Search Results - (Author, Cooperation:P. M. O'Connor)

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  1. 1
    Staff View
    Publication Date:
    2014-11-11
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; *Fossils ; Herbivory ; *Mammals ; Mosaicism ; *Phylogeny ; Skull/*anatomy & histology ; Species Specificity ; Tooth/anatomy & histology
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2013-05-17
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Cercopithecidae/anatomy & histology/*classification ; *Fossils ; History, Ancient ; Hominidae/anatomy & histology/*classification ; Mandible/anatomy & histology ; *Phylogeny ; Tanzania ; Tooth/anatomy & histology
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    O'Connor, P. M. ; Fox, B. W.
    Springer
    Published 1987
    Staff View
    ISSN:
    1432-0843
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary The technique of alkaline elution was employed to study the interactions of methylene dimethane sulphonate (MDMS) and formaldehyde (HCHO) with DNA from Yoshida lymphosarcoma cells treated with these agents. MDMS and HCHO produced a proteinase sensitive filter retention which indicated the presence of DNA-protein cross-links. MDMS also produced some proteinase K-resistant filter retention which was believed to indicate DNA-interstrand cross-linking, whilst only single-strand breaks could be detected following treatment with HCHO. Co-incubation with semicarbazide prevented all DNA-protein cross-links induced by MDMS and HCHO as well as single-strand breaks, most obvious following HCHO treatment. Semicarbazide also reduced HCHO-induced cytotoxicity in the Yoshida lymphosarcoma cell line, while no significant alteration in MDMS-induced cytotoxicity was observed. These results suggest that HCHO-induced DNA-protein cross-links and singlestrand breaks do not contribute to MDMS-induced cytotoxicity, and therefore the small but significant level of MDMS-induced DNA-interstrand cross-links is the most likely cytotoxic lesion of this agent.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00296247

    Articles: DFG German National Licenses