Search Results - (Author, Cooperation:R. Lim)
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1Latest Papers from Table of Contents or Articles in PressLee, A. R., Lim, K.-H., Park, E.-S., Kim, D. H., Park, Y. K., Park, S., Kim, D.-S., Shin, G.-C., Kang, H. S., Won, J., Sim, H., Ha, Y. N., Jae, B., Choi, S. I., Kim, K.-H.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-08-01Publisher: The American Society for Microbiology (ASM)Print ISSN: 0022-538XElectronic ISSN: 1098-5514Topics: MedicinePublished by: -
2Latest Papers from Table of Contents or Articles in PressK. Wilhelm ; K. Happel ; G. Eelen ; S. Schoors ; M. F. Oellerich ; R. Lim ; B. Zimmermann ; I. M. Aspalter ; C. A. Franco ; T. Boettger ; T. Braun ; M. Fruttiger ; K. Rajewsky ; C. Keller ; J. C. Bruning ; H. Gerhardt ; P. Carmeliet ; M. Potente
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-01-07Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Proliferation ; Cell Respiration ; Endothelium, Vascular/cytology/*growth & development/*metabolism ; Female ; Forkhead Transcription Factors/deficiency/genetics/*metabolism ; Glycolysis ; Human Umbilical Vein Endothelial Cells/cytology/metabolism ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Proto-Oncogene Proteins c-myc/deficiency/genetics/metabolism ; Signal TransductionPublished by: -
3Latest Papers from Table of Contents or Articles in PressWang, C., Liu, R., Lim, G.-H., de Lorenzo, L., Yu, K., Zhang, K., Hunt, A. G., Kachroo, A., Kachroo, P.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-05-31Publisher: American Association for the Advancement of Science (AAAS)Electronic ISSN: 2375-2548Topics: Natural Sciences in GeneralPublished by: -
4Latest Papers from Table of Contents or Articles in PressY M Polishchuk, A N Bogdanov, I N Muratov, V Y Polishchuk, A Lim, R M Manasypov, L S Shirokova and O S Pokrovsky
Institute of Physics (IOP)
Published 2018Staff ViewPublication Date: 2018-03-17Publisher: Institute of Physics (IOP)Print ISSN: 1748-9318Electronic ISSN: 1748-9326Topics: BiologyEnergy, Environment Protection, Nuclear Power EngineeringPublished by: -
5Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-05-19Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Public health, Open access, Global healthPublished by: -
6Articles: DFG German National LicensesStaff View
ISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract— In further experiments on the effects of antibiotic agents on protein synthesis in the goldfish brain, doses of intracranially-injected puromycin or acetoxycycloheximide higher than those previously employed did not hasten the onset of inhibition of incorporation of intraperitoneally-injected [3H]leucine into brain protein.The antibiotic-resistant incorporation was not due to the presence of labelled blood protein in the brain. After the intracranial injection of labelled puromycin, the appearance of radioactivity in the acid-soluble fraction of brain was blocked by acetoxycycloheximide. Repeated daily intracranial or intraperitoneal injections of puromycin were lethal, and acetoxycycloheximide was not protective, indicating that peptidyl-puromycin was present in the brain but did not account for the lethality of puromycin. Behavioural experiments argued against but did not totally exclude the possibility that peptidyl-puromycin was responsible for the amnestic effect of puromycin. Puromycin aminonucleoside, O-methyl tyrosine and 5-guanylyl methylenediphosphonate had little or no effect on protein synthesis in brain, but gougerotin was slightly inhibitory.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract— Protein metabolism of goldfish brain was studied in vivo by means of intraperitoneal or intracranial injections of [3H]leucine and compared with concomitant studies in the mouse. Heterogeneity of turnover values was observed. Long turnover times were seen relative to other organs examined. The free amino acid pools of goldfish brain were determined, and the fate of tritium from labelled leucine was followed at various times after injection.Following ‘chasing’ with large amounts of unlabelled leucine or protein inhibitors shortly after isotope injection, further incorporation was arrested, but examination of the labelled protein over a period of 2 weeks indicated a slow decay, similar to that seen without ‘chasing’.Possible use of ‘pulse-chase’ experiments in vivo in animals is discussed in relation to behavioural studies.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesPesquera-Lepatan, L. M. B. ; Hernandez, F. G. ; Lim, R. D. ; Chua, M. N.
Oxford, UK : Blackwell Science Ltd
Published 2004Staff ViewISSN: 1365-2516Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary. Continuous infusion (CI) of factor VIII concentrates has been demonstrated to be cost-effective method in maintaining stable levels of FVIII activity in haemophilia A patients with major bleeding or undergoing major surgery. Cryoprecipitates remain the major source of FVIII in developing countries-like the Philippines because of limited availability and high cost of concentrates. To support the use of cryoprecipitate as alternative to FVIII concentrate for CI in centres with no factor concentrates, FVIII levels in 37 bags of random cryoprecipitate were measured at 0, 2, 4 and 6 h after thawing, kept at room temperature with bacteriological culture studies performed on the sixth hour. The mean FVIII content at hour 0 was 108.10 U per bag. Type ORh+ blood had lower FVIII content (±78.91 U per bag) compared with blood types ARh+ (±121.64 U per bag) and BRh+ (±117.04 U per bag). The units stored 〈6 months had higher FVIII content (±117.74 U per bag) compared with those stored for over 6- but 〈12-months (±66.77 U per bag). The mean rate of decline of FVIII activity at 2, 4 and 6 h was statistically significant at 10.35% (P = 0.000), 21.49% (P = 0.000) and 29.41% (P = 0.000) from baseline, respectively, using the paired t-test. Similar finding was found across different blood types and storage duration. Only one of 37 bags grew Staphylococcus aureus on day 10 of incubation.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesLim, L. L. ; Wai, C. T. ; Lee, Y. M. ; Kong, H. L. ; Lim, R. ; Koay, E. ; Lim, S. G.
Oxford, UK : Blackwell Science Ltd
Published 2002Staff ViewISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background : Chronic hepatitis B virus carriers receiving chemotherapy develop a high hepatitis B virus reactivation rate (38–53%) with a high mortality (37–60%). Few studies have characterized the efficacy of lamivudine in the treatment of chemotherapy-induced hepatitis B virus reactivation.Aim : To determine whether lamivudine prophylaxis reduces chemotherapy-induced hepatitis B virus reactivation and mortality.Methods : The medical records of all hepatitis B surface antigen-positive patients with malignancy treated with chemotherapy since 1995 at the National University Hospital of Singapore were identified, and divided into those who received lamivudine prophylaxis before chemotherapy (P) and those who did not (NP).The parameters examined included gender, age, malignancy type, steroid usage, number of chemotherapy courses and regimens, follow-up duration and hepatitis B virus status. The outcome measures were hepatitis B virus reactivation (abrupt rise of serum alanine aminotransferase to 〉 200 IU/L) and reactivation death. Patients with primary hepatoma or liver metastasis were excluded.Results : Thirty-five patients were identified: 16 in the P group and 19 in the NP group. The baseline characteristics of the two groups were similar. Seven of the 19 patients in the NP group and none of the 16 patients in the P group developed reactivation (36.8% vs. 0%, P=0.009). Six of the seven patients in the NP group who developed reactivation received lamivudine at that time, but five died (mortality, 71.4%), whilst no patient in the P group died from reactivation (P=0.064).Conclusions : Prophylactic lamivudine appears to prevent hepatitis B virus reactivation and its associated mortality in patients treated with chemotherapy. This should be confirmed with prospective studies.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0005-2736Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStover, C. K. ; Pham, X. Q. ; Erwin, A. L. ; Mizoguchi, S. D. ; Warrener, P. ; Hickey, M. J. ; Brinkman, F.S. L. ; Hufnagle, W. O. ; Kowalik, D. J. ; Lagrou, M. ; Garber, R. L. ; Goltry, L. ; Tolentino, E. ; Westbrock-Wadman, S. ; Yuan, Y. ; Brody, L. L. ; Coulter, S. N. ; Folger, K. R. ; Kas, A. ; Larbig, K. ; Lim, R. ; Smith, K. ; Spencer, D. ; Wong, G. K.-S. ; Wu, Z.
[s.l.] : Macmillian Magazines Ltd.
Published 2000Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Pseudomonas aeruginosa is a ubiquitous environmental bacterium that is one of the top three causes of opportunistic human infections. A major factor in its prominence as a pathogen is its intrinsic resistance to antibiotics and disinfectants. Here we report the complete sequence of P. ...Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Since substance P (ref. 5), a polypeptide like bradykinin, is found to be present in high concentration in dorsal roots and the nuclei of the dorsal column6'7, it has been suggested that it might function as the chemical transmitter of the first order of sensory-neurones8. It stimulates the sensory ...Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0003-2697Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0005-2795Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0005-2795Keywords: (Pig brain) ; Glia ; Maturation factor ; Multiple molecular formSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0005-2795Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0003-2697Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 0014-4827Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 0014-4827Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0014-4827Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: