Search Results - (Author, Cooperation:J. C. Lin)
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1Staff View
Publication Date: 2018-02-03Publisher: Institute of Physics (IOP)Print ISSN: 1757-8981Electronic ISSN: 1757-899XTopics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPublished by: -
2Staff View
Publication Date: 2018-02-03Publisher: Institute of Physics (IOP)Print ISSN: 1757-8981Electronic ISSN: 1757-899XTopics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPublished by: -
3D. W. Parsons ; M. Li ; X. Zhang ; S. Jones ; R. J. Leary ; J. C. Lin ; S. M. Boca ; H. Carter ; J. Samayoa ; C. Bettegowda ; G. L. Gallia ; G. I. Jallo ; Z. A. Binder ; Y. Nikolsky ; J. Hartigan ; D. R. Smith ; D. S. Gerhard ; D. W. Fults ; S. VandenBerg ; M. S. Berger ; S. K. Marie ; S. M. Shinjo ; C. Clara ; P. C. Phillips ; J. E. Minturn ; J. A. Biegel ; A. R. Judkins ; A. C. Resnick ; P. B. Storm ; T. Curran ; Y. He ; B. A. Rasheed ; H. S. Friedman ; S. T. Keir ; R. McLendon ; P. A. Northcott ; M. D. Taylor ; P. C. Burger ; G. J. Riggins ; R. Karchin ; G. Parmigiani ; D. D. Bigner ; H. Yan ; N. Papadopoulos ; B. Vogelstein ; K. W. Kinzler ; V. E. Velculescu
American Association for the Advancement of Science (AAAS)
Published 2010Staff ViewPublication Date: 2010-12-18Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adult ; Cerebellar Neoplasms/*genetics/metabolism ; Child ; DNA Copy Number Variations ; DNA-Binding Proteins/genetics/metabolism ; *Genes, Neoplasm ; Genes, Tumor Suppressor ; Histone-Lysine N-Methyltransferase/genetics/metabolism ; Histones/metabolism ; Humans ; Medulloblastoma/*genetics/metabolism ; Methylation ; MicroRNAs/genetics ; *Mutation ; Neoplasm Proteins/genetics/metabolism ; Oligonucleotide Array Sequence Analysis ; Point Mutation ; Sequence Analysis, DNA ; Signal TransductionPublished by: -
4P. Han ; W. Li ; C. H. Lin ; J. Yang ; C. Shang ; S. T. Nurnberg ; K. K. Jin ; W. Xu ; C. Y. Lin ; C. J. Lin ; Y. Xiong ; H. C. Chien ; B. Zhou ; E. Ashley ; D. Bernstein ; P. S. Chen ; H. S. Chen ; T. Quertermous ; C. P. Chang
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-08-15Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cardiac Myosins/genetics ; Cardiomegaly/*genetics/*pathology/prevention & control ; Cardiomyopathies/genetics/pathology/prevention & control ; Chromatin/genetics/metabolism ; Chromatin Assembly and Disassembly ; DNA Helicases/antagonists & inhibitors/chemistry/genetics/metabolism ; Feedback, Physiological ; Heart Failure/genetics/pathology/prevention & control ; Histone Deacetylases/metabolism ; Humans ; Mice ; Myocardium/metabolism/pathology ; Myosin Heavy Chains/*genetics ; Nuclear Proteins/antagonists & inhibitors/chemistry/genetics/metabolism ; Organ Specificity ; Poly(ADP-ribose) Polymerases/metabolism ; Protein Binding ; Protein Structure, Tertiary ; RNA, Long Noncoding/antagonists & inhibitors/*genetics/metabolism ; Transcription Factors/antagonists & inhibitors/chemistry/genetics/metabolismPublished by: -
5J. L. Van Nostrand ; C. A. Brady ; H. Jung ; D. R. Fuentes ; M. M. Kozak ; T. M. Johnson ; C. Y. Lin ; C. J. Lin ; D. L. Swiderski ; H. Vogel ; J. A. Bernstein ; T. Attie-Bitach ; C. P. Chang ; J. Wysocka ; D. M. Martin ; L. D. Attardi
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-08-15Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Abnormalities, Multiple/genetics/*metabolism ; Alleles ; Animals ; Apoptosis/genetics ; CHARGE Syndrome/*genetics/*metabolism ; Cell Cycle Checkpoints/genetics ; Craniofacial Abnormalities/genetics/metabolism ; DNA-Binding Proteins/deficiency/genetics/metabolism ; Ear/abnormalities ; Embryo, Mammalian/abnormalities/metabolism ; Female ; Fibroblasts ; Gene Deletion ; Heterozygote ; Humans ; Male ; Mice ; Mutant Proteins/metabolism ; *Phenotype ; Promoter Regions, Genetic/genetics ; Tumor Suppressor Protein p53/*genetics/*metabolismPublished by: -
6Lai, H.-C., Chang, C.-J., Lin, C.-S., Wu, T.-R., Hsu, Y.-J., Wu, T.-S., Lu, J.-J., Martel, J., Ojcius, D. M., Ku, C.-L., Young, J. D., Lu, C.-C.
The American Association of Immunologists (AAI)
Published 2018Staff ViewPublication Date: 2018-08-21Publisher: The American Association of Immunologists (AAI)Print ISSN: 0022-1767Electronic ISSN: 1550-6606Topics: MedicinePublished by: -
7Shamir, N. ; Lin, J. C. ; Gomer, R.
College Park, Md. : American Institute of Physics (AIP)
Published 1989Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: The existence of Cu overlayers on O/W(110) and CO/W(110) was investigated using thermal desorption, work function, UPS, XPS, and energy loss measurements. It was shown that these layers exist and have very different properties from O/Cu/W(110) and CO/Cu/W(110), respectively. The most striking fact is that the work function at Cu monolayer coverage (slightly higher in the case of CO/W(110), probably because of Cu second layer formation and gaps in the first Cu layer) is almost that of Cu1/W(110) regardless of the underlying adsorbate. HeI UPS spectra show a Cu d-band structure even at Cu submonolayer coverages for Cu/O/W and for Cu1/CO/W(110). A loss peak at 4.64 eV was found for both systems [and for Cu8/W(110)] at θCu≥0.2 for O/W(110), and at θCu≥0.6 for CO/W(110). This is tentatively interpreted as a Cu interband transition. Unexpectedly small shifts in Cu2p3/2 and O1s binding energies were found under all conditions; the reasons for the virtual absence of shifts are not understood. The main conclusion of this work is that overlayers of Cu on top of other adsorbates show metallic properties even at submonolayer Cu coverages.Type of Medium: Electronic ResourceURL: -
8Chang, W. C. ; Wu, D. C. ; Lin, J. C. ; Chen, C. J.
[S.l.] : American Institute of Physics (AIP)
Published 1996Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: The effect of nitrogen interstitial in α-Fe crystalline on the magnetic soft properties of Fe87.5Ta12.5Nx films has been investigated. The magnetic soft properties can be improved by carefully controlling the nitrogen flow ratio during sputtering and the postannealing to result in a film with fine grain size and low magnetostriction. Using x-ray diffraction technique, the nitrogen content in the α-Fe crystalline of FeTaN film can be estimated from the effect of lattice expansion of α-Fe crystalline due to nitrogen interstitial. It is found that the film with about 7.5 at. % N2 in α-Fe crystalline exhibits the best magnetic soft properties of Br=1.6 T, Hc=0.2 Oe and μi(1 MHz)=3400, respectively. X-ray diffraction analysis is found to provide a proper and an easy way to identify the suitable condition for growing excellent magnetic soft FeTaN thin films. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
9Wang, S. J. ; Lin, J. C. ; Liou, W. R. ; Luo, Y. C. ; Cheng, C. Y.
Woodbury, NY : American Institute of Physics (AIP)
Published 1996Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: In this work, the realization of AlxGa1−xAs/GaAs two-step barrier diode is presented. Experimental observation on the current–voltage characteristics of the two-step barrier diode is reported. At both room temperature and 77 K, it shows a strong negative differential resistance under forward bias while no similar phenomenon was observed under reverse bias. Such an asymmetric current–voltage characteristic would open the possibility of negative differential resistance in an ac field in the absence of a dc bias. Theoretical simulation and experimental current–voltage characteristics are compared and discussed. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
10Liu, W.-K. ; Hayashi, M. ; Lin, J.-C. ; Chang, H.-C. ; Lin, S. H.
College Park, Md. : American Institute of Physics (AIP)
Published 1997Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: The dephasing and energy relaxation contributions to the line width in infrared (IR) and sum-frequency generation (SFG) spectra of adsorbates are derived from the generalized master equation approach. Expression for the line shift is also obtained. The anharmonic interaction between the adsorbate and the substrate is expanded in a polynomial in terms of the adsorbate and phonon coordinates, and the dephasing is shown to be mainly due to two-phonon processes, while two-phonon, three-phonon or four-phonon processes can contribute to energy relaxation, depending on the relative values of the adsorbate vibrational and the phonon frequencies. The temperature-dependence data of the IR absorption for C(111):H is found to be consistent with the theory, and the large line width for C(111):D can be accounted for by the efficient two-phonon energy relaxation process which is not available for C(111):H due to the higher adsorbate vibrational frequency for C(111):H. © 1997 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
11Staff View
ISSN: 1089-7666Source: AIP Digital ArchiveTopics: PhysicsNotes: The quantitative, instantaneous structure of a stationary wave undergoing breaking in the spilling mode is characterized using high-image-density particle image velocimetry. The breaker originates from a sharp trough of the free surface. The essentially discontinuous slope of the surface, in the presence of flow separation beneath it, serves as a source of vorticity, giving rise to vorticity concentrations in a separated mixing layer. The region between this vorticity layer and the free surface is turbulent; it has insignificant levels of vorticity compared to the mixing layer.Type of Medium: Electronic ResourceURL: -
12Staff View
ISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: Infrared polarization spectroscopy of the stretching motion of physisorbed CO2 has been used as a probe for the heterogeneity of hydrogen-terminated diamond single crystal surfaces. At the substrate temperature of 83 K, band shape, photometry, and isotherm measurements all indicate that the CO2 molecules are first adsorbed on defect sites, followed by adsorption on terraces that yields a single sharp spectral feature at 2333 cm−1 with FWHM=6 cm−1. Nearly 20% of the surface sites on the as-polished C(111)-1×1:H surfaces are defects © 1995 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
13Sheridan, J. ; Lin, J.-C. ; Rockwell, D.
[S.l.] : American Institute of Physics (AIP)
Published 1995Staff ViewISSN: 1089-7666Source: AIP Digital ArchiveTopics: PhysicsNotes: For the same Froude number and depth of submergence beneath a free surface, the wake of a cylinder exhibits two admissible states. The first state involves a jet-like flow generally attached to the free surface; it gives rise to a large-amplitude, quasistationary wave. In the second state, the jet is detached from the free-surface, which exhibits only mild distortion. The critical feature of the transformation between these two states involves the formation of a separated vorticity layer from the free-surface and its interaction with the vorticity layer from the surface of the cylinder. This transformation can occur spontaneously over a time scale much longer than the Kármán period. © 1995 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
14Lin, J.-C. ; Sheridan, J. ; Rockwell, D.
[S.l.] : American Institute of Physics (AIP)
Published 1996Staff ViewISSN: 1089-7666Source: AIP Digital ArchiveTopics: PhysicsNotes: A horizontal cylinder intersecting a free surface is subjected to controlled vertical perturbations, and the consequent vortex formation is characterized by high-image-density particle image velocimetry, which leads to instantaneous patterns of velocity, vorticity, and streamlines. For the limiting case of the stationary cylinder, the near wake does not exhibit rapid formation of organized vortical structures in a manner similar to Kármán vortices. Application of perturbations, however, generates phase-locked vortex formation over a wide range of excitation frequencies, even at relatively low amplitudes, indicating that the near wake in presence of a free surface is convectively, rather than absolutely, unstable. At a sufficiently high value of excitation frequency, the formation of the initial vortex undergoes an abrupt change in timing, which is analogous to that occurring for Kármán vortex formation from a completely submerged cylinder. All of these features of the near wake are interpreted in terms of foci, saddle points, and reattachment points of the streamwise topology. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
15Chyu, C. ; Lin, J.-C. ; Sheridan, J. ; Rockwell, D.
[S.l.] : American Institute of Physics (AIP)
Published 1995Staff ViewISSN: 1089-7666Source: AIP Digital ArchiveTopics: PhysicsNotes: The formation length of Kármán vortices can be drastically reduced by small-amplitude excitation at a frequency much higher than the natural frequency of Kármán vortex formation, namely the Kelvin–Helmholtz (KH) frequency of the separating shear layer. Phase-locked patterns of KH vortices are attainable. These spatially stationary patterns coexist, however, with the spatial and temporal development of the Kármán vortices. © 1995 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
16Lin, J.-C. ; Vorobieff, P. ; Rockwell, D.
[S.l.] : American Institute of Physics (AIP)
Published 1996Staff ViewISSN: 1089-7666Source: AIP Digital ArchiveTopics: PhysicsNotes: A cinematographic system allows acquisition of high-image-density PIV images in the cross-flow plane of the near-wake of a cylinder at a Reynolds number of 10 000. Images were acquired at a temporal resolution corresponding to 1% of the period of formation of the large-scale spanwise (Kármán) vortices. Such a sequence of images leads to three-dimensional space–time representations, which show the relationship between the instantaneous concentrations of streamwise vorticity and the phase of formation of the large-scale Kármán vortices. The first spatial correlations of instantaneous streamwise vorticity, taken over the cross-flow plane, reveal that the predominant concentrations of streamwise vorticity maintain a spanwise wavelength of approximately one cylinder diameter. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
17Lin, J.-C. ; Chen, K.-H. ; Chang, H.-C. ; Tsai, C.-S. ; Lin, C.-E. ; Wang, J.-K.
College Park, Md. : American Institute of Physics (AIP)
Published 1996Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: The temperature dependence of infrared absorption spectra of CH and CD on diamond nanocrystal surfaces has been investigated. Phase relaxation was closely examined by analyzing frequency shifts and line broadening in the spectra. Based on the model of Persson and Ryberg [Phys. Rev. B 40, 10 273 (1989)], coupling phonons responsible for the pure dephasing process were found to resonate at ω0≈1200 cm−1 for the CH stretch. By including both the phase and energy relaxation in the linewidth analysis and assuming that energy relaxes via three-phonon emission, we estimate a pure dephasing time of T*2≈340 ps at room temperature. This value is one order of magnitude larger than the energy relaxation time, T1≈19 ps, measured by Chin et al. [Europhys. Lett. 30, 399 (1995)] on a C(111) single crystal surface. We interpret the anomalous observation to be the result of the high frequency of the coupling phonons. For the CD stretches, however, severe line broadening due to exceedingly rapid energy relaxation disallows accurate determination of T*2. Since CH and CD stretches have similar thermal and inhomogeneous broadening characteristics, the lifetime of the latter is estimated to be T1≈220 fs. This T1 value is one of the shortest vibrational energy relaxation times for any adsorbate on a dielectric surface. Systematic comparison of these anomalous results with the measurements of SiH stretches on Si(100) and Si(111) is given. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
18Cheng, C.-L. ; Lin, J.-C. ; Chang, H.-C. ; Wang, J.-K.
College Park, Md. : American Institute of Physics (AIP)
Published 1996Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: The stretching motions of CH on diamond C(111) single- and nanocrystal surfaces have been investigated using Fourier transform infrared spectroscopy. The observations at 800 K indicate a band center of 2835.7 cm−1 and a heterogeneous broadening of 3 cm−1 for the monohydride CH stretch on ideally hydrogen-terminated C(111)-1×1 surfaces at 0 K. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
19Staff View
ISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: The low energy electron diffraction technique was used to study the hydrogen chemisorption induced structural instability on the diamond C(111) surface. From the quantitative analysis of diffraction spots intensity on the as-dosed, partially desorbed, and annealed hydrogenated C(111) surfaces, the correlation between the (1×1)↔(2×1) phase transformation, hydrogen coverage, and surface temperature is shown. Thermal treatment with partial hydrogen desorption on the fully hydrogenated C(111) surface induces a (1×1)–(2×1) reconstruction with the observable half-order spots intensity (I1/2) emerging only after heating the substrate to 1270 K. Conversely, thermal annealing of the partially hydrogenated C(111) surface without desorbing H causes the size shrinking of the (2×1) domains as well as the relaxation of the hydrogenated domains. The temperature effect of I1/2 summarized from both thermal studies reveals that the (2×1) domain instability originated from the relaxation of the hydrogenated domains at elevated temperatures. In addition, the H chemisorption behavior on C(111) at different surface temperatures suggests that the terrace edges could be the preferential sites for the initial H adsorption and the growth of the hydrogenated domains might predominantly start from the terrace boundaries at a surface temperature as low as 125 K. The present study also allows us to tentatively propose that there might exist a low-temperature chemisorption state in addition to the hydrogenated metastable state as suggested by the sum-frequency generation spectroscopy and theoretical studies. A possible mechanism for the hydrogen chemisorption induced structural transformation is also discussed. © 1998 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
20Cheng, C.-L. ; Lin, J.-C. ; Chang, H.-C.
College Park, Md. : American Institute of Physics (AIP)
Published 1997Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: This research investigates the infrared absorption intensity and isotope-dependent frequency shifts of CH stretching on diamond C(111) single-crystal surfaces by Fourier transform infrared spectroscopy (IRS). By employing single-pass direct absorption and in situ surface oxidation methods, a single sharp feature at νm=2832.2±0.9 cm−1 with a FWHM of Γ(approximate)6 cm−1 is observed at 800 K. Systematic measuring of how band intensity depends on hydrogen etching time indicates that a well hydrogen-terminated C(111)-1×1 can be prepared only after prolonged exposure of the surface to H, generated by hot W filaments, at 1100 K. A study of the band intensity at saturation, and assuming an electronic polarizability of αe=0.65 Å3 for the CH bond as that in CH4, yields an integrated cross section σ¯z=5.5×10−18 cm for the CH stretching motion along the internuclear axis. Additional measurements of band position as a function of mixed isotope concentrations afford a stretching frequency of νi=2816.2±0.9 cm−1 for a single CH isolated in a monolayer of CD oscillators at 800 K. The frequency shift of νm−νi=16.0 cm−1 is too large for dipole coupling theories to explain. The implications of the present findings with regard to applying IRS for quantitatively characterizing CVD diamondlike carbon films are discussed. © 1997 American Institute of Physics.Type of Medium: Electronic ResourceURL: