Search Results - (Author, Cooperation:C. Wright)
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1Martin, H. C., Jones, W. D., McIntyre, R., Sanchez-Andrade, G., Sanderson, M., Stephenson, J. D., Jones, C. P., Handsaker, J., Gallone, G., Bruntraeger, M., McRae, J. F., Prigmore, E., Short, P., Niemi, M., Kaplanis, J., Radford, E. J., Akawi, N., Balasubramanian, M., Dean, J., Horton, R., Hulbert, A., Johnson, D. S., Johnson, K., Kumar, D., Lynch, S. A., Mehta, S. G., Morton, J., Parker, M. J., Splitt, M., Turnpenny, P. D., Vasudevan, P. C., Wright, M., Bassett, A., Gerety, S. S., Wright, C. F., Fitz; Patrick, D. R., Firth, H. V., Hurles, M. E., Barrett, J. C., on behalf of the Deciphering Developmental Disorders Study
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-12-07Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Genetics, Medicine, DiseasesPublished by: -
2Nimmervoll, B. V., Boulos, N., Bianski, B., Dapper, J., De; Cuypere, M., Shelat, A., Terranova, S., Terhune, H. E., Gajjar, A., Patel, Y. T., Freeman, B. B., Onar-Thomas, A., Stewart, C. F., Roussel, M. F., Guy, R. K., Merchant, T. E., Calabrese, C., Wright, K. D., Gilbertson, R. J.
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-04-04Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
3Riva, A., Patel, V., Kurioka, A., Jeffery, H. C., Wright, G., Tarff, S., Shawcross, D., Ryan, J. M., Evans, A., Azarian, S., Bajaj, J. S., Fagan, A., Patel, V., Mehta, K., Lopez, C., Simonova, M., Katzarov, K., Hadzhiolova, T., Pavlova, S., Wendon, J. A., Oo, Y. H., Klenerman, P., Williams, R., Chokshi, S.
BMJ Publishing Group
Published 2018Staff ViewPublication Date: 2018-04-07Publisher: BMJ Publishing GroupPrint ISSN: 0017-5749Electronic ISSN: 1468-3288Topics: MedicineKeywords: Open access, GutPublished by: -
4Dodd, W., Tang, L., Lone, J.-C., Wimberly, K., Wu, C.-W., Consalvo, C., Wright, J. E., Pujol, N., Choe, K. P.
Genetics Society of America (GSA)
Published 2018Staff ViewPublication Date: 2018-04-05Publisher: Genetics Society of America (GSA)Print ISSN: 0016-6731Topics: BiologyPublished by: -
5B. J. Fowler ; B. D. Gelfand ; Y. Kim ; N. Kerur ; V. Tarallo ; Y. Hirano ; S. Amarnath ; D. H. Fowler ; M. Radwan ; M. T. Young ; K. Pittman ; P. Kubes ; H. K. Agarwal ; K. Parang ; D. R. Hinton ; A. Bastos-Carvalho ; S. Li ; T. Yasuma ; T. Mizutani ; R. Yasuma ; C. Wright ; J. Ambati
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-11-22Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Alu Elements ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/*pharmacology/therapeutic use ; Apoptosis/drug effects ; Carrier Proteins/metabolism ; Caspase 1/metabolism ; Choroidal Neovascularization/drug therapy ; Disease Models, Animal ; Geographic Atrophy/drug therapy ; Graft vs Host Disease/drug therapy ; Hepatitis/drug therapy ; Inflammasomes/*drug effects ; Liver/drug effects ; Mice ; Receptors, Purinergic P2X7/metabolism ; Retinal Pigment Epithelium/drug effects/metabolism/physiology ; Reverse Transcriptase Inhibitors/*pharmacology/therapeutic usePublished by: -
6C. Schwitzer ; L. Chikhi ; G. Donati ; M. Irwin ; S. E. Johnson ; R. A. Mittermeier ; H. Peacock ; J. Ratsimbazafy ; J. Razafindramanana ; E. E. Louis, Jr. ; I. C. Colquhoun ; J. Tinsman ; R. Dolch ; M. Lafleur ; S. Nash ; E. Patel ; B. Randrianambinina ; T. Rasolofoharivelo ; P. C. Wright
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-04-26Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; *Endangered Species ; *Extinction, Biological ; *Lemur ; MalePublished by: -
7C. Schwitzer ; R. A. Mittermeier ; S. E. Johnson ; G. Donati ; M. Irwin ; H. Peacock ; J. Ratsimbazafy ; J. Razafindramanana ; E. E. Louis, Jr. ; L. Chikhi ; I. C. Colquhoun ; J. Tinsman ; R. Dolch ; M. LaFleur ; S. Nash ; E. Patel ; B. Randrianambinina ; T. Rasolofoharivelo ; P. C. Wright
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-02-22Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; *Endangered Species ; *Extinction, Biological ; *Lemur ; Madagascar ; Male ; RiskPublished by: -
8Z. Zhou ; A. T. Tang ; W. Y. Wong ; S. Bamezai ; L. M. Goddard ; R. Shenkar ; S. Zhou ; J. Yang ; A. C. Wright ; M. Foley ; J. S. Arthur ; K. J. Whitehead ; I. A. Awad ; D. Y. Li ; X. Zheng ; M. L. Kahn
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-03-31Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: ADAM Proteins/metabolism ; Animals ; Animals, Newborn ; Carrier Proteins/genetics/metabolism ; Disease Models, Animal ; Endothelial Cells/enzymology/*metabolism ; Female ; Hemangioma, Cavernous, Central Nervous System/etiology/*metabolism/pathology ; Humans ; Kruppel-Like Transcription Factors/deficiency/*metabolism ; MAP Kinase Kinase Kinase 3/deficiency/*metabolism ; *MAP Kinase Signaling System ; Male ; Mice ; Protein Binding ; rho GTP-Binding Proteins/metabolismPublished by: -
9Yongping Fu, Weihao Zheng, Xiaoxia Wang, Matthew P. Hautzinger, Dongxu Pan, Lianna Dang, John C. Wright, Anlian Pan, Song Jin
American Chemical Society (ACS)
Published 2018Staff ViewPublication Date: 2018-11-09Publisher: American Chemical Society (ACS)Print ISSN: 0002-7863Electronic ISSN: 1520-5126Topics: Chemistry and PharmacologyPublished by: -
10M. W. Carroll ; D. A. Matthews ; J. A. Hiscox ; M. J. Elmore ; G. Pollakis ; A. Rambaut ; R. Hewson ; I. Garcia-Dorival ; J. A. Bore ; R. Koundouno ; S. Abdellati ; B. Afrough ; J. Aiyepada ; P. Akhilomen ; D. Asogun ; B. Atkinson ; M. Badusche ; A. Bah ; S. Bate ; J. Baumann ; D. Becker ; B. Becker-Ziaja ; A. Bocquin ; B. Borremans ; A. Bosworth ; J. P. Boettcher ; A. Cannas ; F. Carletti ; C. Castilletti ; S. Clark ; F. Colavita ; S. Diederich ; A. Donatus ; S. Duraffour ; D. Ehichioya ; H. Ellerbrok ; M. D. Fernandez-Garcia ; A. Fizet ; E. Fleischmann ; S. Gryseels ; A. Hermelink ; J. Hinzmann ; U. Hopf-Guevara ; Y. Ighodalo ; L. Jameson ; A. Kelterbaum ; Z. Kis ; S. Kloth ; C. Kohl ; M. Korva ; A. Kraus ; E. Kuisma ; A. Kurth ; B. Liedigk ; C. H. Logue ; A. Ludtke ; P. Maes ; J. McCowen ; S. Mely ; M. Mertens ; S. Meschi ; B. Meyer ; J. Michel ; P. Molkenthin ; C. Munoz-Fontela ; D. Muth ; E. N. Newman ; D. Ngabo ; L. Oestereich ; J. Okosun ; T. Olokor ; R. Omiunu ; E. Omomoh ; E. Pallasch ; B. Palyi ; J. Portmann ; T. Pottage ; C. Pratt ; S. Priesnitz ; S. Quartu ; J. Rappe ; J. Repits ; M. Richter ; M. Rudolf ; A. Sachse ; K. M. Schmidt ; G. Schudt ; T. Strecker ; R. Thom ; S. Thomas ; E. Tobin ; H. Tolley ; J. Trautner ; T. Vermoesen ; I. Vitoriano ; M. Wagner ; S. Wolff ; C. Yue ; M. R. Capobianchi ; B. Kretschmer ; Y. Hall ; J. G. Kenny ; N. Y. Rickett ; G. Dudas ; C. E. Coltart ; R. Kerber ; D. Steer ; C. Wright ; F. Senyah ; S. Keita ; P. Drury ; B. Diallo ; H. de Clerck ; M. Van Herp ; A. Sprecher ; A. Traore ; M. Diakite ; M. K. Konde ; L. Koivogui ; N. Magassouba ; T. Avsic-Zupanc ; A. Nitsche ; M. Strasser ; G. Ippolito ; S. Becker ; K. Stoecker ; M. Gabriel ; H. Raoul ; A. Di Caro ; R. Wolfel ; P. Formenty ; S. Gunther
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-06-18Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
11Staff View
ISSN: 1432-0843Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Thirteen patients with hepatic tumors, from the Boston Center for Liver Transplantation, have been transplanted among a total of 169 recipients. Ten were transplanted primarily for tumor, while three other patients harbored incidental tumors. Two perioperative deaths occurred (15%). Eight patients had hepatocellular carcinoma, one hepatoblastoma and four bile duct (Klatskin) tumors. Two of the bile duct cancers recurred with patient deaths at 9 and 10 months. The remaining nine patients are alive from between 1 month and 36 months postoperatively. A selected review of the literature allowed analysis of followup on 185 patients transplanted for tumor. Overall, the proportion of patients transplanted for tumor was 16%. Fifty-two percent of patients had hepatocellular carcinomas (HCC), 24% cholangiocarcinomas, 10% other primary liver tumors, and 14% metastatic hepatic tumors. Median survival for HCC was 1 year; 90-day mortality was 30%. Actuarial survival for 1, 2 and 3 years was 49%, 37% and 30% respectively. Fibrolamellar HCC and incidental HCC had significantly better results than other HCC. Tumor recurrence was present in 72% of autopsies after 90 days. Transplantation for HCC has satisfactory results in selected patients and may be improved by adjuvant chemotherapy. The median survival with cholangiocarcinomas was 8 months; 90-day mortality was 40%. Actuarial survival for 1 year was 36%. Recurrence was present in 100% of autopsies after 90 days. Survival after transplantation for this tumor was similar to that observed in patients not undergoing surgical treatment. Median survival for 18 other primary hepatic tumors was 16 months. Transplantation in carefully selected patients with these other primary tumors appears warranted. Although experience overall with transplantation for metastatic disease has been relatively unfavorable, each histological type must be considered independently.Type of Medium: Electronic ResourceURL: -
12Staff View
ISSN: 0017-789XTopics: General, InterdisciplinaryURL: -
13Staff View
ISSN: 0193-3973Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PsychologyType of Medium: Electronic ResourceURL: -
14Staff View
ISSN: 1432-2323Source: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Résumé Les tumeurs de la partie supérieure de l'abre biliaire vont de pair avec un taux de résection très faible et une survie de courte durée par rapport aux autres localisations tumorales biliaires. Des 25 malades qui subirent une résection pour ce type de lésion, 3 ont été traités par une hépatectomie droite étendue, 6 par une hépatectomie gauche, et 16 par une résection après dissection des éléments de la triade portale. Le taux global de mortalité fut de 4%, aucun opéré n'étant décédé après résection hépatique. La survie actuarielle à 1, 3, et 5 ans fut respectivement de 84%, de 44%, et de 35%, tous les décès survenant au decours de l'intervention étant le fait du processus néoplasique. La survie fut plus longue chez les malades opérés à titre curatif que les malades opérés à titre palliatif. La survie fut plus longue après lobectomie hépatique qu'après résection-squelettisation, ce fait ne revÊtant pas de signification statistique. Le taux de survie après résection hépatique fut meilleur que le taux de survie après les différentes interventions palliatives; la qualité de la vie après résection fut également supérieure. Les auteurs aboutissent à la conclusion que la résection représente l'opération de choix pour tenter de guérir ce type de cancer mais elle n'est justifiée que si la mortalité post-opératoire est faible. Les méthodes de sélection des malades susceptibles de la subir sont exposées comme sont décrites les techniques opératoires pratiquées.Abstract: Resumen Los tumores del tercio proximal del canal biliar están asociados con las tasas más bajas de resectabilidad y la más pobre supervivencia entre todos los tumores de la vía biliar. De 25 pacientes que fueron sometidos a resección por tumores de localización proximal, se realizó lobectomía derecha ampliada en 3, lobectomía izquierda en 6, y resección por esqueletización en 16. La mortalidad operatoria global fue de 4% y de 0 para la resección hepática. La supervivencia actuarial a 1, 3, y 5 años fue de 84%, 44%, y 35%, respectivamente, y casi todos los pacientes murieron con enfermedad presente. La supervivencia fue más prolongada en los pacientes con resección curativa que en los pacientes con resección paliativa. La supervivencia fue más prolongada después de lobectomía hepática que de resección por esqueletización, pero la diferencia no llegó a tener significancia estadística. La supervivencia de los 25 pacientes que fueron sometidos a resección se compara favorablemente con la supervivencia de 131 pacientes tratados estrictamente con procedimientos paliativos y la calidad de la vida de los pacientes con resección también fue mejor. Nuestra conclusión es que la resección agresiva para curación es el procedimiento de elección en pacientes seleccionados con cáncer de la vía biliar proximal, pero que ésta debe ser realizada con una baja mortalidad operatoria para que tenga justificación. Se describen los criterios actuales de selección junto con las técnicas operatorias.Notes: Abstract Tumors in the proximal third of the bile duct are associated with the lowest rates of resectability and poorest survival of tumors in all locations in the duct. Of 25 patients who underwent resection for tumors located proximally, 3 had extended right hepatic lobectomy, 6 had left hepatic lobectomy, and 16 had skeletonization resection. The operative mortality rate was 4% overall and 0 for patients undergoing hepatic resection. Actuarial survival at 1, 3, and 5 years was 84%, 44%, and 35%, respectively, with almost all patients dying with disease. Survival was longer for patients who had curative resection than for those who had palliative resection. Survival was longer after hepatic lobectomy than after skeletonization resection but was not statistically significant. Survival for the 25 patients who underwent resection compared favorably with the survival of 131 patients treated by strictly palliative procedures, and the quality of life for patients with resection was also improved. We conclude that aggressive resection for cure is the procedure of choice in selected patients with proximal bile duct cancer, but that it must be performed with low operative mortality. Current patient selection and operative techniques are described.Type of Medium: Electronic ResourceURL: -
15Staff View
ISSN: 0037-7732Topics: SociologyNotes: BOOK REVIEWSURL: -
16Staff View
ISSN: 0010-2601Topics: General, InterdisciplinaryTheology and Religious StudiesURL: -
17Staff View
Publication Date: 2018-05-10Publisher: Institute of Physics Publishing (IOP)Electronic ISSN: 1748-0221Topics: PhysicsPublished by: -
18Bankaitis, E. D., Bechard, M. E., Gu, G., Magnuson, M. A., Wright, C. V. E.
The Company of Biologists
Published 2018Staff ViewPublication Date: 2018-09-29Publisher: The Company of BiologistsPrint ISSN: 0950-1991Electronic ISSN: 1477-9129Topics: BiologyPublished by: -
19Sanchez-Arevalo Lobo, V. J., Fernandez, L. C., Carrillo-de-Santa-Pau, E., Richart, L., Cobo, I., Cendrowski, J., Moreno, U., del Pozo, N., Megias, D., Breant, B., Wright, C. V., Magnuson, M., Real, F. X.
BMJ Publishing Group
Published 2018Staff ViewPublication Date: 2018-03-09Publisher: BMJ Publishing GroupPrint ISSN: 0017-5749Electronic ISSN: 1468-3288Topics: MedicinePublished by: -
20Wright, C. D. ; Heyes, N. A. E. ; Clegg, W. W.
[S.l.] : American Institute of Physics (AIP)
Published 1991Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: In the search for a directly overwritable magneto-optic recording system, that based upon the magnetic field modulation method looks quite favorable. This approach also enables submicron domains to be written, so increasing attainable storage densities. Here we report on the results of such field modulation studies performed in situ using our magneto-optical scanning laser microscope (SLM). Bit patterns were recorded in TbFeCo films by continuous laser irradiation coupled with the application of an alternating magnetic field supplied by a small, purpose built electromagnet having a peak field of approximately 4 kOe. The recorded domain structures were then imaged using the SLM in its polar Kerr mode. Recorded patterns were overwritten and the resulting bit patterns observed.Type of Medium: Electronic ResourceURL: