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  1. 1
    W. F. Laurance ; D. C. Useche ; J. Rendeiro ; M. Kalka ; C. J. Bradshaw ; S. P. Sloan ; S. G. Laurance ; M. Campbell ; K. Abernethy ; P. Alvarez ; V. Arroyo-Rodriguez ; P. Ashton ; J. Benitez-Malvido ; A. Blom ; K. S. Bobo ; C. H. Cannon ; M. Cao ; R. Carroll ; C. Chapman ; R. Coates ; M. Cords ; F. Danielsen ; B. De Dijn ; E. Dinerstein ; M. A. Donnelly ; D. Edwards ; F. Edwards ; N. Farwig ; P. Fashing ; P. M. Forget ; M. Foster ; G. Gale ; D. Harris ; R. Harrison ; J. Hart ; S. Karpanty ; W. J. Kress ; J. Krishnaswamy ; W. Logsdon ; J. Lovett ; W. Magnusson ; F. Maisels ; A. R. Marshall ; D. McClearn ; D. Mudappa ; M. R. Nielsen ; R. Pearson ; N. Pitman ; J. van der Ploeg ; A. Plumptre ; J. Poulsen ; M. Quesada ; H. Rainey ; D. Robinson ; C. Roetgers ; F. Rovero ; F. Scatena ; C. Schulze ; D. Sheil ; T. Struhsaker ; J. Terborgh ; D. Thomas ; R. Timm ; J. N. Urbina-Cardona ; K. Vasudevan ; S. J. Wright ; G. J. Arias ; L. Arroyo ; M. Ashton ; P. Auzel ; D. Babaasa ; F. Babweteera ; P. Baker ; O. Banki ; M. Bass ; I. Bila-Isia ; S. Blake ; W. Brockelman ; N. Brokaw ; C. A. Bruhl ; S. Bunyavejchewin ; J. T. Chao ; J. Chave ; R. Chellam ; C. J. Clark ; J. Clavijo ; R. Congdon ; R. Corlett ; H. S. Dattaraja ; C. Dave ; G. Davies ; M. Beisiegel Bde ; N. da Silva Rde ; A. Di Fiore ; A. Diesmos ; R. Dirzo ; D. Doran-Sheehy ; M. Eaton ; L. Emmons ; A. Estrada ; C. Ewango ; L. Fedigan ; F. Feer ; B. Fruth ; J. G. Willis ; U. Goodale ; S. Goodman ; J. C. Guix ; P. Guthiga ; W. Haber ; K. Hamer ; I. Herbinger ; J. Hill ; Z. Huang ; I. F. Sun ; K. Ickes ; A. Itoh ; N. Ivanauskas ; B. Jackes ; J. Janovec ; D. Janzen ; M. Jiangming ; C. Jin ; T. Jones ; H. Justiniano ; E. Kalko ; A. Kasangaki ; T. Killeen ; H. B. King ; E. Klop ; C. Knott ; I. Kone ; E. Kudavidanage ; J. L. Ribeiro ; J. Lattke ; R. Laval ; R. Lawton ; M. Leal ; M. Leighton ; M. Lentino ; C. Leonel ; J. Lindsell ; L. Ling-Ling ; K. E. Linsenmair ; E. Losos ; A. Lugo ; J. Lwanga ; A. L. Mack ; M. Martins ; W. S. McGraw ; R. McNab ; L. Montag ; J. M. Thompson ; J. Nabe-Nielsen ; M. Nakagawa ; S. Nepal ; M. Norconk ; V. Novotny ; S. O'Donnell ; M. Opiang ; P. Ouboter ; K. Parker ; N. Parthasarathy ; K. Pisciotta ; D. Prawiradilaga ; C. Pringle ; S. Rajathurai ; U. Reichard ; G. Reinartz ; K. Renton ; G. Reynolds ; V. Reynolds ; E. Riley ; M. O. Rodel ; J. Rothman ; P. Round ; S. Sakai ; T. Sanaiotti ; T. Savini ; G. Schaab ; J. Seidensticker ; A. Siaka ; M. R. Silman ; T. B. Smith ; S. S. de Almeida ; N. Sodhi ; C. Stanford ; K. Stewart ; E. Stokes ; K. E. Stoner ; R. Sukumar ; M. Surbeck ; M. Tobler ; T. Tscharntke ; A. Turkalo ; G. Umapathy ; M. van Weerd ; J. V. Rivera ; M. Venkataraman ; L. Venn ; C. Verea ; C. V. de Castilho ; M. Waltert ; B. Wang ; D. Watts ; W. Weber ; P. West ; D. Whitacre ; K. Whitney ; D. Wilkie ; S. Williams ; D. D. Wright ; P. Wright ; L. Xiankai ; P. Yonzon ; F. Zamzani
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-07-27
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Agriculture/statistics & numerical data ; Animals ; *Biodiversity ; Conservation of Natural Resources/*statistics & numerical data ; Data Collection ; Ecology/statistics & numerical data ; Endangered Species/*statistics & numerical data ; Environmental Pollution/adverse effects/statistics & numerical data ; Fires/statistics & numerical data ; Forestry/statistics & numerical data ; Interviews as Topic ; Mining/statistics & numerical data ; Population Growth ; Rain ; Reproducibility of Results ; Research Personnel ; Surveys and Questionnaires ; Temperature ; Trees/*physiology ; *Tropical Climate
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Winter, T. A. ; Wright, J. ; Ghosh, S. ; Jahnsen, J. ; Innes, A. ; Round, P.

    Oxford, UK : Blackwell Science Ltd
    Published 2004
    Staff View
    ISSN:
    1365-2036
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Background : CDP870 is a PEGylated Fab′ fragment of a humanized monoclonal antibody that neutralizes tumour necrosis factor-α.Aim : To evaluate the safety and efficacy of a single intravenous dose of CDP870 or placebo over a 12-week period in patients with moderate-to-severe Crohn's disease.Methods : Ninety-two adult patients with Crohn's disease (Crohn's Disease Activity Index: 220–450 points) were randomized to receive CDP870 [1.25 (n = 2), 5 (n =26), 10 (n = 17) or 20 mg/kg (n = 23)] or placebo (n = 24). Crohn's Disease Activity Index scores were determined at weeks 0, 2, 4, 8 and 12. The primary end-point was the percentage of patients achieving clinical response [i.e. a decrease in Crohn's Disease Activity Index score ≥ 100 points or remission (Crohn's Disease Activity Index score: ≤150 points)] at week 4 in the intent-to-treat population.Results : The percentage of patients achieving the primary end-point was comparable across all treatment groups (56.0%, 60.0%, 58.8% and 47.8% for placebo, CDP870 5, 10 and 20 mg/kg, respectively). The remission rate at week 2 was 47.1% with CDP870 10 mg/kg vs. 16.0% for placebo (P = 0.041). All treatments were well-tolerated: adverse events, reported by 43 patients treated with CDP870 and 15 patients treated with placebo, were mainly mild-to-moderate in intensity. There were no infusion reactions.Conclusions : A single intravenous dose of CDP870 was well-tolerated by patients with Crohn's disease. While no statistically significant difference in clinical response rates between CDP870 and placebo was observed, clinical benefit in terms of remission was demonstrated.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2036.2004.02285.x

    Articles: DFG German National Licenses