Search Results - (Author, Cooperation:the Handan Eye Study Group)

Clinical & Experimental Ophthalmology, Wiley, Vol. 46, No. 8 ( 2018-11), p. 873-881

Provision of refractive changes is important to predict eye care needs for aging population. Background To provide 5‐year refractive changes in a rural Chinese adult population. Design Population‐based longitudinal study. Participants At baseline, 6830 subjects aged 30+ years took part in the Handan Eye Study. A total of 5394 of the 6323 survivors (85.3%) participated in the 5‐year follow‐up. Methods Ocular examinations including standardized refraction were performed according to the same protocol at both baseline and follow‐up. Main Outcome Measures Change in spherical equivalent (SE; sphere + 1/2 cylinder) and astigmatism. Results A total of 3970 right eyes were available for refraction analysis. The 5‐year change in SE for all subjects was +0.17 diopters (D), and was −0.21D, +0.14D, +0.40D and +0.08D for subjects aged 30–39, 40–49, 50–59, and 60–69 years, respectively. By binary regression analysis, myopic shift was associated with severe nuclear opacity, longer axil length, diabetes and large change of lens power, while hyperopic shift was associated with older age and ocular hypertension at baseline. There was a mean change of 0.18D in the against‐the‐rule astigmatism. Conclusions and Relevance There was a myopic shift for those 30–39 years old and a hyperopic shift from 40 to 69 years old in a rural Chinese adult population. Those with severe nuclear opacity, longer axil length, diabetes and large change of lens power tended to have a myopic shift, while those being older and having ocular hypertension at baseline were prone to have a hyperopic shift. There was also an increase in against‐the‐rule astigmatism in this population.

Online Resource

1442-6404, 1442-9071

English

Wiley

2018

2094910-8

Acta Ophthalmologica, Wiley, Vol. 101, No. 1 ( 2023-02)

To determine the 5‐year incidence of primary glaucoma and its associated risk factors in rural northern China. Methods Population‐based cohort study. A total of 5184 participants aged 30 years and older, without glaucoma at baseline, were subjected to comprehensive standardized interviews and ophthalmic and systemic examinations at baseline and after a 5‐year interval in the Handan Eye Study. Incident glaucoma was diagnosed by a consensus panel of five senior glaucoma specialists. Univariate and multivariable logistic regression analyses were performed to identify the baseline risk factors that could predict the incidence of glaucoma. Results During the 5‐year follow‐up, incident primary glaucoma developed in 82 subjects (1.6%; 95% confidence interval [CI], 1.2%–1.9%). The age‐ and gender‐standardized incidence of glaucoma among subjects ≥40 years old was 2.1% (0.4% annually), calculated according to the 2010 Chinese census. A higher age (odds ratio [OR] , 1.06; 95% CI, 1.04–1.09; p  〈  0.001), higher intraocular pressure (IOP) (OR, 1.11; 95% CI, 1.02–1.20; p =  0.017), and vertical cup disc ratio (VCDR) ≥ 0.60 (OR, 5.30; 95% CI, 3.22–8.73; p  〈  0.001) were found to be associated with an increased risk of incident glaucoma. For each year, older age and each mmHg higher IOP, the risks of primary glaucoma increased by 1.2% and 2.0% per year, respectively. Conclusion We reported the 5‐year incidence of primary glaucoma in a rural Chinese population and found that older age, higher IOP, and VCDR ≥ 0.60 at baseline could help in identifying those at highest risk of disease development.

Online Resource

1755-375X, 1755-3768

English

Wiley

2023

2466981-7

Acta Ophthalmologica, Wiley, Vol. 89, No. 4 ( 2011-06), p. e336-e343

Online Resource

1755-375X

English

Wiley

2011

2466981-7

Translational Vision Science & Technology, Association for Research in Vision and Ophthalmology (ARVO), Vol. 10, No. 8 ( 2021-07-28), p. 25-

Online Resource

2164-2591

English

Association for Research in Vision and Ophthalmology (ARVO)

2021

2674602-5

Ophthalmic and Physiological Optics, Wiley, Vol. 38, No. 3 ( 2018-05), p. 337-345

To determine the cumulative five‐year incidence and progression of myopic maculopathy in a rural Chinese adult population. Methods The Handan Eye Study was a population‐based longitudinal study. In 2006, 6830 subjects aged 30+ years participated in this study (baseline). Five years later, 5394 subjects (follow‐up rate: 85.3%) took part in the follow‐up study. Participants had a detailed eye examination, including visual acuity, standardized refraction and fundus photography according to a similar protocol at both baseline and follow‐up. Myopic maculopathy was defined as any of the following signs: diffuse chorioretinal atrophy, patchy chorioretinal atrophy, macular atrophy, lacquer cracks and myopic choroidal neovascularization at the posterior pole. Parapapillary atrophy was assessed separately. Results Of 5394 participants, 5078 (10 021 eyes) had gradable fundus photographs. Over the five years, four participants (five eyes) developed new myopic maculopathy, with an eye‐specific incidence of 0.05% (95% CI , 0.02–0.10%). Among the 51 eyes with myopic maculopathy at baseline, the progression occurred in 18 eyes (35.3%), with new signs of patchy chorioretinal atrophy in 11 eyes (21.6%), diffuse chorioretinal atrophy in seven eyes (13.7%), lacquer cracks in three eyes (6.9%), macular atrophy in three eyes (6.9%) and myopic choroidal neovascularization in two eyes (3.9%). By multivariable analysis, female gender ( OR , 9.14; p  =   0.004) and higher educational level ( OR , 8.24; p  =   0.004) were associated with a higher risk of progression of myopic maculopathy, whereas lower myopia at baseline ( OR , 0.79; p  〈   0.0001) and hypertension ( OR , 0.21; p  =   0.017) were associated with a reduced risk. Conclusions The five‐year incidence of myopic maculopathy was 0.05% in rural Chinese adults aged 30+ years. The progression rate in participants with myopic maculopathy was 35.3%, indicating the importance of regular follow‐up for these patients.

Online Resource

0275-5408, 1475-1313

English

Wiley

2018

2008422-5

Ophthalmic Epidemiology, Informa UK Limited, Vol. 16, No. 2 ( 2009-01), p. 115-127

Online Resource

0928-6586, 1744-5086

English

Informa UK Limited

2009

1483138-7

Graefe's Archive for Clinical and Experimental Ophthalmology, Springer Science and Business Media LLC, Vol. 259, No. 11 ( 2021-11), p. 3501-3509

Online Resource

0721-832X, 1435-702X

English

Springer Science and Business Media LLC

2021

1459159-5

Graefe's Archive for Clinical and Experimental Ophthalmology, Springer Science and Business Media LLC, Vol. 261, No. 1 ( 2023-01), p. 201-211

Online Resource

0721-832X, 1435-702X

English

Springer Science and Business Media LLC

2023

1459159-5

Clinical & Experimental Ophthalmology, Wiley, Vol. 46, No. 4 ( 2018-05), p. 389-399

The data may support the notion that the intra‐ocular pressure (IOP)‐related factors and vascular factors were implicated concurrently in glaucomatous optic nerve damage. Background To study the association of intraocular pressure (IOP)‐related factors, IOP, trans‐lamina cribrosa pressure difference (TLCPD), cerebrospinal fluid pressure (CSFP) and retinal vessel diameters (RVD), central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE) with neuro‐retinal rim area (RA). Design A population‐based, cross‐sectional study. Participants A total of 6830 people aged 30 years and over. Methods All participants underwent a comprehensive eye examination, fundus photograph‐based measurements of RVD and Heidelberg retinal tomogram (HRT) measurement of optic disc. Main Outcome Measures RA, CRAE, CRVE, IOP, body mass index (BMI), CSFP and TLCPD. Results Primary open‐angle glaucoma (POAG) was diagnosed using two separate methods: 67 from expert consensus, and 125 from the International Society of Geographical and Epidemiologic Ophthalmology (ISGEO) classification. After excluding of those with high myopia or without gradable HRT images, 4194 non‐glaucoma and 40 POAG were analysed for determinants of RA. On multivariable analysis determinants of reduced RA were POAG ( P   〈  0.001), higher IOP ( P  = 0.03), higher refractive error ( P   〈  0.01), longer axial length ( P  = 0.01), CRVE ( P   〈  0.001), lower BMI ( P  = 0.015), older age ( P   〈  0.001) smaller disc area ( P   〈  0.001) and higher TLCPD ( P  = 0.03). When age and/or BMI were omitted from the model, reduced RA was also associated with lower CSFP ( P   〈  0.001). Conclusions and Relevance Reduced RA is associated with narrow CRVE and higher IOP or lower CSFP. The data supports the concurrent role of IOP‐related and vascular factors in glaucomatous optic nerve damage.

Online Resource

1442-6404, 1442-9071

English

Wiley

2018

2094910-8