Search Results - (Author, Cooperation:S. Maheswaran)
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1Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2015-11-13Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Drug Resistance, Neoplasm/*drug effects ; *Epithelial-Mesenchymal Transition ; Female ; Lung Neoplasms/*pathology/*secondary ; Male ; Mammary Neoplasms, Experimental/*drug therapy/*pathology ; Neoplasm Metastasis/*pathology ; Pancreatic Neoplasms/*drug therapy/*pathologyPublished by: -
2Latest Papers from Table of Contents or Articles in PressD. T. Ting ; D. Lipson ; S. Paul ; B. W. Brannigan ; S. Akhavanfard ; E. J. Coffman ; G. Contino ; V. Deshpande ; A. J. Iafrate ; S. Letovsky ; M. N. Rivera ; N. Bardeesy ; S. Maheswaran ; D. A. Haber
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-01-15Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Carcinoma in Situ/genetics/pathology ; Carcinoma, Pancreatic Ductal/genetics/pathology ; Colonic Neoplasms/genetics/pathology ; DNA Methylation ; DNA, Neoplasm/genetics ; DNA, Satellite/*genetics ; Female ; Gene Expression ; Gene Expression Profiling ; Heterochromatin/chemistry/genetics ; Humans ; Long Interspersed Nucleotide Elements ; Lung Neoplasms/genetics/pathology ; Male ; Mice ; Mice, Nude ; Neoplasms/*genetics/pathology ; Neurosecretory Systems/metabolism ; Ovarian Neoplasms/genetics/pathology ; Pancreatic Neoplasms/*genetics/pathology ; Prostatic Neoplasms/genetics/pathology ; RNA, Neoplasm/*genetics/metabolism ; RNA, Untranslated/*genetics/metabolism ; Transcription, GeneticPublished by: -
3Latest Papers from Table of Contents or Articles in PressM. Yu ; A. Bardia ; B. S. Wittner ; S. L. Stott ; M. E. Smas ; D. T. Ting ; S. J. Isakoff ; J. C. Ciciliano ; M. N. Wells ; A. M. Shah ; K. F. Concannon ; M. C. Donaldson ; L. V. Sequist ; E. Brachtel ; D. Sgroi ; J. Baselga ; S. Ramaswamy ; M. Toner ; D. A. Haber ; S. Maheswaran
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-02-02Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Biomarkers, Tumor/genetics/metabolism ; Breast Neoplasms/blood/genetics/*pathology ; Cell Count ; Cell Movement ; Epithelial Cells/pathology ; *Epithelial-Mesenchymal Transition ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Mesoderm/pathology ; Mice ; Neoplasm Transplantation ; Neoplastic Cells, Circulating/metabolism/*pathology ; RNA, Neoplasm/chemistry/genetics ; Transcription, Genetic ; Transforming Growth Factor beta/genetics/metabolismPublished by: -
4Latest Papers from Table of Contents or Articles in PressD. T. Miyamoto ; Y. Zheng ; B. S. Wittner ; R. J. Lee ; H. Zhu ; K. T. Broderick ; R. Desai ; D. B. Fox ; B. W. Brannigan ; J. Trautwein ; K. S. Arora ; N. Desai ; D. M. Dahl ; L. V. Sequist ; M. R. Smith ; R. Kapur ; C. L. Wu ; T. Shioda ; S. Ramaswamy ; D. T. Ting ; M. Toner ; S. Maheswaran ; D. A. Haber
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-09-19Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Androgen Antagonists/pharmacology/*therapeutic use ; Animals ; Cell Line, Tumor ; Drug Resistance, Neoplasm/*genetics ; Humans ; Male ; Mice ; Neoplastic Cells, Circulating/drug effects/*metabolism ; Phenylthiohydantoin/*analogs & derivatives/pharmacology/therapeutic use ; Prostate/drug effects/metabolism/pathology ; Prostatic Neoplasms/*drug therapy/*pathology ; Proto-Oncogene Proteins/genetics/metabolism ; RNA Splicing ; Receptors, Androgen/*genetics ; Sequence Analysis, RNA/methods ; Signal Transduction ; Single-Cell Analysis/methods ; Transcriptome ; Wnt Proteins/genetics/*metabolism ; Xenograft Model Antitumor AssaysPublished by: -
5Latest Papers from Table of Contents or Articles in PressM. Yu ; A. Bardia ; N. Aceto ; F. Bersani ; M. W. Madden ; M. C. Donaldson ; R. Desai ; H. Zhu ; V. Comaills ; Z. Zheng ; B. S. Wittner ; P. Stojanov ; E. Brachtel ; D. Sgroi ; R. Kapur ; T. Shioda ; D. T. Ting ; S. Ramaswamy ; G. Getz ; A. J. Iafrate ; C. Benes ; M. Toner ; S. Maheswaran ; D. A. Haber
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-07-12Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antineoplastic Agents/*pharmacology/therapeutic use ; Breast Neoplasms/*drug therapy/genetics ; Cell Culture Techniques ; Cell Separation ; Culture ; Drug Resistance, Neoplasm/*genetics ; Drug Screening Assays, Antitumor/methods ; Estrogen Receptor alpha/genetics ; Female ; Gene Frequency ; Humans ; Mice ; Microfluidics/methods ; *Molecular Targeted Therapy ; Mutation ; Neoplastic Cells, Circulating/*drug effects/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Sequence Analysis, DNA ; Tumor Cells, Cultured ; Xenograft Model Antitumor AssaysPublished by: -
6Latest Papers from Table of Contents or Articles in PressM. Yu ; D. T. Ting ; S. L. Stott ; B. S. Wittner ; F. Ozsolak ; S. Paul ; J. C. Ciciliano ; M. E. Smas ; D. Winokur ; A. J. Gilman ; M. J. Ulman ; K. Xega ; G. Contino ; B. Alagesan ; B. W. Brannigan ; P. M. Milos ; D. P. Ryan ; L. V. Sequist ; N. Bardeesy ; S. Ramaswamy ; M. Toner ; S. Maheswaran ; D. A. Haber
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-07-06Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Survival ; Contact Inhibition ; Disease Models, Animal ; Gene Expression Regulation, Neoplastic/*genetics ; Genes, Neoplasm/genetics ; Humans ; MAP Kinase Kinase Kinases/antagonists & inhibitors ; Mice ; Neoplasm Metastasis/*genetics ; Neoplastic Cells, Circulating/*metabolism ; Pancreatic Neoplasms/*genetics/*pathology ; RNA, Messenger/analysis/biosynthesis ; Sequence Analysis, RNA ; Wnt Proteins/genetics/*metabolism ; Wnt Signaling Pathway/*genetics ; Wnt2 Protein/genetics/metabolismPublished by: -
7Articles: DFG German National LicensesStaff View
ISSN: 0921-4526Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0921-4526Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1573-7446Keywords: cattle ; cyclosporin A ; macrophages ; pasteurellosis ; pentoxifylline ; pneumonia ; procoagulant activity ; retinoic acid ; tissue factorSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Local and systemic activation of coagulation is frequently associated with bacterial sepsis. The coagulopathy is due, at least in part, to expression of tissue factor (TF) by monocytes and macrophages. The purpose of this study was to evaluate the expression of procoagulant activity by bovine alveolar macrophages, leukocytes and platelets, and to determine the relative potency of three chemical inhibitors of TF expression (pentoxifylline, retinoic acid, and cyclosporin A). Bovine alveolar macrophages were stimulated with lipopolysaccharide (LPS) derived from Pasteurella haemolytica or recombinant bovine tumour nervous factor (TNF) and dose- and time-dependent effects on TF expression were studied. LPS and TNF induced TF expression in alveolar macrophages and LPS treatment of whole blood induced TF expression in mononuclear cells. Neutrophils and platelets also expressed procoagulant activity, but this activity was not inhibited by anti-bovine TF monoclonal antibody. Pentoxifylline (40 μmol/L), retinoic acid (0.01 mmol/L) and cyclosporin A (0.08 μmol/L) inhibited TF expression when added concurrently with LPS or TNF, but not when added 4 h after stimulation. TF mRNA was not detected in unstimulated alveolar macrophages by Northern blot analysis. In contrast, exposure to LPS or TNF for 6 h induced marked expression of TF mRNA, which was inhibited by treatment with pentoxifylline, retinoic acid and cyclosporin A. Expression of TNF by alveolar macrophages stimulated with LPS was also inhibited by these compounds. Our results indicate that procoagulant activity expressed by alveolar macrophages and monocytes is associated with expression of TF, whereas procoagulant activity expressed by neutrophils and platelets is not. The concentrations of pentoxifylline and retinoic acid necessary for inhibition of TF expression in vitro may not be achievable in vivo owing to their toxic effects. However, the in vitro concentration of cyclosporin A that inhibited TF expression did not exceed the plasma concentration observed in humans, and therefore may be useful for inhibition of TF expression in vivo.Type of Medium: Electronic ResourceURL: