Search Results - (Author, Cooperation:G. Fleischhack)

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  1. 1
    A. S. Morrissy ; L. Garzia ; D. J. Shih ; S. Zuyderduyn ; X. Huang ; P. Skowron ; M. Remke ; F. M. Cavalli ; V. Ramaswamy ; P. E. Lindsay ; S. Jelveh ; L. K. Donovan ; X. Wang ; B. Luu ; K. Zayne ; Y. Li ; C. Mayoh ; N. Thiessen ; E. Mercier ; K. L. Mungall ; Y. Ma ; K. Tse ; T. Zeng ; K. Shumansky ; A. J. Roth ; S. Shah ; H. Farooq ; N. Kijima ; B. L. Holgado ; J. J. Lee ; S. Matan-Lithwick ; J. Liu ; S. C. Mack ; A. Manno ; K. A. Michealraj ; C. Nor ; J. Peacock ; L. Qin ; J. Reimand ; A. Rolider ; Y. Y. Thompson ; X. Wu ; T. Pugh ; A. Ally ; M. Bilenky ; Y. S. Butterfield ; R. Carlsen ; Y. Cheng ; E. Chuah ; R. D. Corbett ; N. Dhalla ; A. He ; D. Lee ; H. I. Li ; W. Long ; M. Mayo ; P. Plettner ; J. Q. Qian ; J. E. Schein ; A. Tam ; T. Wong ; I. Birol ; Y. Zhao ; C. C. Faria ; J. Pimentel ; S. Nunes ; T. Shalaby ; M. Grotzer ; I. F. Pollack ; R. L. Hamilton ; X. N. Li ; A. E. Bendel ; D. W. Fults ; A. W. Walter ; T. Kumabe ; T. Tominaga ; V. P. Collins ; Y. J. Cho ; C. Hoffman ; D. Lyden ; J. H. Wisoff ; J. H. Garvin, Jr. ; D. S. Stearns ; L. Massimi ; U. Schuller ; J. Sterba ; K. Zitterbart ; S. Puget ; O. Ayrault ; S. E. Dunn ; D. P. Tirapelli ; C. G. Carlotti ; H. Wheeler ; A. R. Hallahan ; W. Ingram ; T. J. MacDonald ; J. J. Olson ; E. G. Van Meir ; J. Y. Lee ; K. C. Wang ; S. K. Kim ; B. K. Cho ; T. Pietsch ; G. Fleischhack ; S. Tippelt ; Y. S. Ra ; S. Bailey ; J. C. Lindsey ; S. C. Clifford ; C. G. Eberhart ; M. K. Cooper ; R. J. Packer ; M. Massimino ; M. L. Garre ; U. Bartels ; U. Tabori ; C. E. Hawkins ; P. Dirks ; E. Bouffet ; J. T. Rutka ; R. J. Wechsler-Reya ; W. A. Weiss ; L. S. Collier ; A. J. Dupuy ; A. Korshunov ; D. T. Jones ; M. Kool ; P. A. Northcott ; S. M. Pfister ; D. A. Largaespada ; A. J. Mungall ; R. A. Moore ; N. Jabado ; G. D. Bader ; S. J. Jones ; D. Malkin ; M. A. Marra ; M. D. Taylor
    Nature Publishing Group (NPG)
    Published 2016
    Staff View
    Publication Date:
    2016-01-14
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    ISSN:
    1433-0415
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Bei Immunsuppression infolge zytostatischer Behandlung ist Fieber häufig das einzige Zeichen einer beginnenden schweren und mitunter lebensbedrohlichen Infektion. Empirisch wird daher wenige Stunden nach Fieberbeginn mit einer i. v.-antibiotischen Breitspektrumtherapie in Form einer Monotherapie oder Kombinationstherapie begonnen [12, 19]. Durch die Therapie mit einem β-Laktam-Antibiotikum allein oder in Kombination mit einem Glykopeptidantibiotikum oder einem Aminoglycosidantibiotikum konnte bei erwachsenen Patienten eine hohe Wirksamkeit in der Behandlung der febrilen Neutropenie belegt werden [8, 10, 18]. Umfangreiche klinische Studien zur Wirksamkeit gleichartiger Therapieschemata in der pädiatrischen Onkologie sind selten. In einer Multizenterstudie wurde geprüft, ob eine Kombinationstherapie mit Ceftazidim und Teicoplanin als Initialtherapie einer antibiotischen Sequentialtherapie bei Kindern und Jugendlichen mit febriler Neutropenie effektiv ist.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/PL00008333

    Articles: DFG German National Licenses
  3. 3
    Fleischhack, G. ; Cipic, D. ; Juettner, J. ; Hasan, C. ; Bode, U.
    Springer
    Published 2000
    Staff View
    ISSN:
    1432-1238
    Keywords:
    Key words Procalcitonin ; PCT ; ¶C-reactive protein ; Febrile neutropenia ; Children and cancer ; gramnegative bacteremia
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Objective: Sensitive parameters of inflammations are rare or of limited validity in neutropenic patients. Procalcitonin (PCT) proven to be a sensitive inflammatory marker in nonneutropenic patients was evaluated for its diagnostic relevance in febrile episodes of neutropenic patients with cancer.¶Methods: Plasma levels of PCT were determined by an immunoluminometric assay in children with febrile neutropenic episodes (n = 376) starting at the date of admission until the resolution of fever and were correlated with serum levels of the C-reactive protein (CrP). Febrile episodes were classified as fever of unknown origin (FUO), microbiologically or clinically documented infections and were also differentiated according to the site of the infection (unknown, bacteremia, respiratory, soft tissue, gastrointestinal and urinary tract infection).¶Results: Independently from the aetiology and the site of infection the PCT peak value occurred mostly on the second hospital day and decreased rapidly in cases of successful antibiotic therapy and with the resolution of fever to the normal range (0.1–0.5 μg/l). The highest PCT peak levels at the onset of fever and during the febrile course were observed in patients with gramnegative bacteremia (n = 22, median 12.1 μg/l, range 0.4–568.2 μg/l). There was a positive correlation between PCT peak levels and CrP peak levels (r = 0.48, p = 0.001) which mostly were observed 24 h later than for PCT.¶Conclusions: PCT is a sensitive and specific parameter in the diagnostic and in the sequential assessment of febrile neutropenic episodes, especially in gramnegative infections. Its diagnostic accuracy in neutropenic patients is clearly higher than that of CrP.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s001340051145

    Articles: DFG German National Licenses
  4. 4
    Utsch, B. ; Fleischhack, G. ; Hasan, C. ; Bode, U.
    Springer
    Published 1999
    Staff View
    ISSN:
    1432-1076
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004310051200

    Articles: DFG German National Licenses
  5. 5
    Staff View
    ISSN:
    1435-702X
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract  · Background: The 2.5-year outcome of a 3-year-old girl with a primary intraconjunctival rhabdomyosarcoma treated by biopsy-controlled combined chemo- and brachytherapy is reported. · Methods: The patient presented with a conjunctival dermoid-like lesion which showed modest growth on 1-month follow-up. The first biopsy appointment was missed because of a viral illness. When she showed up 3 months later a further increase in size was obvious and several incisional biopsies were taken immediately. · Results: Light microscopy revealed an undifferentiated subepithelial small cell tumour. On immunohistochemistry the tumour reacted with vimentin and desmin antibodies. Thus, the diagnosis of an embryonal rhabdomyosarcoma was made. The patient underwent 9 cycles of polychemotherapy and the tumour mass disappeared macroscopically. However, immunohistochemistry of incisional biopsies showed residual tumour cells. The latter were eradicated by an individually shaped strontium-90 applicator. · Conclusion: At 2.5 years after biopsy-controlled combined chemotherapy and brachytherapy the patient is free of tumour at a manageable level of complications. This new approach appears to be a good alternative in the treatment of primary conjunctival rhabdomyosarcomas since it takes advantage of the unique location of this rare tumour and avoids hemifacial retardation, known to be induced by external beam radiation.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004170050173

    Articles: DFG German National Licenses