Search Results - (Author, Cooperation:J. Sekelsky)

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  1. 1
    K. P. Kohl ; C. D. Jones ; J. Sekelsky
    American Association for the Advancement of Science (AAAS)
    Published 2012
    Staff View
    Publication Date:
    2012-12-12
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Cell Cycle Proteins/classification/metabolism ; *Crossing Over, Genetic ; DNA Helicases/*antagonists & inhibitors/metabolism ; Drosophila/*genetics ; Drosophila Proteins/classification/*metabolism ; *Evolution, Molecular ; Meiosis ; Phylogeny ; Selection, Genetic ; Tsetse Flies/*genetics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    ISSN:
    1432-0886
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract. This paper reports on a new role for mei-41 in cell cycle control during meiosis. This function is revealed by the requirement of mei-41 for the precocious anaphase observed in crossover-defective mutants. Normally in Drosophila oocytes, tension on the meiotic spindle causes a metaphase I arrest. This tension results because crossovers, and the resulting chiasmata, hold homologs together that are being pulled by kinetochore microtobules toward opposite spindle poles. In the absence of tension, such as in a recombination-defective mutant, metaphase arrest is not observed and meiosis proceeds through the two divisions. Here we show that in some recombination-defective mutants, the precocious anaphase requires the mei-41 gene product. For example, metaphase arrest is not observed in mei-218 mutants because of the severe reduction in crossing over. In mei-41 mei-218 double mutants, however, metaphase arrest was restored. The effect of mei-41 is dependent on double-strand break formation. Thus, in mutants that fail to initiate meiotic recombination the absence of mei-41 has no effect.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004120050411

    Articles: DFG German National Licenses
  3. 3
    Brady, M. M., McMahan, S., Sekelsky, J.
    Genetics Society of America (GSA)
    Published 2018
    Staff View
    Publication Date:
    2018-01-30
    Publisher:
    Genetics Society of America (GSA)
    Print ISSN:
    0016-6731
    Topics:
    Biology
    Published by:
    http://www.genetics-gsa.org/

    Latest Papers from Table of Contents or Articles in Press