Search Results - (Author, Cooperation:L. Anders)

2018-01-11

American Heart Association (AHA)

0194-911X

Medicine

Basic Science Research, Endothelium/Vascular Type/Nitric Oxide, Vascular Disease

2018-02-03

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Geosciences

Computer Science

Medicine

Natural Sciences in General

Physics

Medicine, Diseases, Microbiology

2014-11-15

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Acetylation ; Base Sequence ; Basic Helix-Loop-Helix Transcription Factors/*genetics ; Binding Sites ; Cell Line, Tumor ; *DNA, Intergenic ; *Enhancer Elements, Genetic ; *Gene Expression Regulation, Neoplastic ; Histones/metabolism ; Humans ; *INDEL Mutation ; Molecular Sequence Data ; *Mutation ; Oncogenes ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*genetics ; Protein Interaction Domains and Motifs ; Proto-Oncogene Proteins/*genetics ; Proto-Oncogene Proteins c-myb/metabolism

2015-11-13

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Acetylation ; Alleles ; Allelic Imbalance ; Binding Sites ; DNA-Binding Proteins/*genetics ; Enhancer Elements, Genetic/*genetics ; Epigenomics ; GATA3 Transcription Factor/metabolism ; Gene Expression Regulation, Neoplastic/genetics ; Genetic Predisposition to Disease/*genetics ; Genome-Wide Association Study ; Genotype ; Histones/chemistry/metabolism ; Humans ; Introns/genetics ; LIM Domain Proteins/*genetics ; Lysine/metabolism ; Neuroblastoma/*genetics ; Organ Specificity ; Polymorphism, Single Nucleotide/*genetics ; Reproducibility of Results ; Transcription Factors/*genetics

2016-01-07

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

1467-8330

Blackwell Publishing Journal Backfiles 1879-2005

Geography

Electronic Resource

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] Use of coloured dye particles as pollen analogues has yielded components of fitness for selected plant individuals4, whereas for favourable cases genetic paternity-exclusion procedures5"7 have allowed pollen parents to be identified for up to 85% of the fruits produced8. But the genetic techniques ...

Electronic Resource

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] Interactions between C. rubra and anthophilous insects were observed on the island of Gotland in the Baltic Sea during 1980-82. The flowers were visited by various insects but regularly only by males of C. fuliginosum and C. campanularum. The males performed repetitive patrolling flights8 between ...

Electronic Resource

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] Floral design ranges from open dish-shaped to stereomorphic with tubes exceeding 30 cm. In "On the Origin of Species', p. 95, Darwin2 reported that certain length relations between the cor-rolla of red clover and the tongue of bees were crucial for successful mutualism and that by the survival of ...

Electronic Resource

1072-8368

Nature Archives 1869 - 2009

Biology

Medicine

[Auszug] We have determined the structure of the homotrimeric dUTPase from Escherichia coli, complexed with an inhibitor and substrate analogue, dUDP. Three molecules of dUDP are found symmetrically bound per trimer, each in a shallow cleft between adjacent subunits, interacting with evolutionary conserved ...

Electronic Resource

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] The rat liver COMT gene was cloned, expressed in Escherichia coli and the protein purified to homogeneity11"13. The enzyme has 221 amino acids and a relative molecular mass of 24,700 (24.7K). Table 1 summarizes the solution of the crystallographic structure and the refinement of COMT in complex ...

Electronic Resource

1432-1939

Pollinator-mediated mating ; Population size ; Pollinator limitation ; Pollen waste ; Orchids

Springer Online Journal Archives 1860-2000

Biology

Abstract In most higher plants sexual interactions are mediated by animal pollinators that affect the number and differential reproductive success of mates. The number and sex of breeding individuals in populations are central factors in evolutionary theory, but the quantitative effect of plant population size on pollinator-mediated mating is understudied. We investigated variation in pollen removal (male function) and fruit set (female function) among flowering populations of different size of two bumblebee-and one butterfly-pollinated, rewardless, pollen-limited, hermaphroditic orchid species in Sweden. As the amount of pollen removed from plants by insects (either absolute or proportional) increased, so did the number of pollinations, whereas the proportions of plants with different pollinator-designated functional sex (male, female, hermaphrodite) depended primarily on the ratio between the amount of fruit set and pollen removed within populations. A larger population size was found to have several effects: (1) the total numbers of pollinia removed and fruits set increased; (2) the proportion of pollen removed from plants decreased; (3) the proportion of flowers pollinated decreased in the butterfly-but was not affected in the bumblebee-pollinated species; (4) the ratio between fruits set and pollinia removed increased linearly in the bumblebee-pollinated species but reached a maximum at c. 80 individuals in the butterfly-pollinated species; (5) the numbers of pollinator-designated pure male and hermaphrodite individuals increased; and (6) the variance in pollinium removal, but not fruit set, increased among individuals. These findings empirically verify the basic importance of population size for the mating structure of outcrossing plants, and indicate that selection for female sexual traits is reinforced when population size is smaller while selection for male sexual traits is reinforced when population size is larger.

Electronic Resource

1615-6110

Angiosperms ; Lamiaceae ; Plectranthus ; P. vestitus ; Pollination ; melittophily ; hovering bees ; Flora of madagascar

Springer Online Journal Archives 1860-2000

Biology

Abstract In a primary forest on the Central Plateau of MadagascarPlectranthus vestitus (Lamiaceae) was principally pollinated by the beePachymelus limbatus (Hymenoptera, Anthophoridae). A species ofStylogaster (Diptera, Conopidae) acted as a co-pollinator. Flower — pollinator interactions are described. The bee performed pollination while hovering, a flower-visit lasting onlyc. 0.3 seconds. Floral features such as shape and size of the corolla tube, and the lack of a landing place suggest specialization to hovering anthophorid beepollinators. Floral biology and pollination in the genusPlectranthus are discussed.

Electronic Resource

1615-6110

Angiosperms ; Rubiaceae ; Ixora ; I. platythyrsa ; Moth-pollination ; secondary pollen presentation ; Flora of Madagascar

Springer Online Journal Archives 1860-2000

Biology

Abstract The pollination biology ofIxora platythyrsa (Rubiaceae) was studied in NW. Madagascar. The plant displayed cream-yellow, nocturnally fragrant, nectariferous, tubular and strongly protandrous flowers. These had an “ixoroid” secondary pollen presentation mechanism: prior to anthesis, anthers exhausted their pollen onto unripe stylar heads. From this position pollen of male-stage flowers later adhered to primarily the probosces of small visiting nocturnal noctuid and geometrid moths. — Pollen was subsequently raked off moths' probosces by receptive, copiously papillose stigmas of female-stage flowers. Principal pollination adaptation was probably to the noctuid moth subfam.Sarrothripinae.

Electronic Resource

0887-3585

enzyme structure ; disorder ; refinement ; high resolution ; Chemistry ; Biochemistry and Biotechnology

Wiley InterScience Backfile Collection 1832-2000

Medicine

The highly refined 1.26 Å structure (R = 0.15) of phosphate-free bovine pancreatic ribonuclease A was modeled with 13 residues having discrete multiple conformations of side chains. These residues are widely distributed over the protein surface, but only one of them, Lys 61, is involved in crystal packing interactions. The discrete conformers have no unusual torsion angles, and their interactions with the solvent and with other atoms of the protein are similar to those residues modeled with a single conformation. For three of the residues-Val 43, Asp 83, and Arg 85-two correlated conformations are found. The observed multiple conformations on the protein surfaces will be of significance in analyzing structure-function relationships and in performing protein engineering.

3 Ill.

Electronic Resource

0887-3585

X-ray crystallography ; carbonic anhydrase ; cyanide ; cyanate ; Chemistry ; Biochemistry and Biotechnology

Wiley InterScience Backfile Collection 1832-2000

Medicine

Carbonic anhydrase is inhibited by the “metal poison” cyanide. Several spectroscopic investigations of carbonic anhydrase where the natural zinc ion has been replaced by cobalt have further strengthened the view that cyanide and cyanate bind directly to the metal. We have determined the structure of human carbonic anhydrase II inhibited by cyanide and cyanate, respectively, by X-ray crystallography. It is shown that the inhibitors replace a molecule of water, which forms a hydrogen bond to the peptide nitrogen of Thr-199 in the native structure. The coordination of the zinc ion is hereby left unaltered compared to the native crystal structure, so that the zinc coordinates three histidines and one molecule of water or hydroxyl ion in a tetrahedral fashion. The binding site of the two inhibitors is identical to what earlier has been suggested to be the position of the substrate (CO2) when attacked by the zinc bound hydroxyl ion. The peptide chain undergoes no significant alterations upon binding of either inhibitor. © 1993 Wiley-Liss, Inc.

3 Ill.

Electronic Resource

0887-3585

refined structures ; mutant ; substrate binding ; zinc coordination ; Chemistry ; Biochemistry and Biotechnology

Wiley InterScience Backfile Collection 1832-2000

Medicine

A complex of carbonic anhydrase (CA) with one of its substrates, bicarbonate, has been studied crystallographically. Human isoenzyme II was mutated at position 200 from threonine to histidine, which results in higher affinity for bicarbonate. The HCO3- ion binds in the active site to the zinc ion as a pseudo-bidentate ligand which gives the metal a coordination geometry between tetrahedral and trigonal bipyramide. The water/hydroxide normally bound with tetrahedral coordination to the zinc is probably replaced by the OH group of the bicarbonate ion. The importance of residues Thr-199 and Glu-106 in controlling the binding orientation of HCO3- is discussed as well as the catalytic mechanism. Both the complex as well as the uncomplexed mutant were studied at 1.9 Å resolution. © 1993 Wiley-Liss, Inc.

4 Ill.

Electronic Resource

2018-07-03

Rockefeller University Press

0022-1007

1540-9538

Medicine

Leukemia & Lymphoma

1438-2385

Springer Online Journal Archives 1860-2000

Process Engineering, Biotechnology, Nutrition Technology

Summary The curing smoke, generated by the smouldering of alder chips, from a commercial food smoking plant was investigated with respect to polynuclear aromatic compounds (PAC). Samples were taken from inside the ovens and in the working zone immediately outside them. Analysis showed that considerable amounts of methyl phenanthrenes were present in the smoke as a major part of the PAC content.

Zusammenfassung Rauch aus einer kommerziellen Räucherei von schwelenden Erlenspänen wurde auf polycyclische aromatische Verbindungen (PAC) untersucht. Proben wurden innerhalb der Öfen und in dem Arbeitsbereich außerhalb der Öfen gezogen. Erhebliche Mengen an Methylphenanthren wurden als Hauptbestandteil des PAC-Inhalts im Rauch nachgewiesen.

Electronic Resource

1432-2161

Osteoarthritis ; Magnetic resonance imaging ; Histopathology ; Radiography ; Marrow

Springer Online Journal Archives 1860-2000

Medicine

Abstract Subchondral signal abnormalities are often present on magnetic resonance (MR) images of patients with osteoarthritis, but no study correlating these changes with histopathology has been published. We selected nine consecutive patients with clinical and radiographic diagnosis of moderate to severe osteoarthritis of the knee scheduled to undergo joint replacement surgery, and performed MR imaging and conventional radiographs preoperatively. After surgery, the resected portions of the femur and tibia underwent gross and microscopic examination, and the findings were correlated with the corresponding findings on the imaging studies. Subchondral MR signal abnormalities of the femur or tibia were present in seven of the nine patients, with intermediate signal on T1-weighted images and low or isointense signal on T2-weighted images. The subchondral signal abnormalities were hemispherical in configuration and corresponded predominantly to fibrous tissue replacing the fatty marrow. A component of trabecular thickening was also present.

Electronic Resource