Search Results - (Author, Cooperation:M. Tojo)

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  1. 1
    D. E. Neafsey ; R. M. Waterhouse ; M. R. Abai ; S. S. Aganezov ; M. A. Alekseyev ; J. E. Allen ; J. Amon ; B. Arca ; P. Arensburger ; G. Artemov ; L. A. Assour ; H. Basseri ; A. Berlin ; B. W. Birren ; S. A. Blandin ; A. I. Brockman ; T. R. Burkot ; A. Burt ; C. S. Chan ; C. Chauve ; J. C. Chiu ; M. Christensen ; C. Costantini ; V. L. Davidson ; E. Deligianni ; T. Dottorini ; V. Dritsou ; S. B. Gabriel ; W. M. Guelbeogo ; A. B. Hall ; M. V. Han ; T. Hlaing ; D. S. Hughes ; A. M. Jenkins ; X. Jiang ; I. Jungreis ; E. G. Kakani ; M. Kamali ; P. Kemppainen ; R. C. Kennedy ; I. K. Kirmitzoglou ; L. L. Koekemoer ; N. Laban ; N. Langridge ; M. K. Lawniczak ; M. Lirakis ; N. F. Lobo ; E. Lowy ; R. M. MacCallum ; C. Mao ; G. Maslen ; C. Mbogo ; J. McCarthy ; K. Michel ; S. N. Mitchell ; W. Moore ; K. A. Murphy ; A. N. Naumenko ; T. Nolan ; E. M. Novoa ; S. O'Loughlin ; C. Oringanje ; M. A. Oshaghi ; N. Pakpour ; P. A. Papathanos ; A. N. Peery ; M. Povelones ; A. Prakash ; D. P. Price ; A. Rajaraman ; L. J. Reimer ; D. C. Rinker ; A. Rokas ; T. L. Russell ; N. Sagnon ; M. V. Sharakhova ; T. Shea ; F. A. Simao ; F. Simard ; M. A. Slotman ; P. Somboon ; V. Stegniy ; C. J. Struchiner ; G. W. Thomas ; M. Tojo ; P. Topalis ; J. M. Tubio ; M. F. Unger ; J. Vontas ; C. Walton ; C. S. Wilding ; J. H. Willis ; Y. C. Wu ; G. Yan ; E. M. Zdobnov ; X. Zhou ; F. Catteruccia ; G. K. Christophides ; F. H. Collins ; R. S. Cornman ; A. Crisanti ; M. J. Donnelly ; S. J. Emrich ; M. C. Fontaine ; W. Gelbart ; M. W. Hahn ; I. A. Hansen ; P. I. Howell ; F. C. Kafatos ; M. Kellis ; D. Lawson ; C. Louis ; S. Luckhart ; M. A. Muskavitch ; J. M. Ribeiro ; M. A. Riehle ; I. V. Sharakhov ; Z. Tu ; L. J. Zwiebel ; N. J. Besansky
    American Association for the Advancement of Science (AAAS)
    Published 2015
    Staff View
    Publication Date:
    2015-01-03
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Anopheles/classification/*genetics ; Base Sequence ; Chromosomes, Insect/genetics ; Drosophila/genetics ; *Evolution, Molecular ; *Genome, Insect ; Humans ; Insect Vectors/classification/*genetics ; Malaria/*transmission ; Molecular Sequence Data ; Phylogeny ; Sequence Alignment
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    J. M. Tubio ; Y. Li ; Y. S. Ju ; I. Martincorena ; S. L. Cooke ; M. Tojo ; G. Gundem ; C. P. Pipinikas ; J. Zamora ; K. Raine ; A. Menzies ; P. Roman-Garcia ; A. Fullam ; M. Gerstung ; A. Shlien ; P. S. Tarpey ; E. Papaemmanuil ; S. Knappskog ; P. Van Loo ; M. Ramakrishna ; H. R. Davies ; J. Marshall ; D. C. Wedge ; J. W. Teague ; A. P. Butler ; S. Nik-Zainal ; L. Alexandrov ; S. Behjati ; L. R. Yates ; N. Bolli ; L. Mudie ; C. Hardy ; S. Martin ; S. McLaren ; S. O'Meara ; E. Anderson ; M. Maddison ; S. Gamble ; C. Foster ; A. Y. Warren ; H. Whitaker ; D. Brewer ; R. Eeles ; C. Cooper ; D. Neal ; A. G. Lynch ; T. Visakorpi ; W. B. Isaacs ; L. van't Veer ; C. Caldas ; C. Desmedt ; C. Sotiriou ; S. Aparicio ; J. A. Foekens ; J. E. Eyfjord ; S. R. Lakhani ; G. Thomas ; O. Myklebost ; P. N. Span ; A. L. Borresen-Dale ; A. L. Richardson ; M. Van de Vijver ; A. Vincent-Salomon ; G. G. Van den Eynden ; A. M. Flanagan ; P. A. Futreal ; S. M. Janes ; G. S. Bova ; M. R. Stratton ; U. McDermott ; P. J. Campbell
    American Association for the Advancement of Science (AAAS)
    Published 2014
    Staff View
    Publication Date:
    2014-08-02
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Carcinogenesis/genetics ; Chromatin/chemistry ; *DNA Transposable Elements ; Exons ; Genome, Human ; Humans ; *Long Interspersed Nucleotide Elements ; Mutagenesis, Insertional ; Neoplasms/*genetics ; *Transduction, Genetic ; Translocation, Genetic
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    OKAMURA, T. ; STEINBERG, M. P. ; TOJO, M. ; NELSON, A. I.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1978
    Staff View
    ISSN:
    1750-3841
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Process Engineering, Biotechnology, Nutrition Technology
    Notes:
    Water was determined with a wide line NMR instrument. Three soy flours were studied: full-fat Bonus variety; laboratory, chloroform-methanol defatted from the same Bonus sample; and commercial, hexane defatted. In case of all three samples, a plot of moisture content vs NMR response at rf 28 db (total water) showed two straight lines; the break occurred at the Bound Water Capacity (BWC). At an instrument setting of rf 0 db (only bound water gives signal), a plot of signal against moisture content, both on a total sample basis, was a triangle; the first increment of water, 3 and 7% for full-fat and defatted, respectively, did not give a signal and the apex of the triangle gave the BWC which was 27.9% for the full-fat and 40.5% for the same soy flour after defatting. When laboratory and commercially defatted samples were compared, the ascending curves coincided but their BWC were 40 and 31%, respectively. BWC values obtained from full-fat readings corrected for oil signal and from commercially defatted flakes were almost the same. Steam heating at 15 psig for 15 min and freezing to a temperature as low as -40°C did not change the water binding characteristics of commercial defatted dry flakes.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2621.1978.tb02352.x

    Articles: DFG German National Licenses
  4. 4
    Staff View
    ISSN:
    0008-6215
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/S0008-6215(00)90619-0

    Articles: DFG German National Licenses
  5. 5
    Tojo, M. ; Kiyosawa, H. ; Iwatsuki, K. ; Nakamura, K. ; Kaneko, F.

    Oxford, UK : Blackwell Science Ltd
    Published 2003
    Staff View
    ISSN:
    1365-2133
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Summary Background Mutations of the patched (Ptc) gene, a developmental regulator implicated in the signalling pathway via sonic hedgehog (Shh) and smoothened (Smo), play an essential pathogenic role in the development of basal cell carcinomas (BCCs). We previously reported the upregulation of Shh signal transducers, including Ptc, Smo and hedgehog-interacting protein, in BCCs. In vertebrates, specific downstream effectors in the Shh signalling pathway include three zinc-finger transcription factors, Gli1, Gli2 and Gli3. Gli1 possesses only an activation domain, while Gli2 and Gli3 contain both activation and repression domains. It remains unclear which of these transcription factors are responsible for the development of BCCs. Objectives To examine the expression pattern of Gli2 mRNA by human BCCs in comparison with those by normal human skin and various skin tumours. Methods We performed quantitative reverse transcriptase–polymerase chain reaction analyses with a series of samples from BCCs, other skin tumours and normal skin. Results We found that Gli2 mRNA expression was enhanced in the BCCs we examined, whereas there was no significant increase in other skin tumours or normal skin. Of four spliced Gli2 isoforms designated Gli2α, β, γ and δ, the expression of Gli2β mRNA was increased the most in BCCs. Conclusions As Gli2β is an isoform spliced at the first splicing site containing a repression domain and consists of an intact activation domain, its overexpression may lead to the upregulation of the Shh signalling pathway, thereby inducing BCCs.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1365-2133.2003.05284.x

    Articles: DFG German National Licenses
  6. 6
    Tojo, M. ; Kiyosawa, H. ; Iwatsuki, K. ; Kaneko, F.

    Oxford, UK : Blackwell Science, Ltd
    Published 2002
    Staff View
    ISSN:
    1365-2133
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Summary Background  Aberrant activation of the hedgehog pathway has been identified in various human tumours, including familial and sporadic basal cell carcinomas (BCCs). It has been postulated that binding of sonic hedgehog protein (SHH) to its receptor, patched protein (PTC), releases the inhibitory effect of PTC against smoothened protein (SMO), another protein of the SHH signalling pathway. The positive SMO signalling is not downregulated in BCCs because of the mutational inactivation of PTC. Recently, hedgehog-interacting protein (HIP) was found to bind to SHH directly and attenuate SHH signalling like PTC, while its expression was induced by SHH signals.Objectives  To examine the expression patterns of HIP, SHH and PTC gene mRNA by human BCCs, in comparison with those by normal human skin and various skin tumours.Methods  We performed quantitative reverse transcriptase–polymerase chain reaction analyses with a series of samples from BCCs, other skin tumours and normal skin.Results  We found that the mRNA expression of both HIP and PTC genes was enhanced in all samples of BCCs, whereas none of the other skin tumours tested exhibited an increased level of such mRNAs as compared with normal skin. The transcription of the SHH gene, however, was at a baseline level in most BCCs.Conclusions  These results indicate that both HIP and PTC gene expression are specifically involved in the development of BCCs, and that the production of HIP is linked with the expression of the PTC gene but not the SHH gene.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1365-2133.2002.04583.x

    Articles: DFG German National Licenses
  7. 7
    Shibata, N. ; Kobayashi, H. ; Tojo, M. ; Suzuki, S.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0003-9861
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0003-9861(86)90379-6

    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    0003-9861
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0003-9861(85)90511-9

    Articles: DFG German National Licenses
  9. 9
    Tojo, M. ; Shibata, N. ; Ban, Y. ; Suzuki, S.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0008-6215
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0008-6215(90)84263-T

    Articles: DFG German National Licenses
  10. 10
    Staff View
    ISSN:
    0008-6215
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0008-6215(89)80006-0

    Articles: DFG German National Licenses
  11. 11
    Staff View
    ISSN:
    1432-0533
    Keywords:
    Mitochondrial myopathy ; Cytochromec oxidase ; Complex IV ; Muscle histochemistry ; Ragged-red fibers
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Muscle biopsies from 16 patients with cytochromec oxidase (CCO) deficiency were examined morphologically. Two siblings had the fatal infantile form. The muscle of the older sister at the age of 5 months had numerous ragged-red fibers (RRF) and increased numbers of lipid droplets; at 28 days the brother had no RRF suggesting that the RRF formed later than 28 days. The muscle pathology in two patients with the benign infantile form improved as they grew older; numbers of RRF, lipid droplets and glycogen particles decreased and CCO activity increased in the second biopsy. In the encephalomyopathic form, RRF were seen in 5 of 12 muscles mostly in patients more than 6 years of age. Muscle spindles and blood vessel walls in the biopsies from three patients with rapid clinical aggravation had no CCO activity, suggesting that enzyme activity differed from tissue to tissue (tissue specificity).
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00687425

    Articles: DFG German National Licenses