Search Results - (Author, Cooperation:G. Habets)
-
1Latest Papers from Table of Contents or Articles in PressC. Zhang ; W. Spevak ; Y. Zhang ; E. A. Burton ; Y. Ma ; G. Habets ; J. Zhang ; J. Lin ; T. Ewing ; B. Matusow ; G. Tsang ; A. Marimuthu ; H. Cho ; G. Wu ; W. Wang ; D. Fong ; H. Nguyen ; S. Shi ; P. Womack ; M. Nespi ; R. Shellooe ; H. Carias ; B. Powell ; E. Light ; L. Sanftner ; J. Walters ; J. Tsai ; B. L. West ; G. Visor ; H. Rezaei ; P. S. Lin ; K. Nolop ; P. N. Ibrahim ; P. Hirth ; G. Bollag
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-10-16Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Line, Tumor ; Enzyme Activation/drug effects ; Female ; Genes, ras/genetics ; Heterocyclic Compounds, 2-Ring/adverse effects/pharmacology ; Humans ; Indoles/adverse effects/pharmacology ; MAP Kinase Signaling System/*drug effects/genetics ; Mice ; Mitogen-Activated Protein Kinases/*metabolism ; Models, Biological ; Mutation/genetics ; Protein Kinase Inhibitors/adverse effects/*pharmacology ; Proto-Oncogene Proteins B-raf/*antagonists & inhibitors/genetics ; Sulfonamides/adverse effects/pharmacologyPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] From the optical mass function of LMC X-3 (2.3 M), the absence of X-ray eclipses, in combination with the observed spectral type and absolute visual magnitude of the B-type companion, Paczynski2 derived a lower limit to the mass of the B-star of 9.0 (6.0 M), that is 5=3.0 M0. By comparing the ...Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 1573-7276Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Non-invasive, non-metastatic mouse BW5147 T-lymphoma cells were treated with non-mutagenic concentrations of the hypomethylating agent 5-azacytidine (5-aza-C). Subsequently, invasive variants were selected on monolayers of rat embryo fibroblasts. The estimated frequency of induction of invasive variants was smaller than 1 in 106 cells. We obtained several independent clones that were stable in the expression of the invasive phenotype. In contrast to the parental cell line, the highly invasive clones produced widespread metastases upon tail vein injection in all the syngeneic AKR mice tested, whereas' clones with an intermediate level of invasiveness formed metastases only in part of the mice tested. DNA analysis using the methylation-sensitive and insensitive restriction enzymes, Hpa-II and Msp-I, respectively, showed that the DNA of the invasive variants remained hypomethylated, up to 6 months after 5-aza-C treatment. 5-aza-C is thus able to induce invasive and metastatic potential in the BW5147 T-lymphoma cells, similar to the activated human c-Ha-ras oncogene or human chromosome 7, as studied previously. The acquisition of invasive and metastatic potential is presumably caused by DNA hypomethylation and thus activation of one or more silent invasion controlling genes.Type of Medium: Electronic ResourceURL: