Search Results - (Author, Cooperation:R. Hodes)
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1Latest Papers from Table of Contents or Articles in PressF. S. Collins ; J. M. Anderson ; C. P. Austin ; J. F. Battey ; L. S. Birnbaum ; J. P. Briggs ; J. A. Clayton ; B. Cuthbert ; R. W. Eisinger ; A. S. Fauci ; J. I. Gallin ; G. H. Gibbons ; R. I. Glass ; M. M. Gottesman ; P. A. Gray ; E. D. Green ; F. B. Greider ; R. Hodes ; K. L. Hudson ; B. Humphreys ; S. I. Katz ; G. F. Koob ; W. J. Koroshetz ; M. S. Lauer ; J. R. Lorsch ; D. R. Lowy ; J. J. McGowan ; D. M. Murray ; R. Nakamura ; A. Norris ; E. J. Perez-Stable ; R. I. Pettigrew ; W. T. Riley ; G. P. Rodgers ; P. A. Sieving ; M. J. Somerman ; C. Y. Spong ; L. A. Tabak ; N. D. Volkow ; E. L. Wilder
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-03-26Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Biomedical Research/*economics ; Humans ; National Institutes of Health (U.S.)/*economicsPublished by: -
2Articles: DFG German National LicensesHODES, R. J. ; SCHMITT-VERHULST, A.-M. ; HATHCOCK, K. S. ; SHEARER, G. M.
Oxford, UK : Blackwell Publishing Ltd
Published 1976Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: In vitro mixed lymphocyte culture (MLC) responses and the in vitro induction of cell-mediated lympholysis (CML) were studied in congenic strain combinations in which the responding and stimulating strains differed either at the entire major histocompatibility complex (MHC) or only at the D end of the MHC. In contrast to previously reported studies, the relative strengths of stimulation by ‘D end only’ differences or by whole MHC differences were examined by stimulating identical responding populations with titrated numbers of stimulating cells that differed from the responder either at the D end only or over the entire MHC. When tested in this manner isolated D-end differences were sufficient to generate significant MLC and CML responses in each combination tested. Several ‘D end only’ differences (the responses of B10.A to B10.A(2R); of B10.A(2R) to B10.A; of B10.D2 to B10.HTG; and of B10.HTG to B10.D2 were several fold less efficient in stimulating MLC and CML responses than were control stimulating cells differing over the whole MHC. In contrast, when the mutant D-end allele da was present on the stimulating cell (the responses of B10.D2 to B10.D2(M504) and of B10 to B10.D2(R106)), stimulation by M isolated D-end difference was comparable to stimulation by broader MHC differences. These findings are discussed in terms of the possible functional complexity of the D region.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 1744-313XSource: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyMedicineNotes: The relationship among different minor lymphocyte stimulatory locus (Mis) determinants, Mlsa, Mlsb, Mlsc and Mlsd, remains unclear. Because of the high degree of cross-reactivity between Mlsa and Mlsd determinants, the weak stimulatory capacity of Mlsc, and the generally non-stimulatory nature of Mlsb, some investigators have recently suggested that Mis is composed of only a single expressed allele originally defined as the a andd alleles. In order to clarify the nature of Mls determinants, T cell clones positively selected for reactivity to the three stimulatory Mls determinants, Mlsa Mlsc and Mlsd, were generated and their specificities defined by extensive genetic studies. The response pattern of these Mls-specific clones as well as the results of primary mixed lymphocyte responses indicated that: (i) Mlsa and Mlsc determinants recognized by T cells are distinct, demonstrating that polymorphism does exist within the Mls system; and (ii) Mlsd is not an independent Mls type since Mlsd determinants are composed of Mlsa and Mlsc determinants and anti-Mlsd T cell responses are, in fact, the sum of anti-Mlsa and anti-Mlsc responses.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesSeldin, M. F. ; Abe, R. ; Steinberg, A. D. ; Hodes, R. J. ; Morse, H. C.
Oxford, UK : Blackwell Publishing Ltd
Published 1988Staff ViewISSN: 1744-313XSource: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyMedicineNotes: The segregation of Mlsa with respect to genes localized distally on mouse chromosome 1 was examined in two sets of recombinant inbred (RI) strains. In order to localize Mlsa, a linkage map based on analysis of both interspecific backcross mice and multiple sets of RI strains was utilized: (centromere) - Ren-1,2-10 centimorgans (cM)-At-3-8cM.-Apo-A2/Ly-17-2 cM-Spna-1-4cM.-Akp-1-(telomere). The Mlsa allele was mapped to a region that extended just centromeric of Ly-17 (one crossover in 40 RI strains) to just telomeric of Spna-1 (no crossover in 40 RI strains). The identification of multiple polymorphic loci in the region of Mlsa should allow precise gene localization and assist in efforts to clone this gene.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0014-4827Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0014-4827Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1744-313XSource: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyMedicineNotes: Although the minor lymphocyte stimulatory locus (Mls) system was originally described as a single-locus, multiple-allelic system, allelism among the genes which encode Mlsa, Mlsc and Mlsd has not been demonstrated formally. In this report, genetic linkage between genes encoding Mlsa and Mlsc was studied by testing responses of unprimed T cells, as well as Mlsa- and Mlsc-specific T cell clones, to the progeny of (AKR/J × C3H/HeJ) F1× B10.BR [(Mlsa×Mlsc)F1×Mlsb] crosses. In addition, the configuration of Mls genes expressed by CBA/J (Mlsd) was evaluated by examining the response pattern of a panel of Mlsd-specific clones to (CBA/J × B10.BR)F1× B10.BR stimulators. Results of these segregation analyses indicated that the Mls system is composed of at least two independent and unlinked genes which encode, respectively, the determinants identified as Mlsa and Mlsc.Type of Medium: Electronic ResourceURL: