Search Results - (Author, Cooperation:E. Howe)
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1Latest Papers from Table of Contents or Articles in PressA. S. Crystal ; A. T. Shaw ; L. V. Sequist ; L. Friboulet ; M. J. Niederst ; E. L. Lockerman ; R. L. Frias ; J. F. Gainor ; A. Amzallag ; P. Greninger ; D. Lee ; A. Kalsy ; M. Gomez-Caraballo ; L. Elamine ; E. Howe ; W. Hur ; E. Lifshits ; H. E. Robinson ; R. Katayama ; A. C. Faber ; M. M. Awad ; S. Ramaswamy ; M. Mino-Kenudson ; A. J. Iafrate ; C. H. Benes ; J. A. Engelman
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-11-15Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Antineoplastic Combined Chemotherapy Protocols/*therapeutic use ; Carcinoma, Non-Small-Cell Lung/*drug therapy/enzymology/genetics ; DNA Mutational Analysis ; Drug Resistance, Neoplasm/*genetics ; Drug Screening Assays, Antitumor ; Enzyme Activation/genetics ; Humans ; Lung Neoplasms/*drug therapy/enzymology/genetics ; MAP Kinase Kinase 1/genetics/metabolism ; Molecular Targeted Therapy/*methods ; Mutation ; *Patient-Specific Modeling ; Protein Kinase Inhibitors/*therapeutic use ; Proto-Oncogene Proteins pp60(c-src)/antagonists & inhibitors ; Pyrimidines/therapeutic use ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Receptor, Epidermal Growth Factor/antagonists & inhibitors ; Receptor, Fibroblast Growth Factor, Type 3/antagonists & inhibitors/genetics ; Sulfones/therapeutic use ; Tumor Cells, CulturedPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 0740-624XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Political ScienceType of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 0001-6918Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PsychologyType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0001-6918Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PsychologyType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0304-4165Keywords: (Heart myofibril) ; Catecholamine ; Light chain ; Myosin ; PhosphorylationSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0304-4165Keywords: (Heart myofibril) ; ATPase ; Ca^2^+ activation ; Cyclic AMP ; Phosphorylation ; TroponinSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0018-2753Topics: HistoryURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0002-9556Topics: PsychologyURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1432-217XSource: Springer Online Journal Archives 1860-2000Topics: SociologyEconomicsNotes: Abstract This paper is concerned with sequences of policies that occur over time in voting models and planning procedures. The framework for our analysis includes assumptions that are satisfied by models in the corresponding literatures, together with other standard assumptions for microeconomic analysis that involve time. The starting point for our analyses is the prespective that results from combining the following (widely held) views: 1) certain voting models and planning procedures can be interpreted as being “non-tatonnement” or “sequential” processes (where each policy in the sequence that is generated is actually experienced by voters or consumers) and 2) an alternative being Pareto optimal in any given period (“temporal Pareto optimality”) is the appropriate efficiency criterion only if the alternative is the final outcome from a tatonnement process-and that, otherwise, one should examine the efficiency of the entire path (using “intertemporal Pareto optimality”). Our first observation about the planning literature is that is has (by and large) neglected the efficiency criterion that is appropriate for the discrete-time procedures that can be interpreted as “non-tatonnement” or “sequential” processes-and that, what's more, such trajectories will (in general) fail to meet this criterion. Our second observation identifies some results that can be used to establish that some of these trajectories will at least be “ultimately” intertemporally Pareto optimal. In our discussion of voting theory, we review Buchanan's opposition to requiring (social) choice consistency for voting procedures-and his argument for this position on (Pareto) efficiency grounds. We then consider voting procedures that can be interpreted as “non-tatonnement” or “sequential” processes and arrive at the conclusion that, in these cases, (i) majority rule cycles are intertemporally Pareto inefficient and (ii) achieving intertemporal Pareto optimality requires choice consistency. We then go on to show that related observations apply to Kramer's normative conclusions about his dynamical model of political equilibrium — and identify some further references where similar observations apply. In the final part of our discussion of voting models, we arrive at the further conclusion that, in the most relevant cases, a trajectory that stays in the temporal Pareto set is not necessarily more desirable (on efficiency grounds) than one that doesn't.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1572-9710Keywords: Sites of Special Scientific Interest in Wales ; upland, lowland and coastal zones ; size variation ; habitat and species diversity ; conservation functionSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: The designation of Sites of Special Scientific Interest (SSSIs) is one of the major statutory measures for wildlife protection in Britain. In this account, procedures for selecting SSSIs are outlined, and the representation of habitats and species in different taxonomic groups which qualify 731 SSSIs notified in Wales (in November 1994) are summarized. Biological SSSIs occupy approximately 9.6% of the total area of Wales. There are significant differences in the numbers and sizes of sites characteristic in the uplands (few large), lowlands (many small) and coast (intermediate). Over 70% of the biological SSSIs have more than one qualifying feature. Most sites (663, 90%) have been selected for one or more habitats, and many sites (328, 45%) have particular species attributes. In relation to their total extent in Wales, some habitats (including ombrotrophic peatland, dwarf-shrub heathland, rich fen and sand dune) have greater proportional representation in SSSIs than others (such as upland grassland, woodland and scrub). These differences reflect conservation priorities for Welsh habitats which are related to the wider British context. As expected, birds and vascular plants contribute to notification of a greater number of sites than other groups; invertebrates, lichens and bryophytes qualify in some sites and require further evaluation in others; except for bats, mammals are comparatively poorly represented as special features. Birds qualify many of the largest SSSIs in Wales (breeding assemblages in the uplands and overwintering wildfowl and waders in estuaries). Possibilities for future refinement of the SSSI series are considered. It is suggested that the establishment of conservation sites is sufficiently advanced in Britain to permit worthwhile examination of the composition and function of the network as a whole against conservation objectives.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1618-2650Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: