Search Results - (Author, Cooperation:M. Perron)

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  1. 1
    T. K. Warren ; R. Jordan ; M. K. Lo ; A. S. Ray ; R. L. Mackman ; V. Soloveva ; D. Siegel ; M. Perron ; R. Bannister ; H. C. Hui ; N. Larson ; R. Strickley ; J. Wells ; K. S. Stuthman ; S. A. Van Tongeren ; N. L. Garza ; G. Donnelly ; A. C. Shurtleff ; C. J. Retterer ; D. Gharaibeh ; R. Zamani ; T. Kenny ; B. P. Eaton ; E. Grimes ; L. S. Welch ; L. Gomba ; C. L. Wilhelmsen ; D. K. Nichols ; J. E. Nuss ; E. R. Nagle ; J. R. Kugelman ; G. Palacios ; E. Doerffler ; S. Neville ; E. Carra ; M. O. Clarke ; L. Zhang ; W. Lew ; B. Ross ; Q. Wang ; K. Chun ; L. Wolfe ; D. Babusis ; Y. Park ; K. M. Stray ; I. Trancheva ; J. Y. Feng ; O. Barauskas ; Y. Xu ; P. Wong ; M. R. Braun ; M. Flint ; L. K. McMullan ; S. S. Chen ; R. Fearns ; S. Swaminathan ; D. L. Mayers ; C. F. Spiropoulou ; W. A. Lee ; S. T. Nichol ; T. Cihlar ; S. Bavari
    Nature Publishing Group (NPG)
    Published 2016
    Staff View
    Publication Date:
    2016-03-05
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Alanine/*analogs & derivatives/pharmacokinetics/pharmacology/therapeutic use ; Amino Acid Sequence ; Animals ; Antiviral Agents/pharmacokinetics/pharmacology/*therapeutic use ; Cell Line, Tumor ; Ebolavirus/drug effects ; Female ; HeLa Cells ; Hemorrhagic Fever, Ebola/*drug therapy/prevention & control ; Humans ; Macaca mulatta/*virology ; Male ; Molecular Sequence Data ; Organ Specificity ; Prodrugs/pharmacokinetics/pharmacology/therapeutic use ; Ribonucleotides/pharmacokinetics/pharmacology/*therapeutic use
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Perron, M., Saragovi, H. U.
    The American Society for Pharmacology and Experimental Therapeutics (ASPET)
    Published 2018
    Staff View
    Publication Date:
    2018-05-04
    Publisher:
    The American Society for Pharmacology and Experimental Therapeutics (ASPET)
    Print ISSN:
    0026-895X
    Electronic ISSN:
    1521-0111
    Topics:
    Chemistry and Pharmacology
    Medicine
    Published by:
    http://www.aspet.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Perron, M. ; Harris*, W. A.
    Springer
    Published 2000
    Staff View
    ISSN:
    1420-9071
    Keywords:
    Key words. Retina; neurogenesis; bHLH transcription factors; proneural genes; Delta-Notch pathway; neurogenic genes; cell determination.
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract. The retina is an excellent system in which to study neural cell fate decision mechanisms. It is an organized laminated structure with a limited array of cell types. During the last 5 years, experiments that perturb normal gene expression have highlighted some molecular mechanisms involved in cellular fate choice in the retina. By controlling when a retinoblast is allowed to differentiate, Delta-Notch signaling plays a critical role in the generation of neuronal diversity in the vertebrate retina. When cells are released from the inhibition mediated by the Delta-Notch pathway, basic helix-loop-helix (bHLH) transcription factors act as intrinsic factors that bias neuroblasts towards particular fates. In this review, we present an overview of the data leading to these conclusions on the role of the Delta-Notch pathway and the bHLH proteins on cell fate decisions during vertebrate retinogenesis.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/PL00000685

    Articles: DFG German National Licenses
  4. 4
    Perron, M. ; Gordon, A. G. ; Bousquet, J.
    Springer
    Published 1995
    Staff View
    ISSN:
    1432-2242
    Keywords:
    DNA fingerprint ; Molecular markers ; Picea mariana ; Picea rubens ; RAPD
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Notes:
    Abstract Species-specific molecular markers were designed to assist in the identification of closely related black spruce (Picea mariana [B.S.P.] Mill.) and red spruce (P. rubens Sarg.) in northeastern North America. Trees from six provenances of black spruce and three provenances of red spruce were sampled from outside the sympatric zone. They were first classified using a composite index of five qualitative morphological traits. The species-specific genetic markers were developed using random amplified polymorphic DNAs (RAPD) and a combination of bulk sample and individual tree analyses. Each species bulk sample was constructed from DNAs obtained from 12 trees that were from outside the sympatric zone and showed a morphological composite index specific of each species. A total of 161 primers were screened with the bulk samples. From these, 52 primers showing segregating fingerprints were further screened with the individual trees. Most of the markers observed were shared by the two species, and there was less diversity in P. rubens. A small number of markers were found to be monomorphic or nearly monomorphic and specific to either P. mariana or P. rubens. These markers remained species-specific when F1 progenies derived from independent intraspecific crosses were screened, and they were subsequently found to co-segregate in hybrids derived from independent interspecific crosses here used as controls.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00220871

    Articles: DFG German National Licenses