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1Latest Papers from Table of Contents or Articles in PressJ. R. Perry ; F. Day ; C. E. Elks ; P. Sulem ; D. J. Thompson ; T. Ferreira ; C. He ; D. I. Chasman ; T. Esko ; G. Thorleifsson ; E. Albrecht ; W. Q. Ang ; T. Corre ; D. L. Cousminer ; B. Feenstra ; N. Franceschini ; A. Ganna ; A. D. Johnson ; S. Kjellqvist ; K. L. Lunetta ; G. McMahon ; I. M. Nolte ; L. Paternoster ; E. Porcu ; A. V. Smith ; L. Stolk ; A. Teumer ; N. Tsernikova ; E. Tikkanen ; S. Ulivi ; E. K. Wagner ; N. Amin ; L. J. Bierut ; E. M. Byrne ; J. J. Hottenga ; D. L. Koller ; M. Mangino ; T. H. Pers ; L. M. Yerges-Armstrong ; J. Hua Zhao ; I. L. Andrulis ; H. Anton-Culver ; F. Atsma ; S. Bandinelli ; M. W. Beckmann ; J. Benitez ; C. Blomqvist ; S. E. Bojesen ; M. K. Bolla ; B. Bonanni ; H. Brauch ; H. Brenner ; J. E. Buring ; J. Chang-Claude ; S. Chanock ; J. Chen ; G. Chenevix-Trench ; J. M. Collee ; F. J. Couch ; D. Couper ; A. D. Coviello ; A. Cox ; K. Czene ; P. D'Adamo A ; G. Davey Smith ; I. De Vivo ; E. W. Demerath ; J. Dennis ; P. Devilee ; A. K. Dieffenbach ; A. M. Dunning ; G. Eiriksdottir ; J. G. Eriksson ; P. A. Fasching ; L. Ferrucci ; D. Flesch-Janys ; H. Flyger ; T. Foroud ; L. Franke ; M. E. Garcia ; M. Garcia-Closas ; F. Geller ; E. E. de Geus ; G. G. Giles ; D. F. Gudbjartsson ; V. Gudnason ; P. Guenel ; S. Guo ; P. Hall ; U. Hamann ; R. Haring ; C. A. Hartman ; A. C. Heath ; A. Hofman ; M. J. Hooning ; J. L. Hopper ; F. B. Hu ; D. J. Hunter ; D. Karasik ; D. P. Kiel ; J. A. Knight ; V. M. Kosma ; Z. Kutalik ; S. Lai ; D. Lambrechts ; A. Lindblom ; R. Magi ; P. K. Magnusson ; A. Mannermaa ; N. G. Martin ; G. Masson ; P. F. McArdle ; W. L. McArdle ; M. Melbye ; K. Michailidou ; E. Mihailov ; L. Milani ; R. L. Milne ; H. Nevanlinna ; P. Neven ; E. A. Nohr ; A. J. Oldehinkel ; B. A. Oostra ; A. Palotie ; M. Peacock ; N. L. Pedersen ; P. Peterlongo ; J. Peto ; P. D. Pharoah ; D. S. Postma ; A. Pouta ; K. Pylkas ; P. Radice ; S. Ring ; F. Rivadeneira ; A. Robino ; L. M. Rose ; A. Rudolph ; V. Salomaa ; S. Sanna ; D. Schlessinger ; M. K. Schmidt ; M. C. Southey ; U. Sovio ; M. J. Stampfer ; D. Stockl ; A. M. Storniolo ; N. J. Timpson ; J. Tyrer ; J. A. Visser ; P. Vollenweider ; H. Volzke ; G. Waeber ; M. Waldenberger ; H. Wallaschofski ; Q. Wang ; G. Willemsen ; R. Winqvist ; B. H. Wolffenbuttel ; M. J. Wright ; D. I. Boomsma ; M. J. Econs ; K. T. Khaw ; R. J. Loos ; M. I. McCarthy ; G. W. Montgomery ; J. P. Rice ; E. A. Streeten ; U. Thorsteinsdottir ; C. M. van Duijn ; B. Z. Alizadeh ; S. Bergmann ; E. Boerwinkle ; H. A. Boyd ; L. Crisponi ; P. Gasparini ; C. Gieger ; T. B. Harris ; E. Ingelsson ; M. R. Jarvelin ; P. Kraft ; D. Lawlor ; A. Metspalu ; C. E. Pennell ; P. M. Ridker ; H. Snieder ; T. I. Sorensen ; T. D. Spector ; D. P. Strachan ; A. G. Uitterlinden ; N. J. Wareham ; E. Widen ; M. Zygmunt ; A. Murray ; D. F. Easton ; K. Stefansson ; J. M. Murabito ; K. K. Ong
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-09-19Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adolescent ; Age Factors ; *Alleles ; Body Mass Index ; Breast Neoplasms/genetics ; Cardiovascular Diseases/genetics ; Child ; Diabetes Mellitus, Type 2/genetics ; Europe/ethnology ; Female ; Genetic Loci/*genetics ; Genome-Wide Association Study ; Genomic Imprinting/genetics ; Humans ; Hypothalamo-Hypophyseal System/physiology ; Intercellular Signaling Peptides and Proteins/genetics ; Male ; Membrane Proteins/genetics ; Menarche/*genetics ; Obesity/genetics ; Ovary/physiology ; *Parents ; Polymorphism, Single Nucleotide/genetics ; Potassium Channels, Tandem Pore Domain/genetics ; Proteins/genetics ; Quantitative Trait Loci/genetics ; Receptors, GABA-B/metabolism ; Receptors, Retinoic Acid/metabolism ; Ribonucleoproteins/geneticsPublished by: -
2Articles: DFG German National LicensesSWIET, M. ; WARD, P. DORRINGTON ; FIDLER, J. ; HORSMAN, A. ; KATZ, D. ; LETSKY, E. ; PEACOCK, M. ; WISE, P. H.
Oxford, UK : Blackwell Publishing Ltd
Published 1983Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary. The relation of heparin therapy to osteoporosis was assessed in a retrospective analysis of 20 women treated during and after pregnancy with subcutaneous heparin for thromboembolism prophylaxis. The phalangeal cortical area ratio was significantly less after long term therapy (〉25 weeks) compared with that after short term therapy (〈7 weeks). The same trend was found in the metacarpal area ratio, although this did not reach statistical significance. The changes were most marked in a woman who had received heparin also in a previous pregnancy. No correlations were found between duration of therapy and back pain, conventional radiology of lumbar spine or the Singh index of femoral trabecular pattern which were within the normal range in all patients. The findings indicate a dose-related demineralization process associated with prophylactic heparin therapy in pregnancy. The correct methods of and criteria for thromboembolism prophylaxis in pregnancy need critical re-examination.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: To assess the potential for atmospheric nitrogen to enter the nonventilated lung following the initiation of single-lung ventilation, the nonventilated lung of 10 patients undergoing video-assisted thoracoscopy was connected to the air in a water-filled spirometer, and gas movement outof and back into the lung was measured. Airway pressure from both lungs and pleural pressure from the nonventilated side were also measured. With each breath of positive-pressure ventilation to the ventilated lung prior to the thoracic cavity being opened to the atmosphere, the pressure transmitted to the opposite hemithorax generated a mean (range) tidal movement of gas in the nonventilated lung of 134 (65–265) ml. In addition, ongoing gas exchange resulted in a progressive influx of gas from the spirometer over the 110–120 s measurement period of a mean (range) volume of155 (70–320) ml. This easily preventable influx of atmospheric nitrogen could, in theory, predispose to arterial desaturation and to delayed lung collapse after the parietal pleura is opened.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: By enhancing gaseous uptake from the non-ventilated lung during procedures performed thoracoscopically, the rapid diffusion properties of nitrous oxide would be expected to speed lung collapse and so facilitate surgery. To assess the effect of nitrous oxide on the speed of absorptive lung collapse, a study was conducted using 11 anaesthetised sheep. Speed of collapse was assessed in an indirect manner by recording the time required in a closed-chest situation for the airway pressure distal to a single lung airway occlusion to decrease to − 1.0 kPa. The influence of nitrous oxide was assessed by comparing the time taken for this decrease in airway pressure when the animal was being mechanically ventilated with 50% nitrous oxide in oxygen with the time taken when using 100% oxygen. In all assessments, it was found that the decrease in airway pressure to − 1.0 kPa occurred in a shorter time when nitrous oxide was used. The findings lend support to the hypothesis that during thoracoscopic surgery, mechanical lung ventilation with an oxygen/nitrous oxide mixture will increase the rate of gaseous uptake from the non-ventilated lung and so hasten its absorptive collapse.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: A study of 10 anaesthetised patients placed in the lateral position for thoracoscopic surgery assessed whether transient increases in pleural pressure on the side of the non-ventilated lung might increase the speed at which gas vents from that lung. The transient increases in pleural pressure were generated by the mediastinal displacement that occurs with each inspiratory phase of positive pressure ventilation of the dependent lung. When combined with a unidirectional valve allowing gas to flow out of the non-ventilated lung, and a second valve allowing ambient airflow into, but not out of, the thoracic cavity via an initial thoracoscopy access site, this mediastinal displacement could conceivably serve to ‘pump’ gas out of the non-ventilated lung. Using the four different combinations of valve inclusion or omission, the volume of gas that vented from the non-ventilated lung into a measuring spirometer was recorded during a 120-s measurement sequence. It was found that the speed of venting was not increased by the transient increases in pleural pressure, and that in all but one of a total of 34 measurement sequences, venting had ceased by the end of the sequence. Gas venting was a mean (SD) of 85.5 (11.9)% complete in 25 s (five breaths), and 96.6 (6.1)% complete in 60 s. This prompt partial lung collapse very likely reflected the passive elastic recoil of the lung, while the failure of transient increases in pleural pressure to result in ongoing venting of gas was probably a consequence of airways closure as the lung collapsed. It is concluded that techniques that aim to speed lung collapse by increasing pleural pressure are unlikely to be effective.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: An ambient pressure oxygen reservoir bag apparatus for connecting to the nonventilated lung as soon as single-lung ventilation is initiated is described. The theoretical benefits are the facilitation of collapse of the lung on the side of surgery and a reduced likelihood of arterial desaturation. Although these main benefits are yet to be proven, the authors believe that the weight of theoretical argument and practical observation serves to justify the use of the apparatus while the outcome of suitably designed clinical trials is awaited. It can be used for all one-lung anaesthetics and is especially recommended for thoracoscopic surgery, where temporary re-expansion of the nonventilated lung is either counter-productive or contraindicated, and where there is a possibility that lung collapse may be delayed.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesHudson-Peacock, M. J. ; Diffey, B.L. ; Farr, P. M.
Oxford, UK : Blackwell Publishing Ltd
Published 1996Staff ViewISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesRockey, D. D. ; Grosenbach, D. ; Hruby, D. E. ; Peacock, M. G. ; Heinzen, R. A. ; Hackstadt, T.
Oxford BSL : Blackwell Science Ltd
Published 1997Staff ViewISSN: 1365-2958Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyMedicineNotes: Chlamydiae are obligate intracellular bacteria that replicate within a non-acidified vacuole called an inclusion. Chlamydia psittaci (strain GPIC) produces a 39 kDa protein (IncA) that is localized to the inclusion membrane. While IncA is present as a single 39 kDa species in purified reticulate bodies, two additional higher Mr forms are found in C. psittaci-infected cells. This finding suggested that IncA may be post-translationally modified in the host cell. Here we present evidence that IncA is a serine/threonine phosphoprotein that is phosphorylated by host cell enzymes. This conclusion is supported by the following experimental findings: (i) treatment of infected cells with inhibitors of host cell phosphatases or kinases altered the electrophoretic migration pattern of IncA; (ii) treatment with calf intestinal alkaline phosphatase eliminated the multiple-banding pattern of IncA, leaving only the protein band with the lowest relative molecular weight; and (iii) radioimmunoprecipitation of lysates of [32P]-orthophosphate-labelled infected HeLa cells with anti-IncA antisera demonstrated that the two highest Mr IncA bands were phosphorylated. A vaccinia-virus recombinant expressing incA was used to determine if HeLa cells can phosphorylate IncA in the absence of a chlamydial background. IncA in lysates of these cells migrated identically to that seen in C. psittaci-infected cells, indicating the host cell was responsible for the phosphorylation of the protein. Microinjection of fluorescently labelled anti-IncA antibodies into C. psittaci-infected HeLa cells resulted in immunostaining of the outer face of the inclusion membrane. Collectively, these results demonstrate that IncA is phosphorylated by the host cell, and regions of IncA are exposed at the cytoplasmic face of the inclusion.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0009-8981Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0009-8981Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 0009-8981Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0009-8981Keywords: 25 Hydroxycholecalciferol ; High performance liquid chromatography ; Plasma ; Purification ; Vitamin D binding proteinSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0009-8981Keywords: Calcium absorption ; Calcium isotope techniquesSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0009-8981Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0009-8981Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0009-8981Keywords: 1,25-Dihydroxycholecalciferol ; 1,25-Dihydroxyergocalciferol ; Antisera ; Specificity pH ; Vitamin D binding globulinSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1559-1816Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: PsychologyNotes: Proposition 209 was the affirmative-action initiative placed on the 1996 general election ballot that asked California voters to determine the future of ethnically targeted state programs. Simultaneous logistic regression was used to examine the extent to which symbolic, traditional, and other racial attitudes, such as the belief that things were better when Blacks and Mexican Americans were segregated from Whites, the belief that minority groups were getting more than their share of resources, and the belief that minority groups were no longer discriminated against were related to support for Proposition 209. The results indicate that symbolic racism and the belief that minorities were accessing more than their share of resources provided stronger explanations for support of the initiative than did other sentiments.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1433-2965Keywords: Bones ; Densitometry ; Fractures ; Osteoporosis ; UltrasoundSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract We studied 336 elderly white women, of whom 22 had previously suffered a hip fracture and 22 had previously suffered a vertebral fracture. All subjects were 60 years old or older with a mean age of 73.7 years. Measurements of ultrasonic transmission velocity (UTV), broad-band ultrasonic attenuation (BUA) and stiffness (STF) were made at the os calcis using a Lunar Achilles ultrasound device. Measurements of lumbar spine bone mineral density (L2–4 BMD) and femoral neck BMD were made using dual-energy X-ray absorptiometry. The fracture groups were significantly older and had more years since menopause than the control groups. Logistic regression showed that measurements of UTV, STF and BUA discriminated between fracture and non-fracture subjects for both the hip (p〈0.001) and spine (p〈0.05). Femoral neck BMD discriminated both hip and vertebral fractures from controls (p〈0.001 andp〈0.01, respectively). Spinal BMD discriminated between subjects with vertebral fractures and those without (p〈0.01), but not hip fractures (p=0.64). For hip fracture, areas under receiver-operating characteristic (ROC) curves were 0.85 for UTV, 0.83 for STF, 0.79 for BUA, 0.78 for femoral neck BMD and 0.53 for spinal BMD. For vertebral fracture, areas under the ROC curve were 0.68 for UTV, 0.70 for STF, 0.66 for BUA, 0.66 for femoral neck BMD and 0.67 for spinal BMD. To determine whether calcaneal ultrasonic measurements discriminated, independently of BMD, fracture from control groups, UTV, BUA and STF were adjusted for BMD, age and years since menopause using multiple regression analysis and the residuals from the regressions were incorporated into a logistic regression analysis. Adjusted ultrasonic measurements discriminated hip fracture from control groups (p〈0.005 for UTV;p〈0.05 for BUA;p〈0.01 for STF) but not vertebral fracture (p=0.37 for UTV;p=0.53 for BUA;p=0.25 for STF). These results show that, when ultrasonic measurements were adjusted for BMD and age, they still discriminated between hip fracture and control groups. This finding supports the hypothesis that ultrasonic measurements contain information about bone strength not contained in bone density measurements that may be useful in predicting hip fractures. Therefore, calcaneal ultrasound measurements may provide a safe, low-cost addition to bone densitometry.Type of Medium: Electronic ResourceURL: