Search Results - (Author, Cooperation:W. Bodmer)

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  1. 1
    Staff View
    Publication Date:
    2015-03-20
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Algorithms ; European Continental Ancestry Group/genetics ; *Genetics, Population ; Great Britain/ethnology ; Haplotypes/*genetics ; Humans ; Polymorphism, Single Nucleotide/*genetics ; Principal Component Analysis
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    ISSN:
    1744-313X
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1744-313X.1995.tb00249.x

    Articles: DFG German National Licenses
  3. 3
    Staff View
    ISSN:
    1744-313X
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1744-313X.1994.tb00222.x

    Articles: DFG German National Licenses
  4. 4
    Oliver, R. T. D. ; Nouri, A. M. E. ; Crosby, D. ; Iles, R. L. ; Navarette, C. ; Martin, J. ; Bodmer, W. ; Festenstein, H.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1989
    Staff View
    ISSN:
    1744-313X
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Medicine
    Notes:
    Expression of beta human chorionic gonadotropin (βhCG) by bladder tumours has been shown to be associated with increased metastases and resistance to treatment with radiotherapy and chemotherapy. Preliminary results from typing frozen tumours using monoclonal antibodies against HLA determinants show reduced or lost expression of one or more antigens in two thirds of patients studied with a trend for more malignant behaviour and inability to generate tumour infiltrating lymphocyte expression using Interleukin-2 in those patients whose tumours demonstrate loss. In this series βhCG expression was only seen in a subgroup of those demonstrating loss of HLA antigen expression. Studies of βhCG secreting bladder cancer cell lines showed that it was possible to induce class II HLA antigen expression with gamma Interferon, and that this treatment but not alpha Interferon reduced βhCG production by the cell line.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1744-313X.1989.tb00485.x

    Articles: DFG German National Licenses
  5. 5
    Staff View
    ISSN:
    1744-313X
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1744-313X.2005.00509.x

    Articles: DFG German National Licenses
  6. 6
    SNARY, D. ; BARNSTABLE, C. J. ; BODMER, W. F. ; GOODFELLOW, P. N. ; CRUMPTON, M. J.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1977
    Staff View
    ISSN:
    1365-3083
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Human Ia antigens were extensively purified (1390-fold increase in specific activity) in 32% yield from BRI8 cells, a lymphoblastoid B-cell line. Purification was monitored by using allogeneic antisera arising by foetal-maternal stimulation. The product, a glycoprotein fraction, contained the la antigens, the HLA-A and -B antigens, and a glycoprotein of unknown function. The glycoptotein fraction was composed of four glycosylated polypeptides with molecular weights of 43,000, 39,000, 33,000, and 28,000, and β2-microglobulin; no polypeptide was linked to another by disulphide bridges. The A and B antigens only were absorbed by antibody against β2-microglobulin. The Ia antigens comprised one each of the 33,000 and 28,000 molecular weight glycosylated polypeptides noncovalently linked together. Thus, only these chains were absorbed by xenogeneic anti-Ia antisera and were cross-linked by dimethyl-3–3′-dithiobispropionimidate dihydrochloride. The dimeric molecule bound deoxycholate (0.26 g/g of protein) and, when solubilized in deoxycholate, has a molecular weight of 77,000. The Ia allo- and xeno-antigenic activities were labile to heating and proteolysis and are probably determined by the polypeptide structure. Xenogeneic specific anti-Ia antisera were raised in rabbits and mice by immunizing with the glycoprotein fraction. These antisera reacted with B lymphocytes and monocytes but not T lymphocytes and fibroblasts. Their Fab fragments blocked the cytotoxicity of the allogeneic antisera for B lymphocytes and were potent inhibitors of the mixed lymphocyte reaction.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-3083.1977.tb02101.x

    Articles: DFG German National Licenses
  7. 7
    Oliver, R. T. D. ; Stephenson, C. A. ; Parkinson, M. C. ; Forman, D. ; Atkinson, A. ; Bodmer, J. ; Bodmer, W. F.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1986
    Staff View
    ISSN:
    1744-313X
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1744-313X.1986.tb01088.x

    Articles: DFG German National Licenses
  8. 8
    BODMER, W. F. ; BROWNING, M. J. ; KRAUSA, P. ; ROWAN, A. ; BICKNELL, D. C. ; BODMER, J. G.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1993
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1749-6632.1993.tb43994.x

    Articles: DFG German National Licenses
  9. 9
    SNARY, D. ; GOODFELLOW, P. ; HAYMAN, M. J. ; BODMER, W. F. ; CRUMPTON, M. J.

    [s.l.] : Nature Publishing Group
    Published 1974
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] If the above views are correct then conclusions on the molecular nature of histocompatibility antigens adduced from these non-detergent solubilised preparations are questionable. Solubilisation procedures relying on degradation also have other disadvantages. The yield of antigen is usually low, ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/247457a0

    Articles: DFG German National Licenses
  10. 10
    BODMER, W. F.

    [s.l.] : Nature Publishing Group
    Published 1972
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] It is still an open question how the genetic polymorphism represented by the principal human histocompatibility system is maintained. But it may have evolved as a consequence of the necessity for cell to cell recognition during development and ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/237139a0

    Articles: DFG German National Licenses
  11. 11
    SNARY, D. ; GOODFELLOW, P. ; BODMER, W. F. ; CRUMPTON, M. J.

    [s.l.] : Nature Publishing Group
    Published 1975
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] HLA activities were measured by inhibition of cytotoxicity11 using peripheral blood lymphocytes with sera 3002X, P2692B and P3812B for HLA-A2, sera 1209F, 10141 and P1595B for HLA-A1, sera P1422B and P1538B for HLA-B8, and sera P1040B and P3428B for HLA-B13. A highly purified preparation of the ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/258240a0

    Articles: DFG German National Licenses
  12. 12
    SANTACHIARA, A. SILVANA ; NABHOLZ, M. ; MIGGIANO, V. ; DARLINGTON, A. J. ; BODMER, W.

    [s.l.] : Nature Publishing Group
    Published 1970
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] Evidence of an active linkage between the human genes that control lactate dehydrogenase B and peptidase B is presented. It is also concluded that there is no link between the genes for lactate dehydrogenase A and lactate dehydrogenase ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/227248a0

    Articles: DFG German National Licenses
  13. 13
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] Two mammalian and four avian cell-derived viral oncogenes encoding proteins with tyrosine-specific protein kinase activity have been described1. One of these, c-fes, is represented within the genomes of two independent isolates of feline sarcoma virus (FeSV), Gardner and Snyder-Theilen, both of ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/299747a0

    Articles: DFG German National Licenses
  14. 14
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] Cryostat sections of human amniotic membranes were studied by immunofluorescence techniques either immediately after collection or following 24 h incubation in RPMI1640 medium (Flow)7. When these sections were independently stained in three laboratories, 02m could not be detected by ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/295325a0

    Articles: DFG German National Licenses
  15. 15
    JONES, E. A. ; GOODFELLOW, P. N. ; BODMER, J. G. ; BODMER, W. F.

    [s.l.] : Nature Publishing Group
    Published 1975
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] By analogy with the mouse, human la antigens have been defined by mixed lymphocyte culture (MLC) inhibition and by serological tests on HL-A identical unrelated individuals2"5. We describe here some new approaches to the ready identification of sera against la-type antigens in man which make use of ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/256650a0

    Articles: DFG German National Licenses
  16. 16
    GOODFELLOW, P. N. ; JONES, E. A. ; VAN HEYNINGEN, V. ; SOLOMON, E. ; BOBROW, M. ; MIGGIANO, V. ; BODMER, W. F.

    [s.l.] : Nature Publishing Group
    Published 1975
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] The genes controlling the HL-A determinants form part of a complex genetic region associated with immune functions including transplantation rejection, mixed lymphocyte culture stimulation, graft versus host response, cell mediated lympholysis, immune response and some complement functions (see ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/254267a0

    Articles: DFG German National Licenses
  17. 17
    PARHAM, P. ; BODMER, W. F.

    [s.l.] : Nature Publishing Group
    Published 1978
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] Fig. 1 Specificity of PA2.1 antibody for cell lines expressing HLA-A2 as measured by indirect trace binding assay. 106 cells were incubated with 50 µl of PA2.1 culture supernatant for 1 h at 4 C, washed three times and then incubated with 125I rabbit F(ab)'2 anti-mouse Fab antibody, 300,000 ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/276397a0

    Articles: DFG German National Licenses
  18. 18
    NABHOLZ, M. ; MIGGIANO, V. ; BODMER, W.

    [s.l.] : Nature Publishing Group
    Published 1969
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] Somatic hybridization between mouse cells and human leucocytes confirms the X-linkage of 8-azaguanine resistance in man and suggests that human lactate dehydrogenase A and B genes are not ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/223358a0

    Articles: DFG German National Licenses
  19. 19
    BODMER, W. F.

    [s.l.] : Nature Publishing Group
    Published 1961
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] The factors used in the linkage experiment were pallid and fidget; they are both recessives and known to be in linkage group V. Both factors are generally associated with fairly severe reductions in viability and fertility. The results were obtained from female coupling and repulsion heterozygotes ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/1901134a0

    Articles: DFG German National Licenses
  20. 20
    Durbin, H. ; Novelli, M. ; Bodmer, W.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0888-7543
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1006/geno.1994.1038

    Articles: DFG German National Licenses