lens extraction were included in the study. All patients underwent IOP measurement preoperatively and at 1 day, 1 week, and 1, 3, and 6 months postoperatively. SS AS-OCT was performed in all subjects preoperatively and 1 month postoperatively. All participants were divided into two groups depending on the presence of glaucomatous optic disc or visual field damage (group A, PAC suspect or PAC; group B, PAC glaucoma). The changes in IOP and anterior chamber angle parameters of SS AS-OCT of each group were compared. Regression analysis was performed to find factors associated with the degree of IOP reduction after lens extraction.Results: Preoperatively, there was no significant difference in IOP between the two groups (16.3 ± 2.5 mmHg vs. 16.9 ± 3.2 mmHg, p = 0.297), but the number of glaucoma medications used was greater in group B (0.6 ± 1.0 vs. 2.0 ± 0.9, p 〈 0.001). Postoperatively, IOP was not significantly different, but the number of medications used was greater in group B (0.2 ± 0.7 vs. 0.9 ± 0.8, p 〈 0.001). Anterior chamber angle parameters including angle opening distance and trabecular-iris angle had a greater increase in group B after lens extraction. However, the residual iridotrabecular contact (ITC) index was significantly greater in group B (5.6 ± 7.0 vs 10.7 ± 12.1, p = 0.014). A greater change in the ITC index was related to a greater degree of IOP reduction (β coefficient, 0.429; p 〈 0.001).Conclusions: Eyes with PAC glaucoma had a greater residual ITC index after lens extraction compared with eyes of other PACD spectrum and required a greater number of glaucoma medications to maintain a similar level of IOP.

Online Resource

1011-8942, 2092-9382

English

Korean Ophthalmological Society

2024

2539835-0

Frontiers in Medicine, Frontiers Media SA, Vol. 11 ( 2024-10-15)

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple systems and classified under connective tissue disorders. Ocular involvement occurs in up to 30% of SLE cases, with the cornea being particularly susceptible to thinning due to immune-complex deposits and its predominantly type I collagen composition. This corneal thinning is clinically significant in glaucoma, where patients with reduced central corneal thickness (CCT) may have up to a threefold increased risk of developing glaucoma, as well as in refractive surgery. However, existing studies on CCT in SLE are limited and marked by substantial heterogeneity in methodology, technology, criteria, and participant numbers, resulting in conflicting findings. Based in our hypothesis that SLE-related corneal lysis may result in decreased CCT, this study aims to determine and compare the mean CCT values between SLE patients and healthy controls to obtain a more precise understanding of the potential relationship. Methods and analysis A cross-sectional observational study will be conducted, enrolling SLE patients and age-and sex-matched healthy controls recruited from ophthalmology consultations. Exclusion criteria will be applied to rule out other corneal thinning risk factors. A pilot study estimated a minimum sample size of 34 participants per group. CCT measurements will be obtained using Zeiss HD Cirrus 5,000 optical coherence tomography (OCT) on a randomly selected eye, following concordance analysis using the Kappa index. Statistical analysis will include descriptive, bivariate, and multivariate methods. The study protocol was approved by the ethics committee. Discussion The cornea’s vulnerability to thinning and lysis in SLE, which impacts CCT, is crucial for the accurate assessment of glaucoma, the leading cause of irreversible blindness worldwide and the second leading cause in Europe. Given that patients with reduced CCT are at a significantly higher risk of developing glaucoma, further research is necessary to understand the association between SLE and CCT. Our study aims to enhance methodological rigor compared to prior research by determining an appropriate sample size and exclusively enrolling SLE patients to increase participant homogeneity. If a significant difference in CCT between groups and an association between CCT and SLE are found, a prospective study will be considered.

Online Resource

2296-858X

Undetermined

Frontiers Media SA

2024

2775999-4

Taiwan Journal of Ophthalmology, Ovid Technologies (Wolters Kluwer Health), Vol. 14, No. 4 ( 2024-10), p. 602-608

The aim of this study is to describe genotype and phenotype of patients with bestrophinopathy. The case records were reviewed retrospectively, findings of multimodal imaging such as color fundus photograph, optical coherence tomography (OCT), fundus autofluorescence, electrophysiological, and genetic tests were noted. Twelve eyes of six patients from distinct Indian families with molecular diagnosis were enrolled. Exon 4 of BEST1 was mutated in 3 cases, while exons 2, 3, and 7 in others. Deletion is seen in Exon 7 and missense mutation in other exons. Sporadic autosomal dominant and recessive inheritance was observed in these families. Two patients had primary angle closure glaucoma with a history of consanguineous marriage and glaucoma in the family. Based on our findings, multifocal vitelliform subretinal deposits were the most common fundus finding in patients with autosomal recessive mutation while macular vitelliform lesion was seen with sporadic or autosomal dominant mutation; however, cosegregation analysis was not done. Baseline OCT showed macular and extramacular subretinal exudates, subretinal fluid, intraretinal cystic and schitic spaces, and thickened photoreceptors outer segment tips. Two patients developed abnormal vasculature and focal choroidal excavation in OCT. A severe reduction in the electro-oculogram Ardens ratio was noted while electroretinography was normal. Bestrophinopathy has a varied presentation with complex genotype-phenotype relationships. OCT is a noninvasive tool for monitoring and prognostication. Genetic testing of other family members should be facilitated.

Online Resource

2211-5056, 2211-5072

English

Ovid Technologies (Wolters Kluwer Health)

2024

2652841-1

Journal of the Pakistan Medical Association, Pakistan Medical Association, Vol. 74, No. 11 ( 2024-10-16), p. 1977-1981

Objective: To compare the complications related to silicone oil, and anatomical and functional outcomes in patients nursed in different postoperative positionings after pars plana vitrectomy with silicone oil injection in retinal surgery. Method: The retrospective cohort study was conducted at the Department of Ophthalmology, King AbdulAziz Medical City, Riyadh, Saudi Arabia, and comprised data of patients who underwent pars plana vitrectomy with silicone oil tamponade from January 2016 to October 2022. The patients were divided into two groups depending on how they were nursed in the postoperative period. Group A patients were nursed in postoperative face-down positioning and group B patients were nursed in the face-up position. Complications related to silicone oil tamponade, visual outcomes and anatomical results were compared between the groups. Data was analyzed using SPSS 26. Results: Of the 157, 97(62%) were males and 60(38%) were females. The overall mean age was 53±20 years. Group A had 87(55.4%) patients, while group B had 70(44.6%). There were 185 eyes involved; 104(56.2%) in group A and 81(43.8%) in group B. Overall, mean postoperative follow-up duration was 25±19 months. Migration of silicone oil in the anterior chamber was more common in group A (p=0.470). Pupil block glaucoma was seen in 2(1.9%) eyes in group A only.Silicone oil-related complications, functional outcomes and anatomical outcomes were non-significantly different between the grpups (p 〉 0.05) except a weak significant difference with respect to redetachments after removal of silicone oil (p=0.047). Conclusion: There was no difference seen in terms of complications as well as anatomical and physiological outcomes related to silicone oil tamponade in face-down or face-up postoperative positioning after pars plana vitrectomy with silicone oil tamponade for complicated retinal detachment surgery. Key Words: Silicone oil, Face-down positioning, Macular folds, Epiretinal membranes, Pblock glaucoma, Silicone oil in anterior chamber.

Online Resource

0030-9982

Undetermined

Pakistan Medical Association

2024

2128872-0