Search Results - (Author, Cooperation:G. Farmer)

2013-10-19

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Class I Phosphatidylinositol 3-Kinases ; *Genetic Predisposition to Disease ; Humans ; Immunologic Deficiency Syndromes/*genetics/immunology/*pathology ; Lymphocytes/immunology ; Mutation ; Pedigree ; Phosphatidylinositol 3-Kinases/*genetics ; Phosphatidylinositol Phosphates/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Respiratory Tract Infections/*genetics/immunology/*pathology

2016-01-29

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

2013-12-18

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Alligators and Crocodiles/physiology ; Animals ; *Biological Evolution ; Birds/physiology ; Bronchi/anatomy & histology/physiology ; Dinosaurs/physiology ; Ecosystem ; Female ; Lizards/anatomy & histology/*physiology ; Lung/anatomy & histology/*physiology ; Phylogeny ; *Respiration

article

2000

Bildung ; Evaluation ; Psychologie ; Kriminologie ; Geschichte (Histor) ; Soziale Arbeit ; Definition ; Fallbeispiel ; Modell ; Organisation ; Strukturanalyse ; Theorie-Praxis-Beziehung

Social work research, Bd. 24 (2000) H. 3, S. 180-189, 1070-5309

English

Tabellen, Literaturangaben

article

2011

Empirische Untersuchung ; Vorurteil ; Vergewaltigung ; Programm ; Sprache ; Messung ; Sexualdelikt ; Soziale Arbeit ; Prävention ; Student ; USA

Social work research, Bd. 35 (2011) H. 2, S. 71-81, 1070-5309

English

Tabellen, Literaturangaben

0888-7543

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Medicine

Electronic Resource

0264-8377

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Electronic Resource

1420-9071

Phenytoin ; fibroblasts ; inositol phosphates ; DNA synthesis

Springer Online Journal Archives 1860-2000

Biology

Medicine

Summary Culture of L-929 fibroblasts in the presence of phenytoin (2.5–5.0 μg/ml) increased DNA synthesis, as indicated by increased [3H]thymidine uptake, while a higher dose (20 μg/ml) inhibited DNA synthesis. In like manner, a low dose of phenytoin (5.0 μg/ml) was effective in increasing inositol 1,4,5-trisphosphate formation while a higher dose (10 μg/ml) tended to inhibit this activity. These data suggest that the formation of inositol phosphate second messengers may play a role in phenytoin-induced fibroblast proliferation and connective tissue growth.

Electronic Resource

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] The primary biochemical defect in VHL is not yet known. We have therefore used genetic-linkage analysis with polymorphic DNA markers as a first step in applying chromosome-specific cloning techniques to the isolation and characterization of the defect. As VHL is associated with inherited ...

Electronic Resource

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] The European Air Chemistry Network (EACN) database used here contains, amongst other data, monthly values for precipitation and nitrate and sulphate concentration2-3. As in ref. 1, extreme outliers in the monthly chemistry data were removed before analysis. Excluding values greater than four ...

Electronic Resource

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] FAURE AND GAC1 have used an unweighted 7-yr running mean of annual Senegal River runoff to predict future rainfall trends in the Sahel. They forecast a return to wetter conditions by 1985. Several questions arise from their analysis. The first is whether the Senegal River runoff reflects Sahelian ...

Electronic Resource

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] The potential importance of climatic change in influencing precipitation acidity has been acknowledged3"6 but not assessed, although significant changes in climate and the atmospheric circulation have occurred in the European area over the past 100 yr (refs 7-9). As the frequency and character of ...

Electronic Resource

1432-0428

Pregnancy ; glucose tolerance test ; blood glucose ; infant ; newborn ; birth weight ; asphyxia neonatorum ; abnormalities

Springer Online Journal Archives 1860-2000

Medicine

Summary To study the effects on the fetus of variations in maternal glucose tolerance, a 25 g rapid intravenous glucose tolerance test was performed at or about 32 weeks gestation in 917 randomly selected nondiabetic women with singleton pregnancies. The results were withheld from the patients and their obstetricians and paediatricians, and no treatment or advice was offered. Fasting plasma glucose and indices of glucose disposal (including a new index which we have termed “summed glucose”) were distributed unimodally, with no evidence of a separate pathological group towards the diabetic end of the distributions. Significant associations were found between maternal glucose metabolism and var ious measures of neonatal nutrition and morbidity, including the incidence of congenital malformations and morbidity related to asphyxia, suggesting that variations within the normal range in maternal glucose metabolism can influence growth and development in the fetus. These relationships were continuous throughout the range of maternal glucose tolerance and were not of predictive value in individual cases.

Electronic Resource

1432-0967

Springer Online Journal Archives 1860-2000

Geosciences

Abstract Nd, Sr and O isotopic data were obtained from silicic ash-flow tuffs and lavas at the Tertiary age (16–9 Ma) Timber (Mountain/Oasis Valley volcanic center (TMOV) in southern Nevada, to assess models for the origin and evolution of the large-volume silicic magma bodies generated in this region. The large-volume (〉900 km3), chemically-zoned, Topopah Spring (TS) and Tiva Canyon (TC) members of the Paintbrush Tuff, and the Rainier Mesa (RM) and Ammonia Tanks (AT) members of the younger Timber Mountain Tuff all have internal Nd and Sr isotopic zonations. In each tuff, high-silica rhyolites have lower initialɛ Nd values (∼1ɛ Nd unit), higher87Sr/86Sr, and lower Nd and Sr contents, than cocrupted trachytes. The TS, TC, and RM members have similarɛ Nd values for high-silica rhyolites (-11.7 to -11.2) and trachytes (-10.5 to -10.7), but the younger AT member has a higherɛ Nd for both compositional types (-10.3 and -9.4). Oxygen isotope data confirm that the TC and AT members were derived from lowɛ Nd magmas. The internal Sr and Nd isotopic variations in each tuff are interpreted to be the result of the incorporation of 20–40% (by mass) wall-rock into magmas that were injected into the upper crust. The lowɛ Nd magmas most likely formed via the incorporation of lowδ 18O, hydrothermally-altered, wall-rock. Small-volume rhyolite lavas and ash-flow tuffs have similar isotopic characteristics to the large-volume ash-flow tuffs, but lavas erupted from extracaldera vents may have interacted with higherδ 18O crustal rocks peripheral to the main magma chamber(s). Andesitic lavas from the 13–14 Ma Wahmonie/Salyer volcanic center southeast of the TMOV have lowɛ Nd (-13.2 to -13.8) and are considered on the basis of textural evidence to be mixtures of basaltic composition magmas and large proportions (70–80%) of anatectic crustal melts. A similar process may have occurred early in the magmatic history of the TMOV. The large-volume rhyolites may represent a mature stage of magmatism after repeated injection of basaltic magmas, crustal melting, and volcanism cleared sufficient space in the upper crust for large magma bodies to accumulate and differentiate. The TMOV rhyolites and 0–10 Ma old basalts that erupted in southern Nevada all have similar Nd and Sr isotopic compositions, which suggests that silicic and mafic magmatism at the TMOV were genetically related. The distinctive isotopic compositions of the AT member may reflect temporal changes in the isotopic compositions of basaltic magmas entering the upper crust, possibly as a result of increasing “basification” of a lower crustal magma source by repeated injection of mantle-derived mafic magmas.

Electronic Resource

1432-1211

Springer Online Journal Archives 1860-2000

Biology

Medicine

Abstract The T-cell mediated immune responses to the male specific minor histocompatibility antigen H-Y in mice have been studied extensively as a model for immune responses to other weak antigens like tumor antigens or autoantigens. In a recent analysis of the strain distribution of the cytotoxic T-cell (Tc-cell) responsiveness to H-Y, it has been found that genes both within and outside the H-2 complex exert an interactive control. Whereas the H-2 b strains all are high responders, independent of their non-H-2 background, other H-2 haplotypes (d, k, and s) only allow for a response if they are combined with certain non-H-2 genes. The H-2-linked immune response genes (Ir-genes) have been previously mapped to the I and K or D region of the H-2 complex, but the mapping of the non-H-2 genes has not yet been established. In this study evidence is presented, using recombinant inbred strains and immunoglobulin heavy chain (Igh) congenic strains of mice, to show that there is more than one non-H-2 Ir-gene involved, that the main controlling genes are not linked to the Igh complex, and that at least one non-H-2 Ir-gene is linked to the H-3 region on chromosome 2. This region includes genes for beta-2-microglobulin (β2m), the Ly-mllalloantigen a polymorphic cell surface glycoprotein (Pgp-1), a B-cell specific antigen Ly-4, a transplantation antigen H-3, and genes (Ir-2) controlling the immune response to Ea-1 and H-13.

Electronic Resource

1573-6865

Springer Online Journal Archives 1860-2000

Biology

Medicine

Summary Both light microscopical and electron microscopical immunocytochemical techniques were utilized to localize CuZnsuperoxide dismutase (SOD) in the duodenum of normal, rachitic and vitamin-D3-replete chicks. This enzyme catalyses the dismutation of the superoxide anion, a toxic free radical generated during the normal aerobic metabolism of most respiring cells. Light microscopy showed no SOD activity associated with the duodenal enterocytes of normal and rachitic chicks. However, in rachitic animals subsequently treated with vitamin D, i.e. vitamin-D-replete chicks, intense immunoreactivity for the enzyme was seen in association with the apical border of the duodenal absorptive cells. Immunostaining for SOD was not seen in goblet cells. With electron microscopy, immunostaining for SOD activity was identified in association with the apical microvilli and, to a lesser degree, with the terminal web, a well as in association with both lysosomes and peroxisomes. From this report it appears that there is a physiological relationship between vitamin D, SOD and the intestinal absorptive cell. However, the precise relationship must await further clarification.

Electronic Resource