Search Results - (Author, Cooperation:J. M. Sikela)

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  1. 1
    L. Carbone ; R. A. Harris ; S. Gnerre ; K. R. Veeramah ; B. Lorente-Galdos ; J. Huddleston ; T. J. Meyer ; J. Herrero ; C. Roos ; B. Aken ; F. Anaclerio ; N. Archidiacono ; C. Baker ; D. Barrell ; M. A. Batzer ; K. Beal ; A. Blancher ; C. L. Bohrson ; M. Brameier ; M. S. Campbell ; O. Capozzi ; C. Casola ; G. Chiatante ; A. Cree ; A. Damert ; P. J. de Jong ; L. Dumas ; M. Fernandez-Callejo ; P. Flicek ; N. V. Fuchs ; I. Gut ; M. Gut ; M. W. Hahn ; J. Hernandez-Rodriguez ; L. W. Hillier ; R. Hubley ; B. Ianc ; Z. Izsvak ; N. G. Jablonski ; L. M. Johnstone ; A. Karimpour-Fard ; M. K. Konkel ; D. Kostka ; N. H. Lazar ; S. L. Lee ; L. R. Lewis ; Y. Liu ; D. P. Locke ; S. Mallick ; F. L. Mendez ; M. Muffato ; L. V. Nazareth ; K. A. Nevonen ; M. O'Bleness ; C. Ochis ; D. T. Odom ; K. S. Pollard ; J. Quilez ; D. Reich ; M. Rocchi ; G. G. Schumann ; S. Searle ; J. M. Sikela ; G. Skollar ; A. Smit ; K. Sonmez ; B. ten Hallers ; E. Terhune ; G. W. Thomas ; B. Ullmer ; M. Ventura ; J. A. Walker ; J. D. Wall ; L. Walter ; M. C. Ward ; S. J. Wheelan ; C. W. Whelan ; S. White ; L. J. Wilhelm ; A. E. Woerner ; M. Yandell ; B. Zhu ; M. F. Hammer ; T. Marques-Bonet ; E. E. Eichler ; L. Fulton ; C. Fronick ; D. M. Muzny ; W. C. Warren ; K. C. Worley ; J. Rogers ; R. K. Wilson ; R. A. Gibbs
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-09-12
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Evolution, Molecular ; Genome/*genetics ; Hominidae/classification/genetics ; Humans ; Hylobates/*classification/*genetics ; *Karyotype ; Molecular Sequence Data ; *Phylogeny ; Retroelements/genetics ; Selection, Genetic ; Transcription Termination, Genetic
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Bourdellès, B. ; Wafford, K. A. ; Kemp, J. A. ; Marshall, G. ; Bain, C. ; Wilcox, A. S. ; Sikela, J. M. ; Whiting, P. J.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1994
    Staff View
    ISSN:
    1471-4159
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Abstract: Using expression cloning, and more recently using polymerase chain reaction cloning approaches, a family of rat N-methyl-d-aspartate (NMDA) receptor subunit cDNAs has been described (NR1, NR2A, NR2B, NR2C, and NR2D). Here we report cloning and sequencing of cDNAs encoding isoforms of the human NR1 subunit (NR1a, NR1d, and NR1e) that differ at their C-terminal end as a result of alternative splicing and also of a cDNA encoding the human NR2A subunit. The deduced amino acid sequences of the human NR1 subunit isoforms differed from the published rat NR1 subunit sequences at only eight positions, all of which were N-terminal to the alternatively spliced domains. The human NR2A subunit deduced amino acid sequence differed from the published rat NR2A subunit sequence at 81 of the 1,464 amino acids, with most of the substitutions being located in the C-terminal half of the subunit. The gene for NR2A has been localised to human chromosome 16. We also report the expression and pharmacological characterisation of recombinant human NR1a/NR2A heteromeric receptors in Xenopus oocytes. These receptors had EC50 values of 2.14 and 2.05 μM for glutamate and glycine, respectively, and an IC50 of 46.8 μM for Mg2+. Responses were antagonised by d-2-amino-5-phosphonovalerate, L-689,560, pH 6.3, zinc, and MK-801. No modulatory effect was observed on application of ifenprodil, confirming previous observations with rat NR1 + NR2A recombinant receptors.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1471-4159.1994.62062091.x

    Articles: DFG German National Licenses
  3. 3
    KEIR, W. J. ; DEITRICH, R. A. ; SIKELA, J. M.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1991
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1749-6632.1991.tb33888.x

    Articles: DFG German National Licenses