Search Results - (Author, Cooperation:M. Wolff)

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  1. 1
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Zeitlin ; R. Zimdar ; M. P. Zorzano Mier
    American Association for the Advancement of Science (AAAS)
    Published 2013
    Staff View
    Publication Date:
    2013-07-23
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Golub, L. M. ; Wolff, M. ; Lee, H. M. ; McNamara, T. F. ; Ramamurthy, N. S. ; Zambon, J. ; Ciancio, S.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1985
    Staff View
    ISSN:
    1600-0765
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Recently, a new mechanism was proposed to explain the therapeutic efficacy of tetracyclines in periodontal disease— that specifically these antibiotics directly inhibit the activity of collagenase (and possibly other collagenolytic enzymes) produced by the host tissues resulting in a reduced rate of collagen breakdown (Golub et al. 1983). In the current studies, the effect of tetracyclines (minocycline, doxycycline, tetracycline) on collagenolytic enzyme activity was examined in human periodontal pockets and in several animal systems. In the clinical studies, gingival crevicular fluid (GCF) was collected on filter paper strips from individual periodontal pockets, the volume measured with the Periotron 6000, and the Gingival Index and pocket depth scored immediately thereafter at the same sites. The strips were incubated with [3H-methyi] collagen maintained in solution (or with 14C-glycine labeled collagen Fibrils), and the radiolabeled collagen degradation products measured in a liquid scintillation spectrometer, Using the techniques of SDS-PAGE and fluorography, the GCF was observed to generate collagen degradation products characteristic of those produced by mammalian collagenase, a finding consistent with previous studies. Both minocycline and tetracycline therapy reduced GCF collagenolytic activity about 70% during the initial weeks of treatment; the clinical parameters also showed improvements at the same time periods. This reduction in collagenolytic activity had largely regressed by 5 weeks after terminating tetracycline therapy and by 19 weeks after minocycline therapy, in the absence of other forms of periodontal treatment. In a preliminary study, 50 days of doxycycline treatment also reduced GCF collagenase activity, an effect which persisted for at least 2 months (but less than 1 year) after terminating its administration. In several studies involving experimental animals, the tetracyclines (1) in vivo, were found to reduce the pathologically excessive collagenase activity in gingiva and skin of diabetic rats; and (2) in vitro, directly inhibited the activity of collagenases from rat PMNL's and rabbit chondrocytes. The data in the current and our previous studies (Golub et al. 1983, Gomes, Golub & Ramamurthy 1984) continue to support the hypothesis that tetracyclines, by directly inhibiting collagenolytic enzyme(s) activity, may be therapeutically useful in treating diseases, such as periodontitis, characterized by excessive collagen breakdown.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1600-0765.1985.tb00405.x

    Articles: DFG German National Licenses
  3. 3
    Golub, L. M. ; Ramamurthy, N. ; McNamara, T. F. ; Gomes, B. ; Wolff, M. ; Casino, A. ; Kapoor, A. ; Zambon, J. ; Ciancio, S. ; Schneir, M. ; Perry, H.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1984
    Staff View
    ISSN:
    1600-0765
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1600-0765.1984.tb01334.x

    Articles: DFG German National Licenses
  4. 4
    Lemmon, M. T. ; Duxbury, T. C. ; Hubbard, M. Y. H. ; Wolff, M. J. ; Squyres, S. W. ; Craig, L. ; Ludwinski, J. M. ; Bell, J. F.

    [s.l.] : Nature Publishing Group
    Published 2005
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] The small martian satellites Phobos and Deimos orbit in synchronous rotation with inclinations of only 0.01° and 0.92°, respectively, relative to the planet's equatorial plane. Thus, an observer at near-equatorial latitudes on Mars could occasionally observe solar eclipses by these ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/nature03437

    Articles: DFG German National Licenses
  5. 5
    Wolff, M.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0022-0981
    Keywords:
    Biomass budget ; Ecosystem structure ; Scallop culture ; Upwelling
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0022-0981(94)90048-5

    Articles: DFG German National Licenses
  6. 6
    Staff View
    ISSN:
    0022-0728
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0022-0728(91)85400-J

    Articles: DFG German National Licenses
  7. 7
    Wolff, M.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0019-1035
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0019-1035(80)90144-X

    Articles: DFG German National Licenses
  8. 8
    Milvy, P. ; Wolff, M.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0027-5107
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0027-5107(77)90169-5

    Articles: DFG German National Licenses
  9. 9
    Staff View
    ISSN:
    0550-3213
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0550-3213(90)90163-8

    Articles: DFG German National Licenses
  10. 10
    Rand, K.H. ; Houck, H. ; Wolff, M.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0890-8508
    Keywords:
    PCR, polymerase chain reaction, Candida albicans, candidemia, disseminated
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1006/mcpr.1994.1030

    Articles: DFG German National Licenses
  11. 11
    Attig, N. ; Pettersson, B. ; Wolff, M.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0370-2693
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0370-2693(87)90856-2

    Articles: DFG German National Licenses
  12. 12
    Perrin-Wolff, M. ; Mishal, Z. ; Bohuon, C. ; Pallardy, M.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0248-4900
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0248-4900(93)90228-7

    Articles: DFG German National Licenses
  13. 13
    Attig, N. ; Karsch, F. ; Petersson, B. ; Satz, H. ; Wolff, M.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0370-2693
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0370-2693(88)91830-8

    Articles: DFG German National Licenses
  14. 14
    Chesters, R. ; Kaufman, H. W. ; Wolff, M. S. ; Hunungton, E. ; Kleinberg, I.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1992
    Staff View
    ISSN:
    1600-051X
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Abstract A potassium citrate-SMFP containing dentifrice was tested in double-blind 8-week clinical trial on subjects with a history of dentinal hypersensitivity. A dentifrice containing SMFP but no potassium salt was used as the control and a 2nd test dentifrice containing potassium nitrate-SMFP was assessed at the same time. The sensitivity of the subjects was evaluated at 0, 3 and 8 weeks using electrical and tactile methods plus a 1-s air blast. The sensitivity scores for each subject at each examination were summarised as a proportion of the examined teeth deemed sensitive. Assessment of any effects of the dentifrices was via an analysis of covariance of the logit transformation of these proportions with the baseline value as the covariate. The use of this novel method of analysis had the advantage of taking into account changes in sensitivity of alt of the teeth, both sensitive and non-sensitive, since electrical measurements indicated effects on both. Of the original 120 subjects. 111 completed the trial and the 3 dentifrice groups remained well balanced for age, sex and sensitivity. All 3 dentifrice groups showed statistically significant reductions in sensitivity over the 8 weeks. However, the potassium citrate-SMFP dentifrice was significantly more effective than either the control SMFP dentifrice, or the potassium nitrate-SMFP dentifrice, at reducing sensitivity after 3 weeks, and this difference plus further sensitivity reduction with all 3 dentifrices was observed after 8 weeks.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1600-051X.1992.tb00463.x

    Articles: DFG German National Licenses
  15. 15
    Lee, H. M. ; Golub, L. M. ; Chan, D. ; Leung, M. ; Schroeder, K. ; Wolff, M. ; Simon, S. ; Crout, R.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1997
    Staff View
    ISSN:
    1600-0765
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    The serum protein, α1-proteinase inhibitor (α1PI), defends the host against serine proteinases, e.g. PMN elastase. Using a rabbit anti-serum against human α1-PI, this protein in GCF was quantified from a standard curve constructed from dot-blot analysis and characterized by Western blot. GCF was collected on filter paper strips from healthy (H), gingivitis (G) and adult periodontitis (AP) patients, then extracted with Tris/NaCl/CaCl2 buffer, pH 7.6. α1-PI concentration increased with G and was highest in AP subjects. H sites only showed intact α1-PI (52 kDa); no degradation fragments (48 kDa) were detected. In G and AP subjects, α1-PI degradation fragments were seen in 17% and 71% of GCF samples, respectively. Both collagenase and α1-Pl-degrading activities in GCF increased with severity of inflammation (GCF flow). Moreover, the α1-PI degrading (or serpinolytic) activity was characterized as a matrix metalloproteinase, probably collagenase, based on its in vitro response to a panel of different proteinase inhibitors including doxycycline. We propose: (1) that collagenase promotes periodontal breakdown not only by degrading collagen, but also by depleting α1-PI regulation of elastase and other serine-proteinases, thereby favoring a broader attack on extracellular matrix (ECM) constituents, and (2) based on a recent longitudinal double-blind study using the techniques described above for α1-PI analysis, that low-dose doxycycline administration to humans with adult periodontitis can inhibit this broad cascade of ECM degradation.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1600-0765.1997.tb01377.x

    Articles: DFG German National Licenses
  16. 16
    Attig, N. ; Petersson, B. ; Wolff, M. ; Gavai, R. V.
    Springer
    Published 1988
    Staff View
    ISSN:
    1434-6052
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Physics
    Notes:
    Abstract Using the pseudo-fermion method to simulate QCD with dynamical quarks we investigate the effects of heavy dynamical quarks of 2 flavours on the deconfinement phase transition in the quenched QCD. As the mass of the quark is decreased the phase transition weakens as expected. Compared to the earlier results with leading order hopping parameter expansion, however, the weakening is less rapid. Our estimated upper bound on the critical mass where the transition becomes continuous is 1.5–2 times lower than earlier results.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01548862

    Articles: DFG German National Licenses
  17. 17
    Wolff, M. E. ; Zanati, G.
    Springer
    Published 1970
    Staff View
    ISSN:
    1420-9071
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Zusammenfassung Die Darstellung verschiedener A-Nor-5α-androstan-Verbindungen, die im A-Ring ein Schwefel-, Selen- oder Tellur-Atom haben, wird beschrieben. Sie besitzen, im Gegensatz zu den entsprechenden Oxa-Verbindungen, anabol-androgene Aktivität. 2, 3-Dithia-5α-androstan-17β-ol-Acetat hatte ebenfalls hohe anabol-androgene Wirksamkeit. Daraus wird geschlossen, dass fÜr die anabol-androgene Aktivität, nicht die elektronischen, sondern die sterischen Eigenschaften der C-2 und C-3 Atome, beziehungsweise ihre Substituenten, von Bedeutung sind.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF02112707

    Articles: DFG German National Licenses
  18. 18
    Staff View
    ISSN:
    1420-9071
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Resumen Se describe la sintesis y prueba de estructura del 3-acetato de (20 S, 21 R)-3β-hidroxi-21-amino-14β, 21-oxidonorcolan-23-oico ácido lactama, el cúal es el derivativo lactama de digitoxigenina. Dicho compuesto posée insignificantes efectos inotrópicos, pero inhibe o retarda la acción inotrópica positiva del 3-acetato de digitoxigenina cuando se ensaya en atria izquierda aislada de cochinillo de Indias o conejo.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01897955

    Articles: DFG German National Licenses
  19. 19
    Wolff, M. E. ; Hansch, C.
    Springer
    Published 1973
    Staff View
    ISSN:
    1420-9071
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Resumen Por primera vez se han analizado las relaciones estructura-función de diez derivados del 9α-cortisol substituido usando técnicas de regresión de parámetros múltiples. Se concluye que los factores electrónicos y estéricos son de mayor importancia al determinar el efecto del substituyente, y que la unión hidrofóbica también es de importante consideración. Se discute el significado de estos resultados.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01946750

    Articles: DFG German National Licenses
  20. 20
    Wolff, M. ; Jelkmann, W.
    Springer
    Published 1991
    Staff View
    ISSN:
    1432-1440
    Keywords:
    Kidney transplantation ; Erythropoietin ; Erythropoiesis ; Renal failure ; Anemia ; Erythrocytosis
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Moderately increased blood levels of endogenous erythropoietin (Epo) usually induce complete restoration of renal anemia after successful kidney transplantation. With good graft function erythropoiesis is maintained by normal Epo serum levels. Persistent anemia can be related to iron deficiency, low excretory graft function, and high dosage of immunosuppressive agents leading to marrow suppression or nephrotoxicity. Acute early rejection is associated with a fall in serum Epo and abrogation of reticulocytosis. About 15% of recipients fail to exhibit the normal feedback regulation and develop a mostly transient post-transplant erythrocytosis. Both an increased sensitivity of erythrocytic progenitors to Epo and inappropriate Epo secretion by the native kidneys may account for this overshooting reaction.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01666817

    Articles: DFG German National Licenses