Search Results - (Author, Cooperation:H. G. Rammensee)

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  1. 1
    Staff View
    Publication Date:
    2014-11-28
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Antibodies, Monoclonal/*therapeutic use ; Antigens, Neoplasm/*genetics/*immunology ; CD8-Positive T-Lymphocytes/*immunology ; Cancer Vaccines/*therapeutic use ; Cell Cycle Checkpoints/*immunology ; Epitopes/genetics ; *Immunotherapy ; Male ; Mice ; Sarcoma/immunology/*therapy ; Vaccines, Synthetic/therapeutic use
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2018-09-04
    Publisher:
    Rockefeller University Press
    Print ISSN:
    0022-1007
    Electronic ISSN:
    1540-9538
    Topics:
    Medicine
    Keywords:
    Tumor Immunology
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Tammiruusu, A. ; Haveri, A. ; Pascolo, S. ; Lahesmaa, R. ; Stevanovic, S. ; Rammensee, H.-G. ; Sarvas, M. ; Puolakkainen, M. ; Vuola, J. M.

    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Published 2005
    Staff View
    ISSN:
    1365-3083
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    CD8+ T cells have been suggested to play an important role in protective immunity against pulmonary Chlamydia pneumoniae infection in mice. Moreover, several classical major histocompatibility complex class I – restricted cytotoxic CD8+ T lymphocytes (CTL) specific for C. pneumoniae– derived peptides have been identified. Here, we studied the outcome of C. pneumoniae infection in human leucocyte antigen (HLA)-A2.1 transgenic mice (HHD mice) that are only able to express a classical human class I molecule (HLA-A2.1). C. pneumoniae infection was self-restricted in HHD mice which were able to develop specific immune responses and a protective immunity against a subsequent rechallenge in a manner comparable to wildtype mice. Furthermore, accumulation of functional and C. pneumoniae-specific T cells to the site of infection was detected after challenge. Antigen processing and HLA-A2.1-dependent presentation was studied by immunizing the HHD mice with chlamydial outer protein N (CopN). Isolation of a peptide-specific CTL line from the CopN-immunized mice suggests that the HLA-A2.1 molecule can support the development of CTL response against a chlamydial protein in mice. These findings suggest that the transgenic mouse model can be used for further characterization of the HLA-A2.1-restricted CD8+ T-cell response during C. pneumoniae infection and for identification of CD8 epitopes from chlamydial antigens.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  4. 4
    Staff View
    ISSN:
    1279-8509
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  5. 5
    Staff View
    ISSN:
    1432-1211
    Keywords:
    Key words MHC ; Peptide motif ; T-cell epitope
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract  The first version of the major histocompatibility complex (MHC) databank SYFPEITHI: database for MHC ligands and peptide motifs, is now available to the general public. It contains a collection of MHC class I and class II ligands and peptide motifs of humans and other species, such as apes, cattle, chicken, and mouse, for example, and is continuously updated. All motifs currently available are accessible as individual entries. Searches for MHC alleles, MHC motifs, natural ligands, T-cell epitopes, source proteins/organisms and references are possible. Hyperlinks to the EMBL and PubMed databases are included. In addition, ligand predictions are available for a number of MHC allelic products. The database content is restricted to published data only.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  6. 6
    Staff View
    ISSN:
    1432-1211
    Keywords:
    Key words HLA ; Peptide motif ; TFA extraction ; Pockets ; MHC ligands
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  7. 7
    Rammensee, H. -G.
    Springer
    Published 1989
    Staff View
    ISSN:
    1432-1211
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    1432-1211
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses