Search Results - (Author, Cooperation:J. Goudsmit)
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1Latest Papers from Table of Contents or Articles in PressC. Dreyfus ; N. S. Laursen ; T. Kwaks ; D. Zuijdgeest ; R. Khayat ; D. C. Ekiert ; J. H. Lee ; Z. Metlagel ; M. V. Bujny ; M. Jongeneelen ; R. van der Vlugt ; M. Lamrani ; H. J. Korse ; E. Geelen ; O. Sahin ; M. Sieuwerts ; J. P. Brakenhoff ; R. Vogels ; O. T. Li ; L. L. Poon ; M. Peiris ; W. Koudstaal ; A. B. Ward ; I. A. Wilson ; J. Goudsmit ; R. H. Friesen
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-08-11Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Animals ; Antibodies, Monoclonal/chemistry/*immunology ; Antibodies, Neutralizing/chemistry/immunology ; Conserved Sequence ; Hemagglutinin Glycoproteins, Influenza Virus/*immunology ; Humans ; Immunodominant Epitopes/chemistry/*immunology ; Influenza B virus/*immunology ; Influenza Vaccines/*immunology ; Mice ; Molecular Sequence Data ; Neutralization Tests ; Orthomyxoviridae Infections/*prevention & control ; Protein ConformationPublished by: -
2Latest Papers from Table of Contents or Articles in PressD. H. Barouch ; J. Liu ; H. Li ; L. F. Maxfield ; P. Abbink ; D. M. Lynch ; M. J. Iampietro ; A. SanMiguel ; M. S. Seaman ; G. Ferrari ; D. N. Forthal ; I. Ourmanov ; V. M. Hirsch ; A. Carville ; K. G. Mansfield ; D. Stablein ; M. G. Pau ; H. Schuitemaker ; J. C. Sadoff ; E. A. Billings ; M. Rao ; M. L. Robb ; J. H. Kim ; M. A. Marovich ; J. Goudsmit ; N. L. Michael
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-01-06Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: AIDS Vaccines/immunology ; Adenoviridae/genetics/immunology ; Animals ; Antibodies, Neutralizing/*immunology ; Enzyme-Linked Immunosorbent Assay ; Female ; HIV-1/immunology ; Macaca mulatta/*immunology ; Male ; Neutralization Tests ; SAIDS Vaccines/*immunology ; Simian Immunodeficiency Virus/*immunology ; Viral Vaccines/immunologyPublished by: -
3Latest Papers from Table of Contents or Articles in PressD. C. Ekiert ; R. H. Friesen ; G. Bhabha ; T. Kwaks ; M. Jongeneelen ; W. Yu ; C. Ophorst ; F. Cox ; H. J. Korse ; B. Brandenburg ; R. Vogels ; J. P. Brakenhoff ; R. Kompier ; M. H. Koldijk ; L. A. Cornelissen ; L. L. Poon ; M. Peiris ; W. Koudstaal ; I. A. Wilson ; J. Goudsmit
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-07-09Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Animals ; Antibodies, Monoclonal/*immunology/isolation & purification ; Antibodies, Neutralizing/*immunology/isolation & purification ; Antibodies, Viral/*immunology/isolation & purification ; Antibody Specificity ; Antigens, Viral/chemistry/genetics/*immunology ; Binding Sites, Antibody ; Conserved Sequence ; Crystallography, X-Ray ; Epitopes/immunology ; Hemagglutinin Glycoproteins, Influenza Virus/chemistry/genetics/*immunology ; Humans ; Influenza A Virus, H3N2 Subtype/immunology ; Influenza A Virus, H7N7 Subtype/genetics/immunology ; Influenza A virus/*immunology ; Influenza Vaccines/immunology ; Influenza, Human/immunology/prevention & control/therapy ; Mice ; Models, Molecular ; Molecular Sequence Data ; Mutation ; Neutralization Tests ; Orthomyxoviridae Infections/immunology/prevention & control ; Protein ConformationPublished by: -
4Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2014-08-26Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Acquired Immunodeficiency Syndrome/blood/*history/immunology ; HIV/immunology ; HIV Antibodies/blood/*history ; History, 20th Century ; History, 21st Century ; Humans ; NetherlandsPublished by: -
5Latest Papers from Table of Contents or Articles in PressA. Impagliazzo ; F. Milder ; H. Kuipers ; M. V. Wagner ; X. Zhu ; R. M. Hoffman ; R. van Meersbergen ; J. Huizingh ; P. Wanningen ; J. Verspuij ; M. de Man ; Z. Ding ; A. Apetri ; B. Kukrer ; E. Sneekes-Vriese ; D. Tomkiewicz ; N. S. Laursen ; P. S. Lee ; A. Zakrzewska ; L. Dekking ; J. Tolboom ; L. Tettero ; S. van Meerten ; W. Yu ; W. Koudstaal ; J. Goudsmit ; A. B. Ward ; W. Meijberg ; I. A. Wilson ; K. Radosevic
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-08-26Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Hemagglutinin Glycoproteins, Influenza Virus/*chemistry/*immunology ; Humans ; Influenza A Virus, H1N1 Subtype/*immunology ; Influenza A Virus, H5N1 Subtype/*immunology ; Influenza Vaccines/*immunology ; Influenza, Human/*prevention & control ; Mice ; Protein Multimerization ; Protein Structure, SecondaryPublished by: -
6Articles: DFG German National LicensesStaff View
ISSN: 0020-1693Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] IT has been known to us for more than a year that there is a large discrepancy between the results of biological vitamin B1 assay and of determination of aneurin by the original method of Jansen1, when both methods are applied to animal tissues. We did not like to ...Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] WE have now worked out Jansen's method1 for the determination of aneurin for the estimation of this vitamin in urine. Most difficulties were overcome by diluting the urine by about three times its volume of water, by working entirely in a nitrogen atmosphere and by substracting ...Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesGoudsmit, J. ; Ljunggren, Kristina ; Smit, Lia ; Jonda, M. ; Fenyö, Eva-Maria
Springer
Published 1988Staff ViewISSN: 1432-8798Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Human antibodies to HIV antigens expressed on the surface of infected cells may inhibit cell fusion with uninfected CD 4-positive cells and mediate killing of the infected cells by effector cells bearing the Fc receptor. Sequential sera from ten HIV-antibody seroconverted men, of which five progressed to ARC or AIDS (CDC stage IV) during the follow-up period of two years, were tested for the ability to inhibit CD 4-dependent cell fusion, (CFI) and to mediate antibody-dependent cellular cytotoxicity (ADCC). Nine patients developed HIV-specific ADCC and seven CFI-antibodies using the HIV strain HTLV-IIIB as target antigen. These antibodies appeared approximately at the same time 2–12 months after primary infection, defined as antibody seroconversion or antigenaemia. ADCC antibodies were detectable at higher titers as compared to CFI-antibodies. All sera of asymptomatic individuals (CDC stage II and III) were CFI antibody positive and had a higher mean ADCC titer as compared to sera from patients progressing to AIDS or ARC. ADCC and CFI antibodies coincided in some cases in the complete absence of core antibodies. Because the relationship between ADCC and CFI was not exclusive it is concluded that distinct domains of the HIV envelope induce natural antibodies mediating ADCC and CFI.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1432-1459Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Zusammenfassung Das gegenwärtig vielfach beschriebene Krankheitsbild der Akrodynie ist unserer Meinung nach nicht eine nosologische Entität, sondern ein klinisches Syndrom, ein Resultat der Einwirkung verschiedener Noxen (Darmtoxine, encephalitisches Virus usw.) auf das periphere Nervensystem, Diencephalon und Mesencephalon. Befällt die Erkrankung ausschließlich die vegetativen Kerne, so entstehen die von Feer beschriebenen Bilder; sind auch das Mesencephalon und periphere Nerven-system angegriffen, dann sieht man die von den Amerikanern beschriebenen Formen der Akrodynie auftreten.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesLangedijk, J. P. M. ; Back, Nicole K. T. ; Kinney-Thomas, Elaine ; Bruck, Claudine ; Francotte, Myriam ; Goudsmit, J. ; Meloen, R. H.
Springer
Published 1992Staff ViewISSN: 1432-8798Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Monoclonal antibodies raised against viral lysate of HIV-1 (strain LAV-1) and against recombinant gp 160 of HIV-1 (strain HTLV IIIB) which neutralized HIV-1 in a type specific manner were mapped with the aid of peptides (Pepscan analysis). Each of these monoclonal antibodies bound to peptides located on the principal neutralizing domain (PND) of HIV-1. We found that the antigenic sites of the MAbs described in this paper are represented by linear peptides of at least 10 amino acids long. The affinity of the MAbs is high for these peptides and in the same order of magnitude as for native gp 160. The fine mapping of the epitopes may reflect structural features of the PND, for instance which amino acid side chains are exposed and which are buried in the protein. Furthermore the fine mapping of the epitopes explained the HIV type-specific neutralizing activity of the MAbs. Antibodies that bound to the tip of the loop (amino acids QRGPGRAF) have a higher neutralizing activity than antibodies that bound to amino acids towards the N-terminal side of the loop (amino acids KSIRI). Furthermore, MAbs that bound to virtually the same amino acids on the tip of the loop (amino acids IQRGPGRAF and RGPGRAFV) had different neutralizing activities due to different affinities for native gp 160. These data reveal that neutralizing activity not only is determined by the affinity of an antibody to the neutralizing site but also by its fine binding specificities to the V 3 loop of gp 120.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesPrins, J. M. ; Sol, C. J. A. ; Renwick, N. ; Goudsmit, J. ; Veenstra, J. ; Reiss, P.
Springer
Published 1999Staff ViewISSN: 1435-4373Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract The case of a patient infected with human immunodeficiency virus type 1 (HIV-1) with Kaposi's sarcoma who presented with fever of unknown origin, severe anemia, thrombocytopenia and hypoalbuminemia but only limited involvement of the skin is presented. Chemotherapy directed at Kaposi's sarcoma resulted in resolution of these clinical signs and symptoms and was associated with a significant reduction in human herpesvirus-8 DNA load in serum, despite continued HIV-1 replication. Such a decreasing human herpesvirus-8 load following Kaposi's sarcoma-directed chemotherapy has not been reported previously. These findings suggest that Kaposi's sarcoma was indeed responsible for the clinical syndrome and that this neoplasm is a source of human herpesvirus-8 virus particle production, which can be inhibited by chemotherapy-induced reduction in tumor burden.Type of Medium: Electronic ResourceURL: