Search Results - (Author, Cooperation:H. Hermeking)

2018-06-05

Rockefeller University Press

0022-1007

1540-9538

Medicine

Solid Tumors

2013-02-22

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Aging/genetics/pathology/*physiology ; Animals ; Apoptosis ; DNA Damage ; Fibrosis/genetics/pathology ; Gene Deletion ; *Gene Expression Regulation ; Gene Knockout Techniques ; Genetic Therapy ; Heart/*physiology ; Mice ; Mice, Inbred C57BL ; MicroRNAs/*genetics/metabolism ; Myocardial Infarction/genetics/pathology/therapy ; Myocardium/cytology/*metabolism/pathology ; Myocytes, Cardiac/cytology/metabolism/pathology ; Substrate Specificity ; Telomere/genetics/metabolism

2018-04-14

The American Association for Cancer Research (AACR)

1078-0432

1557-3265

Medicine

1434-601X

Springer Online Journal Archives 1860-2000

Physics

Abstract Many body Green's function techniques are applied to show that the three current correlation function relating the one photon photoemission current to the applied external field may be expressed by one and two particle correlation properties only for arbitrary many body interactions. An analysis of the double time derivative of the three current correlation function leads to a generalization for arbitrary many body interaction of a formula frequently used for calculations of the photocurrent in the independent electron model. Implications are discussed for the case that only electrostatic electron-electron interactions are present.

Electronic Resource

1432-1440

Lithotripsy ; Gallstones ; Fragmentation ; Extracorporeal shock-wave lithotripsy ; Physics of shock waves

Springer Online Journal Archives 1860-2000

Medicine

Summary These in vitro studies define the basic physical laws regarding work and energy for the successful fragmentation of human gallstones. For this purpose a standardized stone model was used consisting of plaster and glass microspheres with physical properties similar to those of human gallstones. All experiments were performed using the lithotripter model MPL9000 (Dornier). The acoustic energy passing stones of 10–30 mm ranged between 8 and 90 mJ per pulse depending on the stone size and energy setting. These results represent the basis for the three following investigations. In the first experiment the relationship between fragmentation and shock wave energy was investigated in a basket with 2 mm mesh size. Thus no layer of small fragments could shadow the acoustic energy for further fragmentation of larger fragments. A constant amount of stone material was found to be fragmented per shock-wave pulse irrespective of stone volume. A low energy threshold (2 mJ/cm3) was observed, below which fragmentation did not occur.In the second experiment, the sieve was covered with a membrane, thus simulating the in vivo situation. The presence of a layer of small fragments hindered the further disintegration of the larger fragments. The attenuation depended to a large extent on original stone volume and acoustic energy per pulse. The corresponding attenuation factor increased with the original stone volume. Thus the fragmentation of a stone with a diameter of 30 mm was attenuated twice as much as a stone of 20 mm size. The critical layer thickness at which no further disintegration took place was 2.5 mm at 18 kV, 4.2 mm at 22 kV, and 5.0 mm at 26 kV. In the third series of experiments we compared the disintegration of one large stone with that of several smaller stones having the same total stone volume at a constant acoustic energy. In this system single stones underwent more complete fragmentation than multiple stones, probably due to the higher threshold energy for intact stones compared to that of fragments of the same size. The information gained in the model system will be of use in the interpretation of clinical results and will contribute to the long-term goal of improving the efficacy of extracorporeal shock-wave lithotripsy.

Electronic Resource