Search Results - (Author, Cooperation:C. Nicholas)
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1Sturgess, Nicholas C. ; Carrington, Christine A. ; Hales, C. Nicholas ; Ashford, Michael L. J.
Springer
Published 1987Staff ViewISSN: 1432-2013Keywords: Nucleotides ; Insulin-secretion ; Sulphonylureas ; Human cells ; Cation channelsSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Cells from a human insulin producing tumour have been studied and single channel currents recorded. We have observed three main cation-selective channels in excised patch experiments. An ATP-sensitive potassium channel is present the activity of which can be inhibited by the oral hypoglycaemic drug, tolbutamide. A calcium-activated nonselective cation channel, which is inhibited by AMP could also be seen. In addition a large conductance potassium selective channel, possibly the “maxi” calcium-activated potassium channel is present in these cells.Type of Medium: Electronic ResourceURL: -
2Asker, John [Verfasser] ; Grosskopf, Brit ; McKinney, C. Nicholas ; Niederle, Muriel ; Roth, Alvin E. ; Weizsaecker, Georg
Published 2004Staff ViewType of Medium: articlePublication Date: 2004Keywords: Didaktik ; Experiment ; Auktion ; Wirtschaftskunde ; Wirtschaftspädagogik ; TheorieIn: The journal of economic education, Bd. 35 (2004) H. 4, S. 330-342, 0022-0485Language: English -
3J. L. Metcalf ; Z. Z. Xu ; S. Weiss ; S. Lax ; W. Van Treuren ; E. R. Hyde ; S. J. Song ; A. Amir ; P. Larsen ; N. Sangwan ; D. Haarmann ; G. C. Humphrey ; G. Ackermann ; L. R. Thompson ; C. Lauber ; A. Bibat ; C. Nicholas ; M. J. Gebert ; J. F. Petrosino ; S. C. Reed ; J. A. Gilbert ; A. M. Lynne ; S. R. Bucheli ; D. O. Carter ; R. Knight
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-12-15Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Bacteria/classification/*metabolism ; Biodegradation, Environmental ; *Cadaver ; Ecosystem ; Fungi/classification/*metabolism ; Mice ; *Microbial Consortia ; Nitrogen Cycle ; Soil/chemistry/classification ; *Soil MicrobiologyPublished by: -
4Meyer, Linda A. ; Wardrop, James L. ; Linn, Robert L. ; Hastings, C. Nicholas
Bloomington, Ill. : Periodicals Archive Online (PAO)
Published 1993Staff ViewISSN: 0022-0671Topics: EducationURL: -
5Staff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Poor fetal growth is linked with long-term detrimental effects on health in adulthood. Here we investigate whether the lifespan of male mice is affected by their growth rate when they were suckling and find that limiting growth during that period not only increases longevity but also protects ...Type of Medium: Electronic ResourceURL: -
6Staff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsType of Medium: Electronic ResourceURL: -
7Nicholson, Linda K. ; Yamazaki, Toshimasa ; Torchia, Dennis A. ; Grzesiek, Stephan ; Bax, Ad ; Stahl, Stephen J. ; Kaufman, Joshua D. ; Wingfield, Paul T. ; Lam, Patrick Y.S ; Jadhav, Prabhakar K. ; Hodge, C. Nicholas ; Domaille, Peter J. ; Chang, Chong-Hwan
[s.l.] : Nature Publishing Group
Published 1995Staff ViewISSN: 1072-8368Source: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] HIV protease is a homodimeric protein whose activity is essential to viral function. We have investigated the molecular dynamics of the HIV protease, thought to be important for proteinase function, bound to high affinity inhibitors using NMR techniques. Analysis of 15N spin relaxation parameters, ...Type of Medium: Electronic ResourceURL: -
8Staff View
ISSN: 1573-4935Source: Springer Online Journal Archives 1860-2000Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
9Staff View
ISSN: 1573-0662Keywords: Hydrogen peroxide ; organic hydroperoxides ; hydroxymethyl hydroperoxide ; ozone ; biogenic hydrocarbons ; alkenesSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyGeosciencesNotes: Abstract The formation and occurrence of hydroperoxides in the troposphere have been studied by laboratory experiments and by preliminary field measurements. Nine alkenes were reacted individually with ozone in a reaction chamber in the presence of excess water, and the amounts of hydrogen peroxide and of nine organic hydroperoxides produced in the gas and aerosol phases and deposited on the chamber walls determined by HPLC. The reactions of ethene, propene, 1-butene and isoprene gave hydroxymethyl hydroperoxide as the major product with no hydrogen peroxide observed. In the case of α- and β-pinene, 2-carene and limonene the major product was hydrogen peroxide. Cis-2-butene produced hydrogen peroxide and methyl hydroperoxide. Preliminary measurements of hydrogen peroxide and five organic hydroperoxides in ambient air were made at Niwot Ridge, Colorado from 24 July–4 August 1989. The gas-phase species were preconcentrated by cryotrapping with subsequent HPLC separation. The gas-phase concentrations of H2O2 ranged from 0.5–2 ppbv with the lowest concentrations being measured at night and the highest under conditions of strong photochemical activity. The maximum concentrations of hydroxymethyl hydroperoxide approximated those of H2O2. Methyl hydroperoxide concentrations ranged from 〈50 to 800 pptv and three other organic hydroperoxides were detected at concentrations below 200 pptv. High volume aerosol samples yielded H2O2 and methyl hydroperoxide concentrations 〈10 ng m-3 while H2O2 and six organic species were detected in rainwater at concentrations in the range 〈0.01–50 μM.Type of Medium: Electronic ResourceURL: -
10Staff View
ISSN: 0887-3585Keywords: computer simulation ; metalloenzymes ; protein/ligand interactions ; rational drug design ; substrate docking ; Chemistry ; Biochemistry and BiotechnologySource: Wiley InterScience Backfile Collection 1832-2000Topics: MedicineNotes: We used molecular dynamics computer simulation to “fly” a small flexible ligand, L-leucine hydroxamic acid, into the active site of thermolysin. The potential, which imposed no constraints between protein and ligand, produced conformations close to the crystallographically determined one. The calculations made use of the combined molecular mechanics/grid method of Luty et al. (J. Comp. Chem. 16:454-464, 1995), in which atoms of the active site are free to move whereas the rest of the protein, assumed to be rigid, is represented as points of a grid, and which also includes an implicit solvation model. The method is sufficiently fast that large sets of simulations could be carried out, enabling statistical sampling and exploration of the effect of initial position and conformation of the ligand on the probability of successful docking. In a charged catalytic Glu/uncharged ligand regime, when the initial position of the ligand was determined by random translations and rotations that kept the center of mass within 8.0 Å of the crystal one, none of the 20 runs placed the ligand correctly. In a second set with uncharged Glu and zwitterionic ligand, 3 of 24 similarly placed random structures flew the ligand in successfully. In a third set with the same protonation scheme as the second the starting positions had randomly determined conformations but kept the hydroxyamate oxygens within 4.0 Å of the zinc; in this case 22 of 25 runs reoriented correctly. A diverse set of energetic, structural, and dynamic criteria was used for evaluation of the calculations. The results indicate the method to be a promising tool for the rational drug design process.Additional Material: 8 Ill.Type of Medium: Electronic Resource -
11Staff View
ISSN: 0268-2605Keywords: Tropospheric chemistry ; lifetimes ; dimethyl sulphide ; reduced sulphur compounds ; hydroxyl ; nitrate ; iodoxyl radicals ; Chemistry ; Organic ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyNotes: Dimethyl sulphide and other reduced sulphur compounds, produced by marine biogenic activity and other processes, play a significant role in the global biogeochemical cycling of the element. The rates of their reactions with atmospheric oxidants are reviewed and their lifetimes in the troposphere due to the various reactions are computed. Sufficient data are available on the tropospheric abundance of the hydroxyl radical (OH) and on the rates of its reactions with the sulphur compounds for reasonable estimates to be made of the sulphur lifetimes with respect to OH. Summertime lifetimes of 14-87 h for (CH3)2S are computed at different latitudes. In the case of the tropospheric concentrations of the nitrate radical (NO3), few data are available. There is a similar paucity of data on its rates of reactions with the sulphur compounds, and so large uncertainties exist in the computed lifetimes. These are, in any case, much longer than those due to OH. The possibility exists that iodine photochemistry, producing iodoxyl (IO) radicals, may efficiently oxidize the reduced sulphur and other organic compounds in the marine troposphere leading to lifetimes of the order of hours. Few data exist on the rates or mechanisms of these reactions and these are identified as representing the greatest uncertainties in the estimates of organosulphur lifetimes in the troposphere.Additional Material: 2 Tab.Type of Medium: Electronic ResourceURL: -
12Staff View
ISSN: 0268-2605Keywords: Organolead emissions ; vehicle exhaust ; Chemistry ; Organic ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyNotes: Species-specific measurements of the five tetraalkyllead compounds used in gasoline and their intermediate decomposition products, the tri- and di-alkyllead species, have been made in vehicle exhaust fumes. Under normal engine running conditions 0.3-3% of the lead emitted in exhaust is as an organic compound, but cold, choked engines emit proportionally much larger amounts of alkyllead. Alkyllead is emitted in both the gas and the aerosol phases.Additional Material: 2 Ill.Type of Medium: Electronic ResourceURL: -
13Luty, Brock A. ; Wasserman, Zelda R. ; Stouten, Pieter F. W. ; Hodge, C. Nicholas ; Zacharias, Martin ; McCammon, J. Andrew
New York, NY [u.a.] : Wiley-Blackwell
Published 1995Staff ViewISSN: 0192-8651Keywords: Computational Chemistry and Molecular Modeling ; BiochemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyComputer ScienceNotes: We present a computational method for prediction of the conformation of a ligand when bound to a macromolecular receptor. The method is intended for use in systems in which the approximate location of the binding site is known and no large-scale rearrangements of the receptor are expected upon formation of the complex. The ligand is initially placed in the vicinity of the binding site and the atomic motions of the ligand and binding site are explicitly simulated, with solvent represented by an implicit solvation model and using a grid representation for the bulk of the receptor protein. These two approximations make the method computationally efficient and yet maintain accuracy close to that of an all-atom calculation. For the benzamidine/trypsin system, we ran 100 independent simulations, in many of which the ligand settled into the low-energy conformation observed in the crystal structure of the complex. The energy of these conformations was lower than and well-separated from that of others sampled. Extensions of this method are also discussed. © 1995 by John Wiley & Sons, Inc.Additional Material: 4 Ill.Type of Medium: Electronic ResourceURL: -
14Peters, Michael [Verfasser] ; Burbules, Nicholas C. [Verfasser]
Lanham : Rowman & Littlefield
Published 2004Staff ViewType of Medium: bookPublication Date: 2004Keywords: Bildungsforschung ; PoststrukturalismusLanguage: EnglishNote: Literaturangaben -
15Debatte - Discussion: Coronation or Educona? Pardon me?!? : Coroziehung oder Erzierona? Wie bitte?!?Bostad, Inga [Verfasser] ; Burbules, Nicholas C. [Verfasser] ; Harford, Judith [Verfasser] ; Hutt, Ethan [Verfasser] ; Ideland, Malin [Verfasser] ; Proctor, Helen [Verfasser] ; Ricken, Norbert [Verfasser] ; Simons, Maarten [Verfasser]
Published 2021Staff ViewType of Medium: articlePublication Date: 2021Keywords: Bildungsgeschichte ; Historiografie ; COVID-19 ; PandemieIn: Bildungsgeschichte, Bd. 11 (2021) H. 1, S. 55-81, 2192-4295Language: English -
16Silberman Keller, Diana [Hrsg.] ; Bekerman, Zvi [Hrsg.] ; Giroux, Henry A. [Hrsg.] ; Burbules, Nicholas C. [Hrsg.]
New York, NY u.a. : Lang
Published 2008Staff ViewType of Medium: bookPublication Date: 2008Keywords: Bildung ; Erziehung ; Kultur ; Film ; Filmanalyse ; Mediennutzung ; Medienwirkung ; Cultural Studies ; Lernen ; Computerspiel ; Interaktives Lernen ; GeschichtsunterrichtLanguage: EnglishNote: Tabellen -
17Kohli, Wendy Reva [Verfasser] ; Burbules, Nicholas C. [Verfasser]
Lanham, Md. : Rowman & Littlefield
Published 2012Staff ViewType of Medium: bookPublication Date: 2012Keywords: Pädagogik ; Feminismus ; WissenschaftsentwicklungLanguage: English -
18Ali, Saba Rasheed [Verfasser] ; Martens, Jessica Kelly [Verfasser] ; Button, Christopher [Verfasser] ; Larma, Nicholas C. [Verfasser]
Published 2011Staff ViewType of Medium: articlePublication Date: 2011Keywords: Messung ; Karriereplanung ; Student ; USAIn: Journal of career development, Bd. 38 (2011) H. 2, S. 128-146, 0894-84531556-08561573-3548Language: English -
19Staff View
Type of Medium: articlePublication Date: 2015Keywords: Forschung ; Bildungsgeschichte ; Fachzeitschrift ; Zitat ; Geschichte (Histor) ; 21. Jahrhundert ; Aufgabe ; Datum ; Fußnote ; NameIn: Paedagogica historica, Bd. 51 (2015) H. 6, S. [716]-726, 0030-92301477-674XLanguage: EnglishNote: Literaturangaben -
20Staff View
Type of Medium: bookPublication Date: 1993Keywords: Kommunikation ; Didaktik ; Unterrichtsstil ; SpracheLanguage: EnglishNote: Literaturangaben S. 167-177