Search Results - (Author, Cooperation:D. R. Robinson)

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  1. 1
    Staff View
    Publication Date:
    2012-06-23
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Cell Proliferation ; Cells, Cultured ; Hepatocyte Nuclear Factor 3-alpha/genetics ; Humans ; Male ; Molecular Sequence Data ; Mutation ; Orchiectomy ; Prostatic Neoplasms/*genetics/pathology ; Receptors, Androgen/metabolism ; Sequence Alignment ; Signal Transduction
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    PRADEL, L. ; BONHIVERS, M. ; ROBINSON, D. R.

    Oxford, UK : Blackwell Science Inc
    Published 2005
    Staff View
    ISSN:
    1550-7408
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Notes:
    All eukaryote cells have cell cycle stages through which they must pass in order to undergo growth, development and division (e.g. G1, S, G2, M, and C). Transition through these stages is controlled by numerous proteins, including cyclin-dependent kinases. Trypanosoma brucei is a parasitic protozoan of global, medical and agricultural importance that does not have many of the classical cell cycle checkpoints found in other eukaryotes such as cell arrest when mitosis is blocked. However, previous work has identified flagellum basal body separation as a novel cell cycle checkpoint in this organism. Essentially, if basal bodies do not separate cell division is blocked. From in silico database searches we have identified a T. brucei protein (we have named TbNEK1), with high homology to NIMA-related kinase family of proteins of Aspergillus nidulans. We have cloned, expressed and made antibodies to this protein, which is located to the basal bodies. In vivo over-expression of TbNEK1 in T. brucei induces cell cycle modifications resulting in the formation of multiple basal bodies, loss of kinetoplast segregation, multinuclated cells and cell division block. These results suggest the role of TbNEK1 is, in part, to modulate basal body replication or function, which subsequently leads to secondary effects that block progression through the cell cycle.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1550-7408.2005.05202003_3_15.x

    Articles: DFG German National Licenses
  3. 3
    Tanvir, N. R. ; Shanks, T. ; Ferguson, H. C. ; Robinson, D. R. T.

    [s.l.] : Nature Publishing Group
    Published 1995
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] New Nubble Space Telescope observations of Cepheid variable stars in the nearby galaxy M96 give a distance to the host galaxy group, Leo I, of 11.6 ± 0.8 Mpc. This value, used in conjunction with several reliable secondary indicators of relative distance, constrains the distances to more ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/377027a0

    Articles: DFG German National Licenses
  4. 4
    Robinson, D. R. ; Dayer, J.-M. ; Krane, S. M.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1979
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1749-6632.1979.tb47122.x

    Articles: DFG German National Licenses