Search Results - (Author, Cooperation:M. J. How)
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1Latest Papers from Table of Contents or Articles in PressH. H. Thoen ; M. J. How ; T. H. Chiou ; J. Marshall
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-01-25Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Behavior, Animal ; *Color ; *Color Vision ; Crustacea/*physiology ; Eye MovementsPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The sensitivity of the RAST using anti-IgE in 125I-labelled IgG fractions of sheep antiserum was compared to that using anti-IgE purified by immunosorbent techniques in tests with three allergens (grass pollens, Aspergillus fumigatus and the detergent enzyme ‘Alcalase’) on sera from 248 workers in a detergent factory. Both anti-IgE reagents measure the same antibody but the RAST procedure using the crude anti-IgE reagent is less sensitive than that using the immunosorbent-purified anti-IgE in its ability to detect circulating IgE in subjects with positive skin-prick tests. In general the agreement between positive RAST and positive skin test was improved when only skin tests equal to or greater than 3 mm were considered positive. With Alcalase, antigen non-specific binding by the crude anti-IgE reagent may give false positive results. Optimal conditions for the preparation of allergosorbents with this allergen are defined. Predictive equations relating the results of RAST and skin test show that the hitherto arbitrary definition of a positive RAST result is statistically valid.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesHOW, M. J. ; GOODWIN, B. F. J. ; JUNIPER, C. P. ; KINSHOTT, A. K.
Oxford, UK : Blackwell Publishing Ltd
Published 1978Staff ViewISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Serological tests of healthy atopic and non-atopic subjects were carried out during medical surveillance of 288 workers in detergent and food manufacturing factories in the same highly industrialized area. Correlations between the serological parameters and various aspects of the clinical history were compared for subgroups in these and control populations. The value of serological tests as aids in the diagnosis of allergic reactivity to the detergent enzyme Alcalase was given particular attention.There was no indication that employment in the detergent factory significantly increased the amount of serum total IgG, IgA or IgM. There was a positive correlation between the amount of serum total IgE and atopy as defined. The need for new standards of normality in the amount of serum total α1-antitrypsin in women receiving oral contraceptives was confirmed. No subjects had a homozygous deficiency of α1-antitrypsin.There was a statistically significant correlation between the level of allergen-specific antibody measured by the RAST and skin prick test weals of 3·0 mm diameter or greater, which were obtained using standardized skin prick test procedure and reagents. The significance of small skin prick test reactions has been evaluated critically.The results of various tests for allergen-specific precipitating antibodies indicated the need for caution in interpreting the results of such tests with allergens such as Alcalase, which contain several antigenic components. Alcalase-specific IgG antibodies were only detected in the sera of persons exposed to enzyme dusts in factories. They were evidence of exposure to the antigens, not of a clinical allergic response, and probably reflect the natural formation of antibody shown to occur with numerous environmental antigens.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesBARKER, S. A. ; BRIMACOMBE, J. S. ; HOW, M. J. ; STACEY, M. ; WILLIAMS, J. M.
[s.l.] : Nature Publishing Group
Published 1961Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] A comparison of the electrophoretic mobilities of the JV-acetyl derivatives of 'pneumosamine' (M& 0-40), 2-amino-2,6-dideoxy-L-galactose (MG 0-29) and 2-amino-2,6-dideoxy-D-glucose (MG 0-0) in borate buffer indicated that the hydroxyl groups on C(3) and C(4) were cis related, since vicinal ...Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Three samples of dental scrapings, taken from various sites on and between the teeth of each of thirty-four patients who had a wide range of dental conditions, were incubated separately at 37 C for 4 h with sterile solutions (0.5 ml.) containing -N-acetylmannosamine (100 g). After dilution and ...Type of Medium: Electronic ResourceURL: