Search Results - (Author, Cooperation:L. A. Akslen)
-
1Latest Papers from Table of Contents or Articles in PressA. I. Ojesina ; L. Lichtenstein ; S. S. Freeman ; C. S. Pedamallu ; I. Imaz-Rosshandler ; T. J. Pugh ; A. D. Cherniack ; L. Ambrogio ; K. Cibulskis ; B. Bertelsen ; S. Romero-Cordoba ; V. Trevino ; K. Vazquez-Santillan ; A. S. Guadarrama ; A. A. Wright ; M. W. Rosenberg ; F. Duke ; B. Kaplan ; R. Wang ; E. Nickerson ; H. M. Walline ; M. S. Lawrence ; C. Stewart ; S. L. Carter ; A. McKenna ; I. P. Rodriguez-Sanchez ; M. Espinosa-Castilla ; K. Woie ; L. Bjorge ; E. Wik ; M. K. Halle ; E. A. Hoivik ; C. Krakstad ; N. B. Gabino ; G. S. Gomez-Macias ; L. D. Valdez-Chapa ; M. L. Garza-Rodriguez ; G. Maytorena ; J. Vazquez ; C. Rodea ; A. Cravioto ; M. L. Cortes ; H. Greulich ; C. P. Crum ; D. S. Neuberg ; A. Hidalgo-Miranda ; C. R. Escareno ; L. A. Akslen ; T. E. Carey ; O. K. Vintermyr ; S. B. Gabriel ; H. A. Barrera-Saldana ; J. Melendez-Zajgla ; G. Getz ; H. B. Salvesen ; M. Meyerson
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-01-07Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adenocarcinoma/genetics/virology ; Carcinoma, Squamous Cell/genetics/virology ; Case-Control Studies ; Cell Cycle Proteins/genetics ; Core Binding Factor beta Subunit/genetics ; DNA Copy Number Variations/genetics ; DNA Mutational Analysis ; DNA-Binding Proteins/genetics ; E1A-Associated p300 Protein/genetics ; Exome/genetics ; F-Box Proteins/genetics ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Genome, Human/*genetics ; Genomics ; HLA-B Antigens/genetics ; Humans ; Mitogen-Activated Protein Kinase 1/genetics ; Mutation/*genetics ; NF-E2-Related Factor 2/genetics ; Papillomaviridae/genetics/physiology ; Papillomavirus Infections/genetics ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins c-ets ; Receptor, ErbB-2/genetics ; Transcription Factors/genetics ; Transcriptome/genetics ; Tumor Suppressor Protein p53/genetics ; Ubiquitin-Protein Ligases/genetics ; Uterine Cervical Neoplasms/*genetics/virology ; Virus Integration/geneticsPublished by: -
2Articles: DFG German National LicensesSalvesen, H. B. ; Akslen, L. A. ; Iversen, T. ; Iversen, O. E.
Oxford, UK : Blackwell Publishing Ltd
Published 1997Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Objective To identify women treated for endometrial carcinoma with increased risk for recurrent disease, to examine how and when recurrences are discovered, and to assess the clinical benefit of routine follow up investigations.Design Retrospective case analysis.Setting Hordaland county, Norway.Population All women treated for endometrial carcinoma in a demographically well defined area, in a 10-year period (1981–1990).Methods Data concerning patient characteristics and course of the disease were collected through review of the medical records, correspondence with the primary physician and from the Norwegian Cancer Registry. Univariate and multivariate survival analysis.Results After curative surgical treatment 249 women diagnosed with endometrial carcinoma were followed for a median period of 9 years (range 4–16) or until death. Among these 249 radically treated patients, 47 had recurrent disease, 32 within the first two years. Ten of the recurrences were diagnosed at routine follow up, but only four were asymptomatic. In our follow up programme, one asymptomatic recurrence was detected for every 653 routine consultations. A low risk group, with FIGO Stage IA/IB or patient age below 60 years at primary operation was identified in multivariate recurrence-free survival analysis. No asymptomatic recurrences were found in this group.Conclusions Low risk women should be considered for an alternative, less frequent follow up. The sensitivity for current practice of routine follow up in detecting asymptomatic recurrences is so low that other beneficial effects should be documented to defend the large resources spent on this programme.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStefansson, I M ; Salvesen, H B ; Immervoll, H ; Akslen, L A
Oxford, UK : Blackwell Science Ltd
Published 2004Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Aims: The relative impact of different prognostic factors is important for endometrial carcinoma patients. The aim of our study was to examine the combined value of histological grade [International Federation of Gynaecology and Obstetrics (FIGO)] and vascular invasion in comparison with tumour cell proliferation assessed by mitotic count and Ki67. The recently proposed binary architectural grade was also evaluated, in addition to age, depth of myometrial infiltration and FIGO stage in our population-based series of 237 endometrioid carcinomas.Methods and results: The tumours were studied for several histological features, including FIGO grade, binary grade, vascular invasion, mitotic count, myometrial invasion and expression of Ki67. FIGO grade was significantly associated with all investigated histological features, including Ki67 expression. Vascular invasion was significantly more frequent in FIGO grade 3 tumours, and was associated with a diffusely infiltrative growth pattern, solid growth, necrosis and deep myometrial invasion. All variables showed a highly significant relationship with patient survival in univariate analysis. In multivariate models, FIGO grade, vascular invasion, and proliferation assessed by Ki67 expression all had independent prognostic influence in this population-based study. Comparing tumour cell proliferation (Ki67) with vascular invasion as a marker of metastatic spread, the latter had a stronger survival impact.Conclusions: Vascular invasion and tumour cell proliferation measured by Ki67 both had independent prognostic influence, and should be considered to identify aggressive tumours of the endometrioid subtype.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1432-2307Keywords: Thyroid cancer ; Classification ; Thyroid capsular invasion ; Lymph node metastasis ; PrognosisSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary In this series of 263 surgically treated cases of thyroid cancer, 12% were finally classified as benign lesions after histopathological review. Difficulty in the assessment of tumour capsule invasion in follicular neoplasms was the most frequent cause of diagnostic error. Squamous metaplasia, clusters of ground glass nuclei and psammoma bodies were found to be the most specific discriminators between papillary and follicular carcinomas. Among papillary carcinomas, tumour diameter above 30 mm, thyroid capsular invasion and regional lymph node metastases were found to be significant prognostic factors according to survival analyses. Of additional practical importance, our results indicate that tumour infiltration in the thyroid capsule should be reported as a marker of early extra-thyroidal extension.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesRaithel, H. J. ; Schaller, K. H. ; Akslen, L. A. ; Myking, A. O. ; Merkve, O. ; Gulsvik, A.
Springer
Published 1989Staff ViewISSN: 1432-1246Keywords: Ni- ; Cr-analyses ; Human lung tissue ; Lung cancer ; Expertise aspectsSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary After inhalative occupational exposure to certain compounds containing nickel and chromium (mostly over many years), an accumulation of these metals may occur in the lung tissue. This is of particular importance, both from a toxicological point of view and with regard to expert reports, since certain nickel and chromium compounds may induce lung cancers. In the context of this study, samples of pulmonary tissue from 34 deceased persons from the Bergen area (Norway) were analysed by atomic absorption spectrometry with regard to their content of chromium and nickel. The deceased comprised 21 men and 13 women. In 15 cases, death resulted from lung cancer; in the other 19 deceased, there was no indication of a malignant disease of the airways. The concentrations of nickel found in the lung tissue do not differ between patients with lung cancer and patients with healthy lungs. On the other hand, the concentration of chromium in the pulmonary tissue in the patients who had died of lung cancer and who had all been inhalative smokers, are higher (statistically significant) than in the nonsmokers or in those with healthy lungs. An accumulation of these two metals in the tumor matrix could not be detected. Both the average nickel and the average chromium concentrations were higher in the persons who had probably been exposed occupationally. Considering the present state of scientific knowledge, the aspects relevant to expert reports which result from the analyses of metals in the pulmonary tissue are discussed.Type of Medium: Electronic ResourceURL: