Search Results - (Author, Cooperation:Y. Nishimura)

2018-01-24

Wiley-Blackwell

0094-8276

1944-8007

Geosciences

Physics

2018-03-13

Wiley-Blackwell

0148-0227

Geosciences

Physics

2013-05-11

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Animals ; Antibodies, Neutralizing/blood/*immunology ; Epitope Mapping ; HIV Antibodies/blood/*immunology ; HIV Infections/blood/*immunology ; HIV-1/*immunology/isolation & purification ; Humans ; Immunodominant Epitopes/chemistry/immunology ; Macaca ; Neutralization Tests ; Protein Conformation ; Serum/immunology

2014-07-26

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Animals ; Cell Cycle Proteins/genetics/*metabolism ; Cell Nucleus/genetics ; Cerebellum/*metabolism/pathology ; GTP-Binding Proteins/genetics/*metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Microfilament Proteins/genetics/*metabolism ; Neurodegenerative Diseases/*genetics ; Point Mutation ; Protein Biosynthesis/*genetics ; RNA Splice Sites/genetics ; RNA, Transfer, Arg/*genetics ; Ribosomes/*metabolism

2015-10-03

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Animals ; Fingers/innervation/physiopathology ; *Functional Laterality ; GABA-A Receptor Agonists/administration & dosage/pharmacology ; Macaca ; Motivation ; *Motor Skills ; Movement ; Muscimol/administration & dosage/pharmacology ; Nucleus Accumbens/*physiopathology ; *Recovery of Function ; Sensorimotor Cortex/drug effects/physiopathology ; Spinal Cord Injuries/*physiopathology/*psychology

2018-12-11

Institute of Physics (IOP)

1757-8981

1757-899X

Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

2016-04-28

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

AIDS Vaccines/administration & dosage/immunology ; Animals ; Antibodies, Monoclonal/administration & dosage/blood/genetics/immunology ; Antibodies, Neutralizing/administration & dosage/blood/genetics/immunology ; Female ; HIV Antibodies/*administration & dosage/blood/genetics/*immunology ; HIV Infections/immunology/prevention & control/transmission ; Half-Life ; Immunoglobulin Fc Fragments/chemistry/genetics/immunology ; Macaca mulatta/immunology/virology ; Male ; Mutation/genetics ; Protein Structure, Tertiary ; SAIDS Vaccines/administration & dosage/immunology ; Simian Acquired Immunodeficiency Syndrome/blood/*immunology/*prevention & control ; Simian Immunodeficiency Virus/*immunology ; Time Factors

2013-11-01

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Antibodies, Neutralizing/*therapeutic use ; Antigens, CD4/metabolism ; Binding Sites/immunology ; HIV Antibodies/*therapeutic use ; HIV Envelope Protein gp120/immunology ; HIV-1/*immunology ; *Immunotherapy ; Macaca/immunology ; Molecular Sequence Data ; Peptide Fragments/immunology ; Simian Acquired Immunodeficiency Syndrome/prevention & control/*therapy ; Simian Immunodeficiency Virus/*physiology ; Time Factors ; Viral Load ; Viremia/*therapy

2012-06-23

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Dependovirus/genetics ; Green Fluorescent Proteins/metabolism ; Hand/*physiology ; Macaca ; Metalloendopeptidases/metabolism ; Motor Cortex/physiology ; Motor Neurons/*physiology ; *Neurosciences ; Synaptic Transmission/genetics/physiology ; Tetanus Toxin/metabolism

2013-07-26

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Body Patterning/drug effects/*physiology ; Cell Differentiation ; Down-Regulation ; Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors/metabolism ; Feedback, Physiological ; Head/physiology ; Logic ; MAP Kinase Signaling System/drug effects ; Phenotype ; Planarians/*anatomy & histology/drug effects/*physiology ; Receptors, Fibroblast Growth Factor/chemistry/metabolism ; Regeneration/drug effects/*physiology ; Stem Cells/cytology/metabolism ; Wnt Proteins/metabolism ; Wnt Signaling Pathway ; beta Catenin/deficiency/genetics/metabolism

2018-03-15

American Association for the Advancement of Science (AAAS)

2375-2548

Natural Sciences in General

1089-7550

AIP Digital Archive

Physics

This article describes a design optimization of an axially laminated rotor of the synchronous reluctance motor, using the optimization method combined with the magnetic field analysis. The magnetic flux distribution in the synchronous reluctance motor is distorted due to the complicated rotor configuration and the influence of magnetic saturation, which results in a large number of local minimum solutions. Therefore, taking account of the magnetic saturation by the finite element method, the authors propose a novel optimization approach by coupling the stochastic search method with the deterministic one. In the optimization process a suitable objective function for the stability of machine performances is also proposed. Finally some numerical results that demonstrate the validity of the proposed approach are presented. © 2000 American Institute of Physics.

Electronic Resource

1089-7674

AIP Digital Archive

Physics

The effect of poloidally mode coupled, ballooning type electrostatic drift waves on a magnetic island has been studied both analytically and numerically. It has been shown quantitatively that particle orbits become stochastic and their behavior can be a possible candidate for the radial plasma transport across a magnetic island of a tokamak. The transport is significant in that it takes place even when the flux surface is not destroyed. The mechanism of the stochasticity generation is understood as an overlapping of secondary islands caused by resonance between periodic particle motions in the magnetic island and Fourier modes of E×B drift due to the electrostatic drift waves. The diffusion process perpendicular to magnetic surface has been analyzed by approximating the distribution to the Gaussian type. In addition, local diffusion process in the vicinity of Kolmogorov, Arnold, and Moser surfaces has been discussed. © 1997 American Institute of Physics.

Electronic Resource

1089-7674

AIP Digital Archive

Physics

A new phenomenon has been found during the nonlinear stage of the tokamak sawtooth crash in relatively high β plasmas. The m/n=1/1 magnetic island evolution gives rise to convection of the pressure inside the q=1 radius and builds up steep pressure gradient across the island separatrix, and thereby trigger ballooning instabilities below the threshold at the equilibrium. Effects of the ballooning modes on the magnetic reconnection process during the sawtooth crash are discussed. © 1999 American Institute of Physics.

Electronic Resource

1089-7674

AIP Digital Archive

Physics

A new Δ′ shooting code has been developed to investigate tokamak plasma tearing mode stability in a cylinder and large aspect ratio (ε≤0.25) toroidal geometries, neglecting toroidal mode coupling. A different computational algorithm is used (shooting out from the singular surface instead of into it) to resolve the strong singularities at the mode rational surface, particularly in the presence of the finite pressure term. Numerical results compare favorably with Furth et al. [H. P. Furth et al., Phys. Fluids 16, 1054 (1973)] results. The effects of finite pressure, which are shown to decrease Δ′, are discussed. It is shown that the distortion of the flux surfaces by the Shafranov shift, which modifies the geometry metric elements, stabilizes the tearing mode significantly, even in a low-β regime before the toroidal magnetic curvature effects come into play. © 1998 American Institute of Physics.

Electronic Resource

1525-1314

Blackwell Publishing Journal Backfiles 1879-2005

Geosciences

The Sangun belt has long been considered to be a major coherent glaucophanitic terrane of Permian to Triassic age, and to be paired with the low-P/T  Hida belt to the north. However, recent progress in geochronology, metamorphic geology, and tectonics has revealed that the belt is in fact comprised of two geologic units of different ages and with contrasting conditions of formation. The older unit is named the Renge belt and the younger the Suo belt. The Renge belt is the oldest of the high-P/T  metamorphic belts in the Japanese Islands and extends from northern Kyushu, through the San-in coastal regions, to the Hida marginal belt. It is characterized by 330–280 Ma ages and the association of glaucophane–schist to epidote–amphibolite facies schists. The Renge belt is also typically associated with meta–ophiolite sequences (470–340 Ma) including serpentinite. The Suo belt is characterized by 230–160 Ma high-P/T  schists closely related to weakly metamorphosed Permian accretionary rocks of the Akiyoshi belt. Metamorphic facies series is from the prehnite–pumpellyite facies through the pumpellyite–actinolite and glaucophane–schist facies to the epidote–amphibolite facies. The belt is widespread in west Kinki to north and central Kyushu via Chugoku, but also stretches further to the southwest and is present in the Ishigaki-Iriomote Islands of the southern Ryukyu Arc. Throughout this belt, there are scattered small blocks or lenses of meta–ophiolite, whose K–Ar ages of relict hornblendes are 590 to 220 Ma. Bounded by low-angle faults and thrusts, both belts define subhorizontal nappes dipping gently north. The geotectonic framework in the Inner Zone of Southwest Japan is made up of, from north to south, the Hida-Oki, Renge, Akiyoshi, Suo, Maizuru plus ultra-Tamba, Mino-Tamba, and Ryoke belts, with a tectonically downward-younging polarity. This has resulted from stepwise accretions during Palaeozoic to Mesozoic time.

Electronic Resource

1077-3118

AIP Digital Archive

Physics

Mesophase pitch-based carbon fibers (MPCFs) have recently been developed for use as high performance anode materials in Li ion secondary batteries, having a microscopic as well as macroscopic structure especially suitable for Li storage. Because of the highly anisotropic diamagnetic moment observed between 50 and 310 K in pristine milled MPCF segments, they can easily be oriented parallel to an applied magnetic field, as observed by scanning electron microscopy. A simple model is proposed to explain both the observed alignment of undoped fibers and the suppression of alignment in B-doped MPCFs for relatively small applied magnetic fields, because of their smaller diamagnetic moment. © 1996 American Institute of Physics.

Electronic Resource

1089-7690

AIP Digital Archive

Physics

Chemistry and Pharmacology

Ultraviolet and visible chemiluminescence have been observed from the reactions of C+ with CO2, NO2, and N2O in a flowing afterglow. The CO+(A–X) chemiluminescence from v′=0–2 was identified in the C++CO2 reaction, while chemiluminescence from levels up to v′=11 was found in the C++NO2 and N2O reactions. The relative vibrational populations of CO+(A) have been determined and are compared with statistical prior distributions. The experimental data show that only about 10% of the total available energy is deposited in the CO+(A) vibration for all cases. The relative rate constants for formation of CO+(A) in the C++CO2, O2, NO2, and N2O reactions are estimated to be 1.0:9.8:18:60, respectively. In the C++N2O reaction, CN(A–X,B–X) chemiluminescence was also observed: the CN(B–X) system is produced exclusively as a result of rotational perturbations between the B and A states. Adiabatic correlation diagrams have been used to explain the specific formation of the emitting excited species.

Electronic Resource

1365-2222

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Background Cow's milk allergy impairs the health and development of many infants since it deprives them of adequate nutrition. Cow's milk fractions contain many allergens, and β-lactoglobulin (BLG) is one of the major allergens.Objective The purpose of this study was to determine T cell epitopes, antigen-presenting molecules and cytokine production by T cells in relation to BLG. The results can provide new therapeutic possibilities of using analogue peptides of BLG for infants with cow's milk allergy.Methods Using a mixture of a panel of overlapping synthetic peptides that cover the entire BLG molecule, we established polyclonal BLG-specific short-term T cell lines and clones from peripheral blood mononuclear cells of four patients with allergy to cow's milk carrying most of the common human leucocyte antigen (HLA) haplotypes seen in the Japanese population. We then identified the T cell epitopes and antigen-presenting molecules, and measured the production of cytokines interleukin (IL)-4, IL-5 and interferon-γ in the culture supernatants.Results The T cell lines established from the four patients responded to seven different peptides. Three of the peptides stimulated the T cells of two donors, regardless of the HLA types. The patterns of inhibition of the proliferative responses of the cell lines by anti-HLA class II antibodies were heterogeneous; three were mainly inhibited by anti-HLA-DR mAbs, and the other was inhibited by anti-HLA-DQ mAbs. High levels of IL-5 were produced by these T cell lines.Conclusions Patients' T cells recognized BLG in association with a variety of HLA-DR or -DQ as antigen-presenting molecules. Although some peptides did have a more potent T cell stimulatory activity than others, the T cell receptor ligands formed with the BLG molecule are heterogeneous. Peptides for the desensitization of T cells of the patients with cow’s milk allergy need to be designed keeping in mind the different requirements in different ethnic groups.

Electronic Resource

1744-313X

Blackwell Publishing Journal Backfiles 1879-2005

Biology

Medicine

To investigate HLA-linked genes controlling the susceptibility and resistance to insulin dependent diabetes mellitus (IDDM), HLA-DQ alleles of 45 Japanese patients with IDDM were analysed, using sequence specific oligonucleotide (SSO). DQA1*0301 and DQBI*04 were positively associated (R.R = 6.6, Pc〈0.05 and R.R. = 4.7 Pc〈0.01) and DQAI*0103 and DQBI*0104 were negatively associated (R.R. =0–2, Pc〈0.01) with IDDM. DQAI*0103 and DQB1*0104 were in strong linkage disequilibrium to encode for DQw6 molecule. Therefore, in a Japanese population, the DQw6 molecule seems to control the resistance to IDDM. To determine whether or not the DQw6 molecule itself can protect against glycosuria and insulitis in NOD mice, these animals were mated with HLA-DQw6 transgenic-C57BL/6 mice (DQw6-B6) and the F1 progeny expressing the DQw6 molecule were backcrossed with NOD mice. Eighty-five female backcross progenies were classified into four groups, according to the MHC classII phenotype; I-Anod/I-Anod DQw6(-), I-Anod/I-Anod DQw6(+), I-Anod/I-Ab DQw6(-) and I-Anod/I-Ab DQw6(+). At the age of 16 weeks, 9.1% of the DQw6(-) I-Ab(-) mice had a glycosuria whereas none of the DQw6(+) I-Ab(-) mice had a glycosuria. At the age of 30 weeks 13.6% of the DQw6(-) I-Ab(-) mice had a glycosuria and 7.7% of the DQw6(+) I-Ab(-) mice had a glycosuria. Histological examinations of the pancreas were performed in the 30 week old mice or after the development of glycosuria. About 50% of I-Ab(-) mice developed insulitis, regardless of the expression of the DQw6 molecule. Thus, the DQw6 molecule seemed to delay the onset of glycosuria but did not protect against glycosuria and insulitis in the NOD mice despite a functional expression.

Electronic Resource