Search Results - (Author, Cooperation:P. Laurent)
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1Latest Papers from Table of Contents or Articles in PressE. Vacchelli ; Y. Ma ; E. E. Baracco ; A. Sistigu ; D. P. Enot ; F. Pietrocola ; H. Yang ; S. Adjemian ; K. Chaba ; M. Semeraro ; M. Signore ; A. De Ninno ; V. Lucarini ; F. Peschiaroli ; L. Businaro ; A. Gerardino ; G. Manic ; T. Ulas ; P. Gunther ; J. L. Schultze ; O. Kepp ; G. Stoll ; C. Lefebvre ; C. Mulot ; F. Castoldi ; S. Rusakiewicz ; S. Ladoire ; L. Apetoh ; J. M. Bravo-San Pedro ; M. Lucattelli ; C. Delarasse ; V. Boige ; M. Ducreux ; S. Delaloge ; C. Borg ; F. Andre ; G. Schiavoni ; I. Vitale ; P. Laurent-Puig ; F. Mattei ; L. Zitvogel ; G. Kroemer
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-10-31Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Alleles ; Animals ; Annexin A1/metabolism/pharmacology ; Anthracyclines/*therapeutic use ; Breast Neoplasms/drug therapy/immunology ; Cell Line, Tumor ; Chemotherapy, Adjuvant ; Colorectal Neoplasms/drug therapy/immunology ; Dendritic Cells/drug effects/immunology ; Female ; Humans ; Immunity, Innate/genetics ; Leukocytes/drug effects/immunology ; Mice ; Neoplasms/*drug therapy/*immunology ; Polymorphism, Single Nucleotide ; Receptors, Formyl Peptide/genetics/*physiology ; T-Lymphocytes/immunologyPublished by: -
2Latest Papers from Table of Contents or Articles in PressP. Laurent ; J. Rodriguez ; J. Wilms ; M. Cadolle Bel ; K. Pottschmidt ; V. Grinberg
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-03-26Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
3Articles: DFG German National LicensesStaff View
ISSN: 0021-9673Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
4Latest Papers from Table of Contents or Articles in PressMark J. Stern, Laurent P. René de Cotret, Martin R. Otto, Robert P. Chatelain, Jean-Philippe Boisvert, Mark Sutton, and Bradley J. Siwick
American Physical Society (APS)
Published 2018Staff ViewPublication Date: 2018-04-13Publisher: American Physical Society (APS)Print ISSN: 1098-0121Electronic ISSN: 1095-3795Topics: PhysicsKeywords: Surface physics, nanoscale physics, low-dimensional systemsPublished by: -
5Articles: DFG German National LicensesReich, Daniel H. ; Lévy, Laurent P. ; Hawthorne, Dean L.
[S.l.] : American Institute of Physics (AIP)
Published 1991Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: Above 2.6 K, CsNiF3 is an excellent example of a soliton-bearing spin-chain system. We have studied the long wavelength excitations in CsNiF3 by spin resonance, using a strip line technique that couples to finite q excitations. In addition to the uniform precession mode, we have observed a magnetostatic resonance. It lies at a lower energy than the uniform mode, consistent with the spectrum expected in linear response. The uniform mode, however, broadens much more rapidly with temperature. We propose that a dipolar magnon-soliton interaction is the dominant channel for the relaxation of long wavelength excitations in this quasi-1D system.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesLévy, Laurent P. ; Ogielski, Andrew T.
College Park, Md. : American Institute of Physics (AIP)
Published 1989Staff ViewISSN: 1089-7658Source: AIP Digital ArchiveTopics: MathematicsPhysicsNotes: It is shown that the measurable nonlinear susceptibilities of third and higher orders probe only a fraction of equilibrium fluctuations, and in general can give only lower bounds on the equilibrium correlation functions. This contrasts with the linear and quadratic response, which completely determines the corresponding correlations by general fluctuation–dissipation theorems. The exactly solvable one-dimensional kinetic Ising model illustrates which fluctuations give rise to dissipation; only two-magnon processes of short wavelength and opposite momenta contribute to the third-order nonlinear susceptibilities, while two- and three-magnon processes contribute to the corresponding equilibrium correlation functions.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: We have measured the nonlinear susceptibilities χ4, χ6, χ8 of dilute AgMn spin glasses above and below the transition temperature Tg as a function of temperature, magnetic field, and frequency. In the static limit, these quantities display very well-defined singularities at Tg with very weak magnetic field dependence. At very low frequencies, we show that the nonlinear susceptibilities χ2n can be related to 2n spin-spin correlation functions by Kubo formulas, and that their measured critical exponents are consistent with the usual scaling hypothesis. Thus, we can infer β=0.9, γ=2.1, and δ=3.0. The nonlinear susceptibilities scale above the transition as power laws of frequency with exponents which depend weakly on temperature. To relate these exponents by dynamic scaling require several ansatz which validity are investigated. In a magnetic field, only one singularity is observed at the same temperature Tg as in zero field, but the frequency dependence of the nonlinear susceptibilities weakens below the transition. We also discuss the frequency dependence of the linear and nonlinear susceptibilities below the spin-glass transition.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: We have studied the magnetization in the spin-glass phase of AgMn under the repetitive application of a small (10 Oe≤h≤50 Oe) magnetic field [asymmetric hysteresis cycles (L. Néel, in Proceedings of the R. A. Welch Foundation Conference on Chemical Res. II, Atomic Structure, Houston, Texas, 1958)] after the sample has been cooled in a static field H (0≤H≤1.1 kOe). When H=0, the magnetization mn in the field off state (h=0) grows as the logarithm of the number of cycles (n), while the magnetization in the on state (h≠0) Mn decreases with cycle number. This weaker response reflects an increase of the stiffness of the spin system after each cycle. At low temperature mn grows linearly with temperature, reaches a maximum around T∼0.6 Tg and decreases as Tg is approached. The effects are larger when the system is prepared in a nonequilibrium state (rapid thermal quenching, or removal of the static field H). The irreversible growth of the magnetization mn scale linearly with Tg (i.e., exchange) for samples of 0.5 and 2.6 at. % Mn concentration. We find that mn grows as the value of H is increased, reaches a maximum around H∼Tg/15 and decreases slowly at higher fields. We suggest as a possible interpretation of this phenomenon, the existence of a cavity in the distribution of local fields acting on the low temperature excitations. Additional information on the role of anisotropic forces will also be presented.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1095-8649Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: The role of gill chloride cells (CCs) and pavement cells (PVCs) in acid-base regulation was evaluated in brown bullhead catfish (Ictalurus nebulosus) subjected to acute hypercapnia (water Pco2=15 torr). Chronic (10 day) cortisol treatment was used as a tool to cause CC proliferation to permit a comparison of the regulatory capacities in groups of fish with widely different gill CC populations. Cortisol (4mg kg−1 day−1) caused a pronounced increase (170%) in the surface area of CCs exposed to the water based on scanning and transmission electron microscope analysis. The density of PVC apical membrane microvilli was significantly increased (20%) by cortisol treatment. Exposure of either group of fish to hypercapnia caused similar changes in gill epithelial morphology including: (i) a marked reduction in the surface area of exposed CCs (52 and 78% reduction in the control and cortisol-treated fish, respectively); and (ii) pronounced increases in PVC apical membrane microvilli density (21 and 27% in the control and cortisol-treated fish, respectively).The rates of Cl− uptake (Jincl−) and Na+ uptake (JinNa+) were elevated (150 and 262%, respectively) in the cortisol-treated fish. Regardless of treatment, Jincl− was markedly reduced to approximately the same levels after 6 h of hypercapnia, JinNa+ was stimulated in the control group and reduced in the cortisol-treated group and thus, after 6 h of hypercapnia, JinNa+ was equal in each group. The similar morphological responses in fish possessing different initial populations suggests that the predominant mechanism of acid-base regulation during hypercapnia, reduction of C1−/HCO3− exchange, is accomplished by removal of the CC-associated C1-/HCO3− exchange sites from the water. The increase in PVC microvilli density during hypercapnia suggests a role for the PVC in acid-base regulation.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1440-1681Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: 1. Irinotecan (also known as CPT-11) is a water soluble, semi-synthetic analogue of 20(S)camptothecin (CPT) with promising activity against a range of tumour types.2. As with all other active analogues of CPT, irinotecan causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I (topo I) and doublestranded DNA. This leads to replication fork-arrest, double DNA strand breaks and, possibly, illegitimate recombination of vital genes.3. This activity is much greater for its metabolite SN-38 and irinotecan is widely considered to be a prodrug of SN-38.4. The anti-topo I activity of CPT is stereoselective at C-20 and irinotecan is synthesized from 20(S)CPT to ensure maximal activity. In aqueous solutions, the lacton ring of CPT under goes reversible and spontaneous hydrolysis to a ring-opened and inactive carboxylate form. In patients, it has been shown that the lactone is the predominant form of SN-38 in plasma, whereas the opposite is true for irinotecan.5. The transformation of irinotecan to SN-38 is catalysed by carboxylesterases. However, this conversion appears relatively inefficient in man.6. Irinotecan and SN-38 show evidence of other metabolic reactions (type I and II), some of which could be subject to pharmacogenetic variablity.7. Therapy with irinotecan is associated with unusual toxicities, such as an acute cholinergic-like syndrome and delayed onset diarrhoea. Although the mechanism for the diarrhoea remains to be defined, the cholinergic toxicity appears to be due to an inhibition of acetylcholinesterase.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesFabre, Jean-Etienne ; Nguyen, MyTrang ; Latour, Anne ; Keifer, Jayne A. ; Audoly, Laurent P. ; Coffman, Thomas M. ; Koller, Beverly H.
[s.l.] : Nature America Inc.
Published 1999Staff ViewISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] Platelet activation is characterized by shape change, induction of fibrinogen receptor expression and release of granular contents, leading to aggregation and plug formation. While this response is essential for hemostasis, it is also important in the pathogenesis of a broad spectrum of diseases, ...Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesQi Chen, Xu ; Stroun, Maurice ; Magnenat, Jean-Luc ; Nicod, Laurent P. ; Kurt, Anne-Marie ; Lyautey, Jacqueline ; Lederrey, Christine ; Anker, Philippe
[s.l.] : Nature Publishing Group
Published 1996Staff ViewISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] Microsatellite instability is an important characteristic of many tumor types1–8 especially those associated with hereditary non–polyposis colorectal carcinoma (HNPCC) syndrome6–8. Microsatellite alterations in 50% of primary small cell lung carcinoma (SCLC) have been ...Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0020-1693Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesVita, N. ; Laurent, P. ; Lefort, S. ; Chalon, P. ; Dumont, X. ; Kaghad, M. ; Gully, D. ; Le Fur, G. ; Caput, D. ; Ferrara, P.
Amsterdam : ElsevierStaff ViewISSN: 0014-5793Keywords: Binding ; Cloning ; HT 29 cell ; Neurotensin ; ReceptorSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0022-1139Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0022-1139Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0022-1139Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 0022-1139Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 0022-1139Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0022-1139Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: