Search Results - (Author, Cooperation:D. Nowak)

2018-01-25

National Academy of Sciences

0027-8424

1091-6490

Biology

Medicine

Natural Sciences in General

2011-09-13

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Alternative Splicing/genetics ; Exome/genetics ; Hematopoiesis/genetics ; Humans ; Mutation/*genetics ; Myelodysplastic Syndromes/*genetics ; Nuclear Proteins/genetics ; Polymorphism, Single Nucleotide/genetics ; RNA Splice Sites/genetics ; RNA Splicing/*genetics ; Ribonucleoproteins/genetics ; Spliceosomes/genetics

2020-04-20

SOLAR II ist das zweite Follow-up einer bevölkerungsbezogenenden Kohorten-Studie. Diese Studie basiert auf einer Kohorte, die 1995/1996 aus damals 9-11jährigen Kindern aus Dresden und München zusammengestellt wurde. Die inzwischen erwachsenen Teilnehmer wurden nun erneut mit dem Ziel untersucht, Zusammenhänge zwischen beruflichen Expositionen und Allergien und Atemwegserkrankungen zu ermitteln. Ein Schwerpunkt der Auswertung galt der Frage, wie sich aus Risikofaktoren, die bereits in der Kindheit erkennbar sind, vorhersagen lässt, dass sich bei Tätigkeitsbeginn in Berufen mit hoher Exposition eine Allergie oder eine Atemwegserkrankung entwickeln wird. Mit den Ergebnissen der Studie kann nicht begründet werden, Jugendlichen mit Risikofaktoren für allergische Atemwegserkrankungen grundsätzlich von Tätigkeiten mit hohem Expositions-Potenzial abzuraten. Die Autoren sprechen sich aber für eine engmaschige arbeitsmedizinische Betreuung junger Erwachsener aus, die am Beginn einer solchen Tätigkeit stehen.

Medizin und Gesundheit ; Wirtschaft ; Medicine and health ; Economics ; Medizin, Sozialmedizin ; Berufsforschung, Berufssoziologie ; Medicine, Social Medicine ; Occupational Research, Occupational Sociology ; Allergie ; Epidemiologie ; Krankheit ; junger Erwachsener ; Jugendlicher ; Berufseinmündung ; Berufswahl ; soziale Faktoren ; Risiko ; Kindheit ; Arbeitsmedizin ; Bayern ; Sachsen ; Bundesrepublik Deutschland ; allergy ; epidemiology ; illness ; young adult ; adolescent ; career start ; occupational choice ; social factors ; risk ; childhood ; occupational medicine ; Bavaria ; Saxony ; Federal Republic of Germany

Abschlussbericht, final report

1398-9995

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Background: The aim of the present study was to determine the distribution of mite allergens in pig-farming environments in comparison to urban homes and the relationship between exposure to mite allergens and sensitization to the respective allergens in 100 pig farmers with work-related respiratory symptoms. Methods: The concentration of storage mite (Lep d 2) and house-dust-mite (Der p 1, and Der f 1, Der 2) allergens in dust collected from five different sampling sites (floor, wall, grain mill, transit floor, and farmers' mattresses) was studied in relationship to the respective sensitization rates. Allergen concentrations in the mattresses were compared to those determined in mattresses from 22 urban dwellers. Results: Median concentrations of Der p 1 and Der 2 in the mattresses of the farmers were significantly higher than in the urban dwellers' samples (53.4 μg/g dust vs 1.05 μg/g dust, P=0.001; 19.6 μg/g dust vs 2.2 μg/g dust, P〈0.0001, respectively). Allergen concentrations in the transit areas were strongly related to bedroom exposure. In a multiple logistic regression model, a weak but significant relationship between Der p 1 exposure and sensitization to Der p 1 was found. Despite these findings, the prevalence of sensitization to mite allergens in the farmers (18%) was comparable to the prevalence in the general population. Conclusions: Allergen exposure at the work place is strongly related to the concentration of allergens in farmers' beds. Exposure to domestic mite allergens should be taken into account when assessing occupational exposure to allergens and the respiratory health of farmers.

Electronic Resource

2018-03-09

American Physical Society (APS)

1098-0121

1095-3795

Physics

Inhomogeneous, disordered, and partially ordered systems

2018-06-05

BMJ Publishing

2044-6055

Medicine

Open access, Occupational and environmental medicine

2018-03-30

American Society of Hematology (ASH)

0006-4971

1528-0020

Biology

Medicine

Transplantation, Lymphoid Neoplasia

2018-03-16

American Heart Association (AHA)

1942-325X

1942-3268

Medicine

Arrhythmias, Sudden Cardiac Death, Stem Cells, Translational Studies, Cardiomyopathy

1471-4159

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Reactive oxygen species are produced as a consequence of normal aerobic metabolism and could be important causative agents of a number of human diseases. Human serum contains many different antioxidants that may have importance of maintenance of antioxidant screen. Blood samples were obtained from healthy volunteers, at young (20–35 years) and old (36–60 years) age. Plasma was prepared and assayed within 3 h from blood collection and analyzed for the antioxidant capacity. At a low pH a ferric tripyridyltriazine (Fe3+-TPTZ) complex is reduced to the ferrous (Fe2+) form that causes changes of sample absorbance at 593 nm. The plasma antioxidant capacity of young and old group corresponded to 22.69 ± 0.86 and 17.59 ± 1.17 μmol of Trolox (a water-soluble analog of vitamin E). Young group had significantly higher ferric reducing/antioxidant power value than old subjects. These suggest that plasma antioxidant capacity declines with volunteers age.Acknowledgement:  The study was financed by a 502-11-809 Med. Univ. grant.

Electronic Resource

1471-4159

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Oxidative stress, initiated by reactive oxygen species is recognized as a pathogenic factor in a variety of organs, e.g. brain, heart, gastric, duodenum, lung. The aim of this study was to estimate plasma TAC of healthy volunteers aged 35–60 years and patients with chronic obstructive pulmonary disease (POCHP). The ferric reducing/antioxidant power (FRAP) assay was used to measure the TAC of human blood plasma. At a low pH a ferric tripyridyltiazine (Fe3+-TPTZ) complex is reduced to the ferrous (Fe2+) form that causes changes at 593 nm. The antioxidant capacity of the control plasma corresponded to 17.59 ± 1.17 μmol of Trolox activity (a water-soluble analog of vitamin E). The antioxidant capacity of the plasma obtained from patients with POCHP corresponded to 23.82 ± 1.82 μmol of Trolox activity and was higher (P 〈 0.02) than from healthy volunteers. This may represent the adaptive response to oxidative stress related to chronic inflammation.Acknowledgement:  This study was financed by a 502-11-809 grant.

Electronic Resource

1745-4557

Blackwell Publishing Journal Backfiles 1879-2005

Process Engineering, Biotechnology, Nutrition Technology

The effect of predrying treatment and conditions of storage on color stability of dried onion was investigated. The variety of onion had little effect on color stability, but storage time prior to drying affected the color of the dried onion. Steeping of sliced onion in water or dipping in starch solution lessened browning and allowed for longer storage. Ascorbic acid in the steeping solution yielded dried onion with a pink unacceptable color. Osmotic dewatering imparted a yellow color to the onion, but improved the color stability of the dried product. Light was an important variable in the storage stability of dried onion.

Electronic Resource

1365-2222

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Background Lower frequencies of asthma and hayfever have been observed in children with contact to livestock. At school age, the amount of endotoxin measured in the dust of children's mattresses is inversely related to the occurrence of atopic asthma, hayfever and atopic sensitization both in children from farming and non-farming households.Objective The aim of the present study was to investigate which home and lifestyle characteristics of farm and non-farm families contribute to endotoxin levels measured in different indoor home environments.Methods In the framework of the Allergy and Endotoxin (ALEX) Study, endotoxin was measured in dust samples from the living room floor and the child's mattress of 319 farmers' families and 493 non-farming families, and in settled dust from stables. Endotoxin content of all dust samples was determined by a kinetic Limulus assay (Limulus-Amebocyte-Lysate test). Information about the child's activities on farms, home characteristics and cleaning behaviours was obtained from parental questionnaires.Results Endotoxin levels in stables did not predict the amount of endotoxin measured in floors or mattresses. However, a dose-dependent association between the child's activity on the farm and indoor home endotoxin levels was observed, both in farm and non-farm children. In non-farm children pet keeping and the frequency of floor cleaning were additionally associated with endotoxin levels, whereas in farm children parental farm activities, study area, time since last cleaning, the mattress type as well as younger age of the children contributed to increased microbial exposure.Conclusion These results demonstrate that regular contact to farm animals increases indoor home endotoxin concentrations, both in farm and non-farm children, and might thus explain the protective effect of contact to livestock on atopic outcomes. To assess children's individual exposure to a microbial environment, measures of mattress dust exposure are needed as stable endotoxin concentrations were not associated with indoor home levels.

Electronic Resource

1365-2222

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Background Within the context of the hygiene hypothesis, we aimed to study the potential association between farming-related risk factors and Toxoplasma gondii (T. gondii) as well as Helicobacter pylori (H. pylori) seropositivity.Methods The study included questionnaire data and serum samples of 321 young adults living in a rural environment. Serum samples were analysed for specific IgE to a common panel of aeroallergens (SX1) as well as IgG against T. gondii and H. pylori.Results Regular contact with animal stables before the age of 3 years (odds ratio (OR) (95% confidence interval): 2.0 [1.0; 4.0]) and unpasteurized milk consumption at age 6 years (1.8 [1.0; 3.3]) were the strongest risk factors for T. gondii infection. None of the farming-related factors were significantly associated with H. pylori infection. Current consumption of raw farm milk was not significantly associated with H. pylori infection (2.1 [0.8; 5.3]). Regular contact with animal houses before the age of 7 years was the strongest predictor for atopy (0.49 [0.26–0.96]). The reduction in risk could not be further decreased by any other factor under consideration. After adjustment for animal house contact, the OR for atopy was decreased by raw milk consumption and H. pylori infection in an additive manner.Conclusion Exposure to farming environments in childhood might predict T. gondii seropositivity in rural subjects. Nevertheless, the strongest predictor for atopy in rural subjects seems to be regular contact with farm animals. Whether T. gondii infection is an intermediate factor in the association between farm contact and atopy needs to be confirmed in larger studies.

Electronic Resource

1365-2222

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

1398-9995

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Background:  An increasing number of studies report pet exposure to be associated with lower risk of asthma and allergies. This ‘protective pet effect’ has been suggested to result from a modified T-helper (Th)2-cell response, or because of increased microbial load in homes where pets are kept. We examined the associations between pet contact and the occurrence of asthma and allergies in children of the rural Allergy and Endotoxin (ALEX) population, taking farm animal contact, endotoxin and cat allergen levels in mattress dust into account.Methods:  Information about contact with pets and farm animals, asthma and allergy were collected for 812 children by a standardized parents’ questionnaire and an interview. Mattress dust endotoxin and cat allergen levels as well as specific IgE and IgG4 antibodies to Fel d1 were determined.Results:  Current contact with dogs was inversely associated with diagnosed hay fever (OR 0.26, 95% CI 0.11–0.57), diagnosed asthma (OR 0.29, 95% CI 0.12–0.71), sensitization to cat allergen (OR 0.48, 95% CI 0.23–0.99) and to grass pollen (OR 0.55, 95% CI 0.33–0.94), but not with increased IgG4 levels. Early and current contact with cats were associated with reduced risk of wheezing (OR 0.48, 95% CI 0.23–1.00, and OR 0.49, 95% CI 0.26–0.92, respectively) and grass pollen sensitization. Adjustment for farm animal contact but not for endotoxin and cat allergen exposure attenuated these associations and the effect of pet was stronger among farmers’ children.Conclusion:  Although pet exposure was very frequent in this rural population, the inverse relation between current dog contact, asthma and allergy was mostly explained by simultaneously occurring exposure to stable animals or was restricted to farm children. In addition, a subtle form of pet avoidance may contribute to the protective effect of pet.

Electronic Resource

1398-9995

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

1398-9995

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Background: Three workers engaged in the manufacture of natural thickener products (Cassia spp., guar, and tamarind flour) were occupationally sensitized to Cassia spp. Therefore, a cross-sectional study on the prevalence of sensitization among and respiratory health of the employees of this plant was conducted. Methods and Results: Sixty-two workers (36 with high, 26 with low exposure) participated in the survey. Skin prick tests and specific IgE tests with extracts of these components revealed that 11.3% were sensitized to Cassia spp. and 9.7% to at least one species of storage mites, with a significantly higher portion of atopic subjects in the sensitized group. Overall, 55% of the subjects reported work-related symptoms (upper and lower airways, eyes, or skin). FVC % pred. was significantly lower in highly exposed workers, while RV % pred. and RV%TLC % pred. were significantly higher in this group. In the multivariate model, sensitization was not a risk factor for impairment of lung function. Conclusions: Dust exposure to flours may not only cause allergic sensitization but also induce chronic changes in lung function.

Electronic Resource

0891-5849

Ambroxol ; Antioxidant ; Deoxyribose oxidation ; Free radicals ; Lipid peroxidation ; Monochlorodimedon chlorination

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Medicine

Electronic Resource

0020-711X

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Electronic Resource

0009-2614

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Physics

Electronic Resource