Search Results - (Author, Cooperation:D. G. Evans)
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1Latest Papers from Table of Contents or Articles in PressE. Ruark ; K. Snape ; P. Humburg ; C. Loveday ; I. Bajrami ; R. Brough ; D. N. Rodrigues ; A. Renwick ; S. Seal ; E. Ramsay ; V. Duarte Sdel ; M. A. Rivas ; M. Warren-Perry ; A. Zachariou ; A. Campion-Flora ; S. Hanks ; A. Murray ; N. Ansari Pour ; J. Douglas ; L. Gregory ; A. Rimmer ; N. M. Walker ; T. P. Yang ; J. W. Adlard ; J. Barwell ; J. Berg ; A. F. Brady ; C. Brewer ; G. Brice ; C. Chapman ; J. Cook ; R. Davidson ; A. Donaldson ; F. Douglas ; D. Eccles ; D. G. Evans ; L. Greenhalgh ; A. Henderson ; L. Izatt ; A. Kumar ; F. Lalloo ; Z. Miedzybrodzka ; P. J. Morrison ; J. Paterson ; M. Porteous ; M. T. Rogers ; S. Shanley ; L. Walker ; M. Gore ; R. Houlston ; M. A. Brown ; M. J. Caufield ; P. Deloukas ; M. I. McCarthy ; J. A. Todd ; C. Turnbull ; J. S. Reis-Filho ; A. Ashworth ; A. C. Antoniou ; C. J. Lord ; P. Donnelly ; N. Rahman
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-12-18Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alleles ; Breast Neoplasms/*genetics ; Cluster Analysis ; Exons ; Female ; Genetic Predisposition to Disease/*genetics ; Humans ; Isoenzymes/genetics ; Lymphocytes/metabolism ; *Mosaicism ; *Mutation ; Ovarian Neoplasms/*genetics ; Phosphoprotein Phosphatases/*genetics ; Sequence Analysis, DNA ; Tumor Suppressor Protein p53/metabolismPublished by: -
2Latest Papers from Table of Contents or Articles in PressChew, W., Moorakonda, R. B., Courtney, E., Soh, H., Li, S. T., Chen, Y., Shaw, T., Allen, J. C., Evans, D. G. R., Ngeow, J.
BMJ Publishing Group
Published 2018Staff ViewPublication Date: 2018-04-28Publisher: BMJ Publishing GroupPrint ISSN: 0022-2593Electronic ISSN: 1468-6244Topics: MedicinePublished by: -
3Latest Papers from Table of Contents or Articles in PressInnes, J., Reali, L., Clayton-Smith, J., Hall, G., Lim, D. H., Burghel, G. J., French, K., Khan, U., Walker, D., Lalloo, F., Evans, D. G. R., McMullan, D., Maher, E. R., Woodward, E. R.
BMJ Publishing Group
Published 2018Staff ViewPublication Date: 2018-01-25Publisher: BMJ Publishing GroupPrint ISSN: 0022-2593Electronic ISSN: 1468-6244Topics: MedicineKeywords: Genetic screening / counsellingPublished by: -
4Latest Papers from Table of Contents or Articles in PressEvans, D. G., Woodward, E., Harkness, E. F., Howell, A., Plaskocinska, I., Maher, E. R., Tischkowitz, M. D., Lalloo, F.
BMJ Publishing Group
Published 2018Staff ViewPublication Date: 2018-06-26Publisher: BMJ Publishing GroupPrint ISSN: 0022-2593Electronic ISSN: 1468-6244Topics: MedicinePublished by: -
5Articles: DFG German National LicensesEvans, D. G. ; Coalson, R. D.
College Park, Md. : American Institute of Physics (AIP)
Published 1994Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: Separation of a many-body system into a primary system plus a bath of background modes enables approximate calculation of electronic absorption spectra and zero-temperature resonance Raman scattering cross sections in cases where there is nonadiabatic coupling between two or more Born–Oppenheimer excited-state potential surfaces. In particular, the low-resolution optical line shape theory recently developed to describe curve-crossing phenomena [D. G. Evans and R. D. Coalson, J. Chem. Phys. 99, 6264 (1993)] is extended to systems where there is a primary nuclear coordinate mode that is characterized by large excited-state displacements and an ensemble of weakly displaced bath modes. The accuracy of the resulting approximation scheme is illustrated using the spectroscopic spin-boson model, in which all surfaces are harmonic, and path integral techniques can be used to obtain exact results. Application to more complicated systems is discussed.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: The short-time charge transfer evolution following photoexcitation in mixed valence compounds is studied using path integral calculations. Due to the large nonadiabatic coupling, path integral calculations using direct path summation techniques are inadequate, and charge transfer dynamics can only be computed using a transfer matrix technique developed by Makri and Makarov. The resulting relaxation is considerably slower than that predicted by low-order perturbation theory. The effects of the solvent on the decay process, and the validity of the golden rule to predict the dynamics of the decay process are investigated. The effects of preparing an initial state that is not a rovibrational state of the acceptor potential energy surface is also examined. These exact calculations show that the large electronic mixing gives rise to very fast oscillations in the electronic state population as the wave function oscillates coherently between the donor and acceptor. This is followed by a slower relaxation induced by the coupling to the dissipative solvent modes, which occurs on time scales ≤100 fs. This information provides insight into the mechanism for oscillations observed in time-resolved transient spectra of these compounds, and suggests substantial limitations of the golden rule picture. © 1998 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesKalyanaraman, C. ; Evans, D. G.
College Park, Md. : American Institute of Physics (AIP)
Published 2001Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: Photo-induced electron transfer experiments examine intrinsically nonequilibrium processes. A theoretical description of photoinduced processes should take into account the fact that the approximations and assumptions made for equilibrium electron transfer need not be appropriate. Under nonequilibrium conditions, anharmonic distortions in the potential energy surfaces of nuclear motion coupled to the electron transfer may effect the dynamics. This work is a study of the effects of anharmonicity on photo-induced electron transfer reactions for condensed phase systems where one vibrational mode is strongly coupled to the electron transfer and a stochastic bath. For this vibrational mode, both harmonic and anharmonic potential energy surfaces for the excited states are considered and the electron transfer dynamics is monitored in a range of system–bath coupling regimes. The study focuses on two effects due to anharmonic distortions of the intramolecular modes: changes to the system Hamiltonian, and differences in the dephasing processes caused by the anharmonic distortions. These calculations show that for small differences in the donor and acceptor state energies, the effects of vibrational anharmonicity is very small. However, when this energy difference is large, the dynamics for anharmonic and harmonic modes is significant. The relative role played by the competing physical processes is easily understood by examining the vibronic state populations obtained using a multistate Redfield approach. © 2001 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesThakker, N. S. ; Evans, D. G. R. ; Homer, K. ; Davies, D. R. ; Armstrong, J. ; Guy, S. ; Harris, R. ; Sloan, P.
Oxford, UK : Blackwell Publishing Ltd
Published 1996Staff ViewISSN: 1600-0714Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Early identification and prophylactic surgery are essential in preventing development of malignancy in colorectal polyps in familial adenomatous polyposis (FAP). Previous studies indicate a 100% cumulative risk of developing colonic polyps in individuals with FAP by the age of 34 yr. However, we have previously reported late-onset and non-penetrance of polyposis in four families. We describe here in detail one of these families with florid oral manifestations detectable on panoramic radiography of the jaws, which were instrumental in the diagnosis of FAP in the index patient and for ascertainment of her family for screening. The pathological adenomatous polyposis coli (APC) gene mutation in this family was shown to segregate with dento-osseous changes. Panoramic jaw radiography is a common examination carried out prior to dental or oral surgical procedures. This case illustrates the importance of appropriate investigations, including family history and colonoscopy, even in relatively older patients with radiological findings such as those described here and in members of their families at risk of FAP.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1570-7458Source: Springer Online Journal Archives 1860-2000Topics: BiologyDescription / Table of Contents: Résumé Un appareil a été construit en vue d'étudier le comportement des larves et nymphes d'Aedes taeniorhynchus soumises à un gradient de température, sous des conditions d'éctairement uniforme. Les larves étaient élevées à une température de 30° et soumises au test avec ou sans possibilité de se nourrir avant ou pendant les périodes d'observation. Les larves nonalimentées manifestaient un preferendum pour des limites de température plus larges et légèrement plus basses que celles observées avec des larves nourries. Ces dernières, à tous les stades larvaires, montrent un preferendum de 30° à 38°, mais le calcul de la température moyenne préférée révèle un accroissement progressif avec l'âge, passant de 31°8 au 1er stade larvaire à 34°6 au début du 4ème stade larvaire. Les larves du 4ème stade, peu avant la nymphose, préfèrent une température légèrement plus basse (moyenne de 33°). Dans un élevage, maintenu pendant plusieurs années au laboratoire à une température de 27°, les larves du début du 4ème stade montrent une réponse presque identique à celles provenant de femelles capturées dans la nature. Quand les larves sont élevées pendant une génération à 24° en lieu de 30° la moyenne du preferendum thermique pour les jeunes larves du 4ème stade est légèrement plus faible (33°5 au lieu de 34°6). Des observations au moyen de photographies par flash électronique montrent que le preferendum thermique est le même à la lumière ou à l'obsurité.Notes: Abstract An apparatus was built to investigate the behavior of Aedes taeniorhynchus larvae and pupae under uniform illumination in a temperature gradient. Larvae were reared at 30.0° C and tested with and without access to food prior to and during the periods of observation. Preferred ranges for starved larvae were greater and spread over slightly lower temperatures than those selected by fed individuals. Fed larvae in all instars preferred the same approximate range, from 30° to 38°, but calculated average preferred temperatures disclosed a progressive increase with age, from 31.8° in the first instar to 34.6° in the early fourth instar. Late fourthinstar larvae (approaching pupation) chose slightly cooler temperatures (average of 33.0°). Animals from a laboratory colony cultured for several years at 27.0° gave, in the early fourth instar, a response almost identical to that shown by progeny of wild-caught females. When temperature for early fourth-instar larvae was slightly lower (33.5° compared with 34.6°). Observations by means of flash photography showed that the range of temperature selected by fed early fourth-instar larvae in total darkness was the same as under uniform illumination.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1572-9680Keywords: agroforestry ; alley cropping ; human ecology ; home gardens ; soil conservation ; Sri Lanka ; uplandsSource: Springer Online Journal Archives 1860-2000Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Abstract The use of contour hedgerows of woody legumes to control soil erosion has been promoted amongst smallholders in the Upper Mahaweli catchment of Sri Lanka since 1988. The success of this program depends greatly on the properties of the different production systems occupying the alleys created by these hedgerows such as: profitability, time taken for profit to be realized, labour requirements, seasonal distribution of labour, environmental and economic stability, biophysical sustainability, the contribution of the system to the domestic needs of the farm family, adoptability of the system and successful management of the hedgerows. These properties were used to evaluate seven desktop farm models with different combinations of: seasonal crops, coffee-pepper intercrop, fodder-dairy, woodlot, and analog forest established in the alleys. The analog forest is a perennial polyculture which, like the traditional forest garden, is structurally and functionally analogous to the natural forest. It was found that a model with 40% seasonal crops, 20% perennial crops (coffee-pepper) and 40% analog forest made the best compromise between the properties under consideration. It is recognized that the socio-economic conditions that determine the appropriateness of this model in the Sri Lankan context are not universal and the extension of the analog forest concept into other tropical uplands is discussed.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1432-1076Keywords: Cytomegalovirus ; Ganciclovir ; Nephrotic syndromeSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract A case of congenital cytomegalovirus infection acquired by intra-uterine blood transfusion and complicated by the nephrotic syndrome is described. Experience with the use of the antiviral agent ganciclovir is reported.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1432-8798Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesHazell, S. L. ; Markesich, D. C. ; Evans, D. J. ; Evans, D. G. ; Graham, D. Y.
Springer
Published 1989Staff ViewISSN: 1435-4373Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Experiments were designed to determine the role of heme and the importance of other factors in the growth ofCampylobacter pylori. Campylobacter pylori strains were tested for their ability to synthesize porphyrin, for their ability to grow and be maintained on basal medium and basal medium supplemented with blood or blood products, and for the influence of bovine serum albumin and catalase on viability. Results indicated thatCampylobacter pylori does not require heme as a source of porphyrin. Growth ofCampylobacter pylori could not be sustained on media containing starch or hemoglobin, but was sustained on media containing erythrocytes, serum, bovine serum albumin or catalase. The ability to grow on media containing bovine serum albumin and catalase suggests that protection from toxic fatty acids and the prevention of toxic product formation may be important factors in the growth and survival ofCampylobacter pylori in vitro. Both bovine serum albumin and catalase combined provide the minimum requirements which allow the spectrum ofCampylobacter pylori present in a single culture to grow on blood-free media.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesHan, S. W. ; Flamm, R. ; Hachem, C. Y. ; Kim, H. Y. ; Clarridge, J. E. ; Evans, D. G. ; Beyer, J. ; Drnec, J. ; Graham, D. Y.
Springer
Published 1995Staff ViewISSN: 1435-4373Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Various transport and storage conditions for the recovery ofHelicobacter pylori from gastric biopsies were evaluated. Gastric mucosal biopsies from 16Helicobacter pylori-infected patients were stored in cysteine-Albimi medium containing 20 % glycerol in a refrigerator (4°C) for 1 and 2 weeks and in a −20°C laboratory freezer for 4 and 12 weeks. Two clinical isolates were stored in saline, Stuart's transport media, cysteine-Albimi broth with 20 % glycerol, brucella broth with 20 % glycerol and skim milk with 17 % glycerol at room temperature, 4°C, −20°C and −70°C. Storage at 4°C for 1 and 2 weeks resulted inHelicobacter pylori recovery from 81 % and 19 % of biopsies, respectively. Storage at −20°C yieldedHelicobacter pylori recovery in 100 % and 57 % after 4 and 12 weeks, respectively. At room temperature after 6 h, theHelicobacter pylori titer was reduced. The best storage media for frozen isolates were skim milk/glycerol, brucella broth/glycerol and cysteine-Albimi/glycerol (in descending order). Recovery was better at −70°C than −20°C.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1435-4373Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Immunoprotection against diarrhea caused by colonization factor antigen/I (CFA/I)-positive, human-associated, enterotoxigenicEscherichia coli was investigated using the adult rabbit intestinal temporary ligation technique. An oral dose of 1×108 viable cells of enterotoxigenicEscherichia coli strain H-10407 (078:H11:CFA/I) produced diarrhea in all animals challenged. Rabbits allowed to survive this challenge dose were re-challenged approximately six weeks later with the result that four of seven (57 %) did not develop diarrhea. Peroral immunization of rabbits with purified CFA/I elicited protection against challenge with strain H-10407; this protection was dose-related and CFA/I-specific. Immunoprotection did not correlate with a systemic antibody response. CFA/I produced a relatively poor immune response in terms of the number of IgM- and IgG-producing cells in the lamina propria of the animals but did elicit a vigorous increase in the number of intestinal IgA- and anti-CFA/I-producing cells. There was a highly significant inverse relationship between the number of IgA- and anti-CFA/I-producing cells in the lamina propria of the rabbits and the diarrhea response to the challenge strain H-10407 (correlation coefficients of −0.616 and −0.678 respectively). It is concluded that anti-CFA/I antibody, probably of the IgA class, is the major immune response to orally administered CFA/I and that this response is highly immunoprotective.Type of Medium: Electronic ResourceURL: