Search Results - (Author, Cooperation:R. Hanada)

2013-03-12

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Amyotrophic Lateral Sclerosis ; Animals ; Animals, Newborn ; Axons/metabolism/pathology ; Cell Death ; Diaphragm/innervation ; Embryo Loss ; Embryo, Mammalian/metabolism/pathology ; Exons/genetics ; Female ; Fibroblasts ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Motor Neurons/*metabolism/*pathology ; Muscular Atrophy, Spinal ; Neuromuscular Diseases/metabolism/pathology ; Oxidative Stress ; RNA Processing, Post-Transcriptional ; RNA, Transfer, Tyr/genetics/*metabolism ; Respiration ; Spinal Nerves/cytology ; Transcription Factors/deficiency/*metabolism ; Tumor Suppressor Protein p53/metabolism ; Tyrosine/genetics/metabolism

2012-07-28

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Biocatalysis ; Colitis/drug therapy/*etiology/*microbiology/pathology ; Dextran Sulfate ; Diarrhea/complications ; Dietary Proteins/metabolism/pharmacology ; Female ; Gene Deletion ; Genetic Predisposition to Disease ; Germ-Free Life ; Homeostasis ; Immunity, Innate ; Intestines/*microbiology/pathology ; Male ; Malnutrition/*complications/metabolism ; *Metagenome ; Mice ; Models, Biological ; Niacinamide/metabolism/pharmacology/therapeutic use ; Peptidyl-Dipeptidase A/deficiency/genetics/*metabolism ; Renin-Angiotensin System/physiology ; TOR Serine-Threonine Kinases/metabolism ; Trinitrobenzenesulfonic Acid ; Tryptophan/*metabolism/pharmacology/therapeutic use

2018-06-29

The American Society for Microbiology (ASM)

0270-7306

1098-5549

Biology

Medicine

0031-9422

5α-oleandrigenin glycoside ; 5α-pregnanolone glucotrioside ; Apocynaceae ; Nerium odorum ; cardiac glycoside ; digitoxigenin gentiotriosyl-digitaloside ; pregnenolone apiosyl-glucoside. ; roots

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Electronic Resource

0031-9422

Anodendron affine ; Apocynaceae ; affinoside. ; cardenolide ; doubly linked cardenolide glycoside ; sarmentogenin glycoside ; seed glycoside

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Electronic Resource

0304-8853

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Physics

Electronic Resource

0165-4608

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Medicine

Electronic Resource

0165-4608

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Medicine

Electronic Resource

0165-4608

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Medicine

Electronic Resource

0165-4608

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Medicine

Electronic Resource

0165-4608

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Medicine

Electronic Resource

0165-4608

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Medicine

Electronic Resource

1437-9813

Keywords Congenital neuroblastoma ; Dumbbell tumor ; Liver metastasis ; Spontaneous regression

Springer Online Journal Archives 1860-2000

Medicine

Abstract We report a patient with a congenital mediastinal dumbbell neuroblastoma (NB) presenting as respiratory distress at birth rather than a neurologic deficit. The tumor did not respond to low-dose chemotherapy, but radiotherapy and surgery were effective. The patient was observed postoperatively without further therapeutic intervention considering the favorable biologic factors despite the appearance of liver metastases, which ultimately regressed spontaneously. The authors believe that most congenital NBs have favorable outcomes with a possibility of spontaneous regression, and that an understanding of the biologic features of tumors is important to avoid overtreatment of lesions with a favorable prognosis.

Electronic Resource

1432-1076

Key words Hepatitis C virus ; Chronic hepatitis C ; Natural history ; Spontaneous remission ; Children

Springer Online Journal Archives 1860-2000

Medicine

Abstract The clinical course of 48 children with chronic hepatitis C (33 boys, 15 girls; mean age: 12.2 years) was monitored for more than 3 years to clarify its natural course. All patients were positive for the second-generation antibody to hepatitis C virus (anti-HCV) and for serum hepatitis C virus (HCV) RNA. All but one patient had a history of blood transfusion. Serum levels of alanine aminotransferase (ALT) had been abnormal for more than 1.5 years. Spontaneous remission defined as a biochemical remission lasting more than 1 year in association with the disappearance of serum HCV RNA, occurred in 4 (8.3%), however, in 25%, HCV RNA was still detectable in the liver even after its disappearance from serum. In this patient, the level of antibody to HCV core antigen (anti-HCV core) did not decrease significantly and serum HCV RNA eventually reappeared. The serum titre of HCV RNA in the 4 children with spontaneous remission was lower than in the remaining 44 children. Spontaneous remission may occur in children with chronic hepatitis C in whom the serum titre of HCV RNA is low and serum level of anti-HCV core decreases significantly. Assessment of the intrahepatic HCV RNA is necessary to confirm complete remission. Conclusion A low serum titre of HCV RNA and a significant decrease in the serum titre of anti-HCV core were associated with spontaneous remission in children with chronic hepatitis C. Intrahepatic HCV RNA assessment is necessary to confirm complete remission.

Electronic Resource

1432-1076

Fatal infectious mononucleosis ; Staphylococcal pyoderma ; Immunodysregulation

Springer Online Journal Archives 1860-2000

Medicine

Abstract We describe a 14-year-old girl with fatal infectious mononucleosis with high fever, pancytopenia, and multiple skin ulcers due toStaphylococcus aureus. Immunological studies revealed low serum IgM, low natural killer (NK) activity, and high CD4/CD8 ratio. Her father had also low NK activity and high CD4/CD8 ratio. It is suggested that she had a dominantly inherited immunodeficiency predisposing to severe Epstein-Barr virus infection.

Electronic Resource

1573-2673

Springer Online Journal Archives 1860-2000

Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Résumé On a développé un modèle de l'effet de Bauschinger dans des matériaux, contenant des héterogénités par utilisation de la théorie de distribution continue de dislocations sur un plan. On a aussi considéré l'effet de durcissement d' écronissage. On a calculé les pertes d' énergie par cycle de tension comme fonction de la tension maximale et on a fait une comparaison avec les études de fatigue de Lazan.

Zusammenfassung Ein Model des Bauschingereffekts in Werkstoffen mit Heterogenitäten wind erörtert under Benützung der Theorie der kontinuierlichen Verteilungen von Versetzungen in einer Ebene. Der Effekt der Arbeitsverfestigung wind betrachtet. Die Energieverluste pro Spannungszyklus werden als Funktion der Maximalspannung berechnet und mit den Dauerfestigkeitsbetrachtungen von Lazan verglichen.

Abstract A model of the Bauschinger effect in materials containing heterogeneities is developed using the theory of continuous dislocation distributions on a plane. The effect of work hardening is considered. Energy losses per stress cycle are calculated as a function of maximum stress and a comparison is made with the fatigue studies of Lazan.

Electronic Resource

1572-9540

Springer Online Journal Archives 1860-2000

Physics

Abstract A Fe−Si (6at%) single crystal with a (110) surface was studied by a Mossbauer spectroscopy as a function of the angle between a crystal axis 〈100〉 and the magnetization direction 〈hk1〉. The difference spectra reveal Si atoms give rise to a magnetic dipolar field, of which magnitude varies with the angle as expected for the Si atom in the 2nd neighbor site. The dipolar field was found to take place at the main lines of Mossbauer spectrum to reveal the Si atom in the 2nd neighbor site never reduces the hyperfine field at the Fe probe nuclei, which supports the earlier proposals by Cranshaw.

Electronic Resource

1572-9540

Springer Online Journal Archives 1860-2000

Physics

Abstract NMR-ON measurements have been performed for60CoFe−Si. The samples of Fe−Si (6 at. %) single crystal dish with the (110) surface were used. Rosonance measurements have been carried out with the magnetization direction along the 〈100〉 and the 〈111〉 axes. Five prominent resonances were found at 166, 162, 151, 147 and 135 Mllz. The resonance at 166 Mllz has been known to be due to60Co without neighbourt Si atoms. The resonances at 151 and 135 Mllz are due to60Co nuclei with one and two Si atom(s) in the 1st neighbour site, respectively. The resonances at 162 and 147 Mllz would be due to the contribution of the 3rd 〈111〉 and the 〈100〉 magnetization axes, the differences of the resonance width have been qualitatively explained using the dipolar field.

Electronic Resource

1572-9540

Springer Online Journal Archives 1860-2000

Physics

Abstract To examine the orientation and magnitude of the electric field gradient (EFG) created by a vacancy at the111In probe site, PAC spectra were measured in a Cd single crystal as a function of the crystal orientation after a quenching and aging treatment at 120 K. The results are compared with calculated spectra based on a point charge model of the EFG created by a vacancy at the site of the probe atom.

Electronic Resource

1572-9540

Springer Online Journal Archives 1860-2000

Physics

Abstract TDPAC spectra of 111 In in a single crystal of Cd are measured as a function of its. orientation relative to the $$\mathop {k_1 }\limits^ \rightharpoonup$$ -direction. The results are compared with the theoretical calculation by Alder et. al.

Electronic Resource