Search Results - (Author, Cooperation:T. O'Connor)

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Kanoni ; S. M. Kerr ; N. M. Khan ; P. Koellinger ; H. A. Koistinen ; M. K. Kooner ; M. Kubo ; J. Kuusisto ; J. Lahti ; L. J. Launer ; R. A. Lea ; B. Lehne ; T. Lehtimaki ; D. C. Liewald ; L. Lind ; M. Loh ; M. L. Lokki ; S. J. London ; S. J. Loomis ; A. Loukola ; Y. Lu ; T. Lumley ; A. Lundqvist ; S. Mannisto ; P. Marques-Vidal ; C. Masciullo ; A. Matchan ; R. A. Mathias ; K. Matsuda ; J. B. Meigs ; C. Meisinger ; T. Meitinger ; C. Menni ; F. D. Mentch ; E. Mihailov ; L. Milani ; M. E. Montasser ; G. W. Montgomery ; A. Morrison ; R. H. Myers ; R. Nadukuru ; P. Navarro ; M. Nelis ; M. S. Nieminen ; I. M. Nolte ; G. T. O'Connor ; A. Ogunniyi ; S. Padmanabhan ; W. R. Palmas ; J. S. Pankow ; I. Patarcic ; F. Pavani ; P. A. Peyser ; K. Pietilainen ; N. Poulter ; I. Prokopenko ; S. Ralhan ; P. Redmond ; S. S. Rich ; H. Rissanen ; A. Robino ; L. M. Rose ; R. Rose ; C. Sala ; B. Salako ; V. Salomaa ; A. P. Sarin ; R. Saxena ; H. Schmidt ; L. J. Scott ; W. R. Scott ; B. Sennblad ; S. 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Chambers ; J. S. Kooner ; D. P. Strachan ; H. Campbell ; J. N. Hirschhorn ; M. Perola ; O. Polasek ; J. F. Wilson
    Nature Publishing Group (NPG)
    Published 2015
    Staff View
    Publication Date:
    2015-07-02
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Biological Evolution ; Blood Pressure/genetics ; Body Height/*genetics ; Cholesterol, LDL/genetics ; *Cognition ; Cohort Studies ; Educational Status ; Female ; Forced Expiratory Volume/genetics ; Genome, Human/genetics ; *Homozygote ; Humans ; Lung Volume Measurements ; Male ; Phenotype
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2013-08-02
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Amino Acid Sequence ; Animals ; Antibodies/*immunology/*toxicity ; Antibodies, Monoclonal/immunology/toxicity ; Binding Sites, Antibody ; Calpain/metabolism ; Cerebellum ; Creutzfeldt-Jakob Syndrome/metabolism ; Cross-Linking Reagents ; Epitope Mapping ; Female ; Immunoglobulin Fab Fragments/immunology/toxicity ; In Vitro Techniques ; Ligands ; Male ; Membrane Glycoproteins/metabolism ; Mice ; Molecular Sequence Data ; NADPH Oxidase/metabolism ; Neurodegenerative Diseases/metabolism ; Oxidative Stress ; *Pliability ; PrPC Proteins/chemistry/genetics/immunology ; Prions/*chemistry/genetics/*immunology ; Reactive Oxygen Species/metabolism ; Sequence Deletion/genetics ; Single-Chain Antibodies/immunology/toxicity
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Kamperschroer, J. H. ; Grisham, L. R. ; Lagin, L. J. ; O'Connor, T. E. ; Newman, R. A. ; Stevenson, T. N. ; von Halle, A. ; Wright, K. E.

    [S.l.] : American Institute of Physics (AIP)
    Published 1995
    Staff View
    ISSN:
    1089-7623
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Electrical Engineering, Measurement and Control Technology
    Notes:
    195 tritium ion source shots were injected into Tokamak Fusion Test Reactor (TFTR) high power plasmas during December 1993–March 1994. In addition, four highly diagnosed pulses were fired into the calorimeter. Analysis of the Doppler shifted Tα emission of the beam in the neutralizer has revealed that the extracted ion compositions for deuterium and tritium are indistinguishable: 0.72±0.04 D+; 0.22±0.02 D+2; 0.07±0.01 D+3 compared to 0.72±0.04 T+; 0.23±0.02 T+2; 0.05±0.01 T+3. The resultant tritium full-energy neutral fraction is higher than for deuterium due to the increased neutralization efficiency at lower velocity. To conserve tritium, it was used only for injection and a few calorimeter test shots, never for ion source conditioning. When used, the gas species were switched to tritium only for the shot in question. This resulted in an approximately 2% deuterium contamination of the tritium beam and vice versa for the first deuterium pulse following tritium. Data from the calorimeter shots indicate that tritium contamination of the deuterium beam cleans up in five to six beam pulses, and is reduced to immeasurable quantities prior to deuterium beam injection. © 1995 American Institute of Physics.
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    Electronic Resource
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    Articles: DFG German National Licenses
  4. 4
    Kamperschroer, J. H. ; Grisham, L. R. ; Newman, R. A. ; O'Connor, T. E. ; Stevenson, T. N. ; von Halle, A. ; Williams, M. D. ; Wright, K. E.

    [S.l.] : American Institute of Physics (AIP)
    Published 1993
    Staff View
    ISSN:
    1089-7623
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Electrical Engineering, Measurement and Control Technology
    Notes:
    Tokamak Fusion Test Reactor (TFTR) deuterium neutral beams have been operated unintentionally with significant quantities of extracted water ions. Water has been observed with an optical multichannel analyzer. These leaks were thermally induced with the contamination level increasing linearly with pulse length. Up to 6% of the beam current was attributed to water ions, corresponding to an instantaneous value of 12% at the end of a 1.5 s pulse. A similar contamination is observed during initial operation of ion sources exposed to air. Operation of new ion sources typically produces a contamination level of ∼2%, with cleanup to undetectable levels in 50–100 beam pulses. Approximately 90% of the water extracted from ion sources with water leaks was deuterated, implying that there is the potential for tritiated water production during TFTR's forthcoming DT operation. It is concluded that isotope exchange in the plasma generator takes place rapidly, most likely as the result of surface catalysis. The primary concern is with O implanted into beam absorbers recombining with tritium, and the subsequent retention of T2O on cryopanels.
    Type of Medium:
    Electronic Resource
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    Articles: DFG German National Licenses
  5. 5
    Kamperschroer, J. H. ; Grisham, L. R. ; Kugel, H. W. ; O'Connor, T. E. ; Stevenson, T. N. ; von Halle, A. ; Williams, M. D.

    [S.l.] : American Institute of Physics (AIP)
    Published 1992
    Staff View
    ISSN:
    1089-7623
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Electrical Engineering, Measurement and Control Technology
    Notes:
    A technique is described whereby the ion dumps inside the TFTR Neutral Beam Test Stand were used to measure thermal profiles of the full-, half-, and third-energy ions. 136 thermocouples were installed on the full-energy ion dump, allowing full beam contours. Additional linear arrays across the widths of the half- and third-energy ion dumps provided a measure of the shape, in the direction parallel to the grid rails, of the half- and third-energy ions, and, hence, of the molecular ions extracted from the source. As a result of these measurements, it was found that the magnet was more weakly focusing, by a factor of 2, than expected, explaining past overheating of the full-energy ion dump. Hollow profiles on the half- and third-energy ion dumps were observed, suggesting that extraction of D+2 and D+3 is primarily from the edge of the ion source. If extraction of half-energy ions is from the edge of the accelerator, a divergence parallel to the grid rails of 0.6°±0.1° is deduced. It is postulated that a nonuniform gas profile near the accelerator is the cause of the hollow partial-energy ion profiles, the pressure being depressed over the accelerator by particles passing through this highly transparent structure. Primary electrons reaching the accelerator produce nonuniform densities of D+2 through the ionization of this gas. D+3 is created through subsequent D+2-gas collisions. A technique of rastering the ion beam across the full-energy dump was examined as a means of reducing the power density. By unbalancing the currents in the two coils of the magnet, on a shot-by-shot basis, by up to a 2:1 ratio, it was possible to move the centerline of the full-energy ion beam sideways by ∼12.5 cm. The adoption of such a technique, with a ramp of the coil imbalance from 2:1 to 1:2 over a beam pulse, could reduce the full-energy ion dump power density by a factor of (approximately-greater-than)1.5.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  6. 6
    Chen, C. Y. ; Bailey, K. ; Li, Y. M. ; O'Connor, T. P. ; Lu, Z.-T.

    [S.l.] : American Institute of Physics (AIP)
    Published 2001
    Staff View
    ISSN:
    1089-7623
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Electrical Engineering, Measurement and Control Technology
    Notes:
    A rf-driven discharge is used to produce a beam of metastable krypton atoms at the 5s(3/2)2 level with an angular flux density of 4×1014 s−1 sr−1 and most probable velocity of 290 m/s, while consuming 7×1016 krypton atoms/s. When operated in a gas-recirculation mode, the source consumes 2×1015 krypton atoms/s with the same atomic-beam output. © 2001 American Institute of Physics.
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    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  7. 7
    Staff View
    ISSN:
    1089-7623
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Electrical Engineering, Measurement and Control Technology
    Notes:
    Data from an E(parallel)B charge exchange neutral analyzer (CENA), which views down the axis of a neutral beamline through an aperture in the target chamber calorimeter of the TFTR neutral beam test facility, exhibit two curious effects. First, there is a turn-on transient lasting tens of milliseconds having a magnitude up to three times that of the steady state level. Second, there is a 720 Hz, up to 20% peak-to-peak fluctuation persisting the entire pulse duration. The turn-on transient occurs as the neutralizer/ion source system reaches a new pressure equilibrium following the effective ion source gas throughput reduction by particle removal as ion beam. Widths of the transient are a function of the gas throughput into the ion source, decreasing as the gas supply rate is reduced. Heating of the neutralizer gas by the beam is assumed responsible, with gas temperature increasing as gas supply rate is decreased. At low gas supply rates, the transient is primarily due to dynamic changes in the neutralizer line density and/or beam species composition. Light emission from the drift duct corroborate the CENA data. At high gas supply rates, dynamic changes in component divergence and/or spatial profiles of the source plasma are necessary to explain the observations. The 720 Hz fluctuation is attributed to a 3% peak-to-peak ripple of 720 Hz on the arc power supply amplified by the quadratic relationship between beam divergence and beam current. Tight collimation by CENA apertures cause it to accept a very small part of the ion source's velocity space, producing a signal linearly proportional to beam divergence. Estimated fluctuations in the peak power density delivered to the plasma under these conditions are a modest 3%–8% peak to peak. The effects of both phenomena on the injected neutral beam can be ameliorated by careful operation of the ion sources.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  8. 8
    Kamperschroer, J. H. ; Grisham, L. R. ; Kokatnur, N. ; Lagin, L. J. ; Newman, R. A. ; O'Connor, T. E. ; Stevenson, T. N. ; Halle, A. von

    [S.l.] : American Institute of Physics (AIP)
    Published 1995
    Staff View
    ISSN:
    1089-7623
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Electrical Engineering, Measurement and Control Technology
    Notes:
    Analysis of Doppler-shifted Balmer-α line emission from the Tokamak Fusion Test Reactor's (TFTR) neutral beam injection systems has revealed that the line shape, which is a direct measure of the velocity distribution function, is well approximated by the sum of two Gaussians, or, alternatively, by a Lorentzian. For the sum of two Gaussians, the wide-divergence part of the distribution contains 40% of the beam power and has a divergence five times that of the narrow part. Assuming a narrow 1/e-divergence of 1.3° (based on fits to the beam shape on the calorimeter), the wide part has a divergence of 6.9°. The entire line shape is also well approximated by a Lorentzian with a half-maximum divergence of 0.9°. Up to now, most fusion neutral beam modelers have assumed a single Gaussian velocity distribution, at the extraction plane, in each direction perpendicular to beam propagation. This predicts a beam transmission efficiency from the ion source to the calorimeter of 97%. Waterflow calorimetry data, however, yield a transmission efficiency of ∼75%, a value in rough agreement with predictions of the two Gaussian or Lorentzian models presented here. The broad wing of the two Gaussian distribution also accurately predicts the loss in the neutralizer. An additional factor in determining the power density at the surface of beam absorbers is the angle at which the particles arrive. Angles are different for particles emitted from different locations on the ion source. To treat this situation, the average angle of incidence is calculated. For beam loss at the exit of the neutralizer, the average angle of incidence is 2.2°, rather than the 4.95° subtended by the center of the ion source. This average angle of incidence is found to be a function of beam divergence. © 1995 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  9. 9
    O'Connor, T. E. ; Windsor, N. R. ; Schreifels, J. A.

    [S.l.] : American Institute of Physics (AIP)
    Published 1989
    Staff View
    ISSN:
    1089-7623
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Electrical Engineering, Measurement and Control Technology
    Notes:
    A simple inexpensive peak detector circuit is described that permits the calculation of peak-to-peak heights during Auger analyzed depth profiles of solid surfaces. This circuit is interfaced with and controlled by a microcomputer where data can be stored and subsequently analyzed.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  10. 10
    Staff View
    ISSN:
    1089-7623
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Electrical Engineering, Measurement and Control Technology
    Notes:
    Energy flow within TFTR neutral beamlines is measured with a waterflow calorimetry system capable of simultaneously measuring the energy deposited within four heating beamlines (three ion sources each), or of measuring the energy deposited in a separate neutral beam test stand. Of the energy extracted from the ion source on the well-instrumented test stand, 99.5±3.5% can be accounted for. When the ion deflection magnet is energized, however, 6.5% of the extracted energy is lost. This loss is attributed to a spray of devious particles onto unmonitored surfaces. A 30% discrepancy is also observed between energy measurements on the internal beamline calorimeter and energy measurements on a calorimeter located in the test stand target chamber. Particle reflection from the flat plate calorimeter in the target chamber, which the incident beam strikes at a near-grazing angle of 12°, is the primary loss of this energy. A slight improvement in energy accountability is observed as the beam pulse length is increased. This improvement is attributed to systematic error in the sensitivity of the energy measurement to small fluctuations in the supply water temperature. An overall accuracy of 15% is estimated for the total power injected into TFTR. Contributions to this error are uncertainties in the beam neutralization efficiency, reionization and beam scrape-off in the drift duct, and fluctuations in the temperature of the supply water.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  11. 11
    Staff View
    ISSN:
    1089-7623
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Electrical Engineering, Measurement and Control Technology
    Notes:
    Five diagnostic systems were used for initial species measurements during tokamak fusion test reactor (TFTR) neutral beam test stand operations involving four ion sources, as well as several different configurations and operating conditions. Initial results were obtained for total neutral species fractions at the beamline input and the beamline output, differential radial profiles of species fractions, angular divergences of species components, species radial power density profiles, and beam impurity components for various conditions.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  12. 12
    Staff View
    ISSN:
    1089-7623
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Electrical Engineering, Measurement and Control Technology
    Notes:
    TFTR long pulse ion sources have been operated with gas fed only into the neutralizer. Gas for the plasma generator entered through the accelerator rather than directly into the arc chamber. This modification has been proposed for tritium beam operation to locate control electronics at ground potential and to simplify tritium plumbing. Source operation with this configuration and with the nominal gas system that feeds gas into both the ion source and the center of the neutralizer are compared. Comparison is based upon accelerator grid currents, beam composition, and neutral power delivered to the calorimeter. Charge exchange in the accelerator can be a significant loss mechanism in both systems at high throughput. A suitable operating point with the proposed system was found that requires 30% less gas than used presently. The extracted D+, D+2, and D+3 fractions of the beam were found to be a function of the gas throughput; at similar throughputs, the two gas feed systems produced similar extracted ion fractions. Operation at the proposed gas efficient point results in a small reduction (relative to the old high throughput mode) in the extracted D+ fraction of the beam from 77% to 71%, with concomitant changes in the D+2 fraction from 18% to 26%, and 6% to 3% for D+3. The injected power is unchanged, ∼2.2 MW at 95 kV.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  13. 13
    CHONCHUBHAIR, Á. NÍ ; O'CONNOR, T. ; O'HAGAN, C.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1994
    Staff View
    ISSN:
    1365-2044
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    We describe a novel method of inserting a silicome tracheal Montgomery T-ube using a gum elastic bougie. the advantages of this method over previously described methods ar discussed.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  14. 14
    O'Connor, T. ; Phelan, D.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1992
    Staff View
    ISSN:
    1365-2044
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  15. 15
    Villegas, R. ; O'Connor, T. P. ; Kerry, J. P. ; Buckley, D. J.

    Oxford, UK : Blackwell Science Ltd
    Published 1999
    Staff View
    ISSN:
    1365-2621
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Process Engineering, Biotechnology, Nutrition Technology
    Notes:
    Summary Samples of cooked ham and bacon were dipped in water or 2, 4 or 6% gelatin solutions. Samples were then packed in oxygen permeable or vacuum packaging film and stored at −18 °C for seven months. Lipid oxidation (TBARS) and colour stability (Hunter a* values) were assessed monthly. The gelatin coating exerted beneficial effects on oxidative and colour stability.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  16. 16
    OROSZLAN, S. I. ; RIZVI, S. ; O'CONNOR, T. E. ; MORA, P. T.

    [s.l.] : Nature Publishing Group
    Published 1964
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] DENSITY-gradient centrifugation has been widely used for the separation of cell particulates and purification of viruses1"4. Among the various substances, sucrose and inorganic salts have been used most frequently to form density gradients. In some instances macro-molecular substances were also ...
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  17. 17
    O'Connor, T. ; Johnson, C. ; Scovell, W.M.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0005-2787
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  18. 18
    O'Connor, T. ; Johnson, C. ; Scovell, W.M.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0005-2787
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  19. 19
    Staff View
    ISSN:
    0301-4622
    Keywords:
    C-form DNA ; DNA structure ; Raman spectroscopy: DNA denaturation
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  20. 20
    Staff View
    ISSN:
    0301-4622
    Keywords:
    DNA structure: Antitumor drug ; Dichlorodiammineplatinum(II) ; Methylmercury(II) ; Mutagen ; Roman spectroscopy
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses