Search Results - (Author, Cooperation:P. Francois)
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1Latest Papers from Table of Contents or Articles in PressC. R. Webster ; P. R. Mahaffy ; G. J. Flesch ; P. B. Niles ; J. H. Jones ; L. A. Leshin ; S. K. Atreya ; J. C. Stern ; L. E. Christensen ; T. Owen ; H. Franz ; R. O. Pepin ; A. Steele ; C. Achilles ; C. Agard ; J. A. Alves Verdasca ; R. Anderson ; D. Archer ; C. Armiens-Aparicio ; R. Arvidson ; E. Atlaskin ; A. Aubrey ; B. Baker ; M. Baker ; T. Balic-Zunic ; D. Baratoux ; J. Baroukh ; B. Barraclough ; K. Bean ; L. Beegle ; A. Behar ; J. Bell ; S. Bender ; M. Benna ; J. Bentz ; G. Berger ; J. Berger ; D. Berman ; D. Bish ; D. F. Blake ; J. J. Blanco Avalos ; D. Blaney ; J. Blank ; H. Blau ; L. Bleacher ; E. Boehm ; O. Botta ; S. Bottcher ; T. Boucher ; H. Bower ; N. Boyd ; B. Boynton ; E. Breves ; J. Bridges ; N. Bridges ; W. Brinckerhoff ; D. Brinza ; T. Bristow ; C. Brunet ; A. Brunner ; W. Brunner ; A. Buch ; M. Bullock ; S. Burmeister ; M. Cabane ; F. Calef ; J. Cameron ; J. Campbell ; B. Cantor ; M. Caplinger ; J. Caride Rodriguez ; M. Carmosino ; I. Carrasco Blazquez ; A. Charpentier ; S. Chipera ; D. Choi ; B. Clark ; S. Clegg ; T. Cleghorn ; E. Cloutis ; G. Cody ; P. Coll ; P. Conrad ; D. Coscia ; A. Cousin ; D. Cremers ; J. Crisp ; A. Cros ; F. Cucinotta ; C. d'Uston ; S. Davis ; M. Day ; M. de la Torre Juarez ; L. DeFlores ; D. DeLapp ; J. DeMarines ; D. DesMarais ; W. Dietrich ; R. Dingler ; C. Donny ; B. Downs ; D. Drake ; G. Dromart ; A. Dupont ; B. Duston ; J. Dworkin ; M. D. Dyar ; L. Edgar ; K. Edgett ; C. Edwards ; L. Edwards ; B. Ehlmann ; B. Ehresmann ; J. Eigenbrode ; B. Elliott ; H. Elliott ; R. Ewing ; C. Fabre ; A. Fairen ; K. Farley ; J. Farmer ; C. Fassett ; L. Favot ; D. Fay ; F. Fedosov ; J. Feldman ; S. Feldman ; M. Fisk ; M. Fitzgibbon ; M. Floyd ; L. Fluckiger ; O. Forni ; A. Fraeman ; R. Francis ; P. Francois ; C. Freissinet ; K. L. French ; J. Frydenvang ; A. Gaboriaud ; M. Gailhanou ; J. Garvin ; O. Gasnault ; C. Geffroy ; R. Gellert ; M. Genzer ; D. Glavin ; A. Godber ; F. Goesmann ; W. Goetz ; D. Golovin ; F. Gomez Gomez ; J. Gomez-Elvira ; B. Gondet ; S. Gordon ; S. Gorevan ; J. Grant ; J. Griffes ; D. Grinspoon ; J. Grotzinger ; P. Guillemot ; J. Guo ; S. Gupta ; S. Guzewich ; R. Haberle ; D. Halleaux ; B. Hallet ; V. Hamilton ; C. Hardgrove ; D. Harker ; D. Harpold ; A. M. Harri ; K. Harshman ; D. Hassler ; H. Haukka ; A. Hayes ; K. Herkenhoff ; P. Herrera ; S. Hettrich ; E. Heydari ; V. Hipkin ; T. Hoehler ; J. Hollingsworth ; J. Hudgins ; W. Huntress ; J. Hurowitz ; S. Hviid ; K. Iagnemma ; S. Indyk ; G. Israel ; R. Jackson ; S. Jacob ; B. Jakosky ; E. Jensen ; J. K. Jensen ; J. Johnson ; M. Johnson ; S. Johnstone ; A. Jones ; J. Joseph ; I. Jun ; L. Kah ; H. Kahanpaa ; M. Kahre ; N. Karpushkina ; W. Kasprzak ; J. Kauhanen ; L. Keely ; O. Kemppinen ; D. Keymeulen ; M. H. Kim ; K. Kinch ; P. King ; L. Kirkland ; G. Kocurek ; A. Koefoed ; J. Kohler ; O. Kortmann ; A. Kozyrev ; J. Krezoski ; D. Krysak ; R. Kuzmin ; J. L. Lacour ; V. Lafaille ; Y. Langevin ; N. Lanza ; J. Lasue ; S. Le Mouelic ; E. M. Lee ; Q. M. Lee ; D. Lees ; M. Lefavor ; M. Lemmon ; A. Lepinette Malvitte ; R. Leveille ; E. Lewin-Carpintier ; K. Lewis ; S. Li ; L. Lipkaman ; C. Little ; M. Litvak ; E. Lorigny ; G. Lugmair ; A. Lundberg ; E. Lyness ; M. Madsen ; J. Maki ; A. Malakhov ; C. Malespin ; M. Malin ; N. Mangold ; G. Manhes ; H. Manning ; G. Marchand ; M. Marin Jimenez ; C. Martin Garcia ; D. Martin ; M. Martin ; J. Martinez-Frias ; J. Martin-Soler ; F. J. Martin-Torres ; P. Mauchien ; S. Maurice ; A. McAdam ; E. McCartney ; T. McConnochie ; E. McCullough ; I. McEwan ; C. McKay ; S. McLennan ; S. McNair ; N. Melikechi ; P. Y. Meslin ; M. Meyer ; A. Mezzacappa ; H. Miller ; K. Miller ; R. Milliken ; D. Ming ; M. Minitti ; M. Mischna ; I. Mitrofanov ; J. Moersch ; M. Mokrousov ; A. Molina Jurado ; J. Moores ; L. Mora-Sotomayor ; J. M. Morookian ; R. Morris ; S. Morrison ; R. Mueller-Mellin ; J. P. Muller ; G. Munoz Caro ; M. Nachon ; S. Navarro Lopez ; R. Navarro-Gonzalez ; K. Nealson ; A. Nefian ; T. Nelson ; M. Newcombe ; C. Newman ; H. Newsom ; S. Nikiforov ; B. Nixon ; E. Noe Dobrea ; T. Nolan ; D. Oehler ; A. Ollila ; T. Olson ; M. A. de Pablo Hernandez ; A. Paillet ; E. Pallier ; M. Palucis ; T. Parker ; Y. Parot ; K. Patel ; M. Paton ; G. Paulsen ; A. Pavlov ; B. Pavri ; V. Peinado-Gonzalez ; L. Peret ; R. Perez ; G. Perrett ; J. Peterson ; C. Pilorget ; P. Pinet ; J. Pla-Garcia ; I. Plante ; F. Poitrasson ; J. Polkko ; R. Popa ; L. Posiolova ; A. Posner ; I. Pradler ; B. Prats ; V. Prokhorov ; S. W. Purdy ; E. Raaen ; L. Radziemski ; S. Rafkin ; M. Ramos ; E. Rampe ; F. Raulin ; M. Ravine ; G. Reitz ; N. Renno ; M. Rice ; M. Richardson ; F. Robert ; K. Robertson ; J. A. Rodriguez Manfredi ; J. J. Romeral-Planello ; S. Rowland ; D. Rubin ; M. Saccoccio ; A. Salamon ; J. Sandoval ; A. Sanin ; S. A. Sans Fuentes ; L. Saper ; P. Sarrazin ; V. Sautter ; H. Savijarvi ; J. Schieber ; M. Schmidt ; W. Schmidt ; D. Scholes ; M. Schoppers ; S. Schroder ; S. Schwenzer ; E. Sebastian Martinez ; A. Sengstacken ; R. Shterts ; K. Siebach ; T. Siili ; J. Simmonds ; J. B. Sirven ; S. Slavney ; R. Sletten ; M. Smith ; P. Sobron Sanchez ; N. Spanovich ; J. Spray ; S. Squyres ; K. Stack ; F. Stalport ; T. Stein ; N. Stewart ; S. L. Stipp ; K. Stoiber ; E. Stolper ; B. Sucharski ; R. Sullivan ; R. Summons ; D. Sumner ; V. Sun ; K. Supulver ; B. Sutter ; C. Szopa ; F. Tan ; C. Tate ; S. Teinturier ; I. ten Kate ; P. Thomas ; L. Thompson ; R. Tokar ; M. Toplis ; J. Torres Redondo ; M. Trainer ; A. Treiman ; V. Tretyakov ; R. Urqui-O'Callaghan ; J. Van Beek ; T. Van Beek ; S. VanBommel ; D. Vaniman ; A. Varenikov ; A. Vasavada ; P. Vasconcelos ; E. Vicenzi ; A. Vostrukhin ; M. Voytek ; M. Wadhwa ; J. Ward ; E. Weigle ; D. Wellington ; F. Westall ; R. C. Wiens ; M. B. Wilhelm ; A. Williams ; J. Williams ; R. Williams ; R. B. Williams ; M. Wilson ; R. Wimmer-Schweingruber ; M. Wolff ; M. Wong ; J. Wray ; M. Wu ; C. Yana ; A. Yen ; A. Yingst ; C. Zeitlin ; R. Zimdar ; M. P. Zorzano Mier
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-07-23Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
2Latest Papers from Table of Contents or Articles in PressD. W. Ming ; P. D. Archer, Jr. ; D. P. Glavin ; J. L. Eigenbrode ; H. B. Franz ; B. Sutter ; A. E. Brunner ; J. C. Stern ; C. Freissinet ; A. C. McAdam ; P. R. Mahaffy ; M. Cabane ; P. Coll ; J. L. Campbell ; S. K. Atreya ; P. B. Niles ; J. F. Bell, 3rd ; D. L. Bish ; W. B. Brinckerhoff ; A. Buch ; P. G. Conrad ; D. J. Des Marais ; B. L. Ehlmann ; A. G. Fairen ; K. Farley ; G. J. Flesch ; P. Francois ; R. Gellert ; J. A. Grant ; J. P. Grotzinger ; S. Gupta ; K. E. Herkenhoff ; J. A. Hurowitz ; L. A. Leshin ; K. W. Lewis ; S. M. McLennan ; K. E. Miller ; J. Moersch ; R. V. Morris ; R. Navarro-Gonzalez ; A. A. Pavlov ; G. M. Perrett ; I. Pradler ; S. W. Squyres ; R. E. Summons ; A. Steele ; E. M. Stolper ; D. Y. Sumner ; C. Szopa ; S. Teinturier ; M. G. Trainer ; A. H. Treiman ; D. T. Vaniman ; A. R. Vasavada ; C. R. Webster ; J. J. Wray ; R. A. Yingst
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-12-11Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Bays ; Carbon Dioxide/analysis/chemistry ; *Exobiology ; Extraterrestrial Environment/*chemistry ; Geologic Sediments/analysis/chemistry ; Hydrocarbons, Chlorinated/*analysis ; *Mars ; Oxygen/analysis/chemistry ; Sulfides/analysis/chemistry ; Volatile Organic Compounds/*analysis ; Water/analysis/chemistryPublished by: -
3Latest Papers from Table of Contents or Articles in PressE. Caffau ; P. Bonifacio ; P. Francois ; L. Sbordone ; L. Monaco ; M. Spite ; F. Spite ; H. G. Ludwig ; R. Cayrel ; S. Zaggia ; F. Hammer ; S. Randich ; P. Molaro ; V. Hill
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-09-03Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
4Latest Papers from Table of Contents or Articles in PressV. M. Lauschke ; C. D. Tsiairis ; P. Francois ; A. Aulehla
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-12-21Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Body Patterning/*physiology ; *Body Size ; Cells, Cultured ; Cues ; Embryo, Mammalian/*anatomy & histology/cytology/*embryology ; Gene Expression Regulation, Developmental ; In Vitro Techniques ; Mesoderm/*anatomy & histology/cytology/*embryology ; Mice ; *Models, Biological ; TemperaturePublished by: -
5Latest Papers from Table of Contents or Articles in PressA. D'Hont ; F. Denoeud ; J. M. Aury ; F. C. Baurens ; F. Carreel ; O. Garsmeur ; B. Noel ; S. Bocs ; G. Droc ; M. Rouard ; C. Da Silva ; K. Jabbari ; C. Cardi ; J. Poulain ; M. Souquet ; K. Labadie ; C. Jourda ; J. Lengelle ; M. Rodier-Goud ; A. Alberti ; M. Bernard ; M. Correa ; S. Ayyampalayam ; M. R. McKain ; J. Leebens-Mack ; D. Burgess ; M. Freeling ; A. M. D. Mbeguie ; M. Chabannes ; T. Wicker ; O. Panaud ; J. Barbosa ; E. Hribova ; P. Heslop-Harrison ; R. Habas ; R. Rivallan ; P. Francois ; C. Poiron ; A. Kilian ; D. Burthia ; C. Jenny ; F. Bakry ; S. Brown ; V. Guignon ; G. Kema ; M. Dita ; C. Waalwijk ; S. Joseph ; A. Dievart ; O. Jaillon ; J. Leclercq ; X. Argout ; E. Lyons ; A. Almeida ; M. Jeridi ; J. Dolezel ; N. Roux ; A. M. Risterucci ; J. Weissenbach ; M. Ruiz ; J. C. Glaszmann ; F. Quetier ; N. Yahiaoui ; P. Wincker
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-07-18Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Conserved Sequence/genetics ; DNA Transposable Elements/genetics ; *Evolution, Molecular ; Gene Duplication/genetics ; Genes, Plant/genetics ; Genome, Plant/*genetics ; Genotype ; Haploidy ; Molecular Sequence Data ; Musa/classification/*genetics ; PhylogenyPublished by: -
6Latest Papers from Table of Contents or Articles in PressT. J. Pugh ; S. D. Weeraratne ; T. C. Archer ; D. A. Pomeranz Krummel ; D. Auclair ; J. Bochicchio ; M. O. Carneiro ; S. L. Carter ; K. Cibulskis ; R. L. Erlich ; H. Greulich ; M. S. Lawrence ; N. J. Lennon ; A. McKenna ; J. Meldrim ; A. H. Ramos ; M. G. Ross ; C. Russ ; E. Shefler ; A. Sivachenko ; B. Sogoloff ; P. Stojanov ; P. Tamayo ; J. P. Mesirov ; V. Amani ; N. Teider ; S. Sengupta ; J. P. Francois ; P. A. Northcott ; M. D. Taylor ; F. Yu ; G. R. Crabtree ; A. G. Kautzman ; S. B. Gabriel ; G. Getz ; N. Jager ; D. T. Jones ; P. Lichter ; S. M. Pfister ; T. M. Roberts ; M. Meyerson ; S. L. Pomeroy ; Y. J. Cho
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-07-24Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Cerebellar Neoplasms/classification/*genetics ; Child ; DEAD-box RNA Helicases/chemistry/genetics/metabolism ; DNA Helicases/chemistry/genetics ; DNA-Binding Proteins/genetics ; Exome/*genetics ; Genome, Human/*genetics ; Hedgehog Proteins/metabolism ; Histone-Lysine N-Methyltransferase/genetics/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; LIM Domain Proteins/genetics ; Medulloblastoma/classification/*genetics ; Models, Molecular ; Mutation/*genetics ; Neoplasm Proteins/genetics ; Nuclear Proteins/chemistry/genetics ; Promoter Regions, Genetic/genetics ; Protein Structure, Tertiary/genetics ; Proto-Oncogene Proteins/genetics ; Receptors, Cell Surface/genetics ; Repressor Proteins/genetics ; Signal Transduction ; TCF Transcription Factors/metabolism ; Transcription Factors/chemistry/genetics ; Tumor Suppressor Protein p53/genetics ; Wnt Proteins/metabolism ; beta Catenin/genetics/metabolismPublished by: -
7FIS Bildung LiteraturdatenbankBonnot, Jean-François P. [Verfasser] ; Bothorel-Witz, Arlette [Verfasser] ; Huck, Dominique [Verfasser]
Published 1993Staff ViewType of Medium: articlePublication Date: 1993Keywords: Empirische Forschung ; Methodologie ; Pilotstudie ; Varietät ; Fremdsprachenunterricht ; Französisch ; Französischunterricht ; Analyse ; ElsassIn: Bulletin de la Commission Interuniversitaire Suisse de Linguistique Appliquée, (1993) H. 57, S. 25-44, 0251-72560259-1383Language: FrenchNote: Literaturangaben, Tabellen -
8FIS Bildung LiteraturdatenbankStaff View
Type of Medium: articlePublication Date: 1988Keywords: Korrektur ; Didaktische Grundlageninformation ; Fortgeschrittenenunterricht ; Artikulatorische Fonetik ; Fonologie ; Interimssprache ; Fremdsprachenunterricht ; Hyperkorrektheit ; Französisch ; Niederländisch ; Hochschule ; KontrastierungIn: International review of applied linguistics in language teaching, Bd. 26 (1988) H. 1, S. 19-34, 0019-042XLanguage: facet.language.fre, facet.language.ger, facet.language.eng -
9Latest Papers from Table of Contents or Articles in PressManna, A. C., Kim, S., Cengher, L., Corvaglia, A., Leo, S., Francois, P., Cheung, A. L.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-01-23Publisher: The American Society for Microbiology (ASM)Print ISSN: 0019-9567Electronic ISSN: 1098-5522Topics: MedicinePublished by: -
10Latest Papers from Table of Contents or Articles in PressFrancois, P., Fujiwara, T., van Ypersele, T.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-09-20Publisher: American Association for the Advancement of Science (AAAS)Electronic ISSN: 2375-2548Topics: Natural Sciences in GeneralPublished by: -
11Latest Papers from Table of Contents or Articles in PressDi You, Haifeng Yang, Srobona Sen, François P. Gabbaï
American Chemical Society (ACS)
Published 2018Staff ViewPublication Date: 2018-07-24Publisher: American Chemical Society (ACS)Print ISSN: 0002-7863Electronic ISSN: 1520-5126Topics: Chemistry and PharmacologyPublished by: -
12Articles: DFG German National LicensesBenabbas, T. ; François, P. ; Androussi, Y. ; Lefebvre, A.
[S.l.] : American Institute of Physics (AIP)
Published 1996Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: Finite element (FE) analysis and transmission electron microscopy (TEM) observations have been used to model stress relaxation in InAs quantum dots deposited on (001) GaAs. TEM observations show that these islands are coherently strained and the corresponding strain contrast is simulated using the dynamical electron diffraction contrast theory. The dot strain fields used for the TEM contrast simulations are deduced from FE calculations. These calculations show that elastic stress relaxation mainly occurs at the crest of the island and that the underlying substrate is under tension. That experimental TEM images and simulated images should match shows that the FE method of determination of the dot strain fields is valid (even in the case of microscopic objects), and that the shape of islands can be specified. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesSeurin, Jean-François P. ; Chuang, Shun Lien
[S.l.] : American Institute of Physics (AIP)
Published 1997Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: An efficient matrix formulation combining a discrete Bessel transform and a beam propagation method for the modeling of vertical-cavity surface-emitting lasers is presented. Devices with circular symmetry are considered. The theory generalizes the concepts of field reflection and transmission coefficients, and generates a round-trip matrix that characterizes the entire structure. The model yields, among other things, the threshold current and intensity distribution at threshold and higher-order mode profiles. We apply the model to the threshold analysis of a gain-guided device. Our theoretical results agree very well with experimental observations on the temperature-dependent threshold characteristics. The optical modal reflection behavior of distributed Bragg reflectors based on our discrete Bessel transform approach is also analyzed and compared to other models. The importance of coupling loss for devices with oxide confinement layers is also discussed. © 1997 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesSeurin, Jean-François P. ; Liu, Guobin ; Chuang, Shun Lien
Woodbury, NY : American Institute of Physics (AIP)
Published 2000Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: We present a detailed theoretical study on the optical and L–I characteristics of implant-apertured index-guided vertical-cavity surface-emitting lasers. Our theory is based on a beam propagation method combined with thermal, gain, and rate-equation models. Spatial hole burning and modal competition are taken into account. Our results are in excellent agreement with the experimental data and show the effect of the current aperture size (determined by the ion implant) on the modal performance of these devices. In particular, the current-aperture size can be fixed independently from the index-guide size to obtain minimum threshold, single-mode operation. © 2000 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesBrissette, François P. ; Leconte, Robert ; Marche, Claude ; Rousselle, Jean
Oxford, UK : Blackwell Publishing Ltd
Published 2003Staff ViewISSN: 1752-1688Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Architecture, Civil Engineering, SurveyingGeographyNotes: : There is a general belief in the public eye that extreme events such as floods are becoming more and more common. This paper explores this hypothesis by examining the historical evolution of annual expected flooding damage on the Chateauguay River Basin, located at the border between the United States and the province of Quebec, Canada. A database of basin land use was constructed for the years 1930 and 1995 to assess anthropogenic changes and their impact on the basin's hydrology. The progressive modification of the likelihood of a flooding event over the same period was then investigated using homogeneity and statistical tests on available hydrometric data. The evolution of the annual expected flooding damage was then evaluated using a coupled hydrologic/hydraulic simulator linked to a damage analysis model. The simulator and model were used to estimate flooding damage over a wide range of flooding return periods, for conditions prevailing in 1963 and 1995. Results of the analysis reveal the absence of any increasing or decreasing trend in the historical occurrence of flooding events. However, a general increase in the annual expected flooding damage was observed for all studied river sections. This increase is linked to an historical increase in damages for a given flooding event, and is the result of unbridled construction and development within the flood zone. To assess for future trends, this study also examined the potential impacts linked to the anticipated global warming. Results indicate that a significant increase in seasonal flooding events and annual expected flooding damage is possible over the next century. In fact, what is now considered a 100-year flooding event for the summer/fall season could become a ten-year event by the end of this century. This shows that potential future impacts linked to climate change should be considered now by engineers, land planners, and decision makers. This is especially critical if a design return period is part of the decision making process.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesPralong, François P. ; Linton, Elizabeth A. ; Favrod-Coune, Charles A. ; Lowry, Phillip J. ; Muller, Alex F. ; Gaillard, Rolf C.
Oxford, UK : Blackwell Publishing Ltd
Published 1990Staff ViewISSN: 1365-2826Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: In this study, we have determined the distribution of corticotropin-releasing factor and vasopressin in the human hypothalamus, and investigated the effect of glucocorticoid administration on the concentrations of both peptides. Corticotropin-releasing factor and vasopressin were measured by a two-site immunoradiometric assay and/or radioimmunoassay. The presence of both peptides was studied in extracts of eleven areas of the human hypothalamus as well as in the pituitary stalk from autopsied patients who had been free of chronic steroid administration (n = 14) or had received Corticosteroids (n = 5). Unlike vasopressin, corticotropin-releasing factor was detected in all extracts: the highest concentration was found in the pituitary stalk, whilst the lowest detectable amounts occurred in the supraoptic and lateral areas and in the mammillary bodies. This pattern of distribution is similar to that reported for the rat hypothalamus. The excellent correlation (R = 0.994) between corticotropin-releasing factor data obtained by immunoradiometric assay and by radioimmunoassay renders the presence of a corticotropin-releasing factor precursor molecule in the extracts highly unlikely. In the human brain extracts, glucocorticoid treatment affected neither the content, nor the distribution of corticotropin-releasing factor and vasopressin. In the rats, dexamethasone administration produced a 50% decrease in the vasopressin content (P 〈 0.05) of the basomedial and dorsal parts of the hypothalamus and had no effect on the corticotropin-releasing factor content of these areas. These results show that the distribution of corticotropin-releasing factor is similar in both human and rat hypothalami. The rat data suggest that negative feedback effects of glucocorticoids involve changes in hypothalamic vasopressin content.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesMcDevitt, D. ; Francois, P ; Vaudaux, P. ; Foster, T. J.
Oxford, UK : Blackwell Publishing Ltd
Published 1995Staff ViewISSN: 1365-2958Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyMedicineNotes: Tn917 mutant of Newman with anti-ClfA Region A sera confirmed that Region A is exposed on the bacterial cell surface. Furthermore, polystyrene beads coated with the Region A protein formed clumps in soluble fibrinogen showing that the ClfA protein alone is sufficient for the clumping phenotype. Western immunoblotting with anti-ClfA Region A antibodies identified the native ClfA receptor as a 185 kDa protein that was released from the cell wall of S. aureus by lysostaphin treatment. A single extensive ligand-binding site was located within Region A of the ClfA protein. Truncated ClfA proteins were expressed in Escherichia coli. Lysates of E. coli and proteins that had been purified by affinity chromatography were tested for (i) their ability to bind fibrinogen in Western ligand blotting experiments, (ii) for their ability to inhibit clumping of bacteria in fibrinogen solution and adherence of bacteria to solid-phase fibrinogen, and (iii) for their ability to neutralize the blocking activity of anti-ClfA Region A antibody. These tests allowed the ligand-binding domain to be localized to a 218-residue segment (residues 332-550) within Region A.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesMcDevitt, D. ; Francois, P. ; Vaudaux, P. ; Foster, T. J.
Oxford, UK : Blackwell Publishing Ltd
Published 1994Staff ViewISSN: 1365-2958Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyMedicineNotes: Four mutants of Staphylococcus aureus strain Newman that were defective in the fibrinogen receptor (clumping factor) were isolated by transposon Tn917 mutagenesis. Southern hybridization analysis of the mutants identified transposon-host DNA junction fragments, one of which was cloned and used to generate a probe to identify and clone the wild-type clumping factor locus (clfA). The mutants failed to form clumps in soluble fibrinogen and adhered poorly to polymethylmethacrylate (PMMA) coverslips coated with fibrinogen. A single copy of the clfA gene, when introduced into the chromosome of the mutant strains, fuily compiemented the ciumping deficiency of these strains and restored the ability of these mutants to adhere to fibrinogen-coated PMMA. in addition, the cloned clfA gene on a shuttle plasmid aiiowed the weakiy ciumping strain 8325-4 to form clumps with the same avidity as the wild-type strain Newman and also significantly enhanced the adherence of 8325-4 strains. Thus the formation of clumps in soluble fibrinogen correlated with adherence of bacteria to solid-phase fibrinogen. The clfA gene encodes a fibrinogen-binding protein with an apparent molecular mass of c. 130 kDa. The amino acid sequence of the protein was deduced from the DNA sequence; it was predicted that a 896 residue protein (molecular mass 92 kDa) would be expressed. The putative ClfA protein has features that suggest that it is associated with the ceil surface. Furthermore it contains a novel 308 residue region comprising dipeptide repeats predominantly of Asp and Ser ending 28 residues upstream from the LPXTG motif common to wall-associated proteins. Significant homology was found between the ClfA protein and the fibronectin-binding proteins of S. S. aureus, particularly in the N-and C-termini.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesGreene, C. ; McDevitt, D. ; Francois, P. ; Vaudaux, P.E. ; Lew, D.P. ; Poster, T.J.
Osney Mead, Oxford OX2 0EL, UK : Blackwell Scientific Publications
Published 1995Staff ViewISSN: 1365-2958Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyMedicineNotes: Staphylococcus aureus 8325-4 has the potential to express two distinct cell wall-associated fibronectin-binding proteins called FnBPA and FnBPB. In order to test if both proteins are expressed in S. aureus and if both are required for promoting bacterial adhesion to fibronectin-coated surfaces, insertion mutations were isolated in each gene. A DNA fragment encoding tetracycline resistance was inserted into fnbA and a fragment encoding erythromycin resistance was inserted into fnbB. A double fnbA fnbB mutant was also constructed. The fnbA and fnbB single mutants showed no significant reduction in their adhesion to polymethylmethacrylate coverslips that had been coated in vitro with fibronectin. However, the double mutant was completely defective in adhesion. Monospecific antibodies directed against the non-conserved N-terminal regions of both proteins confirmed the lack of expression of FnBPs in the mutant strains. Wild-type fnbA and fnbB genes cloned seperately on a multicopy plasmid were each able to restore fully the adhesion-defective phenotype of the 8325-4 fnbA fnbB mutant. This demonstrates that both fnb genes are expressed in S. aureus and that both contribute to the ability of strain 8325-4 to adhere to fibronectin-coated surfaces. The double mutant was also defective in adhesion to coverslips that had been removed from tissue cages implanted subcutaneously in guinea-pigs, which suggests that fibronectin is important in promoting attachment of S. aureus to biomaterial in vivo.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesCORDER, ROGER ; PRALONG, FRANÇOIS P. ; TURNILL, DORA ; GAILLARD, ROLF C.
Oxford, UK : Blackwell Publishing Ltd
Published 1990Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: