Search Results - (Author, Cooperation:P. Tamayo)
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1Latest Papers from Table of Contents or Articles in PressT. J. Pugh ; S. D. Weeraratne ; T. C. Archer ; D. A. Pomeranz Krummel ; D. Auclair ; J. Bochicchio ; M. O. Carneiro ; S. L. Carter ; K. Cibulskis ; R. L. Erlich ; H. Greulich ; M. S. Lawrence ; N. J. Lennon ; A. McKenna ; J. Meldrim ; A. H. Ramos ; M. G. Ross ; C. Russ ; E. Shefler ; A. Sivachenko ; B. Sogoloff ; P. Stojanov ; P. Tamayo ; J. P. Mesirov ; V. Amani ; N. Teider ; S. Sengupta ; J. P. Francois ; P. A. Northcott ; M. D. Taylor ; F. Yu ; G. R. Crabtree ; A. G. Kautzman ; S. B. Gabriel ; G. Getz ; N. Jager ; D. T. Jones ; P. Lichter ; S. M. Pfister ; T. M. Roberts ; M. Meyerson ; S. L. Pomeroy ; Y. J. Cho
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-07-24Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Cerebellar Neoplasms/classification/*genetics ; Child ; DEAD-box RNA Helicases/chemistry/genetics/metabolism ; DNA Helicases/chemistry/genetics ; DNA-Binding Proteins/genetics ; Exome/*genetics ; Genome, Human/*genetics ; Hedgehog Proteins/metabolism ; Histone-Lysine N-Methyltransferase/genetics/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; LIM Domain Proteins/genetics ; Medulloblastoma/classification/*genetics ; Models, Molecular ; Mutation/*genetics ; Neoplasm Proteins/genetics ; Nuclear Proteins/chemistry/genetics ; Promoter Regions, Genetic/genetics ; Protein Structure, Tertiary/genetics ; Proto-Oncogene Proteins/genetics ; Receptors, Cell Surface/genetics ; Repressor Proteins/genetics ; Signal Transduction ; TCF Transcription Factors/metabolism ; Transcription Factors/chemistry/genetics ; Tumor Suppressor Protein p53/genetics ; Wnt Proteins/metabolism ; beta Catenin/genetics/metabolismPublished by: -
2Articles: DFG German National LicensesDaily, J. P. ; Scanfeld, D. ; Pochet, N. ; Le Roch, K. ; Plouffe, D. ; Kamal, M. ; Sarr, O. ; Mboup, S. ; Ndir, O. ; Wypij, D. ; Levasseur, K. ; Thomas, E. ; Tamayo, P. ; Dong, C. ; Zhou, Y. ; Lander, E. S. ; Ndiaye, D. ; Wirth, D. ; Winzeler, E. A. ; Mesirov, J. P. ; Regev, A.
[s.l.] : Nature Publishing Group
Published 2007Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Infection with the malaria parasite Plasmodium falciparum leads to widely different clinical conditions in children, ranging from mild flu-like symptoms to coma and death. Despite the immense medical implications, the genetic and molecular basis of this diversity remains largely unknown. ...Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 0021-9991Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Computer SciencePhysicsType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0920-5632Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0378-4371Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0378-4371Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0378-4371Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0167-2789Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1572-9974Source: Springer Online Journal Archives 1860-2000Topics: Computer ScienceEconomicsNotes: Abstract Risk assessment of financialintermediaries is an area of renewed interest due tothe financial crises of the 1980's and 90's. Anaccurate estimation of risk, and its use in corporateor global financial risk models, could be translatedinto a more efficient use of resources. One importantingredient to accomplish this goal is to find accuratepredictors of individual risk in the credit portfoliosof institutions. In this context we make a comparativeanalysis of different statistical and machine learningmodeling methods of classification on a mortgage loandata set with the motivation to understand theirlimitations and potential. We introduced a specificmodeling methodology based on the study of errorcurves. Using state-of-the-art modeling techniques webuilt more than 9,000 models as part of the study. Theresults show that CART decision-tree models providethe best estimation for default with an average 8.31%error rate for a training sample of 2,000 records. Asa result of the error curve analysis for this model weconclude that if more data were available,approximately 22,000 records, a potential 7.32% errorrate could be achieved. Neural Networks provided thesecond best results with an average error of 11.00%.The K-Nearest Neighbor algorithm had an averageerror rate of 14.95%. These results outperformed thestandard Probit algorithm which attained an averageerror rate of 15.13%. Finally we discuss thepossibilities to use this type of accurate predictivemodel as ingredients of institutional and global riskmodels.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1572-9613Keywords: Cluster acceleration ; critical slowing down ; Swendsen-Wang algorithm ; Wolff algorithm ; Fortuin-Kasteleyn mapping ; Coniglio-Klein clustersSource: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract We present an extensive study of a new Monte Carlo acceleration algorithm introduced by Wolff for the Ising model. It differs from the Swendsen-Wang algorithm by growing and flipping single clusters at a random seed. In general, it is more efficient than Swendsen-Wang dynamics ford〉2, giving zero critical slowing down in the upper critical dimension. Monte Carlo simulations give dynamical critical exponentsz w=0.33±0.05 and 0.44+0.10 ind=2 and 3, respectively, and numbers consistent withz w=0 ind=4 and mean-field theory. We present scaling arguments which indicate that the Wolff mechanism for decorrelation differs substantially from Swendsen-Wang despite the apparent similarities of the two methods.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1572-9613Keywords: Nucleation ; metastability ; Ising model ; Metropolis ; Swendsen-Wang ; spinodal point ; critical dynamicsSource: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract The behavior of the metastable nearest neighbor Ising model governed by Swendsen-Wang dynamics (SW) is investigated ind=2. The results are compared to those obtained in standard Metropolis dynamics. Both the SW and Metropolis systems are observed to decay from the metastable state via the formation of nucleating droplets. Nucleation rates are measured and found to agree with those predicted by classical nucleation theory. The growth rates of the droplets are observed to differ between the two dynamics. In addition, the dynamic critical exponentz is measured in a mean-field (Curie-Weiss) metastable Ising model at the spinodal. It is found that for SW dynamics,z=2. Since this is the same value as that obtained in the Metropolis case, this result shows that SW does not change the dynamical universality class at the spinodal.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1572-9613Source: Springer Online Journal Archives 1860-2000Topics: PhysicsType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1572-9613Keywords: Directed percolation ; inhomogeneous cellular automata ; cellular automata classification ; phase transitions ; complexitySource: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract A probabilistic one-dimensional cellular automaton model by Domany and Kinzel is mapped into an inhomogeneous cellular automaton with the Boolean functions XOR and AND as transition rules. Wolfram's classification is recovered by varying the frequency of these two simple rules and by quenching or annealing the inhomogeneity. In particular, “class 4” is related to critical behavior in directed percolation. Also, the critical slowing down of second-order phase transitions is related to a stochastic version of the classical “halting problem” of computation theory.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1573-4803Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract The push-pull fatigue behaviour of a 355 stainless steel 2024-T8 aluminium alloy composite, has been studied at constant stress. The S-N curve shows a fatigue strength of 20 kg/mm2. Microhardness measurements reveal that little fatigue hardening takes place within the matrix; also, hardness numbers are similar in fatigued specimens, irrespective of the applied stress amplitude. The increase in damping capacity for increasing stress amplitudes, is attributed to increased delamination at the fibre-matrix interface, in the early fatigue stages. This result is also confirmed by optical microscopy. It is inferred that the sequence of failure weakness in the composite is: fibre-matrix interface, matrix and, finally, fibres. A fatigue strength/tensile strength ratio of 0.16 for this material is noticeably low, but fatigue properties of the composite can be improved by enhancing the fibre-matrix bonding.Type of Medium: Electronic ResourceURL: