Search Results - (Author, Cooperation:K. A. Caldwell)
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1Latest Papers from Table of Contents or Articles in PressS. Treusch ; S. Hamamichi ; J. L. Goodman ; K. E. Matlack ; C. Y. Chung ; V. Baru ; J. M. Shulman ; A. Parrado ; B. J. Bevis ; J. S. Valastyan ; H. Han ; M. Lindhagen-Persson ; E. M. Reiman ; D. A. Evans ; D. A. Bennett ; A. Olofsson ; P. L. DeJager ; R. E. Tanzi ; K. A. Caldwell ; G. A. Caldwell ; S. Lindquist
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-10-29Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Alzheimer Disease/*genetics/*metabolism ; Amyloid beta-Peptides/chemistry/genetics/*metabolism ; Animals ; Animals, Genetically Modified ; Caenorhabditis elegans/cytology/genetics/metabolism ; Cell Membrane/metabolism ; Cells, Cultured ; Clathrin/metabolism ; Cytoskeleton/metabolism ; Disease Susceptibility ; *Endocytosis ; Genetic Association Studies ; Genetic Testing ; Glutamates/metabolism ; Humans ; Monomeric Clathrin Assembly Proteins/genetics/metabolism ; Neurons/physiology ; Peptide Fragments/chemistry/genetics/*metabolism ; Protein Multimerization ; Protein Transport ; Rats ; Risk Factors ; *Saccharomyces cerevisiae/cytology/genetics/growth & development/metabolism ; Saccharomyces cerevisiae Proteins/genetics/metabolism ; Secretory PathwayPublished by: -
2Latest Papers from Table of Contents or Articles in PressD. F. Tardiff ; N. T. Jui ; V. Khurana ; M. A. Tambe ; M. L. Thompson ; C. Y. Chung ; H. B. Kamadurai ; H. T. Kim ; A. K. Lancaster ; K. A. Caldwell ; G. A. Caldwell ; J. C. Rochet ; S. L. Buchwald ; S. Lindquist
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-10-26Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Benzimidazoles/chemistry/*pharmacology ; Caenorhabditis elegans ; Cells, Cultured ; *Cytoprotection ; Drug Evaluation, Preclinical ; Endosomal Sorting Complexes Required for Transport/*genetics ; Gene Regulatory Networks/*drug effects ; Neurodegenerative Diseases/*metabolism ; Neurons/*drug effects/metabolism ; Neuroprotective Agents/*pharmacology ; Parkinson Disease/metabolism ; Rats ; Saccharomyces cerevisiae/drug effects ; Saccharomyces cerevisiae Proteins/*genetics ; Small Molecule Libraries/chemistry/pharmacology ; Ubiquitin-Protein Ligase Complexes/*genetics ; Ubiquitin-Protein Ligases/*genetics ; alpha-Synuclein/*metabolismPublished by: -
3Articles: DFG German National LicensesStaff View
ISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1432-2242Keywords: Wheat proteins ; Aluminum lactate extraction ; Genome donors ; Wheat evolutionSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Summary Endosperm protein components from common bread wheats (Triticum aestivum L.) and related species were extracted with aluminum lactate, pH 3.2, and examined by electrophoresis in the same buffer. Electrophoretic patterns of the albumins and globulins were compared to evaluate the possibility that a particular species might have contributed its genome to tetraploid or hexaploid wheat. Together with protein component mobilities, differential band staining with Coomassie Brilliant Blue R250 was employed to test the identity or non-identity of bands. Eight species and 63 accessions, representative of Triticum and Aegilops were tested. Considerable intraspecific variation was observed for patterns of diploid but not for tetraploid or hexaploid species. Patterns of some accessions of Triticum urartu agreed closely with major parts of the patterns of Triticum dicoccoides and T. aestivum. A fast-moving, green band was found in all accessions of T. urartu and of Triticum boeoticum, however, that was not found in those of T. dicoccoides or T. aestivum. This band was present in all accessions of Triticum araraticum and Triticum zhukovskyi. Patterns of Aegilops longissima, which has been suggested as the donor of the B genome, differed substantially from those of T. dicoccoides and T. aestivum. Finally, two marker proteins of intermediate mobility were also observed and may be used to discriminate between accessions of T. araraticum/T. zhukovskyi and those of T. dicoccoides/T. aestivum.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesShibko, S. ; Caldwell, K. A. ; Sawant, P. L. ; Tappel, A. L.
Philadelphia : Wiley-Blackwell
Published 1963Staff ViewISSN: 0095-9898Keywords: Life and Medical Sciences ; Cell & Developmental BiologySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyMedicineAdditional Material: 5 Tab.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0192-253XKeywords: Spermatogenesis ; meiosis ; synapsis ; synaptonemal complex ; G2-M transition ; okadaic acid ; actinomycin D ; camptothecin ; Life and Medical Sciences ; GeneticsSource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyNotes: An impediment to the investigation of mammalian spermatogenic meiosis has been the lack of an appropriate system for experimental manipulation of meiotic prophase cells. We report here the use of a simple system for the short-term culture of pachytene spermatocytes. We have assayed parameters of cell function pertinent to meiotic prophase, namely chromosome pairing and synapsis. During the culture period of 24-48 hr, cells maintained typical pachytene morphology, chromatin condensation patterns, and chromosome pairing, as assessed by light and electron microscopy. Uridine incorporation, monitored by autoradiography, reflected the chromosomal distribution found in vivo in that the autosomal chromosomes were transcriptionally active, while the sex chromosomes were not. Thus features of chromosome pairing and sex chromatin inactivation are maintained in these cultures. We have conducted experiments to demonstrate that cultured pachytene spermatocytes can be useful for the analysis of agents, some of which may be suspected mutagens, that might affect chromosome structure and function during meiosis. Treatment of cells with actinomycin D revealed a differential effect on chromatin condensation in the autosomes versus the sex chromosomes. Carnptothecin, a topoisomerase inhibitor, induced desynapsis of paired chromosomes. Okadaic acid, a phosphatase inhibitor, induced premature metaphase-I condensation of pachytene chromosomes. This last experiment suggests that these cultured cells may be useful for analysis of meiotic cell cycle controls. Taken together, these results demonstrate a culture system that can be useful for analysis of meiotic events as well as in screening for potential mutagenic agents that might affect meiotic chromosome structure and function. © 1995 Wiley-Liss, Inc.Additional Material: 8 Ill.Type of Medium: Electronic ResourceURL: