Search Results - (Author, Cooperation:Y. Kawaoka)

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  1. 1
    Staff View
    Publication Date:
    2013-07-12
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Antiviral Agents/pharmacology ; Cells, Cultured ; Chickens/virology ; DNA-Directed RNA Polymerases/antagonists & inhibitors ; Dogs ; Enzyme Inhibitors/pharmacology ; Female ; Ferrets/virology ; Humans ; Influenza A Virus, H1N1 Subtype/drug effects/enzymology ; *Influenza A virus/chemistry/drug effects/isolation & purification/pathogenicity ; Influenza, Human/drug therapy/*virology ; Macaca fascicularis/virology ; Madin Darby Canine Kidney Cells ; Male ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Monkey Diseases/pathology/virology ; Neuraminidase/antagonists & inhibitors ; Orthomyxoviridae Infections/pathology/transmission/*virology ; Quail/virology ; Swine/virology ; Swine, Miniature/virology ; *Virus Replication/drug effects
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2012-01-28
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; *Biomedical Research ; Disease Models, Animal ; Ferrets ; Humans ; *Influenza A Virus, H5N1 Subtype/pathogenicity ; Influenza, Human/transmission/virology ; Orthomyxoviridae Infections/*transmission/virology
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2012-06-23
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adaptation, Physiological ; Air Microbiology ; Amino Acid Substitution ; Animals ; Birds ; *Evolution, Molecular ; Genetic Fitness ; Glycosylation ; Hemagglutinin Glycoproteins, Influenza Virus/*genetics/metabolism ; High-Throughput Nucleotide Sequencing ; Humans ; Influenza A Virus, H5N1 Subtype/*genetics/*pathogenicity ; Influenza in Birds/virology ; Influenza, Human/immunology/transmission/*virology ; Mammals ; Models, Biological ; Mutation ; Orthomyxoviridae Infections/transmission/*virology ; Probability ; RNA Replicase/*genetics ; Receptors, Virus/metabolism ; Respiratory System/*virology ; Selection, Genetic ; Sialic Acids/metabolism ; Viral Proteins/*genetics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Staff View
    Publication Date:
    2013-01-25
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Biomedical Research/*trends ; Birds ; Humans ; *Influenza A Virus, H5N1 Subtype ; Influenza in Birds/*transmission/*virology ; Influenza, Human/*transmission/*virology
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Staff View
    Publication Date:
    2013-08-10
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Drug Resistance, Multiple, Viral/*genetics ; Humans ; Influenza A virus/*genetics/*pathogenicity ; Influenza Vaccines/genetics/immunology ; Influenza in Birds/*transmission/*virology ; Influenza, Human/*prevention & control/transmission/virology ; Pandemics/*prevention & control ; Poultry ; Security Measures
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Staff View
    Publication Date:
    2013-08-09
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  7. 7
    A. Marzi ; P. Halfmann ; L. Hill-Batorski ; F. Feldmann ; W. L. Shupert ; G. Neumann ; H. Feldmann ; Y. Kawaoka
    American Association for the Advancement of Science (AAAS)
    Published 2015
    Staff View
    Publication Date:
    2015-03-31
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Ebola Vaccines/administration & dosage/adverse effects/*immunology ; Ebolavirus/drug effects/*immunology/radiation effects ; Gamma Rays ; Guinea Pigs ; Hemorrhagic Fever, Ebola/*prevention & control ; Hydrogen Peroxide/pharmacology ; Macaca fascicularis ; Mice ; RNA, Viral/immunology ; Vaccines, Attenuated/administration & dosage/adverse effects/immunology ; Viral Proteins/immunology ; Virus Replication
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  8. 8
    R. A. Fouchier ; A. Garcia-Sastre ; Y. Kawaoka
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-01-24
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Biohazard Release/prevention & control ; Bioterrorism/prevention & control ; Ferrets/virology ; Global Health ; Hemagglutinin Glycoproteins, Influenza Virus/genetics/metabolism ; Humans ; Influenza A Virus, H5N1 Subtype/*genetics/*pathogenicity ; Influenza, Human/*transmission/*virology ; Risk Assessment ; Virology/*legislation & jurisprudence ; Zoonoses/*transmission/*virology
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  9. 9
    Staff View
    Publication Date:
    2012-06-23
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adaptation, Physiological/*genetics ; Animals ; Bioterrorism/prevention & control ; Birds/virology ; Body Fluids/virology ; Cell Line ; Dogs ; Evolution, Molecular ; Female ; Ferrets/*virology ; HEK293 Cells ; HeLa Cells ; Hemagglutinin Glycoproteins, Influenza Virus/genetics/metabolism ; Hot Temperature ; Humans ; Influenza A Virus, H1N1 Subtype/genetics/pathogenicity/physiology ; Influenza A Virus, H5N1 Subtype/genetics/*pathogenicity/physiology ; Influenza in Birds/transmission/virology ; Influenza, Human/prevention & control/transmission/virology ; Molecular Epidemiology/methods ; Orthomyxoviridae Infections/*transmission/*virology ; Pandemics ; Population Surveillance/methods ; Protein Stability ; Reassortant Viruses/genetics/isolation & purification/*pathogenicity/physiology ; Receptors, Virus/chemistry/metabolism ; Respiratory System/anatomy & histology/*virology ; Security Measures ; Zoonoses/transmission/virology
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  10. 10
    Y. Kawaoka
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-01-27
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Ferrets/virology ; Humans ; Influenza A Virus, H5N1 Subtype/genetics/*pathogenicity/physiology ; Influenza, Human/epidemiology/*transmission/*virology ; Pandemics/*prevention & control ; Zoonoses/transmission/virology
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  11. 11
    Staff View
    Publication Date:
    2013-04-26
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Birds/metabolism/virology ; Chick Embryo ; Crystallography, X-Ray ; Ferrets/*virology ; Hemagglutinin Glycoproteins, Influenza Virus/*chemistry/genetics/*metabolism ; *Host Specificity ; Humans ; Influenza A Virus, H5N1 Subtype/chemistry/*genetics/*metabolism/pathogenicity ; Models, Biological ; Models, Molecular ; Mutation ; Orthomyxoviridae Infections/*transmission/*virology ; Protein Conformation ; Receptors, Virus/*metabolism ; Species Specificity
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  12. 12
    R. A. Fouchier ; A. Garcia-Sastre ; Y. Kawaoka
    Nature Publishing Group (NPG)
    Published 2013
    Staff View
    Publication Date:
    2013-01-29
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Birds ; Humans ; Influenza A Virus, H5N1 Subtype/*physiology ; Influenza in Birds/*transmission ; Influenza, Human/transmission ; Orthomyxoviridae Infections/transmission ; Research/*standards ; Safety Management
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  13. 13
    Staff View
    Publication Date:
    2013-08-09
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Birds ; Drug Resistance, Viral ; Humans ; Influenza A virus/*genetics/pathogenicity ; Influenza in Birds/transmission/*virology ; Orthomyxoviridae Infections/transmission/*virology ; Pandemics/prevention & control ; Research/standards ; Viral Proteins/genetics/metabolism ; Viral Vaccines
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  14. 14
    Webster, R.G. ; Shortridge, K.F. ; Kawaoka, Y.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1997
    Staff View
    ISSN:
    1574-695X
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1574-695X.1997.tb01056.x

    Articles: DFG German National Licenses
  15. 15
    Ito, T. ; Okazaki, K. ; Kawaoka, Y. ; Takada, A. ; Webster, R. G. ; Kida, H.
    Springer
    Published 1995
    Staff View
    ISSN:
    1432-8798
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary To provide information on the mechanism of perpetuation of influenza viruses among waterfowl reservoirs in nature, virological surveillance was carried out in Alaska during their breeding season in summer from 1991 to 1994. Influenza viruses were isolated mainly from fecal samples of dabbling ducks in their nesting places in central Alaska. The numbers of subtypes of 108 influenza virus isolates were 1 H2N3, 37 H3N8, 55 H4N6, 1 H7N3, 1 H8N2, 1 H10N2, 11 H10N7, and H10N9. Influenza viruses were also isolated from water samples of the lakes where they nest. Even in September of 1994 when the most ducks had left for migration to south, viruses were still isolated from the lake water. Phylogenetic analysis of the NP genes of the representative isolates showed that they belong to the North American lineage of avian influenza viruses, suggesting that the majority of the waterfowls breeding in central Alaska migrate to North America and not to Asia. The present results support the notion that influenza viruses have been maintained in waterfowl population by water-borne transmission and revealed the mechanism of year-by-year perpetuation of the viruses in the lakes where they breed.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01322743

    Articles: DFG German National Licenses
  16. 16
    Staff View
    ISSN:
    1432-8798
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary.  Monoclonal antibodies against the PB2 of A/Puerto Rico/8/34 (A/PR/ 8/34) (H1N1) were prepared in order to define the functional domains of the RNA polymerase of influenza virus. The fifteen monoclonal antibodies that were generated were divided into 4 groups on the basis of ELISA binding to PB2 or its peptide fragments. Six Group I antibodies that bound to the PB2 N-terminal region (amino acids 1–104) did not inhibit transcription by the viral ribonucleoprotein complex. A single Group II antibody recognizing the region of amino acids 206–259 inhibited ApG-primed transcription. Groups III and IV antibodies bound to the C-terminal region of amino acids 660–759. Of these, Group III antibodies inhibited transcription. The present results identify multiple monoclonal antibody binding domains in PB2, two of which, when bound by antibodies, negatively affect viral RNA transcription.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s007050070068

    Articles: DFG German National Licenses
  17. 17
    Kawaoka, Y. ; Webster, R. G.
    Springer
    Published 1989
    Staff View
    ISSN:
    1432-8798
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary A severe influenza outbreak occurred in horses in South Africa in 1986. The causative agent was identified as an influenza virus [A/Equine/Johannesburg/86 (H3N8)]. Antigenic analyses of the hemagglutinin (HA) with ferret antisera and monoclonal antibodies showed that the Eq/Johannesburg/86 virus is similar to recent equine H3 viruses. The nucleotide sequence analysis on the HA genes of Eq/Johannesburg/86 and other equine H3 influenza viruses, together with the epidemiological data, clearly demonstrated that the Eq/Johannesburg/86 virus was derived from a virus that had been circulating in horses in the United States in 1986–87. The epidemiological information suggests that the unusually severe influenza outbreak in South Africa may be due to the lack of immunity to these viruses in the horse population.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01311048

    Articles: DFG German National Licenses
  18. 18
    Staff View
    ISSN:
    1432-8798
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Swine are an animal reservoir for influenza viruses capable of causing disease in humans. A serological survey in 1988–1989 demonstrates that subtype H1 influenza viruses continue to circulate at high frequency among swine in the north-central U.S.A. (average 51% incidence). Subtype H3 viruses antigenically similar to current human H3 viruses are circulating at low frequency (average 1.1%), particularly in the southeast U.S.A.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01319247

    Articles: DFG German National Licenses
  19. 19
    Staff View
    ISSN:
    1432-8798
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary.  To obtain reagents to functionally map the PA protein, we produced monoclonal antibodies specific to this protein. Twenty-two monoclonal antibodies reacting with PA protein in ELISA were divided into 10 groups on the basis of competitive binding patterns to this protein. Of these, seventeen monoclonal antibodies bound to PA polypeptide spanning amino acids 101–400 and three bound to that of amino acids 518–600, while the other two did not react with any PA polypeptides tested with the exception of the intact PA. Among these monoclonal antibodies, only five reacted with PA in A/PR/8/34 virus-infected cells in indirect immunofluorescence assay. Thus, we obtained monoclonal antibodies that recognize at least 10 distinct regions of the PA molecule. These monoclonal antibodies should be useful in dissecting functions of the PA protein.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s007050050687

    Articles: DFG German National Licenses
  20. 20
    Kawaoka, Y. ; Bordwell, Elizabeth ; Webster, R. G.
    Springer
    Published 1987
    Staff View
    ISSN:
    1432-8798
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary The sites of replication of influenza A viruses in ferrets and pigs were studied. The majority of the swine, equine, and avian influenza A viruses tested were recovered from the intestinal tract of ferrets as well as from the respiratory tract; most of the human influenza viruses studied were recovered only from the respiratory tract. In contrast with ferrets, only Hong Kong/1/68 (H 3 N 2) influenza virus was recovered from the intestinal tract of pigs. Despite the large biological variability found in ferrets and in pigs, the results do establish that the majority of influenza viruses have the potential to replicate in the intestinal tissues of some mammals. Additionally, the study suggests that there are differences among the influenza A viruses in tissue tropism in different mammals. Both viral and host genetic factors determine the tissue tropism of influenza viruses in mammals.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01310984

    Articles: DFG German National Licenses