Search Results - (Author, Cooperation:I. Gordon)
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1Staff View
Publication Date: 2012-06-08Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Diet ; Food ; Gastrointestinal Tract/*microbiology ; Humans ; Interdisciplinary Communication ; *Metagenome ; Metagenomics ; Microbial Consortia ; Probiotics ; Sequence Analysis, DNA ; Symbiosis ; SynbioticsPublished by: -
2M. I. Smith ; T. Yatsunenko ; M. J. Manary ; I. Trehan ; R. Mkakosya ; J. Cheng ; A. L. Kau ; S. S. Rich ; P. Concannon ; J. C. Mychaleckyj ; J. Liu ; E. Houpt ; J. V. Li ; E. Holmes ; J. Nicholson ; D. Knights ; L. K. Ursell ; R. Knight ; J. I. Gordon
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-02-01Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acids/metabolism ; Animals ; Arachis ; Carbohydrate Metabolism ; Child, Preschool ; Diseases in Twins/*microbiology ; Feces/microbiology ; Female ; Gastrointestinal Tract/*microbiology ; Germ-Free Life ; Humans ; Infant ; Kwashiorkor/diet therapy/epidemiology/*microbiology ; Longitudinal Studies ; Malawi/epidemiology ; Male ; *Metagenome ; Mice ; Mice, Inbred C57BLPublished by: -
3M. Wu ; N. P. McNulty ; D. A. Rodionov ; M. S. Khoroshkin ; N. W. Griffin ; J. Cheng ; P. Latreille ; R. A. Kerstetter ; N. Terrapon ; B. Henrissat ; A. L. Osterman ; J. I. Gordon
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-10-03Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Bacteroides/*genetics/*metabolism ; DNA Transposable Elements/*genetics ; *Diet ; Gastrointestinal Tract/*microbiology ; Gene Library ; Genetic Fitness/*genetics ; Genetic Loci ; Genetic Markers ; Germ-Free Life ; Humans ; Mice ; Mutagenesis, Insertional/*methods ; Prebiotics ; Sequence Analysis, DNA/*methods ; Xylans/metabolismPublished by: -
4J. J. Faith ; J. L. Guruge ; M. Charbonneau ; S. Subramanian ; H. Seedorf ; A. L. Goodman ; J. C. Clemente ; R. Knight ; A. C. Heath ; R. L. Leibel ; M. Rosenbaum ; J. I. Gordon
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-07-06Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adult ; Bacteria/classification/genetics/isolation & purification ; Body Composition ; Caloric Restriction ; Family ; Feces/microbiology ; Female ; Gastrointestinal Tract/*microbiology ; Genome, Bacterial/genetics ; Genomic Instability ; Humans ; Male ; *Metagenome ; Models, Biological ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; Time Factors ; Weight Loss ; Young AdultPublished by: -
5V. K. Ridaura ; J. J. Faith ; F. E. Rey ; J. Cheng ; A. E. Duncan ; A. L. Kau ; N. W. Griffin ; V. Lombard ; B. Henrissat ; J. R. Bain ; M. J. Muehlbauer ; O. Ilkayeva ; C. F. Semenkovich ; K. Funai ; D. K. Hayashi ; B. J. Lyle ; M. C. Martini ; L. K. Ursell ; J. C. Clemente ; W. Van Treuren ; W. A. Walters ; R. Knight ; C. B. Newgard ; A. C. Heath ; J. I. Gordon
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-09-07Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: *Adiposity ; Adult ; Animals ; Bacteroidetes/genetics/*physiology ; Cecum/metabolism/microbiology ; Diet, Fat-Restricted ; Feces/microbiology ; Female ; Gastrointestinal Tract/*microbiology ; Germ-Free Life ; Humans ; Metabolome ; Metagenome/genetics/*physiology ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Obesity/genetics/*metabolism ; Thinness/microbiology ; Twins ; Weight Gain ; Young AdultPublished by: -
6D. Corti ; J. Misasi ; S. Mulangu ; D. A. Stanley ; M. Kanekiyo ; S. Wollen ; A. Ploquin ; N. A. Doria-Rose ; R. P. Staupe ; M. Bailey ; W. Shi ; M. Choe ; H. Marcus ; E. A. Thompson ; A. Cagigi ; C. Silacci ; B. Fernandez-Rodriguez ; L. Perez ; F. Sallusto ; F. Vanzetta ; G. Agatic ; E. Cameroni ; N. Kisalu ; I. Gordon ; J. E. Ledgerwood ; J. R. Mascola ; B. S. Graham ; J. J. Muyembe-Tamfun ; J. C. Trefry ; A. Lanzavecchia ; N. J. Sullivan
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-02-27Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adult ; Animals ; Antibodies, Monoclonal/*administration & dosage/immunology/isolation & ; purification ; Antibodies, Neutralizing/*administration & dosage/immunology/isolation & ; Antibodies, Viral/*administration & dosage/immunology/isolation & purification ; Clinical Trials as Topic ; Disease Outbreaks ; Ebolavirus/*immunology ; Female ; Hemorrhagic Fever, Ebola/epidemiology/*prevention & control ; Humans ; Macaca ; Male ; Molecular Sequence Data ; SurvivorsPublished by: -
7L. V. Blanton ; M. R. Charbonneau ; T. Salih ; M. J. Barratt ; S. Venkatesh ; O. Ilkaveya ; S. Subramanian ; M. J. Manary ; I. Trehan ; J. M. Jorgensen ; Y. M. Fan ; B. Henrissat ; S. A. Leyn ; D. A. Rodionov ; A. L. Osterman ; K. M. Maleta ; C. B. Newgard ; P. Ashorn ; K. G. Dewey ; J. I. Gordon
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-02-26Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Bacteria/*classification ; Bifidobacterium/physiology ; Body Weight ; Bone Development ; Clostridiales/physiology ; Disease Models, Animal ; Feces/microbiology ; Femur/growth & development ; Gastrointestinal Microbiome/*physiology ; Germ-Free Life ; Humans ; Infant ; Infant Nutrition Disorders/metabolism/*microbiology ; Malawi ; Male ; Mice ; Mice, Inbred C57BLPublished by: -
8S. Subramanian ; S. Huq ; T. Yatsunenko ; R. Haque ; M. Mahfuz ; M. A. Alam ; A. Benezra ; J. DeStefano ; M. F. Meier ; B. D. Muegge ; M. J. Barratt ; L. G. VanArendonk ; Q. Zhang ; M. A. Province ; W. A. Petri, Jr. ; T. Ahmed ; J. I. Gordon
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-06-05Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Bacteria/classification/genetics ; *Bacterial Physiological Phenomena ; Bangladesh ; *Biodiversity ; Feces/microbiology ; Female ; Gastrointestinal Tract/microbiology ; Humans ; Infant ; Infant Nutrition Disorders/diet therapy/*microbiology ; Male ; *Microbiota ; Models, Biological ; Nutritional Status ; RNA, Ribosomal, 16S/geneticsPublished by: -
9A. Hsiao ; A. M. Ahmed ; S. Subramanian ; N. W. Griffin ; L. L. Drewry ; W. A. Petri, Jr. ; R. Haque ; T. Ahmed ; J. I. Gordon
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-09-19Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Bangladesh ; Child ; Cholera/*microbiology ; Cohort Studies ; Diarrhea/microbiology ; Feces/microbiology ; Gene Expression Regulation, Bacterial ; Germ-Free Life ; Health ; Humans ; Intestines/*microbiology ; Male ; Metagenome/genetics ; Mice ; Microbiota/genetics/*physiology ; Quorum Sensing/physiology ; Ruminococcus/isolation & purification/*physiology ; Vibrio cholerae/genetics/isolation & purification/*pathogenicity/*physiology ; Virulence/genetics ; Virulence Factors/genetics/metabolismPublished by: -
10B. D. Muegge ; J. Kuczynski ; D. Knights ; J. C. Clemente ; A. Gonzalez ; L. Fontana ; B. Henrissat ; R. Knight ; J. I. Gordon
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-05-21Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: *Adaptation, Physiological ; Amino Acids/biosynthesis ; Animals ; Bacteria/classification/genetics/metabolism ; Biological Evolution ; Biostatistics ; Caloric Restriction ; *Diet ; Enzymes/genetics/metabolism ; Feces/*microbiology ; Gastrointestinal Tract/*microbiology/physiology ; Genes, Bacterial ; Genes, rRNA ; Humans ; Least-Squares Analysis ; Mammals/*microbiology/physiology ; Metagenome/*physiology ; Monte Carlo Method ; *Phylogeny ; Proteins/metabolism ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNAPublished by: -
11A. L. Kau ; P. P. Ahern ; N. W. Griffin ; A. L. Goodman ; J. I. Gordon
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-06-17Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Diet/trends ; Gastrointestinal Tract/*immunology/*microbiology ; Humans ; Immune System/*immunology ; Metagenome/*immunology ; Metagenomics ; Milk, Human/immunology ; Nutritional Physiological Phenomena/*physiology ; Obesity/immunology/microbiologyPublished by: -
12C. A. Lozupone ; J. I. Stombaugh ; J. I. Gordon ; J. K. Jansson ; R. Knight
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-09-14Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: *Biodiversity ; Diet ; Environment ; Health ; Humans ; Intestines/metabolism/*microbiology ; *Metagenome/geneticsPublished by: -
13J. J. Faith ; N. P. McNulty ; F. E. Rey ; J. I. Gordon
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-05-21Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Bacteroides/genetics/physiology ; Biomass ; Caseins/administration & dosage ; Desulfovibrio/genetics/physiology ; *Diet ; Dietary Carbohydrates/administration & dosage ; Dietary Fats, Unsaturated/administration & dosage ; Dietary Proteins/administration & dosage ; Dietary Sucrose/administration & dosage ; Escherichia coli/genetics/physiology ; Feces/*microbiology ; Gastrointestinal Tract/*microbiology ; Gene Expression Profiling ; Gene Expression Regulation, Bacterial ; *Germ-Free Life ; Gram-Negative Bacteria/*physiology ; Gram-Positive Bacteria/genetics/*physiology ; Humans ; Infant ; Infant Food ; Linear Models ; Male ; *Metagenome ; Mice ; Mice, Inbred C57BL ; Models, AnimalPublished by: -
14J. Henao-Mejia ; E. Elinav ; C. Jin ; L. Hao ; W. Z. Mehal ; T. Strowig ; C. A. Thaiss ; A. L. Kau ; S. C. Eisenbarth ; M. J. Jurczak ; J. P. Camporez ; G. I. Shulman ; J. I. Gordon ; H. M. Hoffman ; R. A. Flavell
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-02-03Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Apoptosis Regulatory Proteins ; Carrier Proteins/metabolism ; Choline ; Colon/microbiology ; Cytoskeletal Proteins/deficiency ; Disease Models, Animal ; *Disease Progression ; Fatty Liver/genetics/*metabolism/*pathology ; Inflammasomes/*metabolism ; Inflammation/metabolism/pathology ; Interleukin-18/deficiency ; Male ; Metagenome ; Methionine/deficiency ; Mice ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease ; Obesity/*metabolism/*pathology ; RNA, Ribosomal, 16S/genetics ; Receptors, Cell Surface/metabolism ; Toll-Like Receptor 4/deficiency/metabolism ; Toll-Like Receptor 9/deficiency/metabolism ; Tumor Necrosis Factor-alpha/deficiency/metabolismPublished by: -
15T. Yatsunenko ; F. E. Rey ; M. J. Manary ; I. Trehan ; M. G. Dominguez-Bello ; M. Contreras ; M. Magris ; G. Hidalgo ; R. N. Baldassano ; A. P. Anokhin ; A. C. Heath ; B. Warner ; J. Reeder ; J. Kuczynski ; J. G. Caporaso ; C. A. Lozupone ; C. Lauber ; J. C. Clemente ; D. Knights ; R. Knight ; J. I. Gordon
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-06-16Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adolescent ; Adult ; Age Factors ; Aged ; Bacteria/*classification/*genetics ; *Biodiversity ; Child ; Child, Preschool ; Feces/microbiology ; Female ; Geography ; Humans ; Infant ; Intestines/*microbiology ; Malawi ; Male ; *Metagenome ; Middle Aged ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Twins, Dizygotic ; Twins, Monozygotic ; United States ; Venezuela ; Young AdultPublished by: -
16Staff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] As a result of oxidation of chlorpromazine with hydrogen peroxide and peroxidase, Cavanaugh2 obtained a red reaction product which had an absorption maximum at 527 mfx as well as an identical absorption in the ultra-violet as the sulphoxide. It was concluded from kinetic data that this substance ...Type of Medium: Electronic ResourceURL: -
17Staff View
ISSN: 0021-8995Keywords: Chemistry ; Polymer and Materials ScienceSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyMechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPhysicsNotes: The water sorption by adult and embryonic native and insoluble collagen was investigated, along with that of calfskin gelatin. Greater sorption was obtainable with the collagen fractions than with gelatin, but the technique could not distinguish the fractions themselves. The suggestion is made that the greater sorption by collagen over gelatin and differences in apparent wettability between the adult and embryonic insoluble collagen might be explained by the formation of helical grooves with aging. Density measurements of the collagen fractions indicate that collagen becomes more crystalline with aging. This also applied to the insoluble collagen. These results are consistent with the view that differences in collagen solubility are due to differences in molecular ordering. The density of the insoluble collagens and gelatin passes through a maximum at 3-4% sorbed water. The phenomenon is explained on the basis of water bridges comprised of a single water molecule double hydrogen bonded to closely aligned chains. A discussion is presented in this connection. A calculation based on the density yields a molecular volume of 4.32 × 10-19 cm.3 For tropocollagen. This is in agreement with the molecular dimensions and consistent with the idea that collagen is formed from an aggregation of the monomer.Additional Material: 4 Ill.Type of Medium: Electronic ResourceURL: -
18Das, A. ; Gordon, I. ; Wagner, P. ; Cannaerts, M. ; Moshchalkov, V. V. ; Bruynseraede, Y.
[S.l.] : American Institute of Physics (AIP)
Published 2001Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: We investigate the thickness dependent properties of manganite films characterized by colossal negative magnetoresistance. Ultrathin, wedge-type films (0–120 Å) of La0.7Ba0.3MnO3 were deposited by laser ablation onto SrTiO3 and LaAlO3 substrates. The films were patterned into strips of different thickness and magneto-transport measurements were performed at temperatures between 5 and 290 K and in magnetic fields up to 5 T. Atomic force- and transmission electron microscopy were done to correlate the microstructure with the transport data. The resistivity of the films increases slightly with decreasing thickness due to substrate-induced compressive strain. Below 50 Å, the resistivity rises abruptly indicating a crossover to discontinuous and finally island-like film growth as confirmed by the microstructural techniques. At thicknesses slightly above the threshold for percolative conduction ((approximate)30 Å), an enhanced low-field magnetoresistance was observed as a signature of spin-dependent tunneling. © 2001 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
19Marston, W.A. ; Blume, P.A. ; Dardik, P. ; Gordon, I. ; Hanft, J.R. ; Hill, R.S. ; Landsman, A.I. ; Lipkin, S. ; Morgan, J. ; Orgill, D. ; Tallis, A.
Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
Published 2005Staff ViewISSN: 1524-475XSource: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: A novel biopolymer composed of porcine gelatin and dextran was used in a randomized controlled pilot clinical trial to treat diabetic foot ulcers to establish safety profile and evaluate effect on wound closure. Fifty-six patients were prospectively randomized at 10 centers (control = 25; E-Matrix = 31). Control patients received routine sharp debridement, off-loading, and hydrogel dressings applied daily. E-Matrix patients received identical wound care with the addition of monthly subcutaneous injections of E-Matrix under the wound surface. Patients were monitored for 12 weeks using wound planimetry and photography. Primary endpoint was safety as measured by adverse event reporting and clinical laboratory analysis. Secondary endpoint was wound closure based on intent to treat.There was no significant difference in the rate of adverse events between treated and control subjects. Overall closure rate for E-Matrix treated wounds was 42%(13 of 31 subjects) compared to 32%(8 of 25 subjects) for controls. Subgroup analysis suggested that E-Matrix may be more effective than control for treatment of larger (〉2 cm2) and older (〉17 weeks duration) wounds (see table).〈table frame="topbot"〉〈tgroup cols="5" align="left"〉〈colspec colnum="1" colname="col1" align="left"/〉〈colspec colnum="2" colname="col2" align="left"/〉〈colspec colnum="3" colname="col3" align="center"/〉〈colspec colnum="4" colname="col4" align="center"/〉〈colspec colnum="5" colname="col5" align="center"/〉〈thead valign="bottom"〉〈row rowsep="1"〉ParameterTreatment GroupNClosed%Closed〈tbody valign="top"〉Size 〉2 cmE-Matrix17847%Control14429%Ulcer duration 〉17 weeksE-Matrix15640%Control15320% Although the study is insufficiently powered to evaluate statistical significance, E-Matrix demonstrated a similar safety profile to control treatment with trends toward improved healing in larger and older wounds. Further randomized trials are necessary to confirm these promising initial results.Type of Medium: Electronic ResourceURL: -
20Staff View
ISSN: 1365-2494Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: The effect of three different vertical structures of a perennial ryegrass-dominated sward, defined by pseudostem heights (cm) — 1·3 low (L), 2·5 medium (M) and 3·5 high (H) — on the bite depth and selection of plant parts within the grazed horizon of the sward by sheep and guanacos was studied. The bite depth (cm) was similar between sheep and guanacos across the different swards (L, 1·5; M, 3·6; H, 3·8) and was related to pre-grazing sward surface height rather than to pseudostem height. There were differences in diet composition between species that were related to differences in selection for plant parts. Sheep had a higher proportion of green leaf in the diet than did guanacos in L (0·84 vs. 0·71, P 〈 0·05) and M (0·75 vs. 0·59, P 〈 0·05) swards, and possibly selected this plant part in H swards in which the proportion of green leaf in the grazed horizon was low (0·45–0·50). Guanacos had a higher proportion of dead leaf and sheath in the diet than did sheep in L (0·23 vs. 0·09, P 〈 0·05) and M (0·30 vs. 0·18, P 〈 0·05) swards, and possibly selected this plant part on these swards, in which the proportion of green leaf in the grazed horizon was high (0·70–0·95). The proportion of pseudostem in the diet of sheep and guanacos was similar across all swards (0·03) and was generally much lower than that in the grazed horizon (0·01–0·18). Guanacos had a higher proportion of dead stem in the diet than did sheep (0·06 vs. 0·02, P 〈 0·05) across all swards, but the proportion was similar to that in the grazed horizon of each sward.Type of Medium: Electronic ResourceURL: