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1Latest Papers from Table of Contents or Articles in PressLinda S. May-Zhang, Valery Yermalitsky, Jiansheng Huang, Tiffany Pleasent, Mark S. Borja, Michael N. Oda, W. Gray Jerome, Patricia G. Yancey, Mac; Rae F. Linton, Sean S. Davies
The American Society for Biochemistry and Molecular Biology (ASBMB)
Published 2018Staff ViewPublication Date: 2018-06-16Publisher: The American Society for Biochemistry and Molecular Biology (ASBMB)Print ISSN: 0021-9258Electronic ISSN: 1083-351XTopics: BiologyChemistry and PharmacologyPublished by: -
2Latest Papers from Table of Contents or Articles in PressLaura Tiemann; Vanessa D. Hohn; Son Ta Dinh; Elisabeth S. May; Moritz M. Nickel; Joachim Gross; Markus Ploner
Nature Publishing Group (NPG)
Published 2018Staff ViewPublication Date: 2018-10-27Publisher: Nature Publishing Group (NPG)Electronic ISSN: 2041-1723Topics: BiologyChemistry and PharmacologyNatural Sciences in GeneralPhysicsPublished by: -
3Latest Papers from Table of Contents or Articles in PressO. Hen ; M. Sargsian ; L. B. Weinstein ; E. Piasetzky ; H. Hakobyan ; D. W. Higinbotham ; M. Braverman ; W. K. Brooks ; S. Gilad ; K. P. Adhikari ; J. Arrington ; G. Asryan ; H. Avakian ; J. Ball ; N. A. Baltzell ; M. Battaglieri ; A. Beck ; S. May-Tal Beck ; I. Bedlinskiy ; W. Bertozzi ; A. Biselli ; V. D. Burkert ; T. Cao ; D. S. Carman ; A. Celentano ; S. Chandavar ; L. Colaneri ; P. L. Cole ; V. Crede ; A. D'Angelo ; R. De Vita ; A. Deur ; C. Djalali ; D. Doughty ; M. Dugger ; R. Dupre ; H. Egiyan ; A. El Alaoui ; L. El Fassi ; L. Elouadrhiri ; G. Fedotov ; S. Fegan ; T. Forest ; B. Garillon ; M. Garcon ; N. Gevorgyan ; Y. Ghandilyan ; G. P. Gilfoyle ; F. X. Girod ; J. T. Goetz ; R. W. Gothe ; K. A. Griffioen ; M. Guidal ; L. Guo ; K. Hafidi ; C. Hanretty ; M. Hattawy ; K. Hicks ; M. Holtrop ; C. E. Hyde ; Y. Ilieva ; D. G. Ireland ; B. I. Ishkanov ; E. L. Isupov ; H. Jiang ; H. S. Jo ; K. Joo ; D. Keller ; M. Khandaker ; A. Kim ; W. Kim ; F. J. Klein ; S. Koirala ; I. Korover ; S. E. Kuhn ; V. Kubarovsky ; P. Lenisa ; W. I. Levine ; K. Livingston ; M. Lowry ; H. Y. Lu ; I. J. MacGregor ; N. Markov ; M. Mayer ; B. McKinnon ; T. Mineeva ; V. Mokeev ; A. Movsisyan ; C. Munoz Camacho ; B. Mustapha ; P. Nadel-Turonski ; S. Niccolai ; G. Niculescu ; I. Niculescu ; M. Osipenko ; L. L. Pappalardo ; R. Paremuzyan ; K. Park ; E. Pasyuk ; W. Phelps ; S. Pisano ; O. Pogorelko ; J. W. Price ; S. Procureur ; Y. Prok ; D. Protopopescu ; A. J. Puckett ; D. Rimal ; M. Ripani ; B. G. Ritchie ; A. Rizzo ; G. Rosner ; P. Roy ; P. Rossi ; F. Sabatie ; D. Schott ; R. A. Schumacher ; Y. G. Sharabian ; G. D. Smith ; R. Shneor ; D. Sokhan ; S. S. Stepanyan ; S. Stepanyan ; P. Stoler ; S. Strauch ; V. Sytnik ; M. Taiuti ; S. Tkachenko ; M. Ungaro ; A. V. Vlassov ; E. Voutier ; N. K. Walford ; X. Wei ; M. H. Wood ; S. A. Wood ; N. Zachariou ; L. Zana ; Z. W. Zhao ; X. Zheng ; I. Zonta
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-10-18Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
4Latest Papers from Table of Contents or Articles in PressK. Mori ; S. M. Weng ; T. Arzberger ; S. May ; K. Rentzsch ; E. Kremmer ; B. Schmid ; H. A. Kretzschmar ; M. Cruts ; C. Van Broeckhoven ; C. Haass ; D. Edbauer
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-02-09Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adaptor Proteins, Signal Transducing/metabolism ; Amyotrophic Lateral Sclerosis/genetics/*metabolism/pathology ; Cerebellum/metabolism/pathology ; DNA Repeat Expansion ; DNA-Binding Proteins/metabolism ; Frontotemporal Lobar Degeneration/genetics/*metabolism/pathology ; Heterozygote ; Hippocampus/metabolism/pathology ; Humans ; Open Reading Frames ; *Protein Biosynthesis ; Proteins/genetics/*metabolismPublished by: -
5Articles: DFG German National LicensesJacobson, May S. ; Kevy, Sherwin V.
Oxford, UK; Malden, USA : Blackwell Science Ltd/Inc.
Published 2004Staff ViewISSN: 1524-475XSource: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background: As many as 500,000 patients are exposed to bovine thrombin (BT) annually. This is increasing with the use of autologous platelet gel (PG) in surgery and in the treatment of chronic wounds (diabetic ulcers). The development of anti-phospholipid antibodies after exposure to bovine thrombin is of concern. We compared the kinetics of growth factor release by autologous thrombin (AT) to BT. Methods: Whole blood is incubated with 95% ethanol and then centrifuged in the SmartPReP™2 system (Harvest Technologies, Plymouth, MA) simultaneously with the preparation of a platelet concentrate (PC). The supernatant containing thrombin activity is collected. Clotting studies were done. The kinetics of growth factor release was determined by collecting the supernatant from the PG at 2 hours and daily thereafter for 7 days. The PC’s were prepared in two concentrations by adjusting the volumes to 10 mL and 7 mL. The activation of the PC was done at a 10:1 ratio (PC:BT) at 7 mL and 10 mL and 3:1 and 5:1 (PC:AT) at 7 mL. Results: Following a 45 minute incubation period the mean clotting time of PC by AT at a 3:1 ratio was 14.3 sec and at a 5:1 ratio was 22 sec (n = 13). Thrombin activity remained stable for 6 hours. Baseline PDGF-AB levels with AT was 50 ng/mL with a maximum of 106 ng/mL. BT using a 10 mL PC had a baseline level of 100 ng/mL with no increase over time. TGF-B1 studies demonstrated an immediate release of 98 ng/mL with a maximum level of 168 ng/mL for AT compared to BT with an initial level of 107 ng/mL and a maximum of 152 ng/ml. Conclusions: AT produces a sustained release of growth factors during a seven-day period that is similar to BT at a 10:1 ratio. AT can be prepared simultaneously with the preparation of a PC.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesBachiller, Daniel ; Klingensmith, John ; Kemp, C. ; Belo, J. A. ; Anderson, R. M. ; May, S. R. ; McMahon, J. A. ; McMahon, A. P. ; Harland, R. M. ; Rossant, J. ; De Robertis, E. M.
[s.l.] : Macmillian Magazines Ltd.
Published 2000Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] In mice, there is evidence suggesting that the development of head and trunk structures is organized by distinctly separated cell populations. The head organizer is located in the anterior visceral endoderm (AVE) and the trunk organizer in the node and anterior primitive streak. In ...Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0020-708XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Energy, Environment Protection, Nuclear Power EngineeringPhysicsType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0022-5193Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesHoffmann, A ; Jamin, A ; Foetisch, K ; May, S ; Aulepp, H ; Haustein, D ; Vieths, S
Copenhagen : Munksgaard International Publishers
Published 1999Staff ViewISSN: 1398-9995Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background: A murine in vitro model of the allergic type I reaction was set up to determine the biologic activity of extracts without involvement of human beings. It is based on β-hexosaminidase release from passively sensitized RBL cells after allergen challenge. The intended application of this RBL cell assay in the field of quality control of allergenic extracts requires its comparison with established methods. Methods: The activity of five standardized birch-pollen prick test solutions was determined in parallel by RBL assay, direct IgE binding, IgE-binding inhibition, major allergen content, histamine-release assay, and skin testing. Results: The RBL cell-release assay corresponded well to other methods if a reagin raised against natural birch-pollen extract was used for passive sensitization. However, in the case of a reagin against recombinant Bet v 1, only a decreased activity was observed, presumably because a reduced number of epitopes were recognized by the monospecific reagin. In contrast to standardized birch-pollen extracts, nonstandardized apple extracts showed poor activity in all assays. Conclusions: This murine model might be a useful tool in the quality control of allergenic extracts. It combines properties of assays based on standardized antisera and of assays that consider IgE cross-linking properties.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1420-9071Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary Radioactive 2-bromo-3-hydroxy-1:4-naphtoquinone has been used for the exploration of the metabolism of substances which influence the course of blood-clotting. It has been found that this substance diffuses very rapidly into the blood, and that the liver is not characterized by any elective fixation-power.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesGehlbach, S. H. ; Bigelow, C. ; Heimisdottir, M. ; May, S. ; Walker, M. ; Kirkwood, J. R.
Springer
Published 2000Staff ViewISSN: 1433-2965Keywords: Key words:Osteoporosis – Vertebral fractureSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract: Osteoporosis-related vertebral fractures have important health consequences for older individuals, including disability and increased mortality. Because these fractures can be prevented with appropriate medications, recognition and treatment of high-risk patients is warranted. A cross-sectional survey was carried out in a large, regional hospital in New England to examine the frequency with which vertebral fractures are identified and treated by clinicians in a population of hospitalized older women who have radiographic evidence of fractures. The study population consisted of 934 women aged 60 years and older who were hospitalized between October 1, 1995 and March 31, 1997, and who had a chest radiograph obtained. Vertebral fractures in the thoracic region were identified by two radiologists. Discharge diagnoses, medical record notes and radiology reports were compared with the results of the radiologists’ readings to determine the frequency with which fractures were identified and appropriate, osteoporosis-preventing medications prescribed. Moderate or severe vertebral fractures were identified for 132 (14.1%) study subjects, but only 17 (1.8%) of the 934 participants had a discharge diagnosis of vertebral fracture. Of these 132, only 17% had fracture noted in the medical record or discharge summary; 50% of contemporaneous radiology reports identified a fracture as present; and 23% of the time it was found in the radiologist’s summary impression. Only 18% of medical records indicated that fracture patients had been prescribed calcium, vitamin D, estrogen replacement or an antiresorptive agent. Relatively few hospitalized older women with radiographically demonstrated vertebral fractures were thus identified or treated by clinicians, suggesting a need for improved recognition.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesCutler, S. J. ; DeWitt Blanton Jr., C. ; Akin, D. T. ; Steinberg, F. B. ; Moore, A. B. ; Lott, J. A. ; Price, T. C. ; May, S. W. ; Pollock, S. H.
Springer
Published 1998Staff ViewISSN: 1420-908XKeywords: Key words: CDB — Carrageenan edema — Adjuvant-induced arthritis — COX-1 and 2 — Substance PSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract. Objective and Design: 1-(Carboxymethyl)-3,5-diphenyl-2-methylbenzene (CDB), a novel arylacetic acid, was evaluated in vivo for its ability to inhibit acute and chronic inflammation as well as acute pain.¶Materials and Methods: The effects of CDB were evaluated using the following assays: 1) acute inflammation induced by the injection of carrageenan, bradykinin and serotonin into the subplantar region of the hind paw of rats; 2) chronic inflammation produced by the injection of Mycobacterium butyricum into the base of the tail of rats; 3) acute pain induced by the i.p. injection of phenyl-p-quinone into mice resulting in the production of writhes; 4) cyclooxygenase (COX) activity, including COX-1 and COX-2, evaluated using whole blood; and 5) activity of peptidylglycine α-monooxygenase (PAM) isolated from Xenopus laevis skin.¶Results: CDB (10 to 100 mg/kg s.c.) produced a dose-dependent inhibition of carrageenan edema (ED50 of 41 mg/kg at 3 h) which continued for up to 12 h. Using a therapeutic dosing regimen, this compound inhibited hind paw inflammation (〉70%) and arthogram scores in rats with adjuvant-induced arthritis. This compound also possessed significant analgesic activity in mice (70% inhibition with 50 mg/kg). CDB, however, lacked inhibitory activity on bradykinin and serotonin-induced edema. In addition, CDB significantly inhibited COX-1 activity (IC50 ≅ 17 μM) while having only a weak inhibitory activity on both COX-2 and PAM activity.¶Conclusions: CDB is an effective anti-inflammatory/analgesic agent whose mechanism of action appears to be associated with inhibition of COX-1 activity.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesMay, S. ; Sturman, G. ; Perrett 〈!-RID="h1"--〉 〈!-ID="h1" Correspondence to: G. Sturman--〉, D.
Springer
Published 1999Staff ViewISSN: 1420-908XSource: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1420-908XSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract We have studied the effect of the macrophage activator, muramyl dipeptide (MDP) on immune inflammation induced in the rat six day subcutaneous air pouch. Treated animals received either 100 μg or 200 μg MDP at the time of challenge and twenty four hours before exudate harvest. Using the thymocyte co-mitogenic assay for lymphocyte activating factor (LAF), 100 μg MDP enhanced LAFactivity whereas 200 μg caused inhibition. Increased dilution of 200 μg exudate in this assay removed this inhibition. Similarly, at the lower dose, MDP caused enhanced production of the acute phase protein alpha 1 glycoprotein, whereas the higher dose had no effect. The present study suggests that macrophage activity can be manipulatedin vivo to produce LAF and naturally occurring inhibitors of LAF. These studies indicate that the stimulation of LAF inhibitors by MDP may be a potential theerapeutic action.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1292-895XKeywords: PACS. 87.16.-b Subcellular structure and processes - 68.10.-m Fluid surfaces and fluid-fluid interfaces - 68.10.Et Interface elasticity, viscosity, and viscoelasticitySource: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract: The line tension of a symmetric, lipid bilayer in its liquid-crystalline state is calculated on the basis of a molecular lipid model. The lipid model extends the opposing forces model by an expression for the conformational free energy of the hydrocarbon chains. We consider a membrane edge that consists of a perturbed bilayer covered by a section of a cylinder-like micelle. The structural rearrangement of the lipids implies an excess free energy which we minimize with respect to the cross-sectional shape of the membrane edge, including both the micellar and the bilayer region. The line tension is derived as a function of molecular lipid properties, like the lipid chain length or the head group interaction strength. We also relate it to the spontaneous curvature of the lipid layer. We find the line tension to become smaller for lipid layers that tend to curve more towards the hydrophobic core. Our predictions for the line tension and their relation to experimentally derived values are discussed.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1432-2072Keywords: Key words Glucose ; Craving ; Nicotine ; CigaretteSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Rationale: Previous research suggests that glucose may reduce desire to smoke during periods of abstinence but a definitive test is needed. Objective: The present study aimed to determine whether a single administration of oral glucose would reduce desire to smoke in abstaining smokers. Methods: Thirty-eight smokers attended the laboratory in the afternoon having not smoked since the previous evening. They rated their desire to smoke immediately before and at 5-min intervals for 20 min after chewing four 3-g glucose tablets (experimental group) or four matched placebo tablets (control group). Results: Ratings of desire to smoke decreased to a greater extent in the experimental than the control group. The effect was apparent after 10 min. There was no difference between the groups in terms of feeling ”sick” or ”satisfied”. Conclusion: A single dose of glucose has a relatively rapid and detectable effect on desire to smoke and the effect is not mediated by feeling sick. Glucose tablets may be useful in helping to control desire to smoke during periods of abstinence.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1432-1351Keywords: Locust ; Neuroanatomy ; Immunohisto ; chemistry ; Vasopressin-like peptidesSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary Antiserum to arginine-vasopressin has been used to characterise the pair of vasopressin-like immunoreactive (VPLI) neurons in the locust. These neurons have cell bodies in the suboesophageal ganglion, each with a bifurcating dorsal lateral axon which gives rise to predominantly dorsal neuropilar branching in every ganglion of the ventral nerve cord. There are extensive beaded fibre plexuses in most peripheral nerves of thoracic and abdominal ganglia, but in the brain, the peripheral plexuses are reduced while neuropilar branching is more extensive, although it generally remains superficial. An array of fibres runs centripetally through the laminamedulla chiasma in the optic lobes. Lucifer Yellow or cobalt intracellular staining of single VPLI cells in the adult suboesophageal ganglion shows that all immunoreactive processes emanate from these two neurons, but an additional midline arborisation (that was only partially revealed by immunostaining) was also observed. Intracellularly staining VPLI cells in smaller larval instars, which permits dye to reach the thoracic ganglia, confirms that there is no similar region of poorly-immunoreactive midline arborisation in these ganglia. It has been previously suggested that the immunoreactive superficial fibres and peripheral plexuses in ventral cord ganglia serve a neurohaemal function, releasing the locust vasopressin-like diuretic hormone, F2. We suggest that the other major region of VPLI arborisation, the poorly immunoreactive midline fibres in the suboesophageal ganglion, could be a region where VPLI cells receive synaptic input. The function of the centripetal array of fibres within the optic lobe is still unclear.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1615-6102Source: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Summary The ultrastructure of quadrifid and bifid hairs which line the inside of the trap in the bladderwortUtricularia monanthos are described. Both types of hair consist of a pedestal cell resting on a special epidermal cell which bears two and four terminal cells in bifids and quadrifids, respectively. The pedestal cell is a transfer cell with an extensive labyrinth of wall ingrowths and cytoplasm containing numerous well differentiated mitochondria. The wall ingrowths contain little structural material and appear to undergo changes in width depending on the activity of the trap. The proximal region of the lateral wall is devoid of ingrowths and is completely impregnated with opaque material slightly different in appearance from that of the adjoining impregnated walls. Numerous compound plasmodesmata connect the protoplast of the pedestal cell to that of the basal epidermal cell. The terminal cells of quadrifids and bifids show a striking differentiation of protoplast and wall associated with their specialization into stalk and arms. The protoplast of the stalk is narrow and contains mostly tubular ER. Abundant simple plasmodesmata traverse the wall between the foot of the stalk and the pedestal cell. The protoplast of the arm displays a large central vacuole, with the nucleus and numerous mitochondria concentrated towards the base of the arm. The walls of the stalk are thick and heavily impregnated with cuticular material in their outer regions, but in the arms the cuticle is very thin and consists of small separate cutin cystoliths. The walls of the arms exhibit short unbranched ingrowths. The structure and function of the hairs is discussed. Materials are probably absorbed by the arms and transported to the pedestal cell. It is suggested that once substances have passed through the cuticle of the arm they are transported by the terminal cells, either symplasticallyvia the protoplast or apoplastically through the walls into the labyrinth of the pedestal cell. Because of the continuous impregnation in the proximal half of the lateral wall of the pedestal cell, all substances must pass through the protoplast of the pedestal cell if they are to be transported into the walls of the trap.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1615-1488Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract A new strategy is presented for discrete optimization problems. This strategy is called the “filtered simulated annealing strategy”. It includes a filter size which may be adjusted by the user. A coarse filter size results in an unfiltered simulated annealing strategy which is quite robust in obtaining the global optimum provided enough cycles are executed. A fine filter size blocks many candidate designs which are viewed as having little potential, and produces good designs quickly. The strategy is applied to a realistic 3D steel frame test problem. Extensive results are presented and the performance of the strategy is analysed for parameter sensitivity. The performance is also compared to that of the well-known branch and bound strategy.Type of Medium: Electronic ResourceURL: