Search Results - (Author, Cooperation:G. Tomasic)
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1Latest Papers from Table of Contents or Articles in PressP. C. Tumeh ; C. L. Harview ; J. H. Yearley ; I. P. Shintaku ; E. J. Taylor ; L. Robert ; B. Chmielowski ; M. Spasic ; G. Henry ; V. Ciobanu ; A. N. West ; M. Carmona ; C. Kivork ; E. Seja ; G. Cherry ; A. J. Gutierrez ; T. R. Grogan ; C. Mateus ; G. Tomasic ; J. A. Glaspy ; R. O. Emerson ; H. Robins ; R. H. Pierce ; D. A. Elashoff ; C. Robert ; A. Ribas
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-11-28Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adaptive Immunity/*immunology ; Aged ; Aged, 80 and over ; Biomarkers ; CD8-Positive T-Lymphocytes/cytology/*immunology ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; *Immunotherapy ; Male ; Melanoma/diagnosis/immunology/pathology/*therapy ; Middle Aged ; *Models, Biological ; Multivariate Analysis ; Programmed Cell Death 1 Receptor/antagonists & inhibitors/genetics/immunology ; Treatment OutcomePublished by: -
2Latest Papers from Table of Contents or Articles in PressL. Boussemart ; H. Malka-Mahieu ; I. Girault ; D. Allard ; O. Hemmingsson ; G. Tomasic ; M. Thomas ; C. Basmadjian ; N. Ribeiro ; F. Thuaud ; C. Mateus ; E. Routier ; N. Kamsu-Kom ; S. Agoussi ; A. M. Eggermont ; L. Desaubry ; C. Robert ; S. Vagner
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-08-01Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antineoplastic Agents/pharmacology ; Cell Death/drug effects ; Cell Line, Tumor ; Colonic Neoplasms/pathology ; *Drug Resistance, Neoplasm/drug effects ; Drug Synergism ; Eukaryotic Initiation Factor-4A/antagonists & inhibitors/metabolism ; Eukaryotic Initiation Factor-4E/metabolism ; Eukaryotic Initiation Factor-4F/*antagonists & inhibitors/chemistry/*metabolism ; Eukaryotic Initiation Factor-4G/metabolism ; Female ; Humans ; Indoles/pharmacology ; MAP Kinase Signaling System/drug effects ; Melanoma/*drug therapy/genetics/pathology ; Mice ; Mitogen-Activated Protein Kinase Kinases/*antagonists & inhibitors ; Phosphorylation/drug effects ; Protein Binding/drug effects ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins B-raf/*antagonists & inhibitors/genetics ; Signal Transduction/drug effects ; Sulfonamides/pharmacology ; Thyroid Neoplasms/pathology ; Triterpenes/pharmacology ; Xenograft Model Antitumor AssaysPublished by: -
3Articles: DFG German National LicensesStaff View
ISSN: 1432-2307Keywords: Breast ; Lobular carcinoma in situ ; Myoepithelial cellsSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Two cases of intralobular carcinoma of the breast showing myoepithelial cell differentiation are reported. One was an in situ lesion localized within a fibroadenoma; the second was predominantly in situ, but areas of invasion were present. The neoplastic cells had round to ovoid nuclei and were polygonal to spindle in shape displaying glycogen rich clear cytoplasm. Alphasmooth muscle actin was present in the cytoplasm of the neoplastic cells in both cases. In one case the same cells displayed cytoplasmic microfilaments at electron microscopic level. Intralobular growth of neoplastic myoepithelial cells has never been described in the literature, and this line of differentiation has to be added to the endocrine and apocrine features occasionally observed in in situ lobular carcinomas of the breast.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesDamiani, S. ; Ludvikova, M. ; Tomasic, G. ; Bianchi, S. ; Gown, A. M. ; Eusebi, V.
Springer
Published 1999Staff ViewISSN: 1432-2307Keywords: Key words Ductal carcinoma in situ ; Immunohistochemistry ; Myoepithelial cells ; Basal lamina ; Smooth muscle actin ; CalponinSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract A retrospective study was made of 38 selected brest tumours with a poorly differentiated in situ duct component. These were classified on haematoxylin and eosin (H&E) as ductal carcinoma in situ (DCIS; 10 cases), DCIS with invasion (17 cases) and DCIS with features suggestive of for stromal invasion (11 cases). The last were these lesions composed of neoplastic ducts with irregular outlines and a myoepithelial layer that was not clearly evident or large neoplastic ducts growing close together or surrounded by inflammatory desmoplastic stroma. Cases of DCIS involving areas of sclerosing adenosis were included in this category. Consecutive sections obtained from each case were studied with a panel of antibodies against myoepithelial cells (alpha smooth muscle actin and calponin) and basal lamina (BL) components (laminin and type IV collagen). It was found that in situ lesions showed well-formed basal lamina and/or an evident myoepithelial layer. These features were lacking in the invasive areas. Nine of the 11 cases with suggestive features of stromal invasion were reclassified as invasive duct carcinoma (5 cases)and DCIS (4 cases), according to the absence or presence of a continuous myoepithelial layer and/or basal lamina. In 2 such cases immunohistochemistry yielded equivocal results and the label ”suggestive of invasion” was therefore pertinent. Immunohistochemistry facilitates the diagnosis of breast DCIS; myoepithelial and basal lamina markers are useful in differentiating microinvasive from in situ ductal carcinomas of the breast.Type of Medium: Electronic ResourceURL: