Search Results - (Author, Cooperation:G. Horev)

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  1. 1
    Y. Hua ; K. Sahashi ; F. Rigo ; G. Hung ; G. Horev ; C. F. Bennett ; A. R. Krainer
    Nature Publishing Group (NPG)
    Published 2011
    Staff View
    Publication Date:
    2011-10-08
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Alternative Splicing/drug effects/genetics ; Animals ; Animals, Newborn ; Carrier Proteins/metabolism ; *Disease Models, Animal ; Glycoproteins/deficiency/metabolism ; Growth Hormone/metabolism ; Humans ; Insulin-Like Growth Factor I/deficiency/metabolism ; Kaplan-Meier Estimate ; Liver/metabolism ; Longevity/drug effects ; Mice ; Mice, Transgenic ; Motor Neurons/drug effects/metabolism/pathology ; Muscular Atrophy, Spinal/genetics/*metabolism/*pathology/physiopathology ; Oligonucleotides, Antisense/administration & dosage/genetics/pharmacology ; RNA Isoforms/analysis/genetics ; RNA, Messenger/analysis/genetics ; Rotarod Performance Test ; Spinal Cord/cytology/metabolism/pathology ; Survival of Motor Neuron 1 Protein/genetics ; Survival of Motor Neuron 2 Protein/genetics/metabolism ; Transgenes
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Horev, G. ; Korenreich, L. ; Ziv, N. ; Grunebaum, M.
    Springer
    Published 1990
    Staff View
    ISSN:
    1432-1998
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Cortical thickening and/or periosteal reaction in long bones of children and adolescents continue to present a diagnostic difficulty for the pediatric radiologist. A history of physical activity points to the possibility of stress fracture, nevertheless bone malignancy or chronic inflammatory changes have to be excluded. The MRI findings in recent cases of stress fractures were confusing. An extensive metadiaphyseal abnormal signal from the medullary cavity was observed. Only the meticulous correlation between the various imaging modalities established the correct diagnosis. Stress fractures can occur in a normal bone that is subjected to repeated trauma, with the strain being less than that which causes an acute fracture. Localized pain is the presenting symptom [1]. This kind of fracture is encountered in adolescents who are often involved in competitive physical exercise. The conventional radiographic examination shows the evidence of the fracture repair rather than the fracture itself: localized periosteal reaction and endosteal thickening. A radiolucent cortical fracture-line is usually not demonstrated [2]. The radiologic appearance can be problematic in the pediatric age and necessitates differentiation from osteomyelitis or bone malignancy. The diagnostic investigation includes multidirectional bone radiographs, Tcm99 polyphosphate bone scientigraphy [3] and computerized tomography [4]. Recently MRI has been added to the diagnostic armamentarium. This paper presents the experience gained in the diagnosis of pediatric stress fractures which were investigated and followed up by MRI. It was found that this modality did not contribute to the establishment of the final diagnosis of stress fracture.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  3. 3
    Staff View
    ISSN:
    1432-1998
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Atlanto-occipital subluxation (AOS) in individuals with Down syndrome is discussed using five new cases and nine patients previously presented in the literature. Although AOS is likely due to ligamentous laxity, it was associated with atlantoaxial instability in only two youngsters. Reducible C1−C2 rotary subluxation was present in a third. Posterior movement of the occiput with respect to C1 occurred on extension and reduced on flexion in all but one individual who demonstrated anterior subluxation. Neurological problems are described in only two individuals: one with severe atlantoaxial subluxation (AAS) and the other with multiple cervical spine anomalies. Since AOS is usually detected on films obtained to screen children with Down syndrome for AAS, the atlanto-occipital joint should be carefully studied on these radiographs. The clinical significance of AOS needs to be determined.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  4. 4
    Horev, G. ; Freud, E. ; Korenreich, L.
    Springer
    Published 1996
    Staff View
    ISSN:
    1432-1998
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Over the past 3 years we have encountered eight cases of masses in the thoracoabdominal junction or paradiaphragmatic region. To determine exact compartmentalization of the tumors prior to treatment, a detailed imaging evaluation, including conventional radiography, ultrasound, computerized tomography, and magnetic resonance imaging, was conducted. Despite these extensive examinations, we erred in three cases with regard to the compartmental limitation of the tumors. The imaging picture of para- or transdiaphragmatic penetration of masses can be very misleading and is at times resolved only at surgery.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  5. 5
    Kornreich, L. ; Horev, G. ; Kaplinsky, C. ; Ziv, N. ; Grünebaum, M.
    Springer
    Published 1991
    Staff View
    ISSN:
    1432-1998
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract The use of GD-DTPA was introduced recently for MR imaging of the body. This paper presents our experience with GD-DTPA enhanced MRI in the evaluation of neuroblastoma in children. The characteristics of the tumor-enhancement are described, its contribution to the diagnosis and the follow-up of this disease are discussed.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  6. 6
    Rathaus, V. ; Grunebaum, M. ; Ziv, N. ; Kornreich, L. ; Horev, G.
    Springer
    Published 1992
    Staff View
    ISSN:
    1432-1998
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract The bubble sign (BS) in the gasless abdomen of the newborn is a helpful clue in the diagnosis of an upper gastrointestinal obstruction. The already swallowed air serves as the natural contrast agent. The single, double and triple BS are described in view of 23 cases indicating the level of the obstruction, and its differential diagnosis is discussed. The presence of BS in the gasless abdomen of the newborn is an indication for surgery until proved otherwise. With the increasing experience by ultrasonography, this modality should be considered as the first bed-side procedure when suspecting upper gastrointestinal obstruction, and then be confirmed by radiograms.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  7. 7
    Staff View
    ISSN:
    1432-1998
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract A preterm infant with a rare association of a multicentric hepatic hemangioendothelioma (MHH) and a large brain hemangioma is described. The imaging investigations and their findings are discussed. It is recommended that whole-body radionuclide imaging with99mTc-labeled red blood cells is employed immediately following ultrasonography to confirm the suspected diagnosis of MHH and to detect other unsuspected hemangiomas.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    1432-1998
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract To evaluate the incidence of abnormal intracranial findings in children with central precocious puberty, 62 children (51 girls, 11 boys) were examined by computerized tomography and/or magnetic resonance imaging (MRI) of the brain. Forty-four had normal examinations; 18 (11 girls, 7 boys) showed intracranial pathologies, including hamartoma of the tuber cinereum (8 cases), parenchymal loss (3 cases), hypothalamicchiasmatic lesions (2 cases), lesions of the corpus callosum (2 cases), suprasellar cyst (1 case), and pineal cyst and mesiotemporal sclerosis (1 case each). Based on the correlation between the clinical and the imaging results of this series, the authors recommend MRI as the imaging method of choice in the investigation of precocious puberty.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  9. 9
    Grunebaum, M. ; Kornreich, L. ; Horev, G. ; Ziv, N.
    Springer
    Published 1996
    Staff View
    ISSN:
    1432-1998
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Brachmann-de Lange syndrome is a well-described congenital disorder. Skeletal anomalies and respiratory infections are its hallmarks. To the known imaging signs, the authors add tracheomegaly, which has not been reported so far.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  10. 10
    Freud, E. ; Blumenfeld, A. ; Zer, M. ; Sandbank, J. ; Horev, G. ; Giler, S.
    Springer
    Published 1996
    Staff View
    ISSN:
    1437-9813
    Keywords:
    Esophageal atresia ; Livaditis procedure ; Esophageal pseudodiverticulum ; Vicryl mesh ; Polyglactin mesh
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Circular esophageal myotomy (CEM) is currently a well-accepted technique for elongation of the upper esophageal pouch in cases of long-gap esophageal atresia (EA). Esophageal pseudodiverticulum is a frequent and perhaps underreported sequela of this technique, characterized by ballooning or outpouching of the esophageal mucosa in the myotomized area. The present study was designed to seek a supplement for the CEM technique in order to avoid possible pseudodiverticulum formation in the myotomized area. We created an animal model to simulate the anatomic conditions present after primary repair of EA facilitated by CEM. Three groups of dogs underwent either cervical (1 group) or thoracic (2 groups) esophageal myectomy. In the cervical and first thoracic groups, the denuded mucosa was left without any support. In the second thoracic group, the denuded mucosal area was wrapped with polyglactin 910 (Vicryl) mesh. In all three groups the esophagus was narrowed by a Marlex mesh ring 3 cm distal to the myectomized zone, simulating a condition resulting from anastomotic narrowing. The dogs underwent barium swallows under fluoroscopy at different postoperative periods and were killed 4 or 6 months after surgery. The esophagi were removed for gross and radiologic investigation under maximal insufflation as well as for histologic assessment. The proposed canine model proved to be useful for study of the myectomized esophagus, mimicking the anatomy and conditions after CEM in long-gap EA repair. Wrapping the denuded mucosa with Vicryl mesh fortified the weakened esophageal wall, thus diminishing the likelihood of future pseudodiverticulum development. In light of the simplicity of the technique and the absence of any evident risk or complications, we recommend that the use of Vicryl mesh wrap be considered during CEM to reinforce the esophageal wall.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  11. 11
    Grunebaum, M. ; Ziv, N. ; Kornreich, L. ; Horev, G. ; Lombrozo, R.
    Springer
    Published 1988
    Staff View
    ISSN:
    1432-1920
    Keywords:
    Ventrieuloperitoneal shunt ; Pseudocyst ; Abscess ; Ultrasound ; Ascaris lumbricoides
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary The installation of the ventriculo-peritoneal shunt (VPS) is on the rise in the pediatric age. Its obstruction is a major cause for further deterioriation of the already present hydrocephalus. Distal VPS obstruction may be due to a pseudocyst, an infected pseudocyst or an abscess-formation within the peritoneal cavity. These pathologies are identified through an abdominal radiograph and ultrasonography. The sonographic signs are described and its differential diagnosis is discussed in relation to 6 diagnosed cases. One VPS was obstructed by Ascaris lumbricoides clinging to its tip within an abscess.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  12. 12
    Staff View
    ISSN:
    1432-1998
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Liver candidiasis is characterised by small abscesses spread throughout the organ at random. These lesions may be identified sonographically. In the active phase of the disease, hepatomegaly is seen together with the “wheel in wheel” phenomenon, the “wagon wheel” appearance and/or the “bull's eye” lesion. Later on, hypoechoic defects develop. When the echogenic foci are revealed, the healing phase is initiated. These manifestations are demonstrated in 4 pediatric oncology patients. The sonographic patterns as well as its differential diagnosis from primary liver tumors, metastatic infiltrations or other abscess formations are discussed.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  13. 13
    Wolf, Y. G. ; Merlob, P. ; Horev, G. ; Litwin, A. ; Katz, S.
    Springer
    Published 1990
    Staff View
    ISSN:
    1432-1076
    Keywords:
    Thoraco-abdominal enteric duplication ; Meningocele ; Dextrocardia ; Chest wall deformity ; Cytomegalovirus
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract We describe an infant with an enteric thoracoabdominal duplication arising in the proximal jejunum and associated with a dorsal meningocele, dextrocardia, agenesis of ribs and hypoplasia of the left arm. Diagnosis was reached post-operatively and the infant died of cytomegalovirus pneumonitis. Results of the postmortem examination are presented. Awareness of this rare malformation is require in norder to reach a timely diagnosis and to plan a suitable operative approach.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  14. 14
    Kornreich, L. ; Horev, G. ; Ziv, N. ; Grunebaum, M.
    Springer
    Published 1992
    Staff View
    ISSN:
    1432-1076
    Keywords:
    Mediastinal cysts ; MRI ; Children
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract The signals obtained from mediastinal cystic lesions in children by magnetic resonance imaging (MRI) have been analysed. The advantages and pitfalls in establishing the final diagnosis by MRI are compared to the conventional radiographic technique and to computed tomography.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses