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1Articles: DFG German National LicensesStaff View
ISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] Speaking at the XIIIth World AIDS Conference in Durban last month, Oxford University immunologist, Andrew McMichael announced the approval for human testing of a DNA/modified vaccinia virus prime boost HIV vaccine he is developing in conjunction with the University of Nairobi in Kenya. ... A ...Type of Medium: Electronic ResourceURL: -
2Articles: DFG German National LicensesStaff View
ISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] Bioethicists meeting in Brussels to discuss human stem cell research, the source of stem cell material, European regulations and patent control of the field, have been urged to take a “cautious middle ground,” particularly on such controversial aspects as the therapeutic cloning of ...Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] In the week that the completion of the working draft of the human genome was jointly announced by political leaders in the United States and Britain, Australia became the first nation to sign a deal with the Celera Genomics Corporation to provide the country's publicly funded researchers with ...Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] Unicellular organisms, human cells and mice have provided insights into the processes of senescence, crisis, genomic instability and cancer in humans. Here, Artandi and DePinho discuss how studies in mice have uncovered a complex interplay between the ARF-p53 pathway, genomic instability due to ...Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] After abandoning plans to establish its own Ph.D.-granting program (Nature Med. 5, 1098; 1999), the US National Institutes of Health (NIH) will increase the number of graduate students undertaking doctoral research and working under university partnerships in its laboratories. NIH will finance the ...Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] CHAGAS DISEASE is a debilitating condition that has a considerable impact on public health in Latin America. Disease pathology seems to be predominantly a consequence of interactions between the causative agent, the protozoan Trypanosoma cruzi, and the host immune system. In infected ...Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] HUMAN CYTOMEGALOVIRUS (HCMV) is the largest of the known herpesviruses, with a genome of over 235 kb and more than 200 potential open reading frames. It is a widespread opportunistic pathogen that causes no obvious clinical manifestation in healthy individuals. On the other hand, it is a leading ...Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesReina-San-Martín, Bernardo ; Degrave, Wim ; Rougeot, Catherine ; Cosson, Alain ; Chamond, Nathalie ; Cordeiro-da-Silva, Anabela ; Arala-Chaves, Mario ; Coutinho, Antonio ; Minoprio, Paola
[s.l.] : Nature America Inc.
Published 2000Staff ViewISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] Lymphocyte polyclonal activation is a generalized mechanism of immune evasion among pathogens. In a mouse model of Trypanosoma cruzi infection (American trypanosomiasis), reduced levels of polyclonal lymphocyte responses correlate with resistance to infection and cardiopathy. We report here the ...Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesTakita, Masatoshi ; Imamura, Toru ; Inoue, Koutarou ; Ikemoto, Mitsushi
[s.l.] : Nature America Inc.
Published 2000Staff ViewISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] Repeated administration of morphine substantially increases its locomotor-enhancing activity, a phenomenon termed locomotor sensitization. Here we show that secreted protein acidic and rich in cysteine (SPARC), an anti-adhesive glycoprotein present in the basolateral amygdala, contributes to the ...Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesGerdts, Volker ; Babiuk, Lorne A. ; van Drunen Littel-van den Hurk, Sylvia ; Griebel, Philip J.
[s.l.] : Nature America Inc.
Published 2000Staff ViewISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] Infectious diseases are the main cause of neonatal morbidity and mortality in humans. The World Health Organization estimated that in 1995 approximately 8 million infants died within the first year of life from infectious diseases, including 5 million during the first week of life. Some of the ...Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesYu, Yajing ; Annala, Alexander J. ; Barrio, Jorge R. ; Toyokuni, Tatsushi ; Satyamurthy, Nagichettiar ; Namavari, Mohammad ; Cherry, Simon R. ; Phelps, Michael E. ; Herschman, Harvey R. ; Gambhir, Sanjiv S.
[s.l.] : Nature America Inc.
Published 2000Staff ViewISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] At present, most methods to image gene expression in rodents, nonhuman primates and humans are limited to the use of fixed tissue obtained from biopsy or after death. Fixed tissue can be assayed for mRNA levels or a protein product using well-established techniques. Reporter genes sensitive to ...Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesSun, Yao-Hui ; Bakshi, Sharmila ; Chalmers, Ronald ; Tang, Christoph M.
[s.l.] : Nature America Inc.
Published 2000Staff ViewISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] The pathogenic bacterium Neisseria meningitidis is an important cause of septicemia and meningitis, especially in childhood. The establishment and maintenance of bacteremic infection is a pre-requisite for all the pathological sequelae of meningococcal infection. To further understand the ...Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesAmagai, M. ; Matsuyoshi, N. ; Wang, Z. H. ; Andl, C. ; Stanley, J. R.
[s.l.] : Nature America Inc.
Published 2000Staff ViewISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] Exfoliative toxin A, produced by Staphylococcus aureus, causes blisters in bullous impetigo and its more generalized form, staphylococcal scalded-skin syndrome. The toxin shows exquisite specificity in causing loss of cell adhesion only in the superficial epidermis. Although exfoliative toxin A ...Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] Genetic research is increasingly turning to studies of sequence variation in genes encoding proteins of known structure and function. The principal question in these studies is whether sequence variation affects protein structure or function, and, for certain genes, whether sequence variation ...Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesKessler, Benedikt M. ; Lennon-Duménil, Ana-Maria ; Shinohara, Mari L. ; Lipes, Myra A. ; Ploegh, Hidde L.
[s.l.] : Nature America Inc.
Published 2000Staff ViewISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] To the Editor The non-obese diabetic (NOD) mouse is an established and widely used model of autoimmune type I diabetes. Besides the involvement of class II-and class I-restricted T cells, additional major histocompatibility complex (MHC) and non-MHC-linked genetic factors contribute to disease ...Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] Having won a small victory in being allowed to experiment on already derived human embryonic stem cells, or human pluripotent stem cells (hPSCs), using government money, US-based scientists are now beginning another battle that would place them on par with their UK counterparts. They are seeking ...Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] Regulations being introduced by the US Food and Drug Administration (FDA) should take the guesswork out of prescribing medicines for children.... From 2 December this year, all new drug applications submitted to the agency must include pediatric study reports—assessment of the safety and ...Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] Sadly, it has taken the suicide of prominent Argentinean surgeon Rene Favaloro to provoke the country's government into preventing bankruptcy at his cardiovascular research foundation, which also provides health care to 700 indigents every year.... The republic's president, Fernando de la Rua, has ...Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] After failing to make any notable investment in genomics research for the past five years, the Italian government is proposing a ‘catch-up’ plan. IL270 billion (US$135 million) is to be dedicated to genomics through a project called IPERGEN, which will fund 6 leading centers and ...Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesHershko, Avram ; Ciechanover, Aaron ; Varshavsky, Alexander
[s.l.] : Nature America Inc.
Published 2000Staff ViewISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] Ubiquitin-mediated protein degradation: The early days Avram Hershko It has been often stated that until recently the ubiquitin system was thought to be mainly a ‘garbage disposal’ for the removal of abnormal or damaged proteins. This statement is certainly not true for those who have ...Type of Medium: Electronic ResourceURL: