Search Results - (Author, Cooperation:R. D. Vale)
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1Latest Papers from Table of Contents or Articles in PressR. D. Vale ; J. DeRisi ; R. Phillips ; R. D. Mullins ; C. Waterman ; T. J. Mitchison
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-12-22Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Curriculum ; *Education, Graduate ; Faculty ; *Interdisciplinary Communication ; Laboratories ; Massachusetts ; Physiology/*education ; *Research ; TeachingPublished by: -
2Latest Papers from Table of Contents or Articles in PressR. J. McKenney ; W. Huynh ; M. E. Tanenbaum ; G. Bhabha ; R. D. Vale
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-07-19Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adaptor Proteins, Signal Transducing/*metabolism ; Animals ; Cytoplasmic Dyneins/chemistry/*metabolism ; Humans ; Mice ; Microtubule-Associated Proteins/*metabolism ; Microtubules/chemistry/*metabolism ; Motion ; Protein Transport ; RatsPublished by: -
3Latest Papers from Table of Contents or Articles in PressX. Su ; J. A. Ditlev ; E. Hui ; W. Xing ; S. Banjade ; J. Okrut ; D. S. King ; J. Taunton ; M. K. Rosen ; R. D. Vale
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-04-09Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Actins/*metabolism ; Adaptor Proteins, Signal Transducing/*metabolism ; Fluorescence Recovery After Photobleaching ; Humans ; Jurkat Cells ; Membrane Proteins/*metabolism ; Mitogen-Activated Protein Kinase Kinases ; Phosphorylation ; Polymerization ; Receptors, Antigen, T-Cell/*agonists ; Signal Transduction ; T-Lymphocytes/*metabolismPublished by: -
4Latest Papers from Table of Contents or Articles in PressJ. M. Berg ; N. Bhalla ; P. E. Bourne ; M. Chalfie ; D. G. Drubin ; J. S. Fraser ; C. W. Greider ; M. Hendricks ; C. Jones ; R. Kiley ; S. King ; M. W. Kirschner ; H. M. Krumholz ; R. Lehmann ; M. Leptin ; B. Pulverer ; B. Rosenzweig ; J. E. Spiro ; M. Stebbins ; C. Strasser ; S. Swaminathan ; P. Turner ; R. D. Vale ; K. VijayRaghavan ; C. Wolberger
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-05-21Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
5Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2012-07-06Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Antigen-Presenting Cells/immunology/metabolism ; Antigens, CD45/genetics/metabolism ; Cell Compartmentation ; Cell Membrane/enzymology ; Cell Transdifferentiation/*genetics ; *Genetic Engineering ; HEK293 Cells ; Histocompatibility Antigens Class II/immunology/metabolism ; Humans ; Lymphocyte Activation/*immunology ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism ; Phosphorylation ; Receptors, Antigen, T-Cell/immunology/*metabolism ; Signal Transduction/immunology ; Synthetic Biology/*methods ; T-Lymphocytes/enzymology/immunology/*metabolism ; Time Factors ; *Transduction, GeneticPublished by: -
6Latest Papers from Table of Contents or Articles in PressA. P. Carter ; C. Cho ; L. Jin ; R. D. Vale
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-02-19Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adenosine Triphosphate/metabolism ; Allosteric Regulation ; Amino Acid Sequence ; Binding Sites ; Crystallography, X-Ray ; Cytoplasmic Dyneins/*chemistry/*metabolism ; Methionine/chemistry ; Microtubules/*metabolism ; Models, Molecular ; Molecular Sequence Data ; Protein Conformation ; Protein Folding ; Protein Multimerization ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Recombinant Fusion Proteins/chemistry ; Saccharomyces cerevisiae Proteins/*chemistry/*metabolismPublished by: -
7Articles: DFG German National LicensesVignali, G. ; Niclas, J. ; Sprocati, M. T. ; Vale, R. D. ; Sirtori, C. ; Navone, F.
Oxford, UK : Blackwell Publishing Ltd
Published 1996Staff ViewISSN: 1460-9568Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Kinesin is a microtubule-based motor protein involved in intracellular organelle transport. Neurons are characterized by the presence of at least two isoforms of conventional kinesin: ubiquitous kinesin, expressed in all cells and tissues, and neuronal kinesin, whose pattern of expression is confined to neuronal cells. In order to investigate whether the two kinesin motors, which are encoded by different genes, may play distinct biological roles in neurons, we studied their expression during neuronal differentiation. Human neuroblastoma SH-SY5Y and IMR32 cells and rat phaeochromocytoma PC12 cells were used as an in vitro system for neuronal differentiation and were induced to differentiate in the presence of retinoic acid, a combination of dibutyryl cAMP and 5-bromodeoxyuridine, and nerve growth factor respectively. The expression level of each kinesin isoform was evaluated by quantitative immunoblot before and after pharmacological treatment. We found that in all cell types the expression level of neuronal kinesin, but not of ubiquitous kinesin, is stimulated during differentiation. In particular, SH-SY5Y cells show a 4.5-fold, IMR32 cells a 3-fold and PC12 cells a 7-fold increase in the level of expression of neuronal kinesin. By Northern blot analysis we found that the selective increase in the expression of neuronal kinesin is paralleled by an increase in its mRNA, indicating that there is a transcriptional control of the expression of this kinesin isoform during differentiation of neuroblastoma and PC12 cells. Our results suggest that these cells represent an adequate model to study the function of conventional kinesin and its isoforms.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Kinesin is a motor protein that uses energy derived from ATP hydrolysis to move organelles along microtubules. Using a new technique for measuring the movement produced in vitro by individual kinesin molecules, it is shown that a single kinesin molecule can move a microtubule for several ...Type of Medium: Electronic ResourceURL: