Search Results - (Author, Cooperation:C. Richter)
-
1M. N. Hopkinson ; C. Richter ; M. Schedler ; F. Glorius
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-06-27Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
2L. Li ; C. Richter ; S. Paetel ; T. Kopp ; J. Mannhart ; R. C. Ashoori
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-05-14Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
3Juratli, T. A., Stasik, S., Zolal, A., Schuster, C., Richter, S., Daubner, D., Juratli, M. A., Thowe, R., Hennig, S., Makina, M., Meinhardt, M., Lautenschlaeger, T., Schackert, G., Krex, D., Thiede, C.
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-11-02Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
4F. J. Hernandez-Molina ; D. A. Stow ; C. A. Alvarez-Zarikian ; G. Acton ; A. Bahr ; B. Balestra ; E. Ducassou ; R. Flood ; J. A. Flores ; S. Furota ; P. Grunert ; D. Hodell ; F. Jimenez-Espejo ; J. K. Kim ; L. Krissek ; J. Kuroda ; B. Li ; E. Llave ; J. Lofi ; L. Lourens ; M. Miller ; F. Nanayama ; N. Nishida ; C. Richter ; C. Roque ; H. Pereira ; M. F. Sanchez Goni ; F. J. Sierro ; A. D. Singh ; C. Sloss ; Y. Takashimizu ; A. Tzanova ; A. Voelker ; T. Williams ; C. Xuan
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-06-14Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Atlantic Ocean ; *Climate Change ; Mediterranean Sea ; Paleontology ; *Seawater ; *Water MovementsPublished by: -
5L. Kuerten, E. Fillis-Tsirakis, C. Richter, J. Mannhart, and H. Boschker
American Physical Society (APS)
Published 2018Staff ViewPublication Date: 2018-08-16Publisher: American Physical Society (APS)Print ISSN: 1098-0121Electronic ISSN: 1095-3795Topics: PhysicsKeywords: Superfluidity and superconductivityPublished by: -
6H. Palike ; M. W. Lyle ; H. Nishi ; I. Raffi ; A. Ridgwell ; K. Gamage ; A. Klaus ; G. Acton ; L. Anderson ; J. Backman ; J. Baldauf ; C. Beltran ; S. M. Bohaty ; P. Bown ; W. Busch ; J. E. Channell ; C. O. Chun ; M. Delaney ; P. Dewangan ; T. Dunkley Jones ; K. M. Edgar ; H. Evans ; P. Fitch ; G. L. Foster ; N. Gussone ; H. Hasegawa ; E. C. Hathorne ; H. Hayashi ; J. O. Herrle ; A. Holbourn ; S. Hovan ; K. Hyeong ; K. Iijima ; T. Ito ; S. Kamikuri ; K. Kimoto ; J. Kuroda ; L. Leon-Rodriguez ; A. Malinverno ; T. C. Moore, Jr. ; B. H. Murphy ; D. P. Murphy ; H. Nakamura ; K. Ogane ; C. Ohneiser ; C. Richter ; R. Robinson ; E. J. Rohling ; O. Romero ; K. Sawada ; H. Scher ; L. Schneider ; A. Sluijs ; H. Takata ; J. Tian ; A. Tsujimoto ; B. S. Wade ; T. Westerhold ; R. Wilkens ; T. Williams ; P. A. Wilson ; Y. Yamamoto ; S. Yamamoto ; T. Yamazaki ; R. E. Zeebe
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-08-31Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: *Altitude ; Atmosphere/chemistry ; Calcium Carbonate/*analysis ; *Carbon Cycle ; Carbon Dioxide/analysis ; Diatoms/metabolism ; Foraminifera/metabolism ; Geologic Sediments/chemistry ; Global Warming/history/statistics & numerical data ; History, 21st Century ; History, Ancient ; Marine Biology ; Oxygen/metabolism ; Pacific Ocean ; Seawater/*chemistry ; TemperaturePublished by: -
7M. Battiato, J. Minár, W. Wang, W. Ndiaye, M. C. Richter, O. Heckmann, J.-M. Mariot, F. Parmigiani, K. Hricovini, and C. Cacho
American Physical Society (APS)
Published 2018Staff ViewPublication Date: 2018-08-18Publisher: American Physical Society (APS)Print ISSN: 0031-9007Electronic ISSN: 1079-7114Topics: PhysicsKeywords: Condensed Matter: Electronic Properties, etc.Published by: -
8C. Richter ; H. Boschker ; W. Dietsche ; E. Fillis-Tsirakis ; R. Jany ; F. Loder ; L. F. Kourkoutis ; D. A. Muller ; J. R. Kirtley ; C. W. Schneider ; J. Mannhart
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-10-08Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
9Chen, Si.-Yi ; Yang, An-Gang ; Chen, Ji-Dai ; Kute, Timothy ; King, C. Richter ; Collier, John ; Cong, Yanping ; Yao, Changping ; Huang, Xue F.
[s.l.] : Nature Publishing Group
Published 1997Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Toxin molecules, such as Pseudomonas exotoxin A (PEA), kill a cell by inactivating the elongation factor-2 (EF-2) in the cytosol2'8, suggesting that mammalian cells can be genetically modified to produce and secrete targeted toxins by using a signal sequence to lead newly synthesized toxins into ...Type of Medium: Electronic ResourceURL: -
10Rosengard, Ariella M. ; Krutzsch, Henry C. ; Shearn, Allen ; Biggs, Joseph R. ; Barker, Edward ; Margulies, Inger M. K. ; King, C. Richter ; Liotta, Lance A. ; Steeg, Patricia S.
[s.l.] : Nature Publishing Group
Published 1989Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The nm23 complementary DNA was identified by differential hybridization to messenger RNA from K-1735 melanoma lines of varying metastatic potentials2; nm23 RNA levels were uniformly reduced in high metastatic potential rodent cell lines (Fig. la). Human infiltrating ductal breast carcinomas from ...Type of Medium: Electronic ResourceURL: -
11King, C. Richter ; Kasprzyk, Philip G. ; Fischer, Paul H. ; Bird, Robert E. ; Turner, Nancy A.
Springer
Published 1996Staff ViewISSN: 1573-7217Keywords: recombinant immunotoxins ; erbB-2 ; pharmacokinetics ; toxicitySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The performance of OLX-209 indicates it should enter phase I clinical testing. OLX-209 is a recombinant toxin targeting theerbB-2 oncoprotein. The design of OLX-209 takes advantage of improvements in immunotoxin technology to produce a molecule that is smaller and more potent than a conventional chemically linked antibody-toxin conjugate. The targeting portion of OLX-209 is a single chain antibody structure derived from the anti-erbB-2 hybridoma, e23. This antibody has unusual specificity in that it does not bind to most normal tissue including peripheral nerve or kidney tissue. Preclinical testing showsin vitro activity against breast cancer cell lines in the pM range. Efficacy testing in five models of human cancer indicates that a dose of 43 µg/kg causes reproducible tumor regressions. Efficacy can be achieved on a variety of schedules of administration. The effective dose results in no measurable change in serum liver enzymes when delivered to mice or primates. The LD10 is over twice the effective dose in mice. The pharmacokinetics indicate a t1/2 of 50 minutes for both mice and cynomolgus monkeys. Serum concentrations of more than ten times those observed at the effective dose can be achieved in monkeys with no evidence of toxicity. Antigenicity of OLX-209 is surprisingly low. These results form the basis for the clinical testing phase for OLX-209.Type of Medium: Electronic ResourceURL: -
12Staff View
ISSN: 1573-3904Keywords: cyclic peptides ; inhibitors ; N-chloroacetyl peptide ; signal transduction ; solid-phase peptide synthesisSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyNotes: Summary One of the critical intracellular signaling pathways involves specific interactions between growth factor receptors and the adaptor protein Grb2. These interactions normally involve specific tyrosine phosphorylated regions in receptors and other cognate proteins. Following the lead of our recent findings that a phage library based non-phosphorylated disulfide linked 11-mer peptide inhibited such interactions, we report here the synthesis of novel redox-stable cyclic peptide analogs. These include thioether cyclized and backbone cyclized structures. The thioether analog was prepared under mild conditions from an N-terminally chloroacetylated and C-terminally cysteine extended peptide precursor. The thioether peptide showed equipotent binding affinity for the Grb2-SH2 domain (IC50=10–15 μM) when compared to the disulfide cyclized lead-peptide. The bioactive thioether linked peptide was demonstrated to offer advantages to the disulfide cyclized peptides under physiological conditions.Type of Medium: Electronic ResourceURL: -
13Staff View
ISSN: 1573-3904Keywords: cyclic peptides ; inhibitors ; N-chloroacetyl peptide ; solid-phase peptide synthesisSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyNotes: Abstract One of the critical intracellular signaling pathways involves specific interactions between growth factor receptors and the adaptor protein Grb2. These interactions normally involve specific tyrosine phosphorylated regions in receptors and other cognate proteins. Following the lead of our recent findings that a phage library based non-phosphorylated disulfide linked 11-mer peptide inhibited such interactions, we report here the synthesis of novel redox-stable cyclic peptide analogs. These include thioether cyclized and backbone cyclized structures. The thioether analog was prepared under mild conditions from an N-terminally chloroacetylated and C-terminally cysteine extended peptide precursor. The thioether peptide showed equipotent binding affinity for the Grb2-SH2 domain (IC50 = 10–15 μM) when compared to the disulfide cyclized lead-peptide. The bioactive thioether linked peptide was demonstrated to offer advantages to the disulfide cyclized peptides under physiological conditions.Type of Medium: Electronic ResourceURL: -
14Staff View
Type of Medium: OnlinePublication Date: 2013Keywords: Kompetenz ; Hauptschule ; Realschule ; Lernaufgabe ; PhysikunterrichtIn: Bernholt, Sascha (Hrsg.), Inquiry-based Learning - Forschendes Lernen., Kiel: IPN-Verlag (2013), S. 644-646, 978-3-89088-360-1Language: German -
15Staff View
Type of Medium: articlePublication Date: 2008Keywords: Erziehung ; Bewegung (Pol) ; Sozialerziehung ; Kinder- und Jugendsport ; Olympische Idee ; Schulsport ; Sport ; Sportpädagogik ; Sportunterricht ; SportwissenschaftIn: Lichamelijke opvoeding, Bd. 96 (2008) H. 3, S. 8-10, 0024-2810Language: Dutch -
16M. Stein, C. Lammers, P.-H. Richter, C. Fuchs, W. Stolz, M. Koch, O. Vänskä, M. J. Weseloh, M. Kira, and S. W. Koch
American Physical Society (APS)
Published 2018Staff ViewPublication Date: 2018-03-27Publisher: American Physical Society (APS)Print ISSN: 1098-0121Electronic ISSN: 1095-3795Topics: PhysicsKeywords: Semiconductors II: surfaces, interfaces, microstructures, and related topicsPublished by: -
17R. C. Nieuwendaal, D. M. De; Longchamp, L. J. Richter, C. R. Snyder, R. L. Jones, S. Engmann, A. Herzing, M. Heeney, Z. Fei, A. B. Sieval, and J. C. Hummelen
American Physical Society (APS)
Published 2018Staff ViewPublication Date: 2018-07-14Publisher: American Physical Society (APS)Print ISSN: 0031-9007Electronic ISSN: 1079-7114Topics: PhysicsKeywords: Condensed Matter: Structure, etc.Published by: -
18Dura, J. A. ; Richter, C. A. ; Majkrzak, C. F. ; Nguyen, N. V.
Woodbury, NY : American Institute of Physics (AIP)
Published 1998Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: We present here a comparison of neutron reflectometry, x-ray reflectometry, and spectroscopic ellipsometry on a thin oxide film. These three probes each independently determine the structure of the film as a function of depth. We find an excellent agreement between the three techniques for measurements of thicknesses and interfacial roughnesses for both the SiO2 and surface contamination layers found in the sample. Realistic models based on interface parameters measured herein indicate that as the SiO2 layers decrease to sizes projected for future generations of electronic devices, both spectroscopic ellipsometry and neutron reflectometry can easily measure SiO2 films to 2 nm thick or less.Type of Medium: Electronic ResourceURL: -
19Dura, J. A. ; Pellegrino, J. G. ; Richter, C. A.
Woodbury, NY : American Institute of Physics (AIP)
Published 1996Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: To explore the role of interface scattering in high electron mobility transistor (HEMT) device performance, a series of samples consisting of both a superlattice and a HEMT structure were grown by molecular beam epitaxy (MBE) at temperatures ranging from 500 to 630 °C. Hall measurements indicate a trend toward higher mobilities in samples grown at higher temperatures. Subsequent x-ray reflectivity measurements were made, and the data were fitted by least-squares refinement of a calculated reflectivity curve determined from a model of the sample structure to obtain the composition profile along the growth direction. These results indicate smoother interfaces for the samples with higher mobilities. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
20Cho, Yong Jai ; Nguyen, N. V. ; Richter, C. A. ; Ehrstein, J. R.
Woodbury, NY : American Institute of Physics (AIP)
Published 2002Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: The optical properties of a set of high-k dielectric HfO2 films annealed at various high temperatures were determined by spectroscopic ellipsometry. The results show that the characteristics of the dielectric functions of these films are strongly affected by high temperature annealing. For a sample annealed at 600 °C, the film becomes polycrystalline, and its dielectric function displays a distinctive peak at 5.9 eV. On the other hand, the film remains amorphous without the 5.9 eV feature after 500 °C annealing. To model the dielectric functions, the Tauc–Lorentz dispersion was successfully adopted for these amorphous and polycrystalline films. The absorption edge was observed to shift to a higher energy at a high temperature annealing. Defects in the films were shown to relate to the appearance of a band tail above the absorption edge, and they appear to diminish with high temperature annealing. © 2002 American Institute of Physics.Type of Medium: Electronic ResourceURL: