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Publication Date: 2018-09-08Publisher: Institute of Physics Publishing (IOP)Electronic ISSN: 1748-0221Topics: PhysicsPublished by: -
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Publication Date: 2018-05-04Publisher: Institute of Physics Publishing (IOP)Electronic ISSN: 1748-0221Topics: PhysicsPublished by: -
3K. Howe ; M. D. Clark ; C. F. Torroja ; J. Torrance ; C. Berthelot ; M. Muffato ; J. E. Collins ; S. Humphray ; K. McLaren ; L. Matthews ; S. McLaren ; I. Sealy ; M. Caccamo ; C. Churcher ; C. Scott ; J. C. Barrett ; R. Koch ; G. J. Rauch ; S. White ; W. Chow ; B. Kilian ; L. T. Quintais ; J. A. Guerra-Assuncao ; Y. Zhou ; Y. Gu ; J. Yen ; J. H. Vogel ; T. Eyre ; S. Redmond ; R. Banerjee ; J. Chi ; B. Fu ; E. Langley ; S. F. Maguire ; G. K. Laird ; D. Lloyd ; E. Kenyon ; S. Donaldson ; H. Sehra ; J. Almeida-King ; J. Loveland ; S. Trevanion ; M. Jones ; M. Quail ; D. Willey ; A. Hunt ; J. Burton ; S. Sims ; K. McLay ; B. Plumb ; J. Davis ; C. Clee ; K. Oliver ; R. Clark ; C. Riddle ; D. Elliot ; G. Threadgold ; G. Harden ; D. Ware ; S. Begum ; B. Mortimore ; G. Kerry ; P. Heath ; B. Phillimore ; A. Tracey ; N. Corby ; M. Dunn ; C. Johnson ; J. Wood ; S. Clark ; S. Pelan ; G. Griffiths ; M. Smith ; R. Glithero ; P. Howden ; N. Barker ; C. Lloyd ; C. Stevens ; J. Harley ; K. Holt ; G. Panagiotidis ; J. Lovell ; H. Beasley ; C. Henderson ; D. Gordon ; K. Auger ; D. Wright ; J. Collins ; C. Raisen ; L. Dyer ; K. Leung ; L. Robertson ; K. Ambridge ; D. Leongamornlert ; S. McGuire ; R. Gilderthorp ; C. Griffiths ; D. Manthravadi ; S. Nichol ; G. Barker ; S. Whitehead ; M. Kay ; J. Brown ; C. Murnane ; E. Gray ; M. Humphries ; N. Sycamore ; D. Barker ; D. Saunders ; J. Wallis ; A. Babbage ; S. Hammond ; M. Mashreghi-Mohammadi ; L. Barr ; S. Martin ; P. Wray ; A. Ellington ; N. Matthews ; M. Ellwood ; R. Woodmansey ; G. Clark ; J. Cooper ; A. Tromans ; D. Grafham ; C. Skuce ; R. Pandian ; R. Andrews ; E. Harrison ; A. Kimberley ; J. Garnett ; N. Fosker ; R. Hall ; P. Garner ; D. Kelly ; C. Bird ; S. Palmer ; I. Gehring ; A. Berger ; C. M. Dooley ; Z. Ersan-Urun ; C. Eser ; H. Geiger ; M. Geisler ; L. Karotki ; A. Kirn ; J. Konantz ; M. Konantz ; M. Oberlander ; S. Rudolph-Geiger ; M. Teucke ; C. Lanz ; G. Raddatz ; K. Osoegawa ; B. Zhu ; A. Rapp ; S. Widaa ; C. Langford ; F. Yang ; S. C. Schuster ; N. P. Carter ; J. Harrow ; Z. Ning ; J. Herrero ; S. M. Searle ; A. Enright ; R. Geisler ; R. H. Plasterk ; C. Lee ; M. Westerfield ; P. J. de Jong ; L. I. Zon ; J. H. Postlethwait ; C. Nusslein-Volhard ; T. J. Hubbard ; H. Roest Crollius ; J. Rogers ; D. L. Stemple
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-04-19Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Chromosomes/genetics ; Conserved Sequence/*genetics ; Evolution, Molecular ; Female ; Genes/genetics ; Genome/*genetics ; Genome, Human/genetics ; Genomics ; Humans ; Male ; Meiosis/genetics ; Molecular Sequence Annotation ; Pseudogenes/genetics ; Reference Standards ; Sex Determination Processes/genetics ; Zebrafish/*genetics ; Zebrafish Proteins/geneticsPublished by: -
4Layadi, A. ; Artman, J. O. ; Hoffman, R. A. ; Jensen, C. L. ; Saunders, D. A. ; Hall, B. O.
[S.l.] : American Institute of Physics (AIP)
Published 1990Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: The magnetic coupling of 20-nm-thick Ni and Ni78Fe22 films through intervening Ag film has been investigated by ferromagnetic resonance (FMR) at 33 GHz. Films were deposited by e-beam evaporation on glass in the order glass/Ag/Ni/Ag/NiFe/Ag. The Ag over- and underlays were 20 nm thick; the central Ag-film thickness was varied between 0 and 20 nm. The coupling of the two ferromagnetic films, A and B, through the interface is modeled by adding −KMA⋅MB to the free energy per unit area. The FMR-mode positions are found from the solutions of a quadratic in K. Subsequently, FMR-mode intensities and linewidths are computed. Input data for these calculations were obtained from observations made on uncoupled Ni and NiFe films. From in-plane dc-field date a variation of K was deduced with a coupling film thickness t of the form exp(−t/τ) with τ equal to 2.68 nm. Limited FMR data taken with the dc field normal to the specimen are consistent with a weak coupling, K∼t−0.83. Little coupling was found in a glass/SiO2/Ni/SiO2/NiFe/SiO2 sequence with the SiO2 films spanning the same thickness range as the Ag in the first sequence. It is believed that the coupling in Ni/Ag/NiFe is dominated by conduction-electron-spin polarization. Some of the coupling may be magnetostatic in origin.Type of Medium: Electronic ResourceURL: -
5Layadi, A. ; Artman, J. O. ; Hall, B. O. ; Hoffman, R. A. ; Jensen, C. L. ; Chakrabarti, D. J. ; Saunders, D. A.
[S.l.] : American Institute of Physics (AIP)
Published 1988Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: We have used ferromagnetic resonance (FMR) at 33 GHz to study the properties of a number of evaporated thin Fe film systems. Values for effective anisotropy field HKeff , g value, and exchange constant A were derived. For Fe on glass, ||HKeff || was found to increase with increasing thickness. These changes were attributed to stress which decreased with film thickness. The presence of a Cu or a Ti underlayer did not seem to affect HKeff for films grown at room temperature. However, Fe/Ti/glass films made at higher substrate temperatures, Ts, did show an increase in ||HKeff ||. The appearance of a spin-wave mode in the Fe films enables us to compute the exchange constant A for Fe, A=(2.12±0.14)×10−6 ergs cm−1. The coupling between two thin Fe films through an intervening Cu layer was investigated. A model predicting the number and position of the peaks in the spectrum as a function of coupling is presented. From experiment it was observed that the coupling remains almost constant through the 50–5-nm Cu thickness range but rises sharply at 2-nm Cu thickness.Type of Medium: Electronic ResourceURL: -
6SAUNDERS, D. M. ; MATHEWS, M. ; LANCASTER, P. A. L.
Oxford, UK : Blackwell Publishing Ltd
Published 1988Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
7SINOSICH, M. J. ; BONIFACIO, M. D. ; SAUNDERS, D. M.
Oxford, UK : Blackwell Publishing Ltd
Published 1988Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
8Staff View
ISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Oxygen saturation was measured by pulse oximetry in 33 psychiatric patients breathing air during recovery from 60 episodes of electroconvulsive therapy. Desaturation to less than 90% occurred in 17% of patients. Oxygen saturation values in recovery were significantly lower than pre-operative saturations (p = 0.0014 using ANOVA), with a significant difference (p = 0.001) for up to 5min in recovery.Type of Medium: Electronic ResourceURL: -
9DAYKIN, A. P. ; BOWEN, D. J. ; SAUNDERS, D. A. ; NORMAN, J.
Oxford, UK : Blackwell Publishing Ltd
Published 1986Staff ViewISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The effects of intravenous morphine (10 mg/70 kg) on the ventilatory response to CO2 were studied in two groups of subjects, young (18-29 years) and old (66-85 years), prior to elective surgery. In both groups morphine caused a signijcant depression of respiration as judged by a reduction in the slope of the CO2 response curve. a reduction in the calculated ventilation at an end tidal CO2 tension of 7.3 kPa, a rise in resting end tidal CO2 and a rise in the CO2 threshold. There were no significant differences between the two groups in the changes produced by the drug, suggesting that acute respiratory depression after a single intravenous injection of morphine is similar in old and young people.Type of Medium: Electronic ResourceURL: -
10Thomas, V. L. ; Sutton, D. N. ; Saunders, D. A.
Oxford, UK : Blackwell Publishing Ltd
Published 1988Staff ViewISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Fifty women of ASA grade 1 or 2 scheduled to undergo minor gynaecological procedures were allocated randomly to two groups. Group A received fentanyl 100 μg intravenously before induction; group B received no sedative or analgesie drugs. Anaesthesia was induced with propofol intravenously and maintained using 67% nitrous oxide in oxygen with incremental doses of propofol. Induction lime and dose were significantly less and mean arterial pressure decreased significantly lower in Group A. These differences were, however, small and the ranges of values were large. The incidence of side effects and subjective assessment of quality of anaesthesia were similar in both groups. Fentanyl did not confer any practical advantage when used with propofol in the techniques described above.Type of Medium: Electronic ResourceURL: -
11ALVAREZ, M. DOLORES ; SAUNDERS, D. E. J. ; VINCENT, J. F. V. ; JERONIMIDIS, G.
Oxford, UK : Blackwell Publishing Ltd
Published 2000Staff ViewISSN: 1745-4603Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Process Engineering, Biotechnology, Nutrition TechnologyNotes: Precise measurements of the deformation and fracture behaviour of food can be difficult because of problems associated with the produce, for example, sample preparation, gripping, size and geometry. The aim of this study was to characterise fruits and vegetables in terms of fracture properties using an established engineering test method and geometry, the Single-Edge Notched Bend (SENB). The SENB geometry was found to be readily applicable to crisp food produce such as carrots, celery, and apples, which exhibit linear elastic behaviour up to fracture. Fracture toughness and fracture energies were found to be in the range 10–50 kPa m1/2 and 40–400 Jm−2, respectively. The structure of these materials was confirmed, using confocal microscopy, and related to the observed fracture behaviour. Cell size and intercellular spaces influenced the values of fracture toughness and fracture energy.Type of Medium: Electronic ResourceURL: -
12VINCENT, J. F. V. ; SAUNDERS, D. E. J. ; BEYTS, P.
Oxford, UK : Blackwell Publishing Ltd
Published 2002Staff ViewISSN: 1745-4603Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Process Engineering, Biotechnology, Nutrition TechnologyNotes: A simple test from materials science, in which a notched beam is bent so that the notch increases in length due to the propagation of a crack, allows determination of a parameter called the Critical Stress Intensity Factor in Mode I fracture, KIC, by means of which the conditions under which the crack will propagate can be quantified. This is shown to track sensory hardness of several apples, carrot, celery and cucumber with remarkable precision, a result predicted by theoretical analysis due to Lucas et al. (2002). Hardness and crunchiness are shown to be indistinguishable and therefore must be identical. Therefore, a mechanical test can reliably replace a sensory test resulting in quicker, cheaper and more accurate estimate of a sensory parameter.Type of Medium: Electronic ResourceURL: -
13Staff View
ISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: Stresses at the edge of an ion-implanted region in a magnetic garnet film have been calculated by analogy with thermal-induced stresses in an elastic half space. From these stresses, magnetoelastic anisotropies have been computed for two different implant profiles. Stress calculations show that stress relaxation near an implantation edge decreases with distance from the edge with an exponential decay length of approximately 4t, where t is the implantation layer thickness. Stress perpendicular to the film surface and shearing stress are significant at the implantation edge, but decrease more quickly with decay lengths of approximately 0.8t and 0.6t, respectively. Because of perpendicular and shearing stresses, the anisotropy under the edge of the implantation mask favors planar magnetization. For similar reasons, the anisotropy in the implanted region near the mask edge favors perpendicular magnetization, effectively causing a shift in the mask edge toward the [112¯] direction. The shift is especially evident in materials with λ111≠λ100 and is on the order of 2.5t for a material with λ111=−λ100.Type of Medium: Electronic ResourceURL: -
14Fernandez-de-Castro, J. J. ; Mowry, G. S. ; Ding, J. ; Giusti, J. ; Saunders, D.
[S.l.] : American Institute of Physics (AIP)
Published 1997Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: As the recording industry increases areal density every year, a magnetoresistive-soft adjacent layer (MR-SAL) head design is desirable with the following qualities: easy to be fabricated in large volume, capable of consistent and stable device-to-device performance, and enough signal to noise ratio to perform at high recording densities and data rates. A new type of MR head with these attributes is described for an areal density equal to 1444 Mb/in.2. The off-track characteristics of this MR head are determined by the sensor edge design which is defined by a permanent magnet (PM) layer. Improved off-track performance was achieved by substituting the spacer layer with the PM outside of the active sensor area. Excellent boundary control stabilization was obtained by the ferromagnetic exchange coupling between the PM and, the SAL and the MR layers. The bit error rate and electrical test results showed acceptable performance at 175 kbpi and 8250 tpi. The above MR head had average values of low frequency amplitude (LFA), PW50, read width and write width equal to 900 μV, 12.4, 72, and 107 μin., respectively. The low frequency symmetry (LFSYM) was 1.1 (Vpos/Vneg) and the position error off-track capability was 26 μin. Finally, the LFA covariance (σ/avg) was found to be 0.22% and the microtrack had no bumps or side lobes. These results indicate that this design and its implementation produce stable heads that can perform on and off track at 1444 Mb/in.2. ©1997 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
15Staff View
ISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
16Hunyor, S. N. ; Saunders, D. M. ; Bellamy, G. R. ; Roffe, D. ; Harford, E. ; Helfgott, A.
Oxford, UK : Blackwell Publishing Ltd
Published 1982Staff ViewISSN: 1440-1681Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: 1. Venous compliance and plasma volume were measured in thirty-one continuously normotensive women early (11-20 weeks) and late (31-40 weeks) in pregnancy and following delivery.2. Mathematically fitted pressure/volume curves, obtained by venous occlusion plethysmography, were analysed according to two describing functions (i) the peak of the first derivative dv/dp max and (ii) a work index, ∫2510p dv.3. The relationship between venous/volume factors seen after delivery, was disturbed during pregnancy, at which time the work index provided evidence for decreased venous compliance.4. Pregnancy could be regarded as a potentially hypertensive state, brought about by a vascular/volume mismatch.Type of Medium: Electronic ResourceURL: -
17Staff View
ISSN: 0167-5923Topics: SociologyURL: -
18Staff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
19Staff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Each ovary of G. morsitans consists of two poly-trophic ovarioles, each at a different stage of development4. Only one egg matures at a time, and a sequence of ovulation occurs so that the first and third eggs are ovulated from the right ovary and the second and fourth eggs from the left ovary. ...Type of Medium: Electronic ResourceURL: -
20Staff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Dissections of teneral females were carried out in 0-9 per cent saline on a microscope slide. The ovarian sheaths were stripped off with a fine needle and the two ovarioles in each ovary released (Fig. 1, a, b). The slide was then drained of the excess saline and the ovaries mounted directly in a ...Type of Medium: Electronic ResourceURL: