Search Results - (Author, Cooperation:D. Bumann)

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  1. 1
    P. Wild ; H. Farhan ; D. G. McEwan ; S. Wagner ; V. V. Rogov ; N. R. Brady ; B. Richter ; J. Korac ; O. Waidmann ; C. Choudhary ; V. Dotsch ; D. Bumann ; I. Dikic
    American Association for the Advancement of Science (AAAS)
    Published 2011
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    Publication Date:
    2011-05-28
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adaptor Proteins, Signal Transducing/metabolism ; *Autophagy ; Cell Line, Tumor ; Cytosol/*microbiology ; HeLa Cells ; Humans ; Immunity, Innate ; Microtubule-Associated Proteins/metabolism ; Models, Biological ; Nuclear Proteins/chemistry/metabolism ; Phosphorylation ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein-Serine-Threonine Kinases/metabolism ; RNA Interference ; Salmonella typhimurium/*growth & development/immunology ; Transcription Factor TFIIIA/chemistry/genetics/*metabolism ; Ubiquitin/metabolism
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2014-04-18
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Autophagy/immunology ; Caspases/*metabolism ; Cytosol/microbiology ; Enzyme Activation ; GTP Phosphohydrolases/*metabolism ; Galectins/immunology ; Gram-Negative Bacteria/growth & development/*immunology/pathogenicity ; Immunity, Innate/immunology ; Inflammasomes/immunology/*metabolism ; Interferon Type I/*immunology ; Lipopolysaccharides/immunology ; Mice ; Phagosomes/immunology/microbiology ; Salmonella typhimurium/growth & development/immunology ; Vacuoles/*microbiology
    Published by:
    http://www.nature.com/

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  3. 3
    Jungblut, P. R. ; Bumann, D. ; Haas, G. ; Zimny-Arndt, U. ; Holland, P. ; Lamer, S. ; Siejak, F. ; Aebischer, A. ; Meyer, T. F.

    Oxford, UK : Blackwell Science Ltd
    Published 2000
    Staff View
    ISSN:
    1365-2958
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Medicine
    Notes:
    Helicobacter pylori, the causative agent of gastritis, ulcer and stomach carcinoma, infects approximately half of the worlds population. After sequencing the complete genome of two strains, 26695 and J99, we have approached the demanding task of investigating the functional part of the genetic information containing macromolecules, the proteome. The proteins of three strains of H. pylori, 26695 and J99, and a prominent strain used in animal models SS1, were separated by a high-resolution two-dimensional electrophoresis technique with a resolution power of 5000 protein spots. Up to 1800 protein species were separated from H. pylori which had been cultivated for 5 days on agar plates. Using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) peptide mass fingerprinting we have identified 152 proteins, including nine known virulence factors and 28 antigens. The three strains investigated had only a few protein spots in common. We observe that proteins with an amino acid exchange resulting in a net change of only one charge are shifted in the two-dimensional electrophoresis (2-DE) pattern. The expression of 27 predicted conserved hypothetical open reading frames (ORFs) and six unknown ORFs were confirmed. The growth conditions of the bacteria were shown to have an effect on the presence of certain proteins. A preliminary immunoblotting study using human sera revealed that this approach is ideal for identifying proteins of diagnostic or therapeutic value. H. pylori 2-DE patterns with their identified protein species were added to the dynamic 2D-PAGE database (). This basic knowledge of the proteome in the public domain will be an effective instrument for the identification of new virulence or pathogenic factors, and antigens of potentially diagnostic or curative value against H. pylori.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1365-2958.2000.01896.x

    Articles: DFG German National Licenses
  4. 4
    Staff View
    ISSN:
    0009-2614
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/S0009-2614(91)85079-C

    Articles: DFG German National Licenses
  5. 5
    Bumann, D. ; Hueck, C. ; Aebischer, T. ; Meyer, T.F.

    Oxford, UK : Blackwell Publishing Ltd
    Published 2000
    Staff View
    ISSN:
    1574-695X
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Medicine
    Notes:
    Live attenuated Salmonella spp. are promising candidates as oral vaccine delivery systems for heterologous antigens. Clinical trials have demonstrated that this approach is feasible for human vaccinations but further optimisation is necessary to obtain a better efficacy. Here, we discuss how existing clinical and pre-clinical data can be used to guide such optimisation efforts.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1574-695X.2000.tb01450.x

    Articles: DFG German National Licenses
  6. 6
    Staff View
    ISSN:
    1569-8041
    Keywords:
    lymphoma ; positron emission tomography ; residual mass ; 18-fluorodeoxyglucose (FDG)
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Background: PET using 18fluorodesoxyglucose (FDG) mayoffer the possibility of differentiating vital from necrotic residual masses. Patients and methods: Seventeen patients with HD and 17 patients withNHL underwent FDG-PET following therapy. According to staging by routinemethods at diagnosis, 7 patients presented stage I, 13 stage II, 5 stage III,and 9 stage IV. A dose of 250–400 MBq FDG was injected and whole-bodyPET was performed 30–60 minutes later. Results: Residual mass was found in 32 patients with routine methods.FDG-PET was negative in 17 patients, who were considered to be in CR. None ofthem relapsed (median follow-up 63 weeks). FDG-PET was positive in 17patients. Sixteen patients had residual mass with routine methods. Fourpatients received radiation after PET. Their median follow-up is 58 weekswithout relapse. Two other patients with lasting CR had FDG uptake outside theresidual mass – one with confirmed pneumonia. Five patients hadhistologically confirmed lymphoma, 2 patients relapsed according to routinemethods. One patient is likely to be false positive because of fracture atlymphoma site. Seven of 10 patients with FDG uptake in the residual mass aftercompleted therapy relapsed. According to routine restaging, 2 patientsachieved CR. In 1 patient an additional focus was found in the humerus inspite of normal scintigraphy with histologically confirmed lymphoma. Therewere no false-negative results, but 3 false-positive results inside and 2false-positive results outside the residual mass after completed therapy. Conclusion: PET performed for evaluation of residual mass aftertreatment of lymphoma has a high predictive value.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1023/A:1008253917337

    Articles: DFG German National Licenses
  7. 7
    Staff View
    Publication Date:
    2018-05-26
    Publisher:
    The American Society for Microbiology (ASM)
    Print ISSN:
    0066-4804
    Electronic ISSN:
    1098-6596
    Topics:
    Biology
    Medicine
    Published by:
    http://www.asm.org/

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