Search Results - (Author, Cooperation:M. Otto)

Ewert, Otto M.

Unknown

364 S.

346200865X

Neue Wissenschaftliche Bibliothek - Psychologie

German

2018-01-23

American Heart Association (AHA)

1524-4539

Medicine

Aortic Valve Replacement/Transcatheter Aortic Valve Implantation

2014-07-22

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Cell Transformation, Neoplastic ; Chromosomes, Human, Pair 8/genetics ; DNA Copy Number Variations/*genetics ; Disease Models, Animal ; Gene Amplification/*genetics ; Gene Dosage/*genetics ; Genes, myc/*genetics ; HCT116 Cells ; Humans ; Mice ; Mice, Inbred C57BL ; Oncogene Protein p55(v-myc)/*genetics/metabolism ; Phenotype ; RNA, Long Noncoding/*genetics

2014-12-10

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Humans ; Immune Evasion/*immunology ; Male ; Staphylococcal Infections/*immunology ; Staphylococcal Protein A/*immunology ; Staphylococcus aureus/*immunology

2018-09-25

BMJ Publishing Group

Medicine

2014-11-02

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Animals ; Drosophila melanogaster/genetics/immunology ; Evolution, Molecular ; Gene Knockdown Techniques ; Host-Pathogen Interactions/genetics/immunology ; Humans ; Macrophages/immunology ; Nerve Growth Factor/genetics/*immunology ; Phagocytosis/genetics/immunology ; Receptor, trkA/genetics/*immunology ; Staphylococcal Infections/genetics/*immunology ; Staphylococcus aureus/*immunology ; Zebrafish/genetics/immunology

2013-11-01

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Bacterial Toxins/*metabolism/pharmacology ; Calcium Signaling/drug effects ; *Cell Degranulation/drug effects ; Culture Media, Conditioned/pharmacology ; Dermatitis, Atopic/immunology/metabolism/*microbiology/pathology ; Female ; Immunoglobulin E/biosynthesis/immunology ; Inflammation/immunology/metabolism/microbiology/pathology ; Interleukin-4/immunology ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; Mast Cells/*cytology/drug effects ; Mice ; Phosphatidylinositol 3-Kinases/metabolism ; Protein-Tyrosine Kinases/metabolism ; Proto-Oncogene Proteins c-kit/genetics/metabolism ; Staphylococcus aureus/metabolism/*pathogenicity

article

2003

Leitbild ; Generation ; Geschichte (Histor) ; Nachhaltigkeit ; Politik ; Sozialstaat ; Bewertung ; Definition ; Entwicklung ; Modell ; Wirkung ; Zukunft

Idee & Tat, Bd. 90 (2003) H. 2, S. 7-9

German

article

1982

Heim ; Heimerzieher ; Integration ; Erzieher

Sozialarbeit, Bd. 14 (1982) H. 11, S. 16-18, 1015-4507

German

book

1994

Arbeitsförderung ; Berufschance ; Beschäftigungspolitik ; Teilnehmer ; Deutschland-Östliche Länder

German

article

1995

Aufmerksamkeit ; Schulleistung ; Schülerbeurteilung

Zeitschrift für Entwicklungspsychologie und pädagogische Psychologie, Bd. 27 (1995) H. 4, S. 313-322, 0049-8637

facet.language.ger, facet.language.eng

Literaturangaben 12, Tabellen 6

article

1988

Familie ; Erziehungsberatung ; Beratung ; Deutschland-BRD

Wandel und Kontinuitaet der Familie in der Bundesrepublik Deutschland., Stuttgart: Enke (1988), S. 259-278

German

Literaturangaben 30, Tabellen 3

book

1987

Übung ; Unterrichtsmaterial ; Textarbeit ; Fremdsprachenunterricht ; Französisch ; Landeskunde ; Chanson ; Materialsammlung ; Paris

French

2018-02-02

The Society of Nuclear Medicine (SNM)

0022-3123

Medicine

2018-10-09

American Physical Society (APS)

1098-0121

1095-3795

Physics

Surface physics, nanoscale physics, low-dimensional systems

2018-11-30

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Geosciences

Computer Science

Medicine

Natural Sciences in General

Physics

1471-4159

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Human lumbar CSF patterns of Aβ peptides were analysed by urea-based β-amyloid sodium dodecyl sulphate polyacrylamide gel electrophoresis with western immunoblot (Aβ-SDS–PAGE/immunoblot). A highly conserved pattern of carboxyterminally truncated Aβ1–37/38/39 was found in addition to Aβ1–40 and Aβ1–42. Remarkably, Aβ1–38 was present at a higher concentration than Aβ1–42, being the second prominent Aβ peptide species in CSF. Patients with Alzheimer's disease (AD, n = 12) and patients with chronic inflammatory CNS disease (CID, n = 10) were differentiated by unique CSF Aβ peptide patterns from patients with other neuropsychiatric diseases (OND, n = 37). This became evident only when we investigated the amount of Aβ peptides relative to their total Aβ peptide concentration (Aβ1–x%, fractional Aβ peptide pattern), which may reflect disease-specific γ-secretase activities. Remarkably, patients with AD and CID shared elevated Aβ1–38% values, whereas otherwise the patterns were distinct, allowing separation of AD from CID or OND patients without overlap. The presence of one or two ApoE ε4 alleles resulted in an overall reduction of CSF Aβ peptides, which was pronounced for Aβ1–42. The severity of dementia was significantly correlated to the fractional Aβ peptide pattern but not to the absolute Aβ peptide concentrations.

Electronic Resource

1540-8167

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Introduction: Modification of AV nodal conduction by radiofrequency ablation (RFA) results in a variable reduction in heart rate during atrial fibrillation (AF). Using AF induced in patients with dual AV nodal pathways as a model, we tested the effect of additional treatment with digitalis (ouabain) and beta-blocker (esmolol). Methods and Results: Ten patients were randomized to control (group I) and studied only before ablation. AF was induced in 30 patients before and after slow pathway ablation (group II). Mean ventricular cycle lengths (AF CLmean) were recorded. Slow pathway conduction was eliminated after ablation in 10 patients (group IIA), whereas slow pathway conduction was still present in 20 patients (group IIB). Compared to pre-RFA there was a 10% increase in AF CLmean post-RFA (P 〈 0.01). During isoproterenol infusion the increase was 8% (P = NS). Adding digitalis and beta-blocker during isoproterenol infusion increased AF CLmean by 75% (95% in group IIA) compared to 36% in group I (P 〈 0.001 II vs I). Conclusion: Slow pathway ablation reduces ventricular rate during AF. Addition of digitalis and beta-blocker during isoproterenol infusion significantly decreases ventricular rate after ablation compared to the control group. The finding suggests that beta-blocker has significant effects on fast AV nodal pathway conduction during induced AF with isoproterenol infusion.

Electronic Resource

1540-8167

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Hemostatic Activation during RF Ablation. Introduction: Catheter ablation may be complicated by clinical thromboembolism in about 1% of patients. Methods and Results: We studied the activation of coagulation (prothrombin fragment 1+2 [PFl+2]). platelets (β-thromboglobulin [β-TG])) and fibrinolysis (plasmin-antiplasmin complexes [PAP) and D-dimer) during radiofrequency (RF) ablation in 13 patients. They received heparin 100 U/kg intravenously alter the initial electrophysiologic study, prior to the delivery of RF current; thereafter 1,000 U/hour throughout the procedure. PF1+2 increased fourfold (P 〈 0.001) during the diagnostic study, but gradually declined to upper reference value during heparin administration. There was a strong correlation between procedure duration prior to heparin bolus (range 39 to 173 min); and (a) the maximal rise of PFl+2 (r = 0.83, P 〈 0.001) and (b) the increase of PFI+2 from baseline to end of the procedure (r = 0.74, P = 0.004). There was no correlation between postheparin changes of PFl+2 and (a) postheparin procedure duration (range 40 to 317 min), (b) number of RF pulses (range 1 to 16). or (c) RF current duration (range 46 to 687 sec). Plasma β-TG concentration showed similar trends. Fibrinolytic activity increased moderately from baseline until heparin administration; then remained around the upper reference values. PAP at the end of procedure and D-dimer at the time of heparin administration both correlated with preheparin procedure duration (r = 0.70, P = 0.007 and r = 0.69, P = 0.01. respectively). All parameters were normal the next morning. Conclusion: Procedure duration prior to heparin administration, and not the delivery of RF current per se, determines activation of hemostasis and fibrinolysis during RF ablation.

Electronic Resource

1471-4159

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Abstract : Two-dimensional polyacrylamide gel electrophoresis of CSF has been used in the diagnosis of Creutzfeldt-Jakob disease (CJD). One of the two diagnostic protein spots was identified as isoform(s) of the 14-3-3 family of abundant brain proteins. This has led to the development of one-dimensional 14-3-3 sodium dodecyl sulfate polyacrylamide gel electrophoresis immunoblot, which is currently used to support the diagnosis of CJD. In the present study employing western blot analysis, we have identified the panel of 14-3-3 isoforms that appear in the CSF of 10 patients with CJD compared with 10 patients with other dementias. The results clearly show that the 14-3-3 isoforms β, γ, ε, and η are present in the CSF of patients with CJD and can be used to differentiate other dementias. 14-3-3η also gave a baseline signal in all patients with other dementias, including six patients with Alzheimer's disease. The presence of 14-3-3η in the CSF of a patient with herpes simplex encephalitis was particularly noteworthy. This study has determined that isoform-specific 14-3-3 antibodies against β, γ, and ε should be considered for the neurochemical differentiation of CJD from other neurodegenerative diseases.

Electronic Resource