Search Results - (Author, Cooperation:P. Hegemann)
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1Latest Papers from Table of Contents or Articles in PressJ. Wietek ; J. S. Wiegert ; N. Adeishvili ; F. Schneider ; H. Watanabe ; S. P. Tsunoda ; A. Vogt ; M. Elstner ; T. G. Oertner ; P. Hegemann
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-03-29Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Action Potentials ; Animals ; Binding Sites ; CA1 Region, Hippocampal/cytology ; Chloride Channels/*chemistry/*metabolism ; Chlorides/*metabolism ; HEK293 Cells ; Humans ; Hydrogen Bonding ; Ion Channel Gating ; Light ; Models, Molecular ; Molecular Dynamics Simulation ; Mutation ; Patch-Clamp Techniques ; Protein Conformation ; Protein Engineering ; Pyramidal Cells/metabolism ; Rats ; Recombinant Fusion Proteins/chemistry ; Rhodopsin/*chemistry/genetics/*metabolism ; TransfectionPublished by: -
2Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2013-08-24Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Epigenesis, Genetic/*genetics/*radiation effects ; Gene Expression Regulation/*radiation effects ; *Light ; Male ; Optogenetics/*methods ; Transcription, Genetic/*radiation effectsPublished by: -
3Latest Papers from Table of Contents or Articles in PressO. Yizhar ; L. E. Fenno ; M. Prigge ; F. Schneider ; T. J. Davidson ; D. J. O'Shea ; V. S. Sohal ; I. Goshen ; J. Finkelstein ; J. T. Paz ; K. Stehfest ; R. Fudim ; C. Ramakrishnan ; J. R. Huguenard ; P. Hegemann ; K. Deisseroth
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-07-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Autistic Disorder/physiopathology ; Disease Models, Animal ; HEK293 Cells ; Hippocampus/cytology ; Humans ; Learning ; Mental Disorders/physiopathology ; Mice ; *Models, Neurological ; Motor Activity ; Neural Inhibition/*physiology ; Neurons/*metabolism ; Opsins/metabolism ; Prefrontal Cortex/*physiology/*physiopathology ; Schizophrenia/physiopathology ; *Social BehaviorPublished by: -
4Latest Papers from Table of Contents or Articles in PressH. E. Kato ; F. Zhang ; O. Yizhar ; C. Ramakrishnan ; T. Nishizawa ; K. Hirata ; J. Ito ; Y. Aita ; T. Tsukazaki ; S. Hayashi ; P. Hegemann ; A. D. Maturana ; R. Ishitani ; K. Deisseroth ; O. Nureki
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-01-24Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Bacteriorhodopsins/chemistry ; Binding Sites ; Cations/*metabolism ; Cattle ; Chlamydomonas reinhardtii/*chemistry/genetics ; Crystallography, X-Ray ; Ion Channel Gating/*radiation effects ; Ion Channels/*chemistry/genetics/radiation effects ; *Light ; Models, Molecular ; Mutation ; Protein Conformation ; Recombinant Fusion Proteins/chemistry/genetics/radiation effects ; Retinaldehyde/metabolism ; Rhodopsin/*chemistry/genetics/radiation effects ; Schiff Bases/chemistry ; Static ElectricityPublished by: -
5Articles: DFG German National LicensesStaff View
ISSN: 0005-2736Keywords: (H. halobium) ; Black lipid membrane ; Chloride transport ; Halide transport ; Halorhodopsin ; PhotocurrentSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0005-2736Keywords: (Halobacterium) ; Black lipid membrane ; Blue light effect ; Cl^- transport ; Halorhodopsin ; PhotochromismSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Keywords: Blue light receptor ; Chlamydomonas reinhardtii ; Phototaxis ; RhodopsinSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Keywords: Halorhodopsin ; Light-driven chloride pump ; Protonated Schiff base ; Resonance Raman spectroscopySource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1432-1017Keywords: Chloride pump ; halorhodopsin ; ion translocation ; theoretical model ; cis-trans isomerizationSource: Springer Online Journal Archives 1860-2000Topics: BiologyPhysicsNotes: Abstract The chromophore in halorhodopsin (HR) which acts as a light-driven chloride pump in halobacteria shares many properties with its counterpart in bacteriorhodopsin (BR): (i) a similar retinal protein interaction, (ii) trans to cis isomerization and (iii) similar intermediates of its photocycle. One major difference between the two chromoproteins is that the HR chromophore does not become deprotonated during its photocycle. A mechanism for the photocycle of HR is presented, which, in close analogy to an earlier proposed mechanism for BR, involves the sequence of all-trans → 13-cis, 14s-cis → 13-cis → all-trans isomerizations of the chromophore, a Schiff base of retinal. In contrast to the situation in BR the 13-cis, 14s-cis→13-cis isomerization is induced not by deprotonation of the retinal Schiff base chromophore but rather by the movement of an anion (Cl-) towards the protonated nitrogen of the Schiff's base. The suggested mechanism involves the Schiff base directly in the chloride translocation in halorhodopsin.Type of Medium: Electronic ResourceURL: