Search Results - (Author, Cooperation:J. Weitz)
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1Latest Papers from Table of Contents or Articles in PressG. F. Weber ; B. G. Chousterman ; S. He ; A. M. Fenn ; M. Nairz ; A. Anzai ; T. Brenner ; F. Uhle ; Y. Iwamoto ; C. S. Robbins ; L. Noiret ; S. L. Maier ; T. Zonnchen ; N. N. Rahbari ; S. Scholch ; A. Klotzsche-von Ameln ; T. Chavakis ; J. Weitz ; S. Hofer ; M. A. Weigand ; M. Nahrendorf ; R. Weissleder ; F. K. Swirski
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-03-15Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; B-Lymphocyte Subsets/immunology ; Cytokines/immunology/metabolism ; Disease Models, Animal ; Humans ; Inflammation ; Interleukin-3/blood/*immunology/metabolism ; Lipopolysaccharides/immunology ; Lymphoid Tissue/immunology ; Mice ; Mice, Inbred BALB C ; Monocytes/immunology ; Myelopoiesis ; Neutrophils/immunology ; Peritonitis/immunology/pathology ; Prognosis ; Sepsis/*immunology/mortality/pathology/therapyPublished by: -
2Latest Papers from Table of Contents or Articles in PressK. Padmanabhan ; M. S. Robles ; T. Westerling ; C. J. Weitz
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-07-07Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Circadian Clocks/*genetics ; Cryptochromes/genetics/metabolism ; DEAD-box RNA Helicases/genetics/metabolism ; *Feedback, Physiological ; *Gene Expression Regulation ; Mice ; Period Circadian Proteins/genetics/metabolism ; RNA Polymerase II/genetics/metabolism ; *Transcription, GeneticPublished by: -
3Latest Papers from Table of Contents or Articles in PressS. A. Melo ; L. B. Luecke ; C. Kahlert ; A. F. Fernandez ; S. T. Gammon ; J. Kaye ; V. S. LeBleu ; E. A. Mittendorf ; J. Weitz ; N. Rahbari ; C. Reissfelder ; C. Pilarsky ; M. F. Fraga ; D. Piwnica-Worms ; R. Kalluri
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-06-25Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Biomarkers/blood ; Cell Line, Tumor ; Exosomes/genetics/*metabolism ; Female ; *Glypicans/blood/metabolism ; HCT116 Cells ; Humans ; MCF-7 Cells ; Male ; Mice ; NIH 3T3 Cells ; Pancreatic Neoplasms/blood/*diagnosis/pathology ; Proto-Oncogene Proteins/metabolism ; ras Proteins/metabolismPublished by: -
4Latest Papers from Table of Contents or Articles in PressH. A. Duong ; M. S. Robles ; D. Knutti ; C. J. Weitz
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-06-18Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: ARNTL Transcription Factors/genetics/metabolism ; Animals ; CLOCK Proteins/genetics/metabolism ; *Circadian Clocks ; *Circadian Rhythm ; Cryptochromes/metabolism ; *Feedback, Physiological ; Histone Deacetylase 1/metabolism ; Histones/metabolism ; Liver/metabolism ; Lung/metabolism ; Mass Spectrometry ; Mice ; Period Circadian Proteins/*genetics/metabolism ; Promoter Regions, Genetic ; RNA-Binding Proteins/genetics/*metabolism ; Recombinant Fusion Proteins/metabolism ; Repressor Proteins/*metabolism ; Transcription, GeneticPublished by: -
5Latest Papers from Table of Contents or Articles in PressAntiphospholipid antibodies and recurrent thrombosis after a first unprovoked venous thromboembolismKearon, C., Parpia, S., Spencer, F. A., Baglin, T., Stevens, S. M., Bauer, K. A., Lentz, S. R., Kessler, C. M., Douketis, J. D., Moll, S., Kaatz, S., Schulman, S., Connors, J. M., Ginsberg, J. S., Spadafora, L., Bhagirath, V., Liaw, P. C., Weitz, J. I., Julian, J. A.
American Society of Hematology (ASH)
Published 2018Staff ViewPublication Date: 2018-05-11Publisher: American Society of Hematology (ASH)Print ISSN: 0006-4971Electronic ISSN: 1528-0020Topics: BiologyMedicineKeywords: Thrombosis and Hemostasis, Clinical Trials and ObservationsPublished by: -
6Articles: DFG German National LicensesHIRSH, J. ; BUCHANAN, M. R. ; OFOSU, F. A. ; WEITZ, J.
Oxford, UK : Blackwell Publishing Ltd
Published 1987Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesWeitz, J. ; Kienle, P. ; Böhrer, H. ; Hofmann, W. ; Theilmann, L. ; Otto, G.
Oxford, UK : Blackwell Science Ltd
Published 1997Staff ViewISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Several halogenated anaesthetic agents have been associated with hepatotoxicity. We report a case of fulminant, fatal hepatic necrosis after uneventful isoflurane anaesthesia in a patient without previous liver disease, who may have been sensitised by previous exposure to enflurane. Although no anti-trifluoroacetyl antibodies could be detected in the patient's serum, isoflurane hepatotoxicity seems very likely to be the reason for fulminant hepatic failure in this patient.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesLOIKE, J. D. ; SILVERSTEIN, R. ; WRIGHT, S. D. ; WEITZ, J. I. ; HUANG, A. J. ; SILVERSTEIN, S. C.
Oxford, UK : Blackwell Publishing Ltd
Published 1992Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1433-0415Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Die prinzipielle Lymphadenektomie ist fester Bestandteil der chirurgischen Therapie von Karzinomen und wird in diagnostischer und therapeutischer Intention durchgeführt. Neue diagnostische Optionen, wie die Sentinel-Lymphknoten-Biopsie, die “Radioimmunguided Surgery” und der Nachweis hämatogen bzw. lymphogen disseminierter Tumorzellen, bieten die Möglichkeit einer Individualisierung der Lymphadenektomie. Je nach Situation, könnte dabei sowohl eine Einschränkung wie auch eine Erweiterung der regionären Lymphadenektomie sinnvoll sein. Der therapeutische und diagnostische Nutzen einer selektionierten Lymphadenektomie muß vor routinemäßiger Anwendung in randomisierten Studien validiert werden.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesWeitz, J. ; Koch, M. ; Lehnert, Th. ; Herfarth, Ch. ; von Knebel Doeberitz, M.
Springer
Published 2000Staff ViewISSN: 1433-0385Keywords: Keywords: Colorectal cancer – Lymph nodes – Isolated disseminated tumor cells – Tumor cell detection. ; Schlüsselwörter: Colorectales Carcinom – Lymphknoten – isolierte disseminierte Tumorzellen – Tumorzelldetektion.Source: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Zusammenfassung. Die 5-Jahres-Überlebensrate von Patienten mit einem colorectalen Carcinom UICC Stadium I und II beträgt 70–80 %, folglich entwickeln mindestens 20–30 % der Patienten dieser Stadien innerhalb von 5 Jahren ein Tumorrezidiv. Als Ursache einer Tumorprogression nach potentiell kurativer Resektion gelten lymphogen oder hämatogen disseminierte Tumorzellen. Durch immunhistochemische und molekularbiologische Methoden gelingt bei einem großen Teil der Patienten im UICC Stadium I bzw. II ein Nachweis von disseminierten Tumorzellen in Lymphknoten. Hierdurch kann möglicherweise eine Patientengruppe identifiziert werden, die ein besonders hohes Rezidivrisiko trägt und damit von einer adjuvanten Therapie profitieren könnte. Die lymphogene Tumorzelldissemination ist bereits in den frühen Stadien des colorectalen Carcinoms ein sehr häufiges Ereignis und kann deutlich öfter als eine hämatogene Tumorzelldissemination nachgewiesen werden. Diese Ergebnisse könnten als Argument für die Bedeutung der Lymphadenektomie auch in frühen Tumorstadien gewertet werden, die Evaluierung der prognostischen Relevanz dieser Befunde in prospektiven Studien steht jedoch noch aus.Notes: Abstract. The 5-year survival of patients with colorectal cancer UICC stage I and II ranges from 70 % to 80 %. Therefore, at least 20 % to 30 % of these patients develop recurrent disease, caused by hematogenic or lymphogenic tumor cell dissemination. Using immunohistochemical or molecular biological methods, disseminated tumor cells can be detected in lymph nodes in a high proportion of patients in UICC stage I or II. The detection of disseminated tumor cells could help to identify a subgroup of patients at risk for disease relapse who could benefit from adjuvant therapy. Lymphogenic tumor cell dissemination seems to be a very common event in early colorectal cancer, preceding hematogenic tumor cell dissemination. Although these observations appear to confirm the therapeutic importance of meticulous lymph node dissection, their prognostic relevance has yet to be determined in prospective studies.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesSergi, C. ; Hofmann, W. J. ; Sinn, P. ; Schnabel, P. A. ; Otto, H. F. ; Weitz, J. ; Otto, G. ; Eckart, A.
Springer
Published 1996Staff ViewISSN: 1432-2307Keywords: Necrotizing fasciitis ; Endocarditis ; Myocarditis ; Epicarditis ; AspergillusSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract A patient with Aspergillus endocarditis, myocarditis and pericarditis is described. A 55-year-old man developed necrotizing fasciitis of the lower abdominal wall, pelvis and right thigh. Despite aggressive surgical débridement and antibiotic coverage, the patient died of multisystem organ failure. Autopsy revealed Aspergillus thromboulcerative endocarditis, myocarditis and pericarditis, acute necrotizing fungal bronchopneumonia and mycotic dissemination to brain, kidney and thyroid gland. A review of the literature showed that in the absence of open-heart surgery Aspergillus endocarditis and myocarditis are very uncommon.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 0002-9556Topics: PsychologyNotes: NOTES AND DISCUSSIONSURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0002-9556Topics: PsychologyURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0002-9556Topics: PsychologyNotes: NOTES AND DISCUSSIONSURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0002-9556Topics: PsychologyURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1432-1238Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0021-9304Keywords: Chemistry ; Polymer and Materials ScienceSource: Wiley InterScience Backfile Collection 1832-2000Topics: MedicineTechnologyNotes: The adsorption of fibrinogen and plasminogen from plasma to silica glass, sulfonated silica glass, and lysinederivatized silica glass has been investigated. The data indicate that the sulfonated material has a high affinity for both fibrinogen and plasminogen, but that the ratio of plasminogen to fibrinogen is greater on the lysinederivatized surface. The adsorption data also suggest plasminogen as a possible contributor to the fibrinogen Vroman effect, whereby initially adsorbed fibrinogen is displaced from the surface. The plasmin activity of plasminogen adsorbed to the lysine-derivatized silica glass and its sulfonated precursor was assessed by both a chromogenic substrate assay and a radioimmunoassay for the plasmin cleavage product of fibrinogen, the Bβ 1-42 peptide. The data indicate that (1) the adsorbed plasminogen is not inherently plasmin-like; (2) the enzymatic activity associated with the bound plasminogen is significantly enhanced on both surfaces in the presence of activator; and (3) in the presence of activator, the plasmin activity per mole of bound plasminogen on the lysinized material is approximately a factor of two greater than on the sulfonated material based on the chromogenic substrate assay, and a factor of four greater based on the Bβ 1-42 radioimmunoassay. The lysinized material thus exhibits several properties that are different from its sulfonated precursor. It adsorbs more plasminogen relative to fibrinogen after the Vroman peak, and this adsorbed plasminogen appears to be in a conformation that is more readily activated to plasmin. Once activated, the surface bound plasmin shows enhanced ability to cleave either a low molecular weight chromogenic substrate or a macromolecular substrate. These properties appear to be directly related to lysine residues on the surface and may be the result of specific conformational changes occurring when plasminogen engages its lysine binding sites. © 1994 John Wiley & Sons, Inc.Additional Material: 3 Ill.Type of Medium: Electronic ResourceURL: